G. David Roodman

  • 23875 Citations
  • 81 h-Index
1975 …2020

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Publications

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Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures

Takahashi, N., MacDonald, B. R., Hon, J., Winkler, M. E., Derynck, R., Mundy, G. R. & Roodman, G. D., Jan 1 1986, In : Journal of Clinical Investigation. 78, 4, p. 894-898 5 p.

Research output: Contribution to journalArticle

Open Access
91 Scopus citations

Regulation of osteoclast differentiation

Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

137 Scopus citations

Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival xbp1 signaling in human multiple myeloma cells

Wang, F. M., Galson, D. L., Roodman, G. D. & Ouyang, H., Oct 1 2011, In : Experimental Hematology. 39, 10, p. 999-1006 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease

Teramachi, J., Hiruma, Y., Ishizuka, S., Ishizuka, H., Brown, J. P., Michou, L., Cao, H., Galson, D. L., Subler, M. A., Zhou, H., Dempster, D. W., Windle, J. J., Roodman, G. D. & Kurihara, N., Jun 1 2013, In : Journal of Bone and Mineral Research. 28, 6, p. 1489-1500 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Role of bone-modifying agents in multiple myeloma: American society of clinical oncology clinical practice guideline update

Anderson, K., Ismaila, N., Flynn, P. J., Halabi, S., Jagannath, S., Ogaily, M. S., Omel, J., Raje, N., Roodman, G. D., Yee, G. C. & Kyle, R. A., Mar 10 2018, In : Journal of Clinical Oncology. 36, 8, p. 812-818 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Role of cytokines in the regulation of bone resorption

Roodman, G. D., Feb 1 1993, In : Calcified Tissue International. 53, 1 Supplement, p. S94-S98

Research output: Contribution to journalArticle

145 Scopus citations

Role of magnetic resonance imaging in the management of patients with multiple myeloma: A consensus statement

Dimopoulos, M. A., Hillengass, J., Usmani, S., Zamagni, E., Lentzsch, S., Davies, F. E., Raje, N., Sezer, O., Zweegman, S., Shah, J., Badros, A., Shimizu, K., Moreau, P., Chim, C. S., Lahuerta, J. J., Hou, J., Jurczyszyn, A., Goldschmidt, H., Sonneveld, P., Palumbo, A. & 8 others, Ludwig, H., Cavo, M., Barlogie, B., Anderson, K., Roodman, G. D., Rajkumar, S. V., Durie, B. G. M. & Terpos, E., Feb 20 2015, In : Journal of Clinical Oncology. 33, 6, p. 657-664 8 p.

Research output: Contribution to journalArticle

175 Scopus citations

Role of stromal-derived cytokines and growth factors in bone metastasis

Roodman, G. D., Feb 1 2003, In : Cancer. 97, 3 SUPPL., p. 733-738 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Role of TAFII-17, a VDR binding protein, in the increased osteoclast formation in Paget's disease

Kurihara, N., Reddy, S. V., Araki, N., Ishizuka, S., Ozono, K., Cornish, J., Cundy, T., Singer, F. R. & Roodman, G. D., Jul 1 2004, In : Journal of Bone and Mineral Research. 19, 7, p. 1154-1164 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Rutologous hematopoietic stem cell transplantation for poof prognosis low grade lymphoka

Frevets, C. O., Vukelia, S., Castro, D. J., Boldt, D., Roodman, G. D., Hilesbeck, S., Adkins, D., Bachier, C., Craig, F., Clare, N., Weismare, A. & Lemaistre, C. F., Dec 1 1996, In : Experimental Hematology. 24, 9, 1 p.

Research output: Contribution to journalArticle

SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-κB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth

Feng, R., Anderson, G., Xiao, G., Elliott, G., Leoni, L., Mapara, M. Y., Roodman, G. D. & Lentzsch, S., Mar 1 2007, In : Blood. 109, 5, p. 2130-2138 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Sequence analysis of measles virus nucleocapsid transcripts in patients with Paget's disease

Friedrichs, W. E., Reddy, S. V., Bruder, J. M., Cundy, T., Cornish, J., Singer, F. R. & Roodman, G. D., Jan 1 2002, In : Journal of Bone and Mineral Research. 17, 1, p. 145-151 7 p.

