G. David Roodman

  • 23000 Citations
  • 79 h-Index
1975 …2020
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Publications 1975 2019

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Article
2007
29 Citations (Scopus)

Treatment strategies for bone disease

Roodman, G. D., Dec 2007, In : Bone Marrow Transplantation. 40, 12, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

Bone Diseases
Osteoclasts
Bone and Bones
Osteoblasts
Osteogenesis
2006
10 Citations (Scopus)

Advances in treating metastatic bone cancer: Summary statement for the First Cambridge Conference

Lipton, A., Berenson, J. R., Body, J. J., Boyce, B. F., Bruland, O. S., Carducci, M. A., Cleeland, C. S., Clohisy, D. R., Coleman, R. E., Cook, R. J., Guise, T., Pearse, R. N., Powles, T. J., Rogers, M. J., Roodman, G. D., Smith, M. R., Suva, L. J., Vessella, R. L., Weilbaecher, K. N. & King, L., Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2

Research output: Contribution to journalArticle

Bone Neoplasms
Bone and Bones
Natural History
Neoplasm Metastasis
Research
97 Citations (Scopus)

Chemokines in multiple myeloma

Aggarwal, R., Ghobrial, I. M. & Roodman, G. D., Oct 2006, In : Experimental Hematology. 34, 10, p. 1289-1295 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Chemokines
Chemokine Receptors
Bone Development
Osteoclasts
22 Citations (Scopus)

Cloning and characterization of the annexin II receptor on human marrow stromal cells

Lu, G., Maeda, H., Reddy, S. V., Kurihara, N., Leach, R., Anderson, J. L. & Roodman, G. D., Oct 13 2006, In : Journal of Biological Chemistry. 281, 41, p. 30542-30550 9 p.

Research output: Contribution to journalArticle

Annexin A2
Cloning
Stromal Cells
Organism Cloning
Bone Marrow
86 Citations (Scopus)

Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma

Francis, L. K., Alsayed, Y., Leleu, X., Jia, X., Singha, U. K., Anderson, J., Timm, M., Ngo, H., Lu, G., Huston, A., Ehrlich, L. A., Dimmock, E., Lentzsch, S., Hideshima, T., Roodman, G. D., Anderson, K. C. & Ghobrial, I. M., Nov 15 2006, In : Clinical Cancer Research. 12, 22, p. 6826-6835 10 p.

Research output: Contribution to journalArticle

tanespimycin
Sirolimus
Multiple Myeloma
Phosphatidylinositol 3-Kinase
Retinoblastoma
1 Citation (Scopus)

Eosinophil chemotactic factor-L (ECF-L) enhances osteoclast formation by increasing ICAM-1 expression

Palacios, V. G., Chung, H. Y., Choi, S. J., Kurihara, N., Lee, J. W., Ehrlich, L. A., Collins, R. & Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 240-243 4 p.

Research output: Contribution to journalArticle

Eosinophil Chemotactic Factors
Osteoclasts
Intercellular Adhesion Molecule-1
RANK Ligand
Lymphocyte Function-Associated Antigen-1
7 Citations (Scopus)

Experimental models of Paget's disease

Kurihara, N., Zhou, H., Reddy, S. V., Garcia Palacios, V., Subler, M. A., Dempster, D. W., Windle, J. J. & Roodman, G. D., Dec 2006, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 21, SUPPL. 2

Research output: Contribution to journalArticle

Osteoclasts
Nucleocapsid
Measles virus
Theoretical Models
Bone and Bones
83 Citations (Scopus)

Expression of measles virus nucleocapsid protein in osteoclasts induces Paget's disease-like bone lesions in mice

Kurihara, N., Zhou, H., Reddy, S. V., Palacios, V. G., Subler, M. A., Dempster, D. W., Windle, J. J. & Roodman, G. D., Mar 2006, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 21, 3, p. 446-455 10 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Measles virus
Osteoclasts
Nucleocapsid
Bone and Bones
58 Citations (Scopus)

MIP-1α (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma

Masih-Khan, E., Trudel, S., Heise, C., Li, Z., Paterson, J., Nadeem, V., Wei, E., Roodman, G. D., Claudio, J. O., Bergsagel, P. L. & Stewart, A. K., Nov 15 2006, In : Blood. 108, 10, p. 3465-3471 7 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 3
Chemokine CCL3
Multiple Myeloma
Bone Diseases
Gene expression
198 Citations (Scopus)

Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition

Giuliani, N., Rizzoli, V. & Roodman, G. D., Dec 15 2006, In : Blood. 108, 13, p. 3992-3996 5 p.

