G. David Roodman

Article

155 Citations (Scopus)

Recombinant human interferon-γ inhibits formation of human osteoclast-like cells

Takahashi, N., Mundy, G. R. & Roodman, G. D., 1986, In : Journal of Immunology. 137, 11, p. 3544-3549 6 p.

Research output: Contribution to journal › Article

Osteoclasts

Interferons

Calcitriol

Bone Resorption

Parathyroid Hormone

91 Citations (Scopus)

Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures

Takahashi, N., MacDonald, B. R., Hon, J., Winkler, M. E., Derynck, R., Mundy, G. R. & Roodman, G. D., 1986, In : Journal of Clinical Investigation. 78, 4, p. 894-898 5 p.

Research output: Contribution to journal › Article

Osteoclasts

Transforming Growth Factor alpha

Bone Marrow

Bone Resorption

Epidermal Growth Factor

136 Citations (Scopus)

Regulation of osteoclast differentiation

Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 100-109 10 p.

Research output: Contribution to journal › Article

Osteoclasts

RANK Ligand

Granulocyte-Macrophage Progenitor Cells

Macrophages

Monocytes

48 Citations (Scopus)

Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival xbp1 signaling in human multiple myeloma cells

Wang, F. M., Galson, D. L., Roodman, G. D. & Ouyang, H., Oct 2011, In : Experimental Hematology. 39, 10, p. 999-1006 8 p.

Research output: Contribution to journal › Article

Endoplasmic Reticulum Stress

Multiple Myeloma

Survival

Inositol

Enzymes

11 Citations (Scopus)

Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease

Teramachi, J., Hiruma, Y., Ishizuka, S., Ishizuka, H., Brown, J. P., Michou, L., Cao, H., Galson, D. L., Subler, M. A., Zhou, H., Dempster, D. W., Windle, J. J., Roodman, G. D. & Kurihara, N., Jun 2013, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 28, 6, p. 1489-1500 12 p.

Research output: Contribution to journal › Article

T Cell Transcription Factor 1

Activating Transcription Factors

Osteoclasts

Vitamin D

Hypersensitivity

31 Citations (Scopus)

Role of bone-modifying agents in multiple myeloma: American society of clinical oncology clinical practice guideline update

Anderson, K., Ismaila, N., Flynn, P. J., Halabi, S., Jagannath, S., Ogaily, M. S., Omel, J., Raje, N., Roodman, G. D., Yee, G. C. & Kyle, R. A., Mar 10 2018, In : Journal of Clinical Oncology. 36, 8, p. 812-818 7 p.

Research output: Contribution to journal › Article

zoledronic acid

pamidronate

Medical Oncology

Multiple Myeloma

Practice Guidelines

145 Citations (Scopus)

Role of cytokines in the regulation of bone resorption

Roodman, G. D., Feb 1993, In : Calcified Tissue International. 53, 1 Supplement

Research output: Contribution to journal › Article

Osteoclasts

Bone Resorption

Cytokines

Bone Marrow

Bone Remodeling

156 Citations (Scopus)

Role of magnetic resonance imaging in the management of patients with multiple myeloma: A consensus statement

Dimopoulos, M. A., Hillengass, J., Usmani, S., Zamagni, E., Lentzsch, S., Davies, F. E., Raje, N., Sezer, O., Zweegman, S., Shah, J., Badros, A., Shimizu, K., Moreau, P., Chim, C. S., Lahuerta, J. J., Hou, J., Jurczyszyn, A., Goldschmidt, H., Sonneveld, P., Palumbo, A. & 8 others, Ludwig, H., Cavo, M., Barlogie, B., Anderson, K., Roodman, G. D., Rajkumar, S. V., Durie, B. G. M. & Terpos, E., Feb 20 2015, In : Journal of Clinical Oncology. 33, 6, p. 657-664 8 p.

