G. David Roodman

  • 23227 Citations
  • 80 h-Index
1975 …2020
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Publications 1975 2019

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155 Citations (Scopus)

Recombinant human interferon-γ inhibits formation of human osteoclast-like cells

Takahashi, N., Mundy, G. R. & Roodman, G. D., 1986, In : Journal of Immunology. 137, 11, p. 3544-3549 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Interferons
Calcitriol
Bone Resorption
Parathyroid Hormone
91 Citations (Scopus)

Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures

Takahashi, N., MacDonald, B. R., Hon, J., Winkler, M. E., Derynck, R., Mundy, G. R. & Roodman, G. D., 1986, In : Journal of Clinical Investigation. 78, 4, p. 894-898 5 p.

Research output: Contribution to journalArticle

Osteoclasts
Transforming Growth Factor alpha
Bone Marrow
Bone Resorption
Epidermal Growth Factor
136 Citations (Scopus)

Regulation of osteoclast differentiation

Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

Osteoclasts
RANK Ligand
Granulocyte-Macrophage Progenitor Cells
Macrophages
Monocytes
48 Citations (Scopus)

Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival xbp1 signaling in human multiple myeloma cells

Wang, F. M., Galson, D. L., Roodman, G. D. & Ouyang, H., Oct 2011, In : Experimental Hematology. 39, 10, p. 999-1006 8 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Multiple Myeloma
Survival
Inositol
Enzymes
11 Citations (Scopus)

Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease

Teramachi, J., Hiruma, Y., Ishizuka, S., Ishizuka, H., Brown, J. P., Michou, L., Cao, H., Galson, D. L., Subler, M. A., Zhou, H., Dempster, D. W., Windle, J. J., Roodman, G. D. & Kurihara, N., Jun 2013, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 28, 6, p. 1489-1500 12 p.

Research output: Contribution to journalArticle

T Cell Transcription Factor 1
Activating Transcription Factors
Osteoclasts
Vitamin D
Hypersensitivity
27 Citations (Scopus)

Role of bone-modifying agents in multiple myeloma: American society of clinical oncology clinical practice guideline update

Anderson, K., Ismaila, N., Flynn, P. J., Halabi, S., Jagannath, S., Ogaily, M. S., Omel, J., Raje, N., Roodman, G. D., Yee, G. C. & Kyle, R. A., Mar 10 2018, In : Journal of Clinical Oncology. 36, 8, p. 812-818 7 p.

Research output: Contribution to journalArticle

zoledronic acid
pamidronate
Medical Oncology
Multiple Myeloma
Practice Guidelines
145 Citations (Scopus)

Role of cytokines in the regulation of bone resorption

Roodman, G. D., Feb 1993, In : Calcified Tissue International. 53, 1 Supplement

Research output: Contribution to journalArticle

Osteoclasts
Bone Resorption
Cytokines
Bone Marrow
Bone Remodeling
154 Citations (Scopus)

Role of magnetic resonance imaging in the management of patients with multiple myeloma: A consensus statement

Dimopoulos, M. A., Hillengass, J., Usmani, S., Zamagni, E., Lentzsch, S., Davies, F. E., Raje, N., Sezer, O., Zweegman, S., Shah, J., Badros, A., Shimizu, K., Moreau, P., Chim, C. S., Lahuerta, J. J., Hou, J., Jurczyszyn, A., Goldschmidt, H., Sonneveld, P., Palumbo, A. & 8 others, Ludwig, H., Cavo, M., Barlogie, B., Anderson, K., Roodman, G. D., Rajkumar, S. V., Durie, B. G. M. & Terpos, E., Feb 20 2015, In : Journal of Clinical Oncology. 33, 6, p. 657-664 8 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Magnetic Resonance Imaging
Bone and Bones
Spinal Nerves
Osteoporotic Fractures
30 Citations (Scopus)
Osteocytes
Bone Diseases
Multiple Myeloma
Osteogenesis
Bone and Bones
55 Citations (Scopus)

Role of stromal-derived cytokines and growth factors in bone metastasis

Roodman, G. D., Feb 1 2003, In : Cancer. 97, 3 SUPPL., p. 733-738 6 p.