Research output: Contribution to journalArticle

Bone Diseases
Osteoblasts
Multiple Myeloma
Bone
Bone and Bones
29 Citations (Scopus)

New potential targets for treating myeloma bone disease

Roodman, G. D., Berenson, Clohisy, Bruland, Suva & Weilbaecher, Oct 15 2006, In : Clinical Cancer Research. 12, 20 PART 2

Research output: Contribution to journalArticle

Bone Diseases
Osteoblasts
Interleukin-3
Osteoclasts
Osteogenesis
49 Citations (Scopus)

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation

Nguyen, A. N., Stebbins, E. G., Henson, M., O'Young, G., Choi, S. J., Quon, D., Damm, D., Reddy, M., Ma, J. Y., Haghnazari, E., Kapoun, A. M., Medicherla, S., Protter, A., Schreiner, G. F., Kurihara, N., Anderson, J., Roodman, G. D., Navas, T. A. & Higgins, L. S., Jun 10 2006, In : Experimental Cell Research. 312, 10, p. 1909-1923 15 p.

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Cell Adhesion
Bone Marrow
Cell Proliferation
7 Citations (Scopus)

Novel approaches in the management of myeloma-related skeletal complications

Reddy, G. K., Mughal, T. I. & Roodman, G. D., Oct 2006, In : Supportive Cancer Therapy. 4, 1, p. 15-18 4 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Bone Neoplasms
Bone Diseases
Diphosphonates
Neoplasm Metastasis
135 Citations (Scopus)

Regulation of osteoclast differentiation

Roodman, G. D., Apr 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

Osteoclasts
RANK Ligand
Granulocyte-Macrophage Progenitor Cells
Macrophages
Monocytes
12 Citations (Scopus)

Role of the microenvironment in multiple myeloma bone disease

Huston, A. & Roodman, G. D., Jun 2006, In : Future Oncology. 2, 3, p. 371-378 8 p.

Research output: Contribution to journalArticle

Bone Diseases
Osteoclasts
Multiple Myeloma
Osteoblasts
Interleukin-3
138 Citations (Scopus)

Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1

Anderson, G., Gries, M., Kurihara, N., Honjo, T., Anderson, J., Donnenberg, V., Donnenberg, A., Ghobrial, I., Mapara, M. Y., Stirling, D., Roodman, G. D. & Lentzsch, S., Apr 15 2006, In : Blood. 107, 8, p. 3098-3105 8 p.

Research output: Contribution to journalArticle

Thalidomide
Osteoclasts
Down-Regulation
Derivatives
Bone
8 Citations (Scopus)

Tumor lysis syndrome following thalidomide and dexamethasone therapy for newly diagnosed multiple myeloma

Huston, A., Brown, J. & Roodman, G. D., Dec 2006, In : Experimental Hematology. 34, 12, p. 1616 1 p.

Research output: Contribution to journalArticle

Immunoglobulin lambda-Chains
Antineoplastic Combined Chemotherapy Protocols
Tumor Lysis Syndrome
Thalidomide
Multiple Myeloma
8 Citations (Scopus)

Ultrastructure of bone cells in Paget's disease of bone

Singer, F. R., Mills, B. G., Gruber, H. E., Windle, J. J. & Roodman, G. D., Dec 2006, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 21, SUPPL. 2

Research output: Contribution to journalArticle

58 Citations (Scopus)

α9β1: A novel osteoclast integrin that regulates osteoclast formation and function

Rao, H., Lu, G., Kajiya, H., Garcia-Palacios, V., Kurihara, N., Anderson, J., Patrene, K., Sheppard, D., Blair, H. C., Windle, J. J., Choi, S. J. & Roodman, G. D., Oct 2006, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 21, 10, p. 1657-1665 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Integrins
Disintegrins
Bone Resorption
Spine
2005
44 Citations (Scopus)
Calcitriol Receptors
Osteoclasts
Bone Resorption
Bone Marrow
Granulocyte-Macrophage Progenitor Cells
43 Citations (Scopus)

Annexin II stimulates RANKL expression through MAPK

Li, F., Chung, H. Y., Reddy, S. V., Lu, G., Kurihara, N., Zhao, A. Z. & Roodman, G. D., Jul 2005, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 20, 7, p. 1161-1167 7 p.