Research output: Contribution to journal › Article

Multiple Myeloma

Magnetic Resonance Imaging

Bone and Bones

Spinal Nerves

Osteoporotic Fractures

31 Citations (Scopus)

Role of osteocytes in multiple myeloma bone disease

Delgado-Calle, J., Bellido, T. & Roodman, G. D., 2014, In : Current Opinion in Supportive and Palliative Care. 8, 4, p. 407-413 7 p.

Research output: Contribution to journal › Article

Osteocytes

Bone Diseases

Multiple Myeloma

Osteogenesis

Bone and Bones

55 Citations (Scopus)

Role of stromal-derived cytokines and growth factors in bone metastasis

Roodman, G. D., Feb 1 2003, In : Cancer. 97, 3 SUPPL., p. 733-738 6 p.

Research output: Contribution to journal › Article

Intercellular Signaling Peptides and Proteins

Cytokines

Neoplasm Metastasis

Bone and Bones

Bone Development

43 Citations (Scopus)

Role of TAFII-17, a VDR binding protein, in the increased osteoclast formation in Paget's disease

Kurihara, N., Reddy, S. V., Araki, N., Ishizuka, S., Ozono, K., Cornish, J., Cundy, T., Singer, F. R. & Roodman, G. D., Jul 2004, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 19, 7, p. 1154-1164 11 p.

Research output: Contribution to journal › Article

Vitamin D-Binding Protein

Calcitriol Receptors

Osteoclasts

measles virus nucleocapsid protein

Transcription Factor TFIID

104 Citations (Scopus)

Role of the bone marrow microenvironment in multiple myeloma

Roodman, G. D., Nov 1 2002, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 17, 11, p. 1921-1925 5 p.

Research output: Contribution to journal › Article

Multiple Myeloma

Bone Marrow

Osteoclasts

Neoplasms

Stromal Cells

12 Citations (Scopus)

Role of the microenvironment in multiple myeloma bone disease

Huston, A. & Roodman, G. D., Jun 2006, In : Future Oncology. 2, 3, p. 371-378 8 p.

Research output: Contribution to journal › Article

Bone Diseases

Osteoclasts

Multiple Myeloma

Osteoblasts

Interleukin-3

Rutologous hematopoietic stem cell transplantation for poof prognosis low grade lymphoka

Frevets, C. O., Vukelia, S., Castro, D. J., Boldt, D., Roodman, G. D., Hilesbeck, S., Adkins, D., Bachier, C., Craig, F., Clare, N., Weismare, A. & Lemaistre, C. F., 1996, In : Experimental Hematology. 24, 9, p. 1140 1 p.

Research output: Contribution to journal › Article

Hematopoietic Stem Cell Transplantation

Drug Therapy

Stem Cells

51 Citations (Scopus)

SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-κB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth

Feng, R., Anderson, G., Xiao, G., Elliott, G., Leoni, L., Mapara, M. Y., Roodman, G. D. & Lentzsch, S., Mar 1 2007, In : Blood. 109, 5, p. 2130-2138 9 p.

Research output: Contribution to journal › Article

Cell growth

Non-Steroidal Anti-Inflammatory Agents

Osteoclasts

Multiple Myeloma

Growth

12 Citations (Scopus)

SDX-308 and SDX-101, non-steroidal anti-inflammatory drugs, as therapeutic candidates for treating hematologic malignancies including myeloma

Lentzsch, S., Elliott, G. & Roodman, G. D., Oct 2007, In : Archiv der Pharmazie. 340, 10, p. 511-516 6 p.

Research output: Contribution to journal › Article

Hematologic Neoplasms

Anti-Inflammatory Agents

Osteoclasts

Tumors

Pharmaceutical Preparations

80 Citations (Scopus)

Sequence analysis of measles virus nucleocapsid transcripts in patients with Paget's disease

Friedrichs, W. E., Reddy, S. V., Bruder, J. M., Cundy, T., Cornish, J., Singer, F. R. & Roodman, G. D., 2002, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 17, 1, p. 145-151 7 p.

