G. David Roodman

  • 23995 Citations
  • 81 h-Index
1975 …2020

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Publications

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Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma

Choi, S. J., Cruz, J. C., Craig, F., Chung, H., Devlin, R. D., Roodman, G. D. & Alsina, M., Jul 15 2000, In : Blood. 96, 2, p. 671-675 5 p.

Research output: Contribution to journalArticle

329 Scopus citations

Macrophage inflammatory protein-1α is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor κB ligand

Man, J. H., Choi, S. J., Kurihara, N., Koide, M., Oba, Y. & David Roodman, G., Jun 1 2001, In : Blood. 97, 11, p. 3349-3353 5 p.

Research output: Contribution to journalArticle

258 Scopus citations

Measles virus nucleocapsid protein, a key contributor to Paget's disease, increases IL-6 expression via down-regulation of FoxO3/Sirt1 signaling

Wang, F. M., Sarmasik, A., Hiruma, Y., Sun, Q., Sammut, B., Windle, J. J., Roodman, G. D. & Galson, D. L., Mar 1 2013, In : Bone. 53, 1, p. 269-276 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget's disease

Teramachi, J., Nagata, Y., Mohammad, K., Inagaki, Y., Ohata, Y., Guise, T., Michou, L., Brown, J. P., Windle, J. J., Kurihara, N. & Roodman, G. D., Mar 1 2016, In : Journal of Clinical Investigation. 126, 3, p. 1012-1022 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Measles virus nucleocapsid transcript expression is not restricted to the osteoclast lineage in patients with Paget's disease of bone

Reddy, S. V., Menaa, C., Singer, F. R., Cundy, T., Cornish, J., Whyte, M. P. & Roodman, G. D., Oct 1 1999, In : Experimental Hematology. 27, 10, p. 1528-1532 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Mechanisms of abnormal bone turnover in Paget's disease

Roodman, G. D., May 1999, In : Bone. 24, 5 SUPPL., p. 39S-40S

Research output: Contribution to journalArticle

10 Scopus citations

Mechanisms of bone lesions in multiple myeloma and lymphoma

Roodman, G. D., Oct 15 1997, In : Cancer. 80, 8 SUPPL., p. 1557-1563 7 p.

Research output: Contribution to journalArticle

146 Scopus citations

Mechanisms of bone resorption in myeloma

Roodman, G. D., Dec 1 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 4, p. 271-272 2 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mechanisms of erythroid suppression in the anemia of chronic disease

Roodman, G. D., Jan 1 1987, In : Blood Cells. 13, 1-2, p. 171-184 14 p.

Research output: Contribution to journalArticle

32 Scopus citations

Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma

Alsayed, Y., Ngo, H., Runnels, J., Leleu, X., Singha, U. K., Pitsillides, C. M., Spencer, J. A., Kimlinger, T., Ghobrial, J. M., Jia, X., Lu, G., Timm, M., Kumar, A., Côté, D., Veilleux, I., Hedin, K. E., Roodman, G. D., Witzig, T. E., Kung, A. L., Hideshima, T. & 3 others, Anderson, K. C., Lin, C. P. & Ghobrial, I. M., Apr 1 2007, In : Blood. 109, 7, p. 2708-2717 10 p.

Research output: Contribution to journalArticle

324 Scopus citations

MIP-1α (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma

Masih-Khan, E., Trudel, S., Heise, C., Li, Z., Paterson, J., Nadeem, V., Wei, E., Roodman, D., Claudio, J. O., Bergsagel, P. L. & Stewart, A. K., Nov 15 2006, In : Blood. 108, 10, p. 3465-3471 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

MIP-1α utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells

Oba, Y., Lee, J. W., Ehrlich, L. A., Chung, H. Y., Jelinek, D. F., Callander, N. S., Horuk, R., Choi, S. J. & Roodman, G. D., Mar 2005, In : Experimental Hematology. 33, 3, p. 272-278 7 p.