Research output: Contribution to journalArticle

Annexin A2
Granulocyte-Macrophage Colony-Stimulating Factor
Osteoclasts
Osteoprotegerin
Bone Marrow Cells
152 Citations (Scopus)

EL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma

Ehrlich, L. A., Chung, H. Y., Ghobrial, I., Choi, S. J., Morandi, F., Colla, S., Rizzoli, V., Roodman, G. D. & Giuliani, N., Aug 15 2005, In : Blood. 106, 4, p. 1407-1414 8 p.

Research output: Contribution to journalArticle

Interleukin-3
Osteoblasts
Multiple Myeloma
Bone
Bone and Bones
13 Citations (Scopus)

High bone turnover markers predict poor outcome in patients with bone metastasis

Roodman, G. D., 2005, In : Journal of Clinical Oncology. 23, 22, p. 4821-4822 2 p.

Research output: Contribution to journalArticle

Predictive Value of Tests
Bone Neoplasms
Bone Remodeling
Bone Resorption
Neoplasm Metastasis
80 Citations (Scopus)

Legumain expression in relation to clinicopathologic and biological variables in colorectal cancer

Murthy, R. V., Arbman, G., Gao, J., Roodman, G. D. & Sun, X. F., Mar 15 2005, In : Clinical Cancer Research. 11, 6, p. 2293-2299 7 p.

Research output: Contribution to journalArticle

asparaginylendopeptidase
Colorectal Neoplasms
Mucous Membrane
Neoplasms
Matrix Metalloproteinase 11
113 Citations (Scopus)

MIP-1α utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells

Oba, Y., Lee, J. W., Ehrlich, L. A., Chung, H. Y., Jelinek, D. F., Callander, N. S., Horuk, R., Choi, S. J. & Roodman, G. D., Mar 2005, In : Experimental Hematology. 33, 3, p. 272-278 7 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Osteoclasts
Stromal Cells
Cell Adhesion
Bone Marrow
9 Citations (Scopus)
Bone Diseases
Multiple Myeloma
Research
Therapeutics
Transplantation
73 Citations (Scopus)

The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma

Ehrlich, L. A. & Roodman, G. D., Dec 2005, In : Immunological Reviews. 208, p. 252-266 15 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Cytokines
Osteoclasts
Osteoblasts
Osteogenesis
2004
3 Citations (Scopus)

Bone metastasis [5] (multiple letters)

Hall, F. M. & Roodman, G. D., Jul 8 2004, In : New England Journal of Medicine. 351, 2, p. 195-196 2 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Bone Remodeling
Osteoclasts
Osteoblasts
Neoplasm Metastasis
8 Citations (Scopus)

Erratum: Myeloma management guidelines: A consensus report from the scientific advisors of the international myeloma foundation (The Hematology Journal (2003) vol, 4 (379-398) 10.1038/sj.thj.6200312)

Durie, B. G. M., Kyle, R. A., Belch, A., Bensinger, W., Blade, J., Boccadoro, M., Child, J. A., Comenzo, R., Djulbegovic, B., Fantl, D., Gahrton, G., Harousseau, J. L., Hungria, V., Joshua, D., Ludwig, H., Mehta, J., Morales, A. R., Morgan, G., Nouel, A., Oken, M. & 9 others, Powles, R., Roodman, G. D., San Miguel, J., Shimizu, K., Singhal, S., Sirohi, B., Sonneveld, P., Tricot, G. & Van Ness, B., 2004, In : Hematology Journal. 5, 3, p. 285 1 p.

Research output: Contribution to journalArticle

Hematologic Diseases
Bone Diseases
Blood Cells
34 Citations (Scopus)

Functional Role for Heat Shock Factors in the Transcriptional Regulation of Human RANK Ligand Gene Expression in Stromal/Osteoblast Cells

Roccisana, J. L., Kawanabe, N., Kajiya, H., Koide, M., Roodman, G. D. & Reddy, S. V., Mar 12 2004, In : Journal of Biological Chemistry. 279, 11, p. 10500-10507 8 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteoblasts
Stromal Cells
Gene expression
Shock
168 Citations (Scopus)

IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells

Lee, J. W., Chung, H. Y., Ehrlich, L. A., Jelinek, D. F., Callander, N. S., Roodman, G. D. & Choi, S. J., Mar 15 2004, In : Blood. 103, 6, p. 2308-2315 8 p.

