G. David Roodman

  • 23227 Citations
  • 80 h-Index
1975 …2020
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Publications 1975 2019

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358 Citations (Scopus)

IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release

Kurihara, N., Bertolini, D., Suda, T., Akiyama, Y. & Roodman, G. D., Jun 1 1990, In : Journal of Immunology. 144, 11, p. 4226-4230 5 p.

Research output: Contribution to journalArticle

Osteoclasts
Interleukin-1
Interleukin-6
Bone Marrow
Calcitriol
44 Citations (Scopus)

Immortalization of osteoclast precursors by targeting bcl-X(L) and Simian Virus 40 large T antigen to the osteoclast lineage in transgenic mice

Hentunen, T. A., Reddy, S. V., Boyce, B. F., Devlin, R., Park, H. R., Chung, H., Selander, K. S., Dallas, M., Kurihara, N., Galson, D. L., Goldring, S. R., Koop, B. A., Windle, J. J. & Roodman, G. D., Jul 1 1998, In : Journal of Clinical Investigation. 102, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

Simian virus 40
Viral Tumor Antigens
Osteoclasts
Transgenic Mice
Bone and Bones
53 Citations (Scopus)

Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia

Pal, R., Monaghan, S. A., Hassett, A. C., Mapara, M. Y., Schafer, P., Roodman, G. D., Ragni, M. V., Moscinski, L., List, A. & Lentzsch, S., Jan 21 2010, In : Blood. 115, 3, p. 605-614 10 p.

Research output: Contribution to journalArticle

Venous Thromboembolism
Neutropenia
Multiple Myeloma
Cathepsin G
Granulocyte Precursor Cells
91 Citations (Scopus)

In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2

Maes, K., Nemeth, E., Roodman, G. D., Huston, A., Esteve, F., Freytes, C., Callander, N., Katodritou, E., Tussing-Humphreys, L., Rivera, S., Vanderkerken, K., Lichtenstein, A. & Ganz, T., Nov 4 2010, In : Blood. 116, 18, p. 3635-3644 10 p.

Research output: Contribution to journalArticle

Hepcidins
Bone Morphogenetic Protein 2
Multiple Myeloma
Anemia
Serum
12 Citations (Scopus)

Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone

Teramachi, J., Zhou, H., Subler, M. A., Kitagawa, Y., Galson, D. L., Dempster, D. W., Windle, J. J., Kurihara, N. & Roodman, G. D., 2014, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 29, 6, p. 1456-1465 10 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Osteoclasts
Interleukin-6
Bone and Bones
Transgenic Mice
39 Citations (Scopus)

Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation

Hiruma, Y., Honjo, T., Jelinek, D. F., Windle, J. J., Shin, J., Roodman, G. D. & Kurihara, N., 2009, In : Blood. 113, 20, p. 4894-4902 9 p.

Research output: Contribution to journalArticle

Cell growth
Osteoclasts
Multiple Myeloma
Stromal Cells
p38 Mitogen-Activated Protein Kinases
27 Citations (Scopus)

Inhibition of erythroid colony formation by autologous bone marrow adherent cells from patients with the anemia of chronic disease

Roodman, G. D., Horadam, V. W. & Wright, T. L., 1983, In : Blood. 62, 2, p. 406-412 7 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Anemia
Bone
Chronic Disease
Bone Marrow
22 Citations (Scopus)

Inhibition of tartrate-resistant acid phosphatase gene expression by hemin and protoporphyrin IX. Identification of a hemin-responsive inhibitor of transcription

Reddy, S. V., Alcantara, O., Roodman, G. D. & Boldt, D. H., Sep 15 1996, In : Blood. 88, 6, p. 2288-2297 10 p.

Research output: Contribution to journalArticle

Hemin
Heroin
Transcription
Acid Phosphatase
Gene expression
40 Citations (Scopus)
Osteoclasts
Interleukin-1
Interferons
Bone Marrow
Granulocyte-Macrophage Progenitor Cells
365 Citations (Scopus)
Interleukin-1
Tumor Necrosis Factor-alpha
Osteoclasts
Bone Resorption
In Vitro Techniques
6 Citations (Scopus)

Interleukin-3: Its biology and potential uses in pediatric hematology/oncology

Sunderland, M. C. & Roodman, G. D., 1991, In : Journal of Pediatric Hematology/Oncology. 13, 4, p. 414-425 12 p.