Research output: Contribution to journalArticle

82 Scopus citations
46 Scopus citations
Open Access
40 Scopus citations

Stimulation of erythroid colony formation in vitro by erythropoietin immobilized on agarose-bound lectins

Roodman, G. D., Spivak, J. L. & Zanjani, E. D., Nov 1981, In : The Journal of Laboratory and Clinical Medicine. 98, 5, p. 684-690 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Studies in Paget's disease and their relevance to oncology

Roodman, G. D., Jan 1 2001, In : Seminars in oncology. 28, 4 SUPPL. 11, p. 15-21 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Summary - Bone resorption session

Roodman, G. D., Dec 1 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 4, p. 292-294 3 p.

Research output: Contribution to journalArticle

SV40 T antigen and telomerase are required to obtain immortalized human adult bone cells without loss of the differentiated phenotype

Darimont, C., Avanti, O., Tromvoukis, Y., Vautravers-Leone, P., Kurihara, N., Roodman, G. D., Colgin, L. M., Tullberg-Reinert, H., Pfeifer, A. M. A., Offord, E. A. & Mace, K., Mar 19 2002, In : Cell Growth and Differentiation. 13, 2, p. 59-67 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment

Huston, A., Leleu, X., Jia, X., Moreau, A. S., Ngo, H. T., Runnels, J., Anderson, J., Alsayed, Y., Roccaro, A., Vallet, S., Hatjiharissi, E., Tai, Y. T., Sportelli, P., Munshi, N., Richardson, P., Hideshima, T., Roodman, D. G., Anderson, K. C. & Ghobrial, I. M., Feb 1 2008, In : Clinical Cancer Research. 14, 3, p. 865-874 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the proliferation of human myeloma cells through mitotic dysregulation and cytoskeleton disruption

Feng, R., Tong, Q., Xie, Z., Cheng, H., Wang, L., Lentzsch, S., Roodman, G. D. & Xie, X. Q., Dec 2015, In : Molecular Carcinogenesis. 54, 12, p. 1796-1806 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting simian virus 40 t antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation and apoptosis of osteoclasts

Boyce, B. F., Wright, K., Reddy, S. V., Koop, B. A., Story, B., Devlin, R., Leach, R. J., Roodman, G. D. & Windle, J. J., Apr 1995, In : Endocrinology. 136, 12, p. 5751-5759 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Tartrate-resistant acid phosphatase gene expression as a facile reporter gene for screening transfection efficiency in mammalian cell cultures

Reddy, S. V., Takahashi, S., Haipek, C., Chirgwin, J. M. & Roodman, G. D., Jan 1 1993, In : BioTechniques. 15, 3, p. 444-446 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation

Sun, Q., Sammut, B., Wang, F. M., Kurihara, N., Windle, J. J., Roodman, G. D. & Galson, D. L., Jan 1 2014, In : Journal of Bone and Mineral Research. 29, 1, p. 90-102 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1

Anderson, G., Gries, M., Kurihara, N., Honjo, T., Anderson, J., Donnenberg, V., Donnenberg, A., Ghobrial, I., Mapara, M. Y., Stirling, D., Roodman, D. & Lentzsch, S., Apr 15 2006, In : Blood. 107, 8, p. 3098-3105 8 p.

Research output: Contribution to journalArticle

142 Scopus citations

The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)

Kyriakou, C., Molloy, S., Vrionis, F., Alberico, R., Bastian, L., Zonder, J. A., Giralt, S., Raje, N., Kyle, R. A., Roodman, D. G. D., Dimopoulos, M. A., Rajkumar, S. V., Durie, B. B. G. & Terpos, E., Mar 1 2019, In : Blood Cancer Journal. 9, 3, 27.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement

Hussein, M. A., Vrionis, F. D., Allison, R., Berenson, J., Berven, S., Erdem, E., Giralt, S., Jagannath, S., Kyle, R. A., LeGrand, S., Pflugmacher, R., Raje, N., Rajkumar, S. V., Randall, L., Roodman, D., Siegel, D., Vescio, R., Zonder, J. & Durie, B. G. M., Jan 1 2008, In : Leukemia. 22, 8, p. 1479-1484 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Transcriptional regulation of the tartrate-resistant acid phosphatase (TRAP) gene by iron