Research output: Contribution to journalArticle

Interleukin-3
Osteoclasts
Macrophage Inflammatory Proteins
Multiple Myeloma
Acute Myeloid Leukemia
1462 Citations (Scopus)

Mechanisms of Bone Metastasis

Roodman, G. D., Apr 15 2004, In : New England Journal of Medicine. 350, 16

Research output: Contribution to journalArticle

Receptor Activator of Nuclear Factor-kappa B
RANK Ligand
Bone Neoplasms
Osteolysis
Bone Remodeling
17 Citations (Scopus)

Paget's disease - A VDR coactivator disease?

Kurihara, N., Ishizuka, S., Demulder, A., Menaa, C. & Roodman, G. D., May 2004, In : Journal of Steroid Biochemistry and Molecular Biology. 89-90, p. 321-325 5 p.

Research output: Contribution to journalArticle

Calcitriol Receptors
Osteoclasts
Transcription
Bone
Mediator Complex Subunit 1
108 Citations (Scopus)

Pathogenesis of myeloma bone disease

Roodman, G. D., Mar 2004, In : Blood Cells, Molecules and Diseases. 32, 2, p. 290-292 3 p.

Research output: Contribution to journalArticle

Bone Diseases
Bone and Bones
Osteoclasts
Stromal Cells
Osteogenesis
44 Citations (Scopus)

Role of TAFII-17, a VDR binding protein, in the increased osteoclast formation in Paget's disease

Kurihara, N., Reddy, S. V., Araki, N., Ishizuka, S., Ozono, K., Cornish, J., Cundy, T., Singer, F. R. & Roodman, G. D., Jul 2004, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 19, 7, p. 1154-1164 11 p.

Research output: Contribution to journalArticle

Vitamin D-Binding Protein
Calcitriol Receptors
Osteoclasts
measles virus nucleocapsid protein
Transcription Factor TFIID
32 Citations (Scopus)

Vitamin D antagonist, TEI-9647, inhibits osteoclast formation induced by 1α,25-dihydroxyvitamin D3 from pagetic bone marrow cells

Ishizuka, S., Kurihara, N., Miura, D., Takenouchi, K., Cornish, J., Cundy, T., Reddy, S. V. & Roodman, G. D., May 2004, In : Journal of Steroid Biochemistry and Molecular Biology. 89-90, p. 331-334 4 p.

Research output: Contribution to journalArticle

Calcitriol
Osteoclasts
Vitamin D
Bone Marrow Cells
Bone
2003
36 Citations (Scopus)

AML-1A and AML-1B regulation of MIP-1α expression in multiple myeloma

Choi, S. J., Oba, T., Callander, N. S., Jelinek, D. F. & Roodman, G. D., May 15 2003, In : Blood. 101, 10, p. 3778-3783 6 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Multiple Myeloma
Acute Myeloid Leukemia
Messenger RNA
Bone
1636 Citations (Scopus)

Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: A report of the International Myeloma Working Group

Kyle, R. A., Child, J. A., Anderson, K., Barlogie, B., Bataille, R., Bensinger, W., Bladé, J., Boccadoro, M., Dalton, W., Dimopoulos, M., Djulbegovic, B., Drayson, M., Durie, B., Facon, T., Fonseca, R., Gahrton, G., Greipp, P., Harousseau, J. L., Harrington, D., Hussein, M. & 19 others, Joshua, D., Ludwig, H., Morgan, G., Oken, M., Powles, R., Richardson, P., Roodman, G. D., San Miguel, J., Shimizu, K., Shustik, C., Sirohi, B., Sonneveld, P., Tricot, G., Turesson, I., Van Ness, B., Vesole, D., Weber, D., Westin, J. & Wheatley, K., Jun 2003, In : British Journal of Haematology. 121, 5, p. 749-757 9 p.

Research output: Contribution to journalArticle

Paraproteinemias
Plasmacytoma
Multiple Myeloma
Plasma Cells
Bone Marrow Cells
15 Citations (Scopus)
Eosinophil Chemotactic Factors
Osteoclasts
Bone Marrow
Conditioned Culture Medium
Osteogenesis
Osteoclasts
Bone Resorption
4 Citations (Scopus)

Mechanisms of bone resorption in myeloma

Roodman, G. D., Dec 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 4, p. 271-272 2 p.

Research output: Contribution to journalArticle

Interleukin-3
Osteoclasts
Bone Resorption
88 Citations (Scopus)
Neoplasm Metastasis
Bone and