Research output: Contribution to journalArticle

Interleukin-3
Hematology
Myelopoiesis
Pediatrics
Basophils
148 Citations (Scopus)

Interleukin-6: A potential mediator of the massive osteolysis in patients with Gorham-Stout disease

Devlin, R. D., Bone, H. G. & Roodman, G. D., 1996, In : Journal of Clinical Endocrinology and Metabolism. 81, 5, p. 1893-1897 5 p.

Research output: Contribution to journalArticle

Essential Osteolysis
Interleukin-6
Serum
Bone
Osteoclasts
58 Citations (Scopus)
Giant Cell Tumor of Bone
Giant Cells
Bone Resorption
Interleukin-6
Bone and Bones
303 Citations (Scopus)

Interleukin 6 - A potential autocrine/paracrine factor in Paget's disease of bone

Roodman, G. D., Kurihara, N., Ohsaki, Y., Kukita, A., Hosking, D., Demulder, A., Smith, J. F. & Singer, F. R., 1992, In : Journal of Clinical Investigation. 89, 1, p. 46-52 7 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Osteoclasts
Interleukin-6
Bone Marrow
Conditioned Culture Medium
213 Citations (Scopus)

Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo

De La Mata, J., Uy, H. L., Guise, T., Story, B., Boyce, B. F., Mundy, G. R. & Roodman, G. D., 1995, In : Journal of Clinical Investigation. 95, 6, p. 2846-2852 7 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Hypercalcemia
Bone Resorption
Interleukin-6
Osteoclasts
187 Citations (Scopus)

International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease.

Terpos, E., Morgan, G., Dimopoulos, M. A., Drake, M. T., Lentzsch, S., Raje, N., Sezer, O., García-Sanz, R., Shimizu, K., Turesson, I., Reiman, T., Jurczyszyn, A., Merlini, G., Spencer, A., Leleu, X., Cavo, M., Munshi, N., Rajkumar, S. V., Durie, B. G. M. & Roodman, G. D., Jun 20 2013, In : Journal of Clinical Oncology. 31, 18, p. 2347-2357 11 p.

Research output: Contribution to journalArticle

zoledronic acid
Bone Diseases
Multiple Myeloma
pamidronate
Diphosphonates
183 Citations (Scopus)

Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase

Halleen, J. M., Räisänen, S., Salo, J. J., Reddy, S. V., Roodman, G. D., Hentunen, T. A., Lehenkari, P. P., Kaija, H., Vihko, P. & Väänänen, H. K., Aug 13 1999, In : Journal of Biological Chemistry. 274, 33, p. 22907-22910 4 p.

Research output: Contribution to journalArticle

Bone Resorption
Acid Phosphatase
Reactive Oxygen Species
Bone
Iron
Osteoclasts
Bone Resorption
24 Citations (Scopus)

In utero bone marrow transplantation of fetal baboons with mismatched adult baboon marrow

Roodman, G. D., Kuehl, T. J., Vandeberg, J. L. & Muirhead, D. Y., 1991, In : Blood Cells. 17, 2, p. 367-375 9 p.

Research output: Contribution to journalArticle

Papio
Bone Marrow Transplantation
Fetus
Bone Marrow
Transplantation
12 Citations (Scopus)

In utero bone marrow transplantation of fetal baboons with mismatched adult marrow: Initial observations

Roodman, G. D., Vandeberg, J. L. & Kuehl, T. J., 1988, In : Bone Marrow Transplantation. 3, 2, p. 141-147 7 p.