Research output: Contribution to journal › Article

Nucleocapsid

Measles virus

Sequence Analysis

Osteoclasts

Bone Marrow

46 Citations (Scopus)

Sequential expression of phenotype markers for osteoclasts during differentiation of precursors for multinucleated cells formed in long term human marrow cultures

Kurihara, N., Gluck, S. & Roodman, G. D., Dec 1990, In : Endocrinology. 127, 6, p. 3215-3221 7 p.

Research output: Contribution to journal › Article

Osteoclasts

Proton Pumps

Calcitonin Receptors

Bone Marrow

Phenotype

39 Citations (Scopus)

Skeletal imaging and management of bone disease.

Roodman, G. D., 2008, In : Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. p. 313-319 7 p.

Research output: Contribution to journal › Article

Bone Diseases

Bone and Bones

Diphosphonates

Positron-Emission Tomography

Therapeutics

5 Citations (Scopus)

Stimulation of erythroid colony formation in vitro by erythropoietin immobilized on agarose-bound lectins

Roodman, G. D., Spivak, J. L. & Zanjani, E. D., 1981, In : Journal of Laboratory and Clinical Medicine. 98, 5, p. 684-690 7 p.

Research output: Contribution to journal › Article

Erythropoietin

Lectins

Sepharose

Methylcellulose

Cell Communication

22 Citations (Scopus)

Studies in Paget's disease and their relevance to oncology

Roodman, G. D., 2001, In : Seminars in Oncology. 28, 4 SUPPL. 11, p. 15-21 7 p.

Research output: Contribution to journal › Article

RANK Ligand

Interleukin-6

Diphosphonates

Osteoclasts

Osteitis Deformans

Summary - Bone resorption session

Roodman, G. D., Dec 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 4, p. 292-294 3 p.

Research output: Contribution to journal › Article

Bone Resorption

25 Citations (Scopus)

SV40 T antigen and telomerase are required to obtain immortalized human adult bone cells without loss of the differentiated phenotype

Darimont, C., Avanti, O., Tromvoukis, Y., Vautravers-Leone, P., Kurihara, N., Roodman, G. D., Colgin, L. M., Tullberg-Reinert, H., Pfeifer, A. M. A., Offord, E. A. & Mace, K., 2002, In : Cell Growth and Differentiation. 13, 2, p. 59-67 9 p.

Research output: Contribution to journal › Article

Polyomavirus Transforming Antigens

Telomerase

Phenotype

Bone and Bones

Osteoblasts

49 Citations (Scopus)

Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment

Huston, A., Leleu, X., Jia, X., Moreau, A. S., Ngo, H. T., Runnels, J., Anderson, J., Alsayed, Y., Roccaro, A., Vallet, S., Hatjiharissi, E., Tai, Y. T., Sportelli, P., Munshi, N., Richardson, P., Hideshima, T., Roodman, G. D., Anderson, K. C. & Ghobrial, I. M., Feb 1 2008, In : Clinical Cancer Research. 14, 3, p. 865-874 10 p.

Research output: Contribution to journal › Article

17-(dimethylaminoethylamino)-17-demethoxygeldanamycin

HSP90 Heat-Shock Proteins

Multiple Myeloma

Bone Marrow

Osteoclasts

4 Citations (Scopus)

Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the proliferation of human myeloma cells through mitotic dysregulation and cytoskeleton disruption

Feng, R., Tong, Q., Xie, Z., Cheng, H., Wang, L., Lentzsch, S., Roodman, G. D. & Xie, X. Q., Dec 1 2015, In : Molecular Carcinogenesis. 54, 12, p. 1796-1806 11 p.