Research output: Contribution to journalArticle

Intercellular Signaling Peptides and Proteins
Cytokines
Neoplasm Metastasis
Bone and Bones
Bone Development
43 Citations (Scopus)

Role of TAFII-17, a VDR binding protein, in the increased osteoclast formation in Paget's disease

Kurihara, N., Reddy, S. V., Araki, N., Ishizuka, S., Ozono, K., Cornish, J., Cundy, T., Singer, F. R. & Roodman, G. D., Jul 2004, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 19, 7, p. 1154-1164 11 p.

Research output: Contribution to journalArticle

Vitamin D-Binding Protein
Calcitriol Receptors
Osteoclasts
measles virus nucleocapsid protein
Transcription Factor TFIID
104 Citations (Scopus)
Multiple Myeloma
Bone Marrow
Osteoclasts
Neoplasms
Stromal Cells
12 Citations (Scopus)

Role of the microenvironment in multiple myeloma bone disease

Huston, A. & Roodman, G. D., Jun 2006, In : Future Oncology. 2, 3, p. 371-378 8 p.

Research output: Contribution to journalArticle

Bone Diseases
Osteoclasts
Multiple Myeloma
Osteoblasts
Interleukin-3

Rutologous hematopoietic stem cell transplantation for poof prognosis low grade lymphoka

Frevets, C. O., Vukelia, S., Castro, D. J., Boldt, D., Roodman, G. D., Hilesbeck, S., Adkins, D., Bachier, C., Craig, F., Clare, N., Weismare, A. & Lemaistre, C. F., 1996, In : Experimental Hematology. 24, 9, p. 1140 1 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Drug Therapy
Stem Cells
51 Citations (Scopus)

SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-κB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth

Feng, R., Anderson, G., Xiao, G., Elliott, G., Leoni, L., Mapara, M. Y., Roodman, G. D. & Lentzsch, S., Mar 1 2007, In : Blood. 109, 5, p. 2130-2138 9 p.

Research output: Contribution to journalArticle

Cell growth
Non-Steroidal Anti-Inflammatory Agents
Osteoclasts
Multiple Myeloma
Growth
12 Citations (Scopus)

SDX-308 and SDX-101, non-steroidal anti-inflammatory drugs, as therapeutic candidates for treating hematologic malignancies including myeloma

Lentzsch, S., Elliott, G. & Roodman, G. D., Oct 2007, In : Archiv der Pharmazie. 340, 10, p. 511-516 6 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Anti-Inflammatory Agents
Osteoclasts
Tumors
Pharmaceutical Preparations
80 Citations (Scopus)

Sequence analysis of measles virus nucleocapsid transcripts in patients with Paget's disease

Friedrichs, W. E., Reddy, S. V., Bruder, J. M., Cundy, T., Cornish, J., Singer, F. R. & Roodman, G. D., 2002, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 17, 1, p. 145-151 7 p.

Research output: Contribution to journalArticle

Nucleocapsid
Measles virus
Sequence Analysis
Osteoclasts
Bone Marrow
46 Citations (Scopus)
Osteoclasts
Proton Pumps
Calcitonin Receptors
Bone Marrow
Phenotype
38 Citations (Scopus)
Bone Diseases
Bone and Bones
Diphosphonates
Positron-Emission Tomography
Therapeutics
5 Citations (Scopus)

Stimulation of erythroid colony formation in vitro by erythropoietin immobilized on agarose-bound lectins

Roodman, G. D., Spivak, J. L. & Zanjani, E. D., 1981, In : Journal of Laboratory and Clinical Medicine. 98, 5, p. 684-690 7 p.

Research output: Contribution to journalArticle

Erythropoietin
Lectins
Sepharose
Methylcellulose
Cell Communication
22 Citations (Scopus)

Studies in Paget's disease and their relevance to oncology

Roodman, G. D., 2001, In : Seminars in Oncology. 28, 4 SUPPL. 11, p. 15-21 7 p.

