G. David Roodman

  • 23227 Citations
  • 80 h-Index
1975 …2020
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Publications 1975 2019

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25 Citations (Scopus)

Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease

Fu, J., Li, S., Feng, R., Ma, H., Sabeh, F., Roodman, G. D., Wang, J., Robinson, S., Guo, X. E., Lund, T., Normolle, D., Mapara, M. Y., Weiss, S. J. & Lentzsch, S., May 2 2016, In : Journal of Clinical Investigation. 126, 5, p. 1759-1772 14 p.

Research output: Contribution to journalArticle

Osteoclasts
Matrix Metalloproteinases
Multiple Myeloma
Bone Diseases
Matrix Metalloproteinase 13
90 Citations (Scopus)

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease

Kurihara, N., Hiruma, Y., Zhou, H., Subler, M. A., Dempster, D. W., Singer, F. R., Reddy, S. V., Gruber, H. E., Windle, J. J. & Roodman, G. D., Jan 4 2007, In : Journal of Clinical Investigation. 117, 1, p. 133-142 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteogenesis
Mutation
Genes
Bone Remodeling
123 Citations (Scopus)

Myeloma bone disease

Callander, N. S. & Roodman, G. D., 2001, In : Seminars in Hematology. 38, 3, p. 276-285 10 p.

Research output: Contribution to journalArticle

Bone Diseases
RANK Ligand
Chemokine CCL3
Stromal Cells
Interleukin-6
26 Citations (Scopus)

Myeloma bone disease: Pathophysiology and management

Silbermann, R. & Roodman, G. D., Jun 2013, In : Journal of Bone Oncology. 2, 2, p. 59-69 11 p.

Research output: Contribution to journalArticle

Bone Diseases
Osteoclasts
Disease Management
Osteoblasts
Bone and Bones
9 Citations (Scopus)
Bone Diseases
Multiple Myeloma
Research
Therapeutics
Transplantation
333 Citations (Scopus)

Myeloma management guidelines: A consensus report from the Scientific Advisors of the International Myeloma Foundation

Durie, B. G. M., Kyle, R. A., Belch, A., Bensinger, W., Blade, J., Boccadoro, M., Child, J. A., Comenzo, R., Djulbegovic, B., Fantl, D., Gahrton, G., Harousseau, J. L., Hungria, V., Joshua, D., Ludwig, H., Mehta, J., Morales, A. R., Morgan, G., Nouel, A., Oken, M. & 9 others, Powles, R., Roodman, G. D., San Miquel, J., Shimizu, K., Singhal, S., Sirohi, B., Sonneveld, P., Tricot, G. & Van Ness, B., 2003, In : Hematology Journal. 4, 6, p. 379-398 20 p.

Research output: Contribution to journalArticle

Guidelines
Expert Testimony
Therapeutics
Internet
Databases
150 Citations (Scopus)

New drugs and novel mechanisms of action in multiple myeloma in 2013: A report from the International Myeloma Working Group (IMWG)

Ocio, E. M., Richardson, P. G., Rajkumar, S. V., Palumbo, A., Mateos, M. V., Orlowski, R., Kumar, S., Usmani, S., Roodman, G. D., Niesvizky, R., Einsele, H., Anderson, K. C., Dimopoulos, M. A., Avet-Loiseau, H., Mellqvist, U. H., Turesson, I., Merlini, G., Schots, R., Mccarthy, P., Bergsagel, L. & 14 others, Chim, C. S., Lahuerta, J. J., Shah, J., Reiman, A., Mikhael, J., Zweegman, S., Lonial, S., Comenzo, R., Chng, W. J., Moreau, P., Sonneveld, P., Ludwig, H., Durie, B. G. M. & Miguel, J. F. S., 2014, In : Leukemia. 28, 3, p. 525-542 18 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Pharmaceutical Preparations
Dexamethasone
Unfolded Protein Response
Kinesin

New opportunities for the management of cancer-related bone complications.