Research output: Contribution to journalArticle

Papio
Bone Marrow Transplantation
Fetus
Bone Marrow
Pregnancy
4 Citations (Scopus)

In vitro cytotoxicity of hepsulfam against human tumor cell lines and primary human tumor colony forming units

Marshall, M. V., Marshall, M. H., Degen, D. R., Roodman, G. D., Kuhn, J. G., Ross, M. E. & Von Hoff, D. D., 1993, In : Stem Cells. 11, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development

Choi, S. J., Roodman, G. D., Feng, J. Q., Song, I. S., Amin, K., Hart, P. S., Wright, J. T., Haruyama, N. & Hart, T. C., Jan 1 2009, In : Developmental Biology. 325, 1, p. 129-137 9 p.

Research output: Contribution to journalArticle

Sequence Deletion
Bone Development
Transgenic Mice
Genes
Osteoclasts
77 Citations (Scopus)

Involvement of hepcidin in the anemia of multiple myeloma

Sharma, S., Nemeth, E., Chen, Y. H., Goodnough, J., Huston, A., Roodman, G. D., Ganz, T. & Lichtenstein, A., Jun 1 2008, In : Clinical Cancer Research. 14, 11, p. 3262-3267 6 p.

Research output: Contribution to journalArticle

Hepcidins
Multiple Myeloma
Anemia
Interleukin-6
Serum
40 Citations (Scopus)

Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption

Reddy, S., Devlin, R., Menaa, C., Nishimura, R., Choi, S. J., Dallas, M., Yoneda, T. & Roodman, G. D., Dec 1998, In : Journal of Cellular Physiology. 177, 4, p. 636-645 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Resorption
Bone
Complementary DNA
Clone Cells
28 Citations (Scopus)

Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors

Yang, P., Myint, K. Z., Tong, Q., Feng, R., Cao, H., Almehizia, A. A., Alqarni, M. H., Wang, L., Bartlow, P., Gao, Y., Gertsch, J., Teramachi, J., Kurihara, N., Roodman, G. D., Cheng, T. & Xie, X. Q., Nov 26 2012, In : Journal of Medicinal Chemistry. 55, 22, p. 9973-9987 15 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB2
Osteoclasts
Osteogenesis
Biological Assay
Databases
80 Citations (Scopus)

Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer

Murthy, R. V., Arbman, G., Gao, J., Roodman, G. D. & Sun, X. F., Mar 15 2005, In : Clinical Cancer Research. 11, 6, p. 2293-2299 7 p.

Research output: Contribution to journalArticle

asparaginylendopeptidase
Colorectal Neoplasms
Mucous Membrane
Neoplasms
Matrix Metalloproteinase 11
323 Citations (Scopus)

Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma

Choi, S. J., Cruz, J. C., Craig, F., Chung, H., Devlin, R. D., Roodman, G. D. & Alsina, M., Jul 15 2000, In : Blood. 96, 2, p. 671-675 5 p.

Research output: Contribution to journalArticle

Chemokine CCL3
Macrophages
Osteoclasts
Multiple Myeloma
Bone Marrow
256 Citations (Scopus)

Macrophage inflammatory protein-1α is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor κB ligand

Man, J. H., Choi, S. J., Kurihara, N., Koide, M., Oba, Y. & Roodman, G. D., Jun 1 2001, In : Blood. 97, 11, p. 3349-3353 5 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Cytoplasmic and Nuclear Receptors
Osteoclasts
Ligands
Bone Marrow
49 Citations (Scopus)

Management of bone disease in multiple myeloma

Terpos, E., Berenson, J., Raje, N. & Roodman, G. D., Feb 2014, In : Expert Review of Hematology. 7, 1, p. 113-125 13 p.

Research output: Contribution to journalArticle

zoledronic acid
Bone Diseases
Multiple Myeloma
pamidronate
Diphosphonates
13 Citations (Scopus)

Measles virus nucleocapsid protein, a key contributor to Paget's disease, increases IL-6 expression via down-regulation of FoxO3/Sirt1 signaling

Wang, F. M., Sarmasik, A., Hiruma, Y., Sun, Q., Sammut, B., Windle, J. J., Roodman, G. D. & Galson, D. L., Mar 2013, In : Bone. 53, 1, p. 269-276 8 p.