Research output: Contribution to journalArticle

RANK Ligand
Interleukin-6
Diphosphonates
Osteoclasts
Osteitis Deformans

Summary - Bone resorption session

Roodman, G. D., Dec 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 4, p. 292-294 3 p.

Research output: Contribution to journalArticle

Bone Resorption
25 Citations (Scopus)

SV40 T antigen and telomerase are required to obtain immortalized human adult bone cells without loss of the differentiated phenotype

Darimont, C., Avanti, O., Tromvoukis, Y., Vautravers-Leone, P., Kurihara, N., Roodman, G. D., Colgin, L. M., Tullberg-Reinert, H., Pfeifer, A. M. A., Offord, E. A. & Mace, K., 2002, In : Cell Growth and Differentiation. 13, 2, p. 59-67 9 p.

Research output: Contribution to journalArticle

Polyomavirus Transforming Antigens
Telomerase
Phenotype
Bone and Bones
Osteoblasts
49 Citations (Scopus)

Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment

Huston, A., Leleu, X., Jia, X., Moreau, A. S., Ngo, H. T., Runnels, J., Anderson, J., Alsayed, Y., Roccaro, A., Vallet, S., Hatjiharissi, E., Tai, Y. T., Sportelli, P., Munshi, N., Richardson, P., Hideshima, T., Roodman, G. D., Anderson, K. C. & Ghobrial, I. M., Feb 1 2008, In : Clinical Cancer Research. 14, 3, p. 865-874 10 p.

Research output: Contribution to journalArticle

17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
HSP90 Heat-Shock Proteins
Multiple Myeloma
Bone Marrow
Osteoclasts
4 Citations (Scopus)

Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the proliferation of human myeloma cells through mitotic dysregulation and cytoskeleton disruption

Feng, R., Tong, Q., Xie, Z., Cheng, H., Wang, L., Lentzsch, S., Roodman, G. D. & Xie, X. Q., Dec 1 2015, In : Molecular Carcinogenesis. 54, 12, p. 1796-1806 11 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Cytoskeleton
Multiple Myeloma
rimonabant
Transcription Factor CHOP
43 Citations (Scopus)

Targeting simian virus 40 T antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation and apoptosis of osteoclasts

Boyce, B. F., Wright, K., Reddy, S. V., Koop, B. A., Story, B., Devlin, R., Leach, R. J., Roodman, G. D. & Windle, J. L., 1995, In : Endocrinology. 136, 12, p. 5751-5759 9 p.

Research output: Contribution to journalArticle

Simian virus 40
Viral Tumor Antigens
Osteoclasts
Transgenic Mice
Apoptosis
36 Citations (Scopus)

Targeting the bone microenvironment in multiple myeloma

Roodman, G. D., May 2010, In : Journal of Bone and Mineral Metabolism. 28, 3, p. 244-250 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone Diseases
Bone and Bones
Spontaneous Fractures
Metabolic Bone Diseases
7 Citations (Scopus)

Tartrate-resistant acid phosphatase gene expression as a facile reporter gene for screening transfection efficiency in mammalian cell cultures

Reddy, S. V., Takahashi, S., Haipek, C., Chirgwin, J. & Roodman, G. D., 1993, In : BioTechniques. 15, 3, p. 444-446 3 p.

Research output: Contribution to journalArticle

Tartrates
Calcium Phosphates
beta-Galactosidase
Acid Phosphatase
Cell culture
14 Citations (Scopus)
Osteoclasts
Phosphotransferases
Monocytes
Interleukin-6
Bone Marrow
139 Citations (Scopus)

Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1

Anderson, G., Gries, M., Kurihara, N., Honjo, T., Anderson, J., Donnenberg, V., Donnenberg, A., Ghobrial, I., Mapara, M. Y., Stirling, D., Roodman, G. D. & Lentzsch, S., Apr 15 2006, In : Blood. 107, 8, p. 3098-3105 8 p.