Lipton, A., Brown, G. A., Mundy, G. R., Roodman, G. D. & Smith, M. R., May 2009, In : Clinical Advances in Hematology and Oncology. 7, 5 Suppl 11

Research output: Contribution to journalArticle

Bone Density Conservation Agents
Bone Neoplasms
Metabolic Bone Diseases
Bone Fractures
Osteogenesis
29 Citations (Scopus)

New potential targets for treating myeloma bone disease

Roodman, G. D., Berenson, Clohisy, Bruland, Suva & Weilbaecher, Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2

Research output: Contribution to journalArticle

Bone Diseases
Osteoblasts
Interleukin-3
Osteoclasts
Osteogenesis
49 Citations (Scopus)

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation

Nguyen, A. N., Stebbins, E. G., Henson, M., O'Young, G., Choi, S. J., Quon, D., Damm, D., Reddy, M., Ma, J. Y., Haghnazari, E., Kapoun, A. M., Medicherla, S., Protter, A., Schreiner, G. F., Kurihara, N., Anderson, J., Roodman, G. D., Navas, T. A. & Higgins, L. S., Jun 10 2006, In : Experimental Cell Research. 312, 10, p. 1909-1923 15 p.

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Cell Adhesion
Bone Marrow
Cell Proliferation
7 Citations (Scopus)

Novel approaches in the management of myeloma-related skeletal complications

Reddy, G. K., Mughal, T. I. & Roodman, G. D., Oct 2006, In : Supportive Cancer Therapy. 4, 1, p. 15-18 4 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone Neoplasms
Bone Diseases
Diphosphonates
Neoplasm Metastasis
20 Citations (Scopus)

Novel targets for myeloma bone disease

Roodman, G. D., Nov 2008, In : Expert Opinion on Therapeutic Targets. 12, 11, p. 1377-1387 11 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Bone
Bone and Bones
Clinical Trials
3 Citations (Scopus)

Nutritional parameters observed during 28-day infusion of recombinant human tumor necrosis factor-α

Hardin, T. C., Koeller, J. M., Kuhn, J. G., Roodman, G. D. & Von Hoff, D. D., 1993, In : Journal of Parenteral and Enteral Nutrition. 17, 6, p. 541-545 5 p.

Research output: Contribution to journalArticle

tumor necrosis factors
resting energy expenditure
Energy Metabolism
Serum
Indirect Calorimetry
24 Citations (Scopus)

Optimal use of bisphosphonates in patients with multiple myeloma.

Terpos, E., Roodman, G. D. & Dimopoulos, M. A., Apr 25 2013, In : Blood. 121, 17, p. 3325-3328 4 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Osteoblast function in myeloma

Roodman, G. D., Jan 1 2011, In : Bone. 48, 1, p. 135-140 6 p.

Research output: Contribution to journalArticle

Osteoblasts
Multiple Myeloma
Bone Diseases
Osteogenesis
Bone and Bones
28 Citations (Scopus)

Osteoclast differentiation

Roodman, G. D., 1991, In : Critical Reviews in Oral Biology and Medicine. 2, 3, p. 389-409 21 p.

Research output: Contribution to journalArticle

Osteoclasts
Cell Differentiation
5 Citations (Scopus)

Osteoclast differentiation and activity

Roodman, G. D., 1998, In : Biochemical Society Transactions. 26, 1, p. 7-13 7 p.

