G. David Roodman

  • 23000 Citations
  • 79 h-Index
1975 …2020
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Publications 1975 2019

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2011
12 Citations (Scopus)

Bone effects of cancer therapies: Pros and cons

Silbermann, R. & Roodman, G. D., Sep 2011, In : Current Opinion in Supportive and Palliative Care. 5, 3, p. 251-257 7 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Bone and Bones
Bone Remodeling
Physiologic Monitoring
Osteoclasts
77 Citations (Scopus)

Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62P392L mutation to paget's disease

Kurihara, N., Hiruma, Y., Yamana, K., Michou, L., Rousseau, C., Morissette, J., Galson, D. L., Teramachi, J., Zhou, H., Dempster, D. W., Windle, J. J., Brown, J. P. & Roodman, G. D., Jan 5 2011, In : Cell Metabolism. 13, 1, p. 23-34 12 p.

Research output: Contribution to journalArticle

Nucleocapsid
Measles virus
Osteoclasts
Mutation
Genes
46 Citations (Scopus)

Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease

D'Souza, S., Del Prete, D., Jin, S., Sun, Q., Huston, A. J., Kostov, F. E., Sammut, B., Hong, C. S., Anderson, J. L., Patrene, K. D., Yu, S., Velu, C. S., Xiao, G., Grimes, H. L., Roodman, G. D. & Galson, D. L., Dec 22 2011, In : Blood. 118, 26, p. 6871-6880 10 p.

Research output: Contribution to journalArticle

Bone Diseases
Osteoblasts
Multiple Myeloma
Mesenchymal Stromal Cells
Bone
40 Citations (Scopus)

Osteoblast function in myeloma

Roodman, G. D., Jan 1 2011, In : Bone. 48, 1, p. 135-140 6 p.

Research output: Contribution to journalArticle

Osteoblasts
Multiple Myeloma
Bone Diseases
Osteogenesis
Bone and Bones
35 Citations (Scopus)

Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms

Holkova, B., Perkins, E. B., Ramakrishnan, V., Tombes, M. B., Shrader, E., Talreja, N., Wellons, M. D., Hogan, K. T., Roodman, G. D., Coppola, D., Kang, L., Dawson, J., Stuart, R. K., Peer, C., Figg, W. D., Kolla, S., Doyle, A., Wright, J., Sullivan, D. M., Roberts, J. D. & 1 others, Grant, S., May 15 2011, In : Clinical Cancer Research. 17, 10, p. 3388-3397 10 p.

Research output: Contribution to journalArticle

alvocidib
Maximum Tolerated Dose
B-Lymphocytes
Febrile Neutropenia
Neoplasms
47 Citations (Scopus)

Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival xbp1 signaling in human multiple myeloma cells

Wang, F. M., Galson, D. L., Roodman, G. D. & Ouyang, H., Oct 2011, In : Experimental Hematology. 39, 10, p. 999-1006 8 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Multiple Myeloma
Survival
Inositol
Enzymes
2010
43 Citations (Scopus)

Activating transcription factor 4 regulates osteoclast differentiation in mice

Cao, H., Yu, S., Yao, Z., Galson, D. L., Jiang, Y., Zhang, X., Fan, J., Lu, B., Guan, Y., Luo, M., Lai, Y., Zhu, Y., Kurihara, N., Patrene, K., Roodman, G. D. & Xiao, G., Aug 2 2010, In : Journal of Clinical Investigation. 120, 8, p. 2755-2766 12 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 4
Osteoclasts
Macrophage Colony-Stimulating Factor
Osteogenesis
Transcription Factors
112 Citations (Scopus)

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

Noonan, K., Marchionni, L., Anderson, J., Pardoll, D., Roodman, G. D. & Borrello, I., Nov 4 2010, In : Blood. 116, 18, p. 3554-3563 10 p.

Research output: Contribution to journalArticle

Lymphocytes
Interleukin-17
Bone Diseases
Multiple Myeloma
Bone
53 Citations (Scopus)

Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia

Pal, R., Monaghan, S. A., Hassett, A. C., Mapara, M. Y., Schafer, P., Roodman, G. D., Ragni, M. V., Moscinski, L., List, A. & Lentzsch, S., Jan 21 2010, In : Blood. 115, 3, p. 605-614 10 p.

Research output: Contribution to journalArticle

Venous Thromboembolism
Neutropenia
Multiple Myeloma
Cathepsin G
Granulocyte Precursor Cells
90 Citations (Scopus)

In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2

Maes, K., Nemeth, E., Roodman, G. D., Huston, A., Esteve, F., Freytes, C., Callander, N., Katodritou, E., Tussing-Humphreys, L., Rivera, S., Vanderkerken, K., Lichtenstein, A. & Ganz, T., Nov 4 2010, In : Blood. 116, 18, p. 3635-3644 10 p.