Research output: Contribution to journalArticle

Thalidomide
Osteoclasts
Down-Regulation
Derivatives
Bone
35 Citations (Scopus)

The pro and con of measles virus in Paget's disease: Con (multiple letters)

Rima, B. K., Gassen, U., Helfrich, M. H., Ralston, S. H., Friedrichs, W. E., Reddy, S. V., Singer, F. J. & Roodman, G. D., Dec 1 2002, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 17, 12, p. 2290-2293 4 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Osteitis Deformans
Amino Acid Sequence Homology
Measles virus
Viral Proteins
10 Citations (Scopus)

The role of bisphosphonates in multiple myeloma

Levy, J. & Roodman, G. D., 2009, In : Current Hematologic Malignancy Reports. 4, 2, p. 108-112 5 p.

Research output: Contribution to journalArticle

Diphosphonates
Multiple Myeloma
Bone Diseases
Bone Density Conservation Agents
Bone and Bones
2 Citations (Scopus)

The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)

Kyriakou, C., Molloy, S., Vrionis, F., Alberico, R., Bastian, L., Zonder, J. A., Giralt, S., Raje, N., Kyle, R. A., Roodman, G. D., Dimopoulos, M. A., Rajkumar, S. V., Durie, B. B. G. & Terpos, E., Mar 1 2019, In : Blood Cancer Journal. 9, 3, 27.

Research output: Contribution to journalArticle

Open Access
Kyphoplasty
Compression Fractures
Multiple Myeloma
Consensus
Pain
73 Citations (Scopus)

The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma

Ehrlich, L. A. & Roodman, G. D., Dec 2005, In : Immunological Reviews. 208, p. 252-266 15 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Cytokines
Osteoclasts
Osteoblasts
Osteogenesis
48 Citations (Scopus)

The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement

Hussein, M. A., Vrionis, F. D., Allison, R., Berenson, J., Berven, S., Erdem, E., Giralt, S., Jagannath, S., Kyle, R. A., LeGrand, S., Pflugmacher, R., Raje, N., Rajkumar, S. V., Randall, L., Roodman, G. D., Siegel, D., Vescio, R., Zonder, J. & Durie, B. G. M., 2008, In : Leukemia. 22, 8, p. 1479-1484 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

The science and practice of bone health in oncology: Managing bone loss and metastasis in patients with solid tumors

Lipton, A., Uzzo, R., Amato, R. J., Ellis, G. K., Hakimian, B., Roodman, G. D. & Smith, M. R., 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, SUPPL. 7

Research output: Contribution to journalArticle

Neoplasm Metastasis
Bone and Bones
Health
Osteoclasts
Neoplasms
57 Citations (Scopus)

The use of biochemical markers of bone remodeling in multiple myeloma: A report of the International Myeloma Working Group

Terpos, E., Dimopoulos, M. A., Sezer, O., Roodman, G. D., Abildgaard, N., Vescio, R., Tosi, P., Garcia-Sanz, R., Davies, F., Chanan-Khan, A., Palumbo, A., Sonneveld, P., Drake, M. T., Harousseau, J. L., Anderson, K. C. & Durie, B. G. M., Oct 2010, In : Leukemia. 24, 10, p. 1700-1712 13 p.

Research output: Contribution to journalArticle

Bone Remodeling
Multiple Myeloma
Biomarkers
Bone and Bones
Bone Diseases
32 Citations (Scopus)

Transcriptional regulation of the tartrate-resistant acid phosphatase (TRAP) gene by iron

Alcantara, O., Reddy, S. V., Roodman, G. D. & Boldt, D. H., 1994, In : Biochemical Journal. 298, 2, p. 421-425 5 p.