Alcantara, O., Reddy, S. V., Roodman, G. D. & Boldt, D. H., Jan 1 1994, In : Biochemical Journal. 298, 2, p. 421-425 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Transforming growth factor β inhibits formation of osteoclast-like cells in long-term human marrow cultures

Chenu, C., Pfeilschifter, J., Mundy, G. R. & Roodman, G. D., Jan 1 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 15, p. 5683-5687 5 p.

Research output: Contribution to journalArticle

Open Access
244 Scopus citations
126 Scopus citations

Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection

Williams, D. M., Bonewald, L. F., Roodman, G. D., Byrne, G. I., Magee, D. M. & Schachter, J., Jan 1 1989, In : Infection and immunity. 57, 5, p. 1351-1355 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Tumor necrosis factor enhances parathyroid hormone-related protein- induced hypercalcemia and bone resorption without inhibiting: Bone formation in vivo

Uy, H. L., Mundy, G. R., Boyce, B. F., Story, B. M., Dunstan, C. R., Yin, J. J., Roodman, G. D. & Guise, T. A., Sep 2 1997, In : Cancer Research. 57, 15, p. 3194-3199 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Tumors producing human tumor necrosis factor induce hypercalcemia and osteoclastic bone resorption in nude mice

Johnson, R. A., Boyce, B. F., Mundy, G. R. & Roodman, G. D., Mar 1989, In : Endocrinology. 124, 3, p. 1424-1427 4 p.

Research output: Contribution to journalArticle

125 Scopus citations

Ultrastructure of bone cells in Paget's disease of bone

Singer, F. R., Mills, B. G., Gruber, H. E., Windle, J. J. & Roodman, G. D., Feb 1 2007, In : Journal of Bone and Mineral Research. 22, SUPPL. 2, p. P51-P54

Research output: Contribution to journalArticle

17 Scopus citations

Use of an in vivo model to determine the effects of interleukin‐1 on cells at different stages in the osteoclast lineage

Uy, H. L., Dallas, M., Calland, J. W., Boyce, B. F., Mundy, G. R. & Roodman, D. G., Feb 1995, In : Journal of Bone and Mineral Research. 10, 2, p. 295-301 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Variable disease severity associated with a Paget's disease predisposition gene

Leach, R. J., Singer, F. R., Cody, J. D. & Roodman, G. D., Oct 7 1999, In : Journal of Bone and Mineral Research. 14, SUPPL. 2, p. 17-20 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Vitamin D antagonist, TEI-9647, inhibits osteoclast formation induced by 1α,25-dihydroxyvitamin D3 from pagetic bone marrow cells

Ishizuka, S., Kurihara, N., Miura, D., Takenouchi, K., Cornish, J., Cundy, T., Reddy, S. V. & Roodman, G. D., May 1 2004, In : Journal of Steroid Biochemistry and Molecular Biology. 89-90, p. 331-334 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

XRK3F2 inhibition of p62-ZZ domain signaling rescues myeloma-induced GFI1-driven epigenetic repression of the Runx2 gene in pre-osteoblasts to overcome differentiation suppression

Adamik, J., Silbermann, R., Marino, S., Sun, Q., Anderson, J. L., Zhou, D., Xie, X. Q., David Roodman, G. & Galson, D. L., Jun 29 2018, In : Frontiers in Endocrinology. 9, JUL, 344.

Research output: Contribution to journalArticle

3 Scopus citations

α9β1: A novel osteoclast integrin that regulates osteoclast formation and function

Rao, H., Lu, G., Kajiya, H., Garcia-Palacios, V., Kurihara, N., Anderson, J., Patrene, K., Sheppard, D., Blair, H. C., Windle, J. J., Choi, S. J. & Roodman, G. D., Oct 1 2006, In : Journal of Bone and Mineral Research. 21, 10, p. 1657-1665 9 p.

Research output: Contribution to journalArticle

59 Scopus citations