Research output: Contribution to journalArticle

116 Scopus citations

Mixed lymphocyte culture reactivity of fetal baboons: Application for in utero bone marrow transplantation

Muirhead, D. Y., Kuehl, T. J., Vandeberg, J. L., Menchaca, E. M., Downs, M. P. & Roodman, G. D., Jan 1 1990, In : Bone Marrow Transplantation. 6, 4, p. 263-267 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption

Lu, Y., Cai, Z., Xiao, G., Keller, E. T., Mizokami, A., Yao, Z., Roodman, G. D. & Zhang, J., Apr 15 2007, In : Cancer Research. 67, 8, p. 3646-3653 8 p.

Research output: Contribution to journalArticle

126 Scopus citations

Multinucleated cells formed in vitro from Paget's bone marrow express viral antigens

Mills, B. G., Frausto, A., Singer, F. R., Ohsaki, Y., Demulder, A. & Roodman, G. D., Jan 1 1994, In : Bone. 15, 4, p. 443-448 6 p.

Research output: Contribution to journalArticle

63 Scopus citations

Multiple myeloma and bone: The fatal interaction

Marino, S. & Roodman, G. D., Aug 1 2018, In : Cold Spring Harbor Perspectives in Medicine. 8, 8, a031286.

Research output: Contribution to journalArticle

6 Scopus citations

Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease

Fu, J., Li, S., Feng, R., Ma, H., Sabeh, F., Roodman, G. D., Wang, J., Robinson, S., Guo, X. E., Lund, T., Normolle, D., Mapara, M. Y., Weiss, S. J. & Lentzsch, S., May 2 2016, In : Journal of Clinical Investigation. 126, 5, p. 1759-1772 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease

Kurihara, N., Hiruma, Y., Zhou, H., Subler, M. A., Dempster, D. W., Singer, F. R., Reddy, S. V., Gruber, H. E., Windle, J. J. & Roodman, G. D., Jan 4 2007, In : Journal of Clinical Investigation. 117, 1, p. 133-142 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

Myeloma bone disease

Callander, N. S. & Roodman, G. D., Jan 1 2001, In : Seminars in Hematology. 38, 3, p. 276-285 10 p.

Research output: Contribution to journalArticle

123 Scopus citations

New opportunities for the management of cancer-related bone complications.

Lipton, A., Brown, G. A., Mundy, G. R., Roodman, G. D. & Smith, M. R., May 2009, In : Clinical advances in hematology & oncology : H&O. 7, 5 Suppl 11, p. 1-30; quiz 31

Research output: Contribution to journalArticle

1 Scopus citations

New potential targets for treating myeloma bone disease

Roodman, G. D., Berenson, Clohisy, Bruland, Suva & Weilbaecher, Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2, p. 6270s-6273s

Research output: Contribution to journalArticle

30 Scopus citations

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation

Nguyen, A. N., Stebbins, E. G., Henson, M., O'Young, G., Choi, S. J., Quon, D., Damm, D., Reddy, M., Ma, J. Y., Haghnazari, E., Kapoun, A. M., Medicherla, S., Protter, A., Schreiner, G. F., Kurihara, N., Anderson, J., Roodman, G. D., Navas, T. A. & Higgins, L. S., Jun 10 2006, In : Experimental Cell Research. 312, 10, p. 1909-1923 15 p.

Research output: Contribution to journalArticle

49 Scopus citations

Nutritional parameters observed during 28-day infusion of recombinant human tumor necrosis factor-α

Hardin, T. C., Koeller, J. M., Kuhn, J. G., Roodman, G. D. & Von Hoff, D. D., Jan 1 1993, In : Journal of Parenteral and Enteral Nutrition. 17, 6, p. 541-545 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Optimal use of bisphosphonates in patients with multiple myeloma

Terpos, E., Roodman, G. D. & Dimopoulos, M. A., Apr 25 2013, In : Blood. 121, 17, p. 3325-3328 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo

Miyagawa, K., Ohata, Y., Delgado-Calle, J., Teramachi, J., Zhou, H., Dempster, D. D., Subler, M. A., Windle, J. J., Chirgwin, J. M., David Roodman, G. & Kurihara, N., Mar 26 2020, In : JCI Insight. 5, 6, e133113.