Research output: Contribution to journalArticle

Acid Phosphatase
Iron
Genes
Luciferases
5' Flanking Region
242 Citations (Scopus)

Transforming growth factor β inhibits formation of osteoclast-like cells in long-term human marrow cultures

Chenu, C., Pfeilschifter, J., Mundy, G. R. & Roodman, G. D., 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 15, p. 5683-5687 5 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Osteoclasts
Granulocyte-Macrophage Progenitor Cells
Bone Marrow
Colony-Stimulating Factors
30 Citations (Scopus)

Treatment strategies for bone disease

Roodman, G. D., Dec 2007, In : Bone Marrow Transplantation. 40, 12, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

Bone Diseases
Osteoclasts
Bone and Bones
Osteoblasts
Osteogenesis
8 Citations (Scopus)

Tumor lysis syndrome following thalidomide and dexamethasone therapy for newly diagnosed multiple myeloma

Huston, A., Brown, J. & Roodman, G. D., Dec 2006, In : Experimental Hematology. 34, 12, p. 1616 1 p.

Research output: Contribution to journalArticle

Immunoglobulin lambda-Chains
Antineoplastic Combined Chemotherapy Protocols
Tumor Lysis Syndrome
Thalidomide
Multiple Myeloma
125 Citations (Scopus)
Erythroid Precursor Cells
HL-60 Cells
Tumor Necrosis Factor-alpha
Cell Line
Growth
35 Citations (Scopus)

Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection

Williams, D. M., Bonewald, L., Roodman, G. D., Byrne, G. I., Magee, D. M. & Schachter, J., 1989, In : Infection and Immunity. 57, 5, p. 1351-1355 5 p.

Research output: Contribution to journalArticle

Chlamydia Infections
Chlamydia trachomatis
Cytotoxins
Tumor Necrosis Factor-alpha
Pneumonia
46 Citations (Scopus)

Tumor necrosis factor enhances parathyroid hormone-related protein- induced hypercalcemia and bone resorption without inhibiting: Bone formation in vivo

Uy, H. L., Mundy, G. R., Boyce, B. F., Story, B. M., Dunstan, C. R., Yin, J. J., Roodman, G. D. & Guise, T., 1997, In : Cancer Research. 57, 15, p. 3194-3199 6 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Hypercalcemia
Bone Resorption
Osteogenesis
Cricetulus
125 Citations (Scopus)

Tumors producing human tumor necrosis factor induce hypercalcemia and osteoclastic bone resorption in nude mice

Johnson, R. A., Boyce, B. F., Mundy, G. R. & Roodman, G. D., 1989, In : Endocrinology. 124, 3, p. 1424-1427 4 p.

Research output: Contribution to journalArticle

Hypercalcemia
Bone Resorption
Nude Mice
Tumor Necrosis Factor-alpha
Cricetulus
16 Citations (Scopus)

Ultrastructure of bone cells in Paget's disease of bone

Singer, F. R., Mills, B. G., Gruber, H. E., Windle, J. J. & Roodman, G. D., Dec 2006, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 21, SUPPL. 2

Research output: Contribution to journalArticle

42 Citations (Scopus)
Osteoclasts
Interleukin-1
Granulocyte-Macrophage Progenitor Cells
Bone Density Conservation Agents
Bone Remodeling
17 Citations (Scopus)
Genes
Age of Onset
Chromosomes, Human, Pair 18
Bone and Bones
Intranuclear Inclusion Bodies
33 Citations (Scopus)

Vitamin D antagonist, TEI-9647, inhibits osteoclast formation induced by 1α,25-dihydroxyvitamin D3 from pagetic bone marrow cells

Ishizuka, S., Kurihara, N., Miura, D., Takenouchi, K., Cornish, J., Cundy, T., Reddy, S. V. & Roodman, G. D., May 2004, In : Journal of Steroid Biochemistry and Molecular Biology. 89-90, p. 331-334 4 p.

Research output: Contribution to journalArticle

Calcitriol
Osteoclasts
Vitamin D
Bone Marrow Cells
Bone
4 Citations (Scopus)

Vitamin E: Good for the heart, bad for the bones?

Roodman, G. D., Apr 2012, In : Nature Medicine. 18, 4, p. 491-492 2 p.

Research output: Contribution to journalArticle

Vitamin E Deficiency
Osteoclasts
Bone Resorption
Vitamin E
Vitamins