Research output: Contribution to journalArticle

Osteoclasts
1 Citation (Scopus)

Osteoclast function in healthy subjects and in patients with Paget's disease

Wirfel, K. L., Bruder, J. M., Vardag, A. & Roodman, G. D., 1999, In : Endocrinologist. 9, 4, p. 263-269 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Healthy Volunteers
Osteoporosis
Bone Resorption
Osteogenesis
40 Citations (Scopus)

Osteoclast function in Paget's disease and multiple myeloma

Roodman, G. D., 1995, In : Bone. 17, 2 SUPPL. 1

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Interleukin-6
Bone Marrow
Bone Resorption
27 Citations (Scopus)
Osteoclasts
Peptides
asparaginylendopeptidase
RANK Ligand
Enzymes
664 Citations (Scopus)

Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures

Takahashi, N., Yamana, H., Yoshiki, S., Roodman, G. D., Roodman, G. D., Jones, S. J., Boyde, A. & Suda, T., 1988, In : Endocrinology. 122, 4, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Marrow
Hormones
Carboxylesterase
salmon calcitonin
21 Citations (Scopus)
Papio
Calcitriol
Osteoclasts
Bone Marrow
Granulocyte-Macrophage Progenitor Cells
41 Citations (Scopus)

Osteoclast-like cells formed in long-term human bone marrow cultures express a similar surface phenotype as authentic osteoclasts

Kukita, T., McManus, L. M., Miller, M., Civin, C. & Roodman, G. D., 1989, In : Laboratory Investigation. 60, 4, p. 532-538 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Marrow
Phenotype
Antigens
Bone and Bones
61 Citations (Scopus)

Osteoclast-like cells form in long-term human bone marrow but not in peripheral blood cultures

Takahashi, N., Kukita, T., MacDonald, B. R., Bird, A., Mundy, G. R., McManus, L. M., Miller, M., Boyde, A., Jones, S. J. & Roodman, G. D., 1989, In : Journal of Clinical Investigation. 83, 2, p. 543-550 8 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Marrow
Monocytes
Sperm Whale
Blood Culture
103 Citations (Scopus)

Osteoclasts are important for bone angiogenesis

Cackowski, F. C., Anderson, J. L., Patrene, K. D., Choksi, R. J., Shapiro, S. D., Windle, J. J., Blair, H. C. & Roodman, G. D., Jan 7 2010, In : Blood. 115, 1, p. 140-149 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone
Bone and Bones
Matrix Metalloproteinase 9
Parathyroid Hormone-Related Protein
104 Citations (Scopus)

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

Kurihara, N., Reddy, S. V., Menaa, C., Anderson, D. & Roodman, G. D., Mar 2000, In : Journal of Clinical Investigation. 105, 5, p. 607-614 8 p.

Research output: Contribution to journalArticle

Nucleocapsid
Measles virus
Osteoclasts
Phenotype
Genes
61 Citations (Scopus)

Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts

Reddy, S. V., Kurihara, N., Menaa, C., Landucci, G., Forthal, D., Koop, B. A., Windle, J. J. & Roodman, G. D., 2001, In : Endocrinology. 142, 7, p. 2898-2905 8 p.

Research output: Contribution to journalArticle

Measles virus
Osteoclasts
Transgenic Mice
Virus Diseases
Bone Marrow
16 Citations (Scopus)

Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption

Dossa, T., Arabian, A., Windle, J. J., Dedhar, S., Teitelbaum, S. L., Ross, F. P., Roodman, G. D. & St-Arnaud, R., Jul 1 2010, In : Journal of Cellular Biochemistry. 110, 4, p. 960-967 8 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Resorption
Bone
Integrins
Alleles
11 Citations (Scopus)

Osteoclasts Pump Iron

Roodman, G. D., May 6 2009, In : Cell Metabolism. 9, 5, p. 405-406 2 p.

Research output: Contribution to journalArticle

Osteoclasts
Iron
Bone Matrix
Organelle Biogenesis
Transferrin
37 Citations (Scopus)

Osteoinductive factor inhibits formation of human osteoclast-like cells

Kukita, A., Bonewald, L., Rosen, D., Seyedin, S., Mundy, G. R. & Roodman, G. D., Apr 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 8, p. 3023-3026 4 p.