Research output: Contribution to journal › Article

Cannabinoid Receptors

Cytoskeleton

Multiple Myeloma

rimonabant

Transcription Factor CHOP

43 Citations (Scopus)

Targeting simian virus 40 T antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation and apoptosis of osteoclasts

Boyce, B. F., Wright, K., Reddy, S. V., Koop, B. A., Story, B., Devlin, R., Leach, R. J., Roodman, G. D. & Windle, J. L., 1995, In : Endocrinology. 136, 12, p. 5751-5759 9 p.

Research output: Contribution to journal › Article

Simian virus 40

Viral Tumor Antigens

Osteoclasts

Transgenic Mice

Apoptosis

36 Citations (Scopus)

Targeting the bone microenvironment in multiple myeloma

Roodman, G. D., May 2010, In : Journal of Bone and Mineral Metabolism. 28, 3, p. 244-250 7 p.

Research output: Contribution to journal › Article

Multiple Myeloma

Bone Diseases

Bone and Bones

Spontaneous Fractures

Metabolic Bone Diseases

7 Citations (Scopus)

Tartrate-resistant acid phosphatase gene expression as a facile reporter gene for screening transfection efficiency in mammalian cell cultures

Reddy, S. V., Takahashi, S., Haipek, C., Chirgwin, J. & Roodman, G. D., 1993, In : BioTechniques. 15, 3, p. 444-446 3 p.

Research output: Contribution to journal › Article

Tartrates

Calcium Phosphates

Molecular Cloning

beta-Galactosidase

Acid Phosphatase

15 Citations (Scopus)

TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation

Sun, Q., Sammut, B., Wang, F. M., Kurihara, N., Windle, J. J., Roodman, G. D. & Galson, D. L., Jan 2014, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 29, 1, p. 90-102 13 p.

Research output: Contribution to journal › Article

Osteoclasts

Phosphotransferases

Monocytes

Interleukin-6

Bone Marrow

141 Citations (Scopus)

Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1

Anderson, G., Gries, M., Kurihara, N., Honjo, T., Anderson, J., Donnenberg, V., Donnenberg, A., Ghobrial, I., Mapara, M. Y., Stirling, D., Roodman, G. D. & Lentzsch, S., Apr 15 2006, In : Blood. 107, 8, p. 3098-3105 8 p.

Research output: Contribution to journal › Article

Thalidomide

Osteoclasts

Down-Regulation

Derivatives

Bone

35 Citations (Scopus)

The pro and con of measles virus in Paget's disease: Con (multiple letters)

Rima, B. K., Gassen, U., Helfrich, M. H., Ralston, S. H., Friedrichs, W. E., Reddy, S. V., Singer, F. J. & Roodman, G. D., Dec 1 2002, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 17, 12, p. 2290-2293 4 p.

Research output: Contribution to journal › Article

Molecular Sequence Data

Osteitis Deformans

Amino Acid Sequence Homology

Measles virus

Viral Proteins

10 Citations (Scopus)

The role of bisphosphonates in multiple myeloma

Levy, J. & Roodman, G. D., 2009, In : Current Hematologic Malignancy Reports. 4, 2, p. 108-112 5 p.

Research output: Contribution to journal › Article

Diphosphonates

Multiple Myeloma

Bone Diseases

Bone Density Conservation Agents

Bone and Bones

2 Citations (Scopus)

The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)

Kyriakou, C., Molloy, S., Vrionis, F., Alberico, R., Bastian, L., Zonder, J. A., Giralt, S., Raje, N., Kyle, R. A., Roodman, G. D., Dimopoulos, M. A., Rajkumar, S. V., Durie, B. B. G. & Terpos, E., Mar 1 2019, In : Blood Cancer Journal. 9, 3, 27.

Research output: Contribution to journal › Article

Open Access

Kyphoplasty

Compression Fractures

Multiple Myeloma

Consensus

Pain

73 Citations (Scopus)

The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma

Ehrlich, L. A. & Roodman, G. D., Dec 2005, In : Immunological Reviews. 208, p. 252-266 15 p.