Research output: Contribution to journalArticle

Interleukin-6
Down-Regulation
Osteoclasts
measles virus nucleocapsid protein
Messenger RNA
15 Citations (Scopus)

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget's disease

Teramachi, J., Nagata, Y., Mohammad, K., Inagaki, Y., Ohata, Y., Guise, T., Michou, L., Brown, J. P., Windle, J. J., Kurihara, N. & Roodman, G. D., Mar 1 2016, In : Journal of Clinical Investigation. 126, 3, p. 1012-1022 11 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteoblasts
Bone Resorption
Osteogenesis
Interleukin-6
33 Citations (Scopus)

Measles virus nucleocapsid transcript expression is not restricted to the osteoclast lineage in patients with Paget's disease of bone

Reddy, S. V., Menaa, C., Singer, F. R., Cundy, T., Cornish, J., Whyte, M. P. & Roodman, G. D., Oct 1999, In : Experimental Hematology. 27, 10, p. 1528-1532 5 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Nucleocapsid
Measles virus
Osteoclasts
Viruses
10 Citations (Scopus)

Mechanisms of abnormal bone turnover in Paget's disease

Roodman, G. D., May 1999, In : Bone. 24, 5 SUPPL.

Research output: Contribution to journalArticle

Morbillivirus Infections
Morbillivirus
Osteitis Deformans
Bone Remodeling
Viral RNA
143 Citations (Scopus)

Mechanisms of bone lesions in multiple myeloma and lymphoma

Roodman, G. D., Oct 15 1997, In : Cancer. 80, 8 SUPPL., p. 1557-1563 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Lymphoma
Bone and Bones
Parathyroid Hormone-Related Protein
Adult T Cell Leukemia Lymphoma
1477 Citations (Scopus)

Mechanisms of Bone Metastasis

Roodman, G. D., Apr 15 2004, In : New England Journal of Medicine. 350, 16

Research output: Contribution to journalArticle

Receptor Activator of Nuclear Factor-kappa B
RANK Ligand
Bone Neoplasms
Osteolysis
Bone Remodeling
4 Citations (Scopus)

Mechanisms of bone resorption in myeloma

Roodman, G. D., Dec 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 4, p. 271-272 2 p.

Research output: Contribution to journalArticle

Interleukin-3
Osteoclasts
Bone Resorption
32 Citations (Scopus)

Mechanisms of erythroid suppression in the anemia of chronic disease

Roodman, G. D., 1987, In : Blood Cells. 13, 1-2, p. 171-184 14 p.

Research output: Contribution to journalArticle

Erythroid Precursor Cells
Anemia
Chronic Disease
Macrophages
Tumor Necrosis Factor-alpha
313 Citations (Scopus)

Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma

Alsayed, Y., Ngo, H., Runnels, J., Leleu, X., Singha, U. K., Pitsillides, C. M., Spencer, J. A., Kimlinger, T., Ghobrial, J. M., Jia, X., Lu, G., Timm, M., Kumar, A., Côté, D., Veilleux, I., Hedin, K. E., Roodman, G. D., Witzig, T. E., Kung, A. L., Hideshima, T. & 3 others, Anderson, K. C., Lin, C. P. & Ghobrial, I. M., Apr 1 2007, In : Blood. 109, 7, p. 2708-2717 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone
Confocal microscopy
CXCR4 Receptors
Bioluminescence
89 Citations (Scopus)
Neoplasm Metastasis
Bone and Bones
Bone Neoplasms
Breast Neoplasms
Prostate
82 Citations (Scopus)

Metastasis and bone loss: Advancing treatment and prevention

Coleman, R. E., Lipton, A., Roodman, G. D., Guise, T., Boyce, B. F., Brufsky, A. M., Clézardin, P., Croucher, P. I., Gralow, J. R., Hadji, P., Holen, I., Mundy, G. R., Smith, M. R. & Suva, L. J., Dec 2010, In : Cancer Treatment Reviews. 36, 8, p. 615-620 6 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Bone and Bones
Neoplasms
Therapeutics
Research
59 Citations (Scopus)