Research output: Contribution to journalArticle

Osteoclasts
Transforming Growth Factors
Bone Matrix
Osteogenesis
Bone and Bones
2 Citations (Scopus)

Pagetic osteoclasts formed in vitro: Absence of paracrystalline inclusions

Roodman, G. D., Ohsaki, Y., Miller, M. M., Demulder, A., Hosking, D., Singer, F. R. & McManus, L. M., Apr 1998, In : Journal of Submicroscopic Cytology and Pathology. 30, 2, p. 315-327 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Nucleocapsid
Distemper
Bone and Bones
Intranuclear Inclusion Bodies
35 Citations (Scopus)

Paget's disease and osteoclast biology

Roodman, G. D., Sep 1996, In : Bone. 19, 3, p. 209-212 4 p.

Research output: Contribution to journalArticle

Osteoclasts
17 Citations (Scopus)

Paget's disease - A VDR coactivator disease?

Kurihara, N., Ishizuka, S., Demulder, A., Menaa, C. & Roodman, G. D., May 2004, In : Journal of Steroid Biochemistry and Molecular Biology. 89-90, p. 321-325 5 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Osteoclasts
Transcription
Bone
Mediator Complex Subunit 1
37 Citations (Scopus)

Paget's Disease of Bone: A Disease of the Osteoclast

Reddy, S. V., Kurihara, N., Menaa, C. & Roodman, G. D., 2001, In : Reviews in Endocrine and Metabolic Disorders. 2, 2, p. 195-201 7 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Bone Diseases
Osteoclasts
RANK Ligand
Chromosomes, Human, Pair 21
1 Citation (Scopus)

Paget's Disease of Bone

Roodman, G. D., 1998, In : Advances in Organ Biology. 5, C, p. 661-675 15 p.

Research output: Contribution to journalArticle

Osteitis Deformans
109 Citations (Scopus)

Pathogenesis of myeloma bone disease

Roodman, G. D., Mar 2004, In : Blood Cells, Molecules and Diseases. 32, 2, p. 290-292 3 p.

Research output: Contribution to journalArticle

Bone Diseases
Bone and Bones
Osteoclasts
Stromal Cells
Osteogenesis
223 Citations (Scopus)

Pathogenesis of myeloma bone disease

Roodman, G. D., 2009, In : Leukemia. 23, 3, p. 435-441 7 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Bone and Bones
Neoplasms
Spontaneous Fractures
88 Citations (Scopus)

Pathogenesis of myeloma bone disease

Roodman, G. D., Feb 1 2010, In : Journal of Cellular Biochemistry. 109, 2, p. 283-291 9 p.

Research output: Contribution to journalArticle

Bone Diseases
Bone
Bone and Bones
Multiple Myeloma
Neoplasm Metastasis
35 Citations (Scopus)

Pathophysiology of Multiple Myeloma Bone Disease

Lentzsch, S., Ehrlich, L. A. & Roodman, G. D., Dec 2007, In : Hematology/Oncology Clinics of North America. 21, 6, p. 1035-1049 15 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Bone Development
Osteoclasts
Osteoblasts
52 Citations (Scopus)

Pathophysiology of myeloma bone disease

Esteve, F. R. & Roodman, G. D., Dec 2007, In : Best Practice and Research: Clinical Haematology. 20, 4, p. 613-624 12 p.

Research output: Contribution to journalArticle

Bone Diseases
Bone
Bone and Bones
Spontaneous Fractures
Bone Resorption
11 Citations (Scopus)

Perspective on the osteoclast: An angiogenic cell?

Cackowski, F. C. & Roodman, G. D., Nov 2007, In : Annals of the New York Academy of Sciences. 1117, p. 12-25 14 p.