Research output: Contribution to journalArticle

Open Access

Osteoclast differentiation and activity

Roodman, G. D., Jan 1 1998, In : Biochemical Society transactions. 26, 1, p. 7-13 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Osteoclast function in Paget's disease and multiple myeloma

Roodman, G. D., Aug 1995, In : Bone. 17, 2 SUPPL. 1, p. S57-S61

Research output: Contribution to journalArticle

39 Scopus citations

Osteoclast inhibitory peptide 2 inhibits osteoclast formation via its c-terminal fragment

Choi, S. J., Kurihara, N., Oba, Y. & Roodman, G. D., Jan 1 2001, In : Journal of Bone and Mineral Research. 16, 10, p. 1804-1811 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures

Takahashi, N., Yamana, H., Yoshiki, S., Suda, T., Roodman, G. D., Mundy, G. R. & Boyde, A., Apr 1 1988, In : Endocrinology. 122, 4, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

668 Scopus citations
21 Scopus citations

Osteoclast-like cells formed in long-term human bone marrow cultures express a similar surface phenotype as authentic osteoclasts

Kukita, T., McManus, L. M., Miller, M., Civin, C. & Roodman, G. D., Jan 1 1989, In : Laboratory Investigation. 60, 4, p. 532-538 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Osteoclast-like cells form in long-term human bone marrow but not in peripheral blood cultures

Takahashi, N., Kukita, T., MacDonald, B. R., Bird, A., Mundy, G. R., McManus, L. M., Miller, M., Boyde, A., Jones, S. J. & Roodman, G. D., 1989, In : Journal of Clinical Investigation. 83, 2, p. 543-550 8 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

Osteoclasts are important for bone angiogenesis

Cackowski, F. C., Anderson, J. L., Patrene, K. D., Choksi, R. J., Shapiro, S. D., Windle, J. J., Blair, H. C. & Roodman, G. D., Jan 7 2010, In : Blood. 115, 1, p. 140-149 10 p.

Research output: Contribution to journalArticle

105 Scopus citations

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype

Kurihara, N., Reddy, S. V., Menaa, C., Anderson, D. & Roodman, G. D., Mar 2000, In : Journal of Clinical Investigation. 105, 5, p. 607-614 8 p.

Research output: Contribution to journalArticle

Open Access
106 Scopus citations

Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts

Reddy, S. V., Kurihara, N., Menaa, C., Landucci, G., Forthal, D., Koop, B. A., Windle, J. J. & Roodman, G. D., Jan 1 2001, In : Endocrinology. 142, 7, p. 2898-2905 8 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations

Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption

Dossa, T., Arabian, A., Windle, J. J., Dedhar, S., Teitelbaum, S. L., Ross, F. P., Roodman, G. D. & St-Arnaud, R., Jul 1 2010, In : Journal of Cellular Biochemistry. 110, 4, p. 960-967 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Osteoinductive factor inhibits formation of human osteoclast-like cells

Kukita, A., Bonewald, L., Rosen, D., Seyedin, S., Mundy, G. R. & Roodman, G. D., Jan 1 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 8, p. 3023-3026 4 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations
100 Scopus citations

Pagetic osteoclasts formed in vitro: Absence of paracrystalline inclusions

Roodman, G. D., Ohsaki, Y., Miller, M. M., Demulder, A., Hosking, D., Singer, F. R. & McManus, L. M., Apr 1 1998, In : Journal of Submicroscopic Cytology and Pathology. 30, 2, p. 315-327 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Paget's disease - A VDR coactivator disease?