Research output: Contribution to journalArticle

Hepcidins
Bone Morphogenetic Protein 2
Multiple Myeloma
Anemia
Serum
79 Citations (Scopus)

Metastasis and bone loss: Advancing treatment and prevention

Coleman, R. E., Lipton, A., Roodman, G. D., Guise, T., Boyce, B. F., Brufsky, A. M., Clézardin, P., Croucher, P. I., Gralow, J. R., Hadji, P., Holen, I., Mundy, G. R., Smith, M. R. & Suva, L. J., Dec 2010, In : Cancer Treatment Reviews. 36, 8, p. 615-620 6 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Bone and Bones
Neoplasms
Therapeutics
Research
77 Citations (Scopus)

Monoclonal gammopathy of undetermined significance: A consensus statement: Guideline

Berenson, J. R., Anderson, K. C., Audell, R. A., Boccia, R. V., Coleman, M., Dimopoulos, M. A., Drake, M. T., Fonseca, R., Harousseau, J. L., Joshua, D., Lonial, S., Niesvizky, R., Palumbo, A., Roodman, G. D., San-Miguel, J. F., Singhal, S., Weber, D. M., Zangari, M., Wirtschafter, E., Yellin, O. & 1 others, Kyle, R. A., Jul 2010, In : British Journal of Haematology. 150, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Guidelines
Paraproteinemias
B-Lymphocytes
Metabolic Bone Diseases
101 Citations (Scopus)

Osteoclasts are important for bone angiogenesis

Cackowski, F. C., Anderson, J. L., Patrene, K. D., Choksi, R. J., Shapiro, S. D., Windle, J. J., Blair, H. C. & Roodman, G. D., Jan 7 2010, In : Blood. 115, 1, p. 140-149 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone
Bone and Bones
Matrix Metalloproteinase 9
Parathyroid Hormone-Related Protein
15 Citations (Scopus)

Osteoclast-specific inactivation of the integrin-linked kinase (ILK) inhibits bone resorption

Dossa, T., Arabian, A., Windle, J. J., Dedhar, S., Teitelbaum, S. L., Ross, F. P., Roodman, G. D. & St-Arnaud, R., Jul 1 2010, In : Journal of Cellular Biochemistry. 110, 4, p. 960-967 8 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Resorption
Bone
Integrins
Alleles
88 Citations (Scopus)

Pathogenesis of myeloma bone disease

Roodman, G. D., Feb 1 2010, In : Journal of Cellular Biochemistry. 109, 2, p. 283-291 9 p.

Research output: Contribution to journalArticle

Bone Diseases
Bone
Bone and Bones
Multiple Myeloma
Neoplasm Metastasis
36 Citations (Scopus)

Targeting the bone microenvironment in multiple myeloma

Roodman, G. D., May 2010, In : Journal of Bone and Mineral Metabolism. 28, 3, p. 244-250 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone Diseases
Bone and Bones
Spontaneous Fractures
Metabolic Bone Diseases
57 Citations (Scopus)

The use of biochemical markers of bone remodeling in multiple myeloma: A report of the International Myeloma Working Group

Terpos, E., Dimopoulos, M. A., Sezer, O., Roodman, G. D., Abildgaard, N., Vescio, R., Tosi, P., Garcia-Sanz, R., Davies, F., Chanan-Khan, A., Palumbo, A., Sonneveld, P., Drake, M. T., Harousseau, J. L., Anderson, K. C. & Durie, B. G. M., Oct 2010, In : Leukemia. 24, 10, p. 1700-1712 13 p.

Research output: Contribution to journalArticle

Bone Remodeling
Multiple Myeloma
Biomarkers
Bone and Bones
Bone Diseases
2009
46 Citations (Scopus)

C/EBPβ regulates transcription factors critical for proliferation and survival of multiple myeloma cells

Pal, R., Janz, M., Galson, D. L., Gries, M., Li, S., Jöhrens, K., Anagnostopoulos, I., Dörken, B., Mapara, M. Y., Borghesi, L., Kardava, L., Roodman, G. D., Milcarek, C. & Lentzsch, S., Oct 29 2009, In : Blood. 114, 18, p. 3890-3898 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Multiple Myeloma
Transcription Factors
Cells
B-Cell Lymphoma
45 Citations (Scopus)

Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone

Yu, S., Franceschi, R. T., Luo, M., Fan, J., Jiang, D., Cao, H., Kwon, T. G., Lai, Y., Zhang, J., Patrene, K., Hankenson, K., Roodman, G. D. & Xiao, G., Oct 23 2009, In : PLoS One. 4, 10, e7583.