Research output: Contribution to journalArticle

Osteoclasts
Macrophages
Endothelial cells
Diphosphonates
Nitrogen
279 Citations (Scopus)
Osteoclasts
Osteoblasts
Interleukin-6
36 Citations (Scopus)

Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms

Holkova, B., Perkins, E. B., Ramakrishnan, V., Tombes, M. B., Shrader, E., Talreja, N., Wellons, M. D., Hogan, K. T., Roodman, G. D., Coppola, D., Kang, L., Dawson, J., Stuart, R. K., Peer, C., Figg, W. D., Kolla, S., Doyle, A., Wright, J., Sullivan, D. M., Roberts, J. D. & 1 others, Grant, S., May 15 2011, In : Clinical Cancer Research. 17, 10, p. 3388-3397 10 p.

Research output: Contribution to journalArticle

alvocidib
Maximum Tolerated Dose
B-Lymphocytes
Febrile Neutropenia
Neoplasms
19 Citations (Scopus)

Phase I trial of bortezomib (PS-341; NSC 681239) and "nonhybrid" (Bolus) infusion schedule of alvocidib (Flavopiridol; NSC 649890) in patients with recurrent or refractory indolent B-cell neoplasms

Holkova, B., Kmieciak, M., Perkins, E. B., Bose, P., Baz, R. C., Roodman, G. D., Stuart, R. K., Ramakrishnan, V., Wan, W., Peer, C. J., Dawson, J., Kang, L., Honeycutt, C., Tombes, M. B., Shrader, E., Weir-Wiggins, C., Wellons, M., Sankala, H., Hogan, K. T., Colevas, A. D. & 6 others, Doyle, L. A., Figg, W. D., Coppola, D., Roberts, J. D., Sullivan, D. & Grant, S., Nov 15 2014, In : Clinical Cancer Research. 20, 22, p. 5652-5662 11 p.

Research output: Contribution to journalArticle

alvocidib
Appointments and Schedules
B-Lymphocytes
Maximum Tolerated Dose
Neoplasms
7 Citations (Scopus)

Phase I trial of dacarbazine with cyclophosphamide, carmustine, etoposide, and autologous stem-cell transplantation in patients with lymphoma and multiple myeloma

Adkins, D. R., Salzman, D., Boldt, D., Kuhn, J., Irvin, R., Roodman, G. D., Lyons, R., Smith, L., Freytes, C. O. & LeMaistre, C. F., Sep 1994, In : Journal of Clinical Oncology. 12, 9, p. 1890-1901 12 p.

Research output: Contribution to journalArticle

Carmustine
Dacarbazine
Stem Cell Transplantation
Etoposide
Multiple Myeloma
121 Citations (Scopus)

Prognostic factors and response to fludarabine therapy in patients with Waldenström macroglobulinemia: Results of United States intergroup trial (Southwest Oncology Group S9003)

Dhodapkar, M. V., Jacobson, J. L., Gertz, M. A., Rivkin, S. E., Roodman, G. D., Tuscano, J. M., Shurafa, M., Kyle, R. A., Crowley, J. J. & Barlogie, B., Jul 1 2001, In : Blood. 98, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Oncology
Hemoglobins
Purine Nucleosides
Immunoglobulin M
38 Citations (Scopus)
Transforming Growth Factors
Dinoprostone
Bone Marrow
Osteoclasts
Prostaglandins
84 Citations (Scopus)

RANK ligand as a therapeutic target for bone metastases and multiple myeloma

Roodman, G. D. & Dougall, W. C., Feb 2008, In : Cancer Treatment Reviews. 34, 1, p. 92-101 10 p.

Research output: Contribution to journalArticle

RANK Ligand
Multiple Myeloma
Neoplasm Metastasis
Bone and Bones
Bone Diseases
1 Citation (Scopus)

Recent developments in Paget's disease

Roodman, G. D., May 2003, In : Advanced Studies in Medicine. 3, 5, p. 286-292 7 p.

Research output: Contribution to journalArticle

Skeleton
Alkaline Phosphatase
Bone and Bones
Diphosphonates
Osteoclasts