Kurihara, N., Ishizuka, S., Demulder, A., Menaa, C. & Roodman, G. D., May 1 2004, In : Journal of Steroid Biochemistry and Molecular Biology. 89-90, p. 321-325 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Paget's Disease of Bone

Roodman, G. D., Dec 1 1998, In : Advances in Organ Biology. 5, C, p. 661-675 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Paget's Disease of Bone: A Disease of the Osteoclast

Reddy, S. V., Kurihara, N., Menaa, C. & Roodman, G. D., Jan 1 2001, In : Reviews in Endocrine and Metabolic Disorders. 2, 2, p. 195-201 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Pathogenesis of myeloma bone disease

Roodman, G. D., Jan 1 2004, In : Blood Cells, Molecules, and Diseases. 32, 2, p. 290-292 3 p.

Research output: Contribution to journalArticle

111 Scopus citations

Perspective on the osteoclast: An angiogenic cell?

Cackowski, F. C. & Roodman, G. D., Nov 2007, In : Annals of the New York Academy of Sciences. 1117, p. 12-25 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Perspectives: Interleukin‐6: An osteotropic factor?

Roodman, G. D., May 1992, In : Journal of Bone and Mineral Research. 7, 5, p. 475-478 4 p.

Research output: Contribution to journalArticle

281 Scopus citations

Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms

Holkova, B., Perkins, E. B., Ramakrishnan, V., Tombes, M. B., Shrader, E., Talreja, N., Wellons, M. D., Hogan, K. T., Roodman, G. D., Coppola, D., Kang, L., Dawson, J., Stuart, R. K., Peer, C., Figg, W. D., Kolla, S., Doyle, A., Wright, J., Sullivan, D. M., Roberts, J. D. & 1 others, Grant, S., May 15 2011, In : Clinical Cancer Research. 17, 10, p. 3388-3397 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Phase I trial of bortezomib (PS-341; NSC 681239) and "nonhybrid" (Bolus) infusion schedule of alvocidib (Flavopiridol; NSC 649890) in patients with recurrent or refractory indolent B-cell neoplasms

Holkova, B., Kmieciak, M., Perkins, E. B., Bose, P., Baz, R. C., Roodman, G. D., Stuart, R. K., Ramakrishnan, V., Wan, W., Peer, C. J., Dawson, J., Kang, L., Honeycutt, C., Tombes, M. B., Shrader, E., Weir-Wiggins, C., Wellons, M., Sankala, H., Hogan, K. T., Colevas, A. D. & 6 others, Doyle, L. A., Figg, W. D., Coppola, D., Roberts, J. D., Sullivan, D. & Grant, S., Nov 15 2014, In : Clinical Cancer Research. 20, 22, p. 5652-5662 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Phase I trial of dacarbazine with cyclophosphamide, carmustine, etoposide, and autologous stem-cell transplantation in patients with lymphoma and multiple myeloma

Adkins, D. R., Salzman, D., Boldt, D., Kuhn, J., Irvin, R., Roodman, G. D., Lyons, R., Smith, L., Freytes, C. O. & LeMaistre, C. F., Sep 1994, In : Journal of Clinical Oncology. 12, 9, p. 1890-1901 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Prognostic factors and response to fludarabine therapy in patients with Waldenström macroglobulinemia: Results of United States intergroup trial (Southwest Oncology Group S9003)

Dhodapkar, M. V., Jacobson, J. L., Gertz, M. A., Rivkin, S. E., David Roodman, G., Tuscano, J. M., Shurafa, M., Kyle, R. A., Crowley, J. J. & Barlogie, B., Jul 1 2001, In : Blood. 98, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

Proposed standard nomenclature for new tumor necrosis factor members involved in the regulation of bone resorption

The American Society For Bone And Mineral Research President'S Committee On Nomenclature, Jan 1 2000, In : Bone. 27, 6, p. 761-764 4 p.

Research output: Contribution to journalArticle

17 Scopus citations