Research output: Contribution to journalArticle

Activating Transcription Factor 4
parathyroid hormone
Parathyroid Hormone
Bone
transcription factors
39 Citations (Scopus)

Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation

Hiruma, Y., Honjo, T., Jelinek, D. F., Windle, J. J., Shin, J., Roodman, G. D. & Kurihara, N., 2009, In : Blood. 113, 20, p. 4894-4902 9 p.

Research output: Contribution to journalArticle

Cell growth
Osteoclasts
Multiple Myeloma
Stromal Cells
p38 Mitogen-Activated Protein Kinases
19 Citations (Scopus)

In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development

Choi, S. J., Roodman, G. D., Feng, J. Q., Song, I. S., Amin, K., Hart, P. S., Wright, J. T., Haruyama, N. & Hart, T. C., Jan 1 2009, In : Developmental Biology. 325, 1, p. 129-137 9 p.

Research output: Contribution to journalArticle

Sequence Deletion
Bone Development
Transgenic Mice
Genes
Osteoclasts

New opportunities for the management of cancer-related bone complications.

Lipton, A., Brown, G. A., Mundy, G. R., Roodman, G. D. & Smith, M. R., May 2009, In : Clinical Advances in Hematology and Oncology. 7, 5 Suppl 11

Research output: Contribution to journalArticle

Bone Density Conservation Agents
Bone Neoplasms
Metabolic Bone Diseases
Bone Fractures
Osteogenesis
10 Citations (Scopus)

Osteoclasts Pump Iron

Roodman, G. D., May 6 2009, In : Cell Metabolism. 9, 5, p. 405-406 2 p.

Research output: Contribution to journalArticle

Osteoclasts
Iron
Bone Matrix
Organelle Biogenesis
Transferrin
223 Citations (Scopus)

Pathogenesis of myeloma bone disease

Roodman, G. D., 2009, In : Leukemia. 23, 3, p. 435-441 7 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Bone and Bones
Neoplasms
Spontaneous Fractures
10 Citations (Scopus)

The role of bisphosphonates in multiple myeloma

Levy, J. & Roodman, G. D., 2009, In : Current Hematologic Malignancy Reports. 4, 2, p. 108-112 5 p.

Research output: Contribution to journalArticle

Diphosphonates
Multiple Myeloma
Bone Diseases
Bone Density Conservation Agents
Bone and Bones
54 Citations (Scopus)

The science and practice of bone health in oncology: Managing bone loss and metastasis in patients with solid tumors

Lipton, A., Uzzo, R., Amato, R. J., Ellis, G. K., Hakimian, B., Roodman, G. D. & Smith, M. R., 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, SUPPL. 7

Research output: Contribution to journalArticle

Neoplasm Metastasis
Bone and Bones
Health
Osteoclasts
Neoplasms
2008
13 Citations (Scopus)

1α,25-Dihydroxyvitamin D3-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells

Ishizuka, S., Kurihara, N., Hiruma, Y., Miura, D., Namekawa, J. I., Tamura, A., Kato-Nakamura, Y., Nakano, Y., Takenouchi, K., Hashimoto, Y., Nagasawa, K. & Roodman, G. D., Jun 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 110, 3-5, p. 269-277 9 p.

Research output: Contribution to journalArticle

Lactams
Calcitriol Receptors
Calcitriol
Rodentia
HL-60 Cells
50 Citations (Scopus)

Advancing treatment for metastatic bone cancer: Consensus recommendations from the second cambridge conference

Coleman, R. E., Guise, T., Lipton, A., Roodman, G. D., Berenson, J. R., Body, J. J., Boyce, B. F., Calvi, L. M., Hadji, P., McCloskey, E. V., Saad, F., Smith, M. R., Suva, L. J., Taichman, R. S., Vessella, R. L. & Weilbaecher, K. N., Oct 15 2008, In : Clinical Cancer Research. 14, 20, p. 6387-6395 9 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Bone and Bones
Therapeutics
Neoplasm Metastasis
Research
144 Citations (Scopus)

Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer

Shiozawa, Y., Havens, A. M., Jung, Y., Ziegler, A. M., Pedersen, E. A., Wang, J., Wang, J., Lu, G., Roodman, G. D., Loberg, R. D., Pienta, K. J. & Taichman, R. S., Oct 1 2008, In : Journal of Cellular Biochemistry. 105, 2, p. 370-380 11 p.