MIP-1α (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma

Masih-Khan, E., Trudel, S., Heise, C., Li, Z., Paterson, J., Nadeem, V., Wei, E., Roodman, G. D., Claudio, J. O., Bergsagel, P. L. & Stewart, A. K., Nov 15 2006, In : Blood. 108, 10, p. 3465-3471 7 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 3
Chemokine CCL3
Multiple Myeloma
Bone Diseases
Gene expression
114 Citations (Scopus)

MIP-1α utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells

Oba, Y., Lee, J. W., Ehrlich, L. A., Chung, H. Y., Jelinek, D. F., Callander, N. S., Horuk, R., Choi, S. J. & Roodman, G. D., Mar 2005, In : Experimental Hematology. 33, 3, p. 272-278 7 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Osteoclasts
Stromal Cells
Cell Adhesion
Bone Marrow
3 Citations (Scopus)

Mixed lymphocyte culture reactivity of fetal baboons: Application for in utero bone marrow transplantation

Muirhead, D. Y., Kuehl, T. J., Vandeberg, J. L., Menchaca, E. M., Downs, M. P. & Roodman, G. D., 1990, In : Bone Marrow Transplantation. 6, 4, p. 263-267 5 p.

Research output: Contribution to journalArticle

Papio
Bone Marrow Transplantation
Lymphocytes
Fetus
Transplants
1 Citation (Scopus)

Model systems of osteoclast differentiation

Roodman, G. D., Dec 1988, In : Journal of Bone and Mineral Metabolism. 6, 3, p. 1-11 11 p.

Research output: Contribution to journalArticle

Osteoclasts
77 Citations (Scopus)

Monoclonal gammopathy of undetermined significance: A consensus statement: Guideline

Berenson, J. R., Anderson, K. C., Audell, R. A., Boccia, R. V., Coleman, M., Dimopoulos, M. A., Drake, M. T., Fonseca, R., Harousseau, J. L., Joshua, D., Lonial, S., Niesvizky, R., Palumbo, A., Roodman, G. D., San-Miguel, J. F., Singhal, S., Weber, D. M., Zangari, M., Wirtschafter, E., Yellin, O. & 1 others, Kyle, R. A., Jul 2010, In : British Journal of Haematology. 150, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Guidelines
Paraproteinemias
B-Lymphocytes
Metabolic Bone Diseases
125 Citations (Scopus)

Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption

Lu, Y., Cai, Z., Xiao, G., Keller, E. T., Mizokami, A., Yao, Z., Roodman, G. D. & Zhang, J., Apr 15 2007, In : Cancer Research. 67, 8, p. 3646-3653 8 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Chemokine CCL2
Bone Resorption
Prostatic Neoplasms
Interleukin-8
61 Citations (Scopus)

Multinucleated cells formed in vitro from Paget's bone marrow express viral antigens

Mills, B. G., Frausto, A., Singer, F. R., Ohsaki, Y., Demulder, A. & Roodman, G. D., 1994, In : Bone. 15, 4, p. 443-448 6 p.

Research output: Contribution to journalArticle

Viral Antigens
Osteoclasts
Bone Marrow
Measles
Viruses
68 Citations (Scopus)

Multiple myeloma.

Anderson, K. C., Shaughnessy, J. D., Barlogie, B., Harousseau, J. L. & Roodman, G. D., 2002, In : Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. p. 214-240 27 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Transplantation
Bone Diseases
Cell Communication
Therapeutics
3 Citations (Scopus)

Multiple myeloma and bone: The fatal interaction

Marino, S. & Roodman, G. D., Aug 1 2018, In : Cold Spring Harbor perspectives in medicine. 8, 8, a031286.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone
Bone and Bones
Bone Diseases
Spontaneous Fractures
207 Citations (Scopus)

Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition

Giuliani, N., Rizzoli, V. & Roodman, G. D., Dec 15 2006, In : Blood. 108, 13, p. 3992-3996 5 p.

Research output: Contribution to journalArticle

Bone Diseases
Osteoblasts
Multiple Myeloma
Bone
Bone and Bones