Research output: Contribution to journal › Article

Multiple Myeloma

Cytokines

Osteoclasts

Osteoblasts

Osteogenesis

48 Citations (Scopus)

The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement

Hussein, M. A., Vrionis, F. D., Allison, R., Berenson, J., Berven, S., Erdem, E., Giralt, S., Jagannath, S., Kyle, R. A., LeGrand, S., Pflugmacher, R., Raje, N., Rajkumar, S. V., Randall, L., Roodman, G. D., Siegel, D., Vescio, R., Zonder, J. & Durie, B. G. M., 2008, In : Leukemia. 22, 8, p. 1479-1484 6 p.

Research output: Contribution to journal › Article

56 Citations (Scopus)

The science and practice of bone health in oncology: Managing bone loss and metastasis in patients with solid tumors

Lipton, A., Uzzo, R., Amato, R. J., Ellis, G. K., Hakimian, B., Roodman, G. D. & Smith, M. R., 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, SUPPL. 7

Research output: Contribution to journal › Article

Neoplasm Metastasis

Bone and Bones

Health

Osteoclasts

Neoplasms

57 Citations (Scopus)

The use of biochemical markers of bone remodeling in multiple myeloma: A report of the International Myeloma Working Group

Terpos, E., Dimopoulos, M. A., Sezer, O., Roodman, G. D., Abildgaard, N., Vescio, R., Tosi, P., Garcia-Sanz, R., Davies, F., Chanan-Khan, A., Palumbo, A., Sonneveld, P., Drake, M. T., Harousseau, J. L., Anderson, K. C. & Durie, B. G. M., Oct 2010, In : Leukemia. 24, 10, p. 1700-1712 13 p.

Research output: Contribution to journal › Article

Bone Remodeling

Multiple Myeloma

Biomarkers

Bone and Bones

Bone Diseases

33 Citations (Scopus)

Transcriptional regulation of the tartrate-resistant acid phosphatase (TRAP) gene by iron

Alcantara, O., Reddy, S. V., Roodman, G. D. & Boldt, D. H., 1994, In : Biochemical Journal. 298, 2, p. 421-425 5 p.

Research output: Contribution to journal › Article

Acid Phosphatase

Iron

Genes

Luciferases

5' Flanking Region

243 Citations (Scopus)

Transforming growth factor β inhibits formation of osteoclast-like cells in long-term human marrow cultures

Chenu, C., Pfeilschifter, J., Mundy, G. R. & Roodman, G. D., 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 15, p. 5683-5687 5 p.

Research output: Contribution to journal › Article

Transforming Growth Factors

Osteoclasts

Granulocyte-Macrophage Progenitor Cells

Bone Marrow

Colony-Stimulating Factors

30 Citations (Scopus)

Treatment strategies for bone disease

Roodman, G. D., Dec 2007, In : Bone Marrow Transplantation. 40, 12, p. 1139-1146 8 p.

Research output: Contribution to journal › Article

Bone Diseases

Osteoclasts

Bone and Bones

Osteoblasts

Osteogenesis

8 Citations (Scopus)

Tumor lysis syndrome following thalidomide and dexamethasone therapy for newly diagnosed multiple myeloma

Huston, A., Brown, J. & Roodman, G. D., Dec 2006, In : Experimental Hematology. 34, 12, p. 1616 1 p.

Research output: Contribution to journal › Article

Immunoglobulin lambda-Chains

Antineoplastic Combined Chemotherapy Protocols

Tumor Lysis Syndrome

Thalidomide

Multiple Myeloma

125 Citations (Scopus)

Tumor necrosis factor-alpha and hematopoietic progenitors: Effects of tumor necrosis factor on the growth of erythroid progenitors CFU-E and BFU-E and the hematopoietic cell lines K562, HL60, and HEL cells

Roodman, G. D., Bird, A., Hutzler, D. & Montgomery, W., 1987, In : Experimental Hematology. 15, 9, p. 928-935 8 p.