Research output: Contribution to journalArticle

Annexin A2
Prostatic Neoplasms
Adhesion
Growth
Osteoblasts
62 Citations (Scopus)

A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment

Hiruma, Y., Kurihara, N., Subler, M. A., Zhou, H., Boykin, C. S., Zhang, H., Ishizuka, S., Dempster, D. W., Roodman, G. D. & Windle, J. J., 2008, In : Human Molecular Genetics. 17, 23, p. 3708-3719 12 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Osteoclasts
Stromal Cells
Bone and Bones
Mutation
29 Citations (Scopus)

Bone building with bortezomib

Roodman, G. D., Feb 1 2008, In : Journal of Clinical Investigation. 118, 2, p. 462-464 3 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone and Bones
Osteogenesis
Postmenopausal Osteoporosis
Proteasome Inhibitors

Erratum: The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement (Leukemia (2008) 101038/leu.2008.127)

Hussein, M. A., Vrionis, F. D., Allison, R., Berenson, J., Berven, S., Erdem, E., Giralt, S., Jagannath, S., Kyle, R. A., LeGrand, S., Pflugmacher, R., Raje, N., Rajkumar, S. V., Randall, R. L., Roodman, G. D., Siegel, D., Vescio, R., Zonder, J. & Durie, B. G. M., 2008, In : Leukemia. 22, 8, p. 1649 1 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Involvement of hepcidin in the anemia of multiple myeloma

Sharma, S., Nemeth, E., Chen, Y. H., Goodnough, J., Huston, A., Roodman, G. D., Ganz, T. & Lichtenstein, A., Jun 1 2008, In : Clinical Cancer Research. 14, 11, p. 3262-3267 6 p.

Research output: Contribution to journalArticle

Hepcidins
Multiple Myeloma
Anemia
Interleukin-6
Serum
20 Citations (Scopus)

Novel targets for myeloma bone disease

Roodman, G. D., Nov 2008, In : Expert Opinion on Therapeutic Targets. 12, 11, p. 1377-1387 11 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Bone
Bone and Bones
Clinical Trials
83 Citations (Scopus)

RANK ligand as a therapeutic target for bone metastases and multiple myeloma

Roodman, G. D. & Dougall, W. C., Feb 2008, In : Cancer Treatment Reviews. 34, 1, p. 92-101 10 p.

Research output: Contribution to journalArticle

RANK Ligand
Multiple Myeloma
Neoplasm Metastasis
Bone and Bones
Bone Diseases
38 Citations (Scopus)
Bone Diseases
Bone and Bones
Diphosphonates
Positron-Emission Tomography
Therapeutics
48 Citations (Scopus)

Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment

Huston, A., Leleu, X., Jia, X., Moreau, A. S., Ngo, H. T., Runnels, J., Anderson, J., Alsayed, Y., Roccaro, A., Vallet, S., Hatjiharissi, E., Tai, Y. T., Sportelli, P., Munshi, N., Richardson, P., Hideshima, T., Roodman, G. D., Anderson, K. C. & Ghobrial, I. M., Feb 1 2008, In : Clinical Cancer Research. 14, 3, p. 865-874 10 p.

Research output: Contribution to journalArticle

17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
HSP90 Heat-Shock Proteins
Multiple Myeloma
Bone Marrow
Osteoclasts
48 Citations (Scopus)

The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement

Hussein, M. A., Vrionis, F. D., Allison, R., Berenson, J., Berven, S., Erdem, E., Giralt, S., Jagannath, S., Kyle, R. A., LeGrand, S., Pflugmacher, R., Raje, N., Rajkumar, S. V., Randall, L., Roodman, G. D., Siegel, D., Vescio, R., Zonder, J. & Durie, B. G. M., 2008, In : Leukemia. 22, 8, p. 1479-1484 6 p.

Research output: Contribution to journalArticle

2007
329 Citations (Scopus)

American society of clinical oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma

Kyle, R. A., Yee, G. C., Somerfield, M. R., Flynn, P. J., Halabi, S., Jagannath, S., Orlowski, R. Z., Roodman, G. D., Twilde, P. & Anderson, K., Jun 10 2007, In : Journal of Clinical Oncology. 25, 17, p. 2464-2472 9 p.

Research output: Contribution to journalArticle

zoledronic acid
pamidronate
Medical Oncology
Diphosphonates
Multiple Myeloma
1 Citation (Scopus)

ASCO 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma: Guideline summary

Kyle, R. A., Yee, G. C., Somerfield, M. R., Flynn, P. J., Halabi, S., Jagannath, S., Orlowski, R. Z., Roodman, G. D., Twilde, P. & Anderson, K., Jul 2007, In : Journal of Oncology Practice. 3, 4, p. 236 1 p.

Research output: Contribution to journalArticle

Diphosphonates
Multiple Myeloma
Practice Guidelines
Guidelines
11 Citations (Scopus)

Bone-breaking cancer treatment

Roodman, G. D., Jan 2007, In : Nature Medicine. 13, 1, p. 25-26 2 p.

Research output: Contribution to journalArticle

Experimental Mammary Neoplasms
Xenograft Model Antitumor Assays
Biological Models
Bone Neoplasms
NF-kappa B
13 Citations (Scopus)

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing in osteoclast precursors expression of LFA-1 and ICAM-1

Garcia-Palacios, V., Yeon Chung, H., Jin Choi, S., Sarmasik, A., Kurihara, N., Won Lee, J., Galson, D. L., Collins, R. & Roodman, G. D., Feb 2007, In : Bone. 40, 2, p. 316-322 7 p.

Research output: Contribution to journalArticle

Eosinophil Chemotactic Factors
Lymphocyte Function-Associated Antigen-1
Osteoclasts
Intercellular Adhesion Molecule-1
RANK Ligand
305 Citations (Scopus)

Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma

Alsayed, Y., Ngo, H., Runnels, J., Leleu, X., Singha, U. K., Pitsillides, C. M., Spencer, J. A., Kimlinger, T., Ghobrial, J. M., Jia, X., Lu, G., Timm, M., Kumar, A., Côté, D., Veilleux, I., Hedin, K. E., Roodman, G. D., Witzig, T. E., Kung, A. L., Hideshima, T. & 3 others, Anderson, K. C., Lin, C. P. & Ghobrial, I. M., Apr 1 2007, In : Blood. 109, 7, p. 2708-2717 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone
Confocal microscopy
CXCR4 Receptors
Bioluminescence
123 Citations (Scopus)

Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption

Lu, Y., Cai, Z., Xiao, G., Keller, E. T., Mizokami, A., Yao, Z., Roodman, G. D. & Zhang, J., Apr 15 2007, In : Cancer Research. 67, 8, p. 3646-3653 8 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Chemokine CCL2
Bone Resorption
Prostatic Neoplasms
Interleukin-8
90 Citations (Scopus)

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease

Kurihara, N., Hiruma, Y., Zhou, H., Subler, M. A., Dempster, D. W., Singer, F. R., Reddy, S. V., Gruber, H. E., Windle, J. J. & Roodman, G. D., Jan 4 2007, In : Journal of Clinical Investigation. 117, 1, p. 133-142 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteogenesis
Mutation
Genes
Bone Remodeling
35 Citations (Scopus)

Pathophysiology of Multiple Myeloma Bone Disease

Lentzsch, S., Ehrlich, L. A. & Roodman, G. D., Dec 2007, In : Hematology/Oncology Clinics of North America. 21, 6, p. 1035-1049 15 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Bone Development
Osteoclasts
Osteoblasts
52 Citations (Scopus)

Pathophysiology of myeloma bone disease

Esteve, F. R. & Roodman, G. D., Dec 2007, In : Best Practice and Research: Clinical Haematology. 20, 4, p. 613-624 12 p.

Research output: Contribution to journalArticle

Bone Diseases
Bone
Bone and Bones
Spontaneous Fractures
Bone Resorption
11 Citations (Scopus)

Perspective on the osteoclast: An angiogenic cell?

Cackowski, F. C. & Roodman, G. D., Nov 2007, In : Annals of the New York Academy of Sciences. 1117, p. 12-25 14 p.

Research output: Contribution to journalArticle

Osteoclasts
Macrophages
Endothelial cells
Diphosphonates
Nitrogen
51 Citations (Scopus)

SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-κB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth

Feng, R., Anderson, G., Xiao, G., Elliott, G., Leoni, L., Mapara, M. Y., Roodman, G. D. & Lentzsch, S., Mar 1 2007, In : Blood. 109, 5, p. 2130-2138 9 p.

Research output: Contribution to journalArticle

Cell growth
Non-Steroidal Anti-Inflammatory Agents
Osteoclasts
Multiple Myeloma
Growth
12 Citations (Scopus)

SDX-308 and SDX-101, non-steroidal anti-inflammatory drugs, as therapeutic candidates for treating hematologic malignancies including myeloma

Lentzsch, S., Elliott, G. & Roodman, G. D., Oct 2007, In : Archiv der Pharmazie. 340, 10, p. 511-516 6 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Anti-Inflammatory Agents
Osteoclasts
Tumors
Pharmaceutical Preparations