Research output: Contribution to journal › Article

Erythroid Precursor Cells

HL-60 Cells

Tumor Necrosis Factor-alpha

Cell Line

Growth

35 Citations (Scopus)

Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection

Williams, D. M., Bonewald, L., Roodman, G. D., Byrne, G. I., Magee, D. M. & Schachter, J., 1989, In : Infection and Immunity. 57, 5, p. 1351-1355 5 p.

Research output: Contribution to journal › Article

Chlamydia Infections

Chlamydia trachomatis

Cytotoxins

Tumor Necrosis Factor-alpha

Pneumonia

46 Citations (Scopus)

Tumor necrosis factor enhances parathyroid hormone-related protein- induced hypercalcemia and bone resorption without inhibiting: Bone formation in vivo

Uy, H. L., Mundy, G. R., Boyce, B. F., Story, B. M., Dunstan, C. R., Yin, J. J., Roodman, G. D. & Guise, T., 1997, In : Cancer Research. 57, 15, p. 3194-3199 6 p.

Research output: Contribution to journal › Article

Parathyroid Hormone-Related Protein

Hypercalcemia

Bone Resorption

Osteogenesis

Cricetulus

125 Citations (Scopus)

Tumors producing human tumor necrosis factor induce hypercalcemia and osteoclastic bone resorption in nude mice

Johnson, R. A., Boyce, B. F., Mundy, G. R. & Roodman, G. D., 1989, In : Endocrinology. 124, 3, p. 1424-1427 4 p.

Research output: Contribution to journal › Article

Hypercalcemia

Bone Resorption

Nude Mice

Tumor Necrosis Factor-alpha

Cricetulus

16 Citations (Scopus)

Ultrastructure of bone cells in Paget's disease of bone

Singer, F. R., Mills, B. G., Gruber, H. E., Windle, J. J. & Roodman, G. D., Dec 2006, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 21, SUPPL. 2

Research output: Contribution to journal › Article

42 Citations (Scopus)

Use of an in vivo model to determine the effects of interleukin-1 on cells at different stages in the osteoclast lineage

Uy, H. L., Dallas, M., Calland, J. W., Boyce, B. F., Mundy, G. R. & Roodman, G. D., 1995, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 10, 2, p. 295-301 7 p.

Research output: Contribution to journal › Article

Osteoclasts

Interleukin-1

Granulocyte-Macrophage Progenitor Cells

Bone Density Conservation Agents

Bone Remodeling

18 Citations (Scopus)

Variable disease severity associated with a Paget's disease predisposition gene

Leach, R. J., Singer, F. R., Cody, J. D. & Roodman, G. D., 1999, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14, SUPPL. 2, p. 17-20 4 p.

Research output: Contribution to journal › Article

Genes

Age of Onset

Chromosomes, Human, Pair 18

Bone and Bones

Intranuclear Inclusion Bodies

33 Citations (Scopus)

Vitamin D antagonist, TEI-9647, inhibits osteoclast formation induced by 1α,25-dihydroxyvitamin D3 from pagetic bone marrow cells

Ishizuka, S., Kurihara, N., Miura, D., Takenouchi, K., Cornish, J., Cundy, T., Reddy, S. V. & Roodman, G. D., May 2004, In : Journal of Steroid Biochemistry and Molecular Biology. 89-90, p. 331-334 4 p.

Research output: Contribution to journal › Article

Calcitriol

Osteoclasts

Vitamin D

Bone Marrow Cells

Bone

4 Citations (Scopus)

Vitamin E: Good for the heart, bad for the bones?

Roodman, G. D., Apr 2012, In : Nature Medicine. 18, 4, p. 491-492 2 p.

Research output: Contribution to journal › Article

Vitamin E Deficiency

Osteoclasts

Bone Resorption

Vitamin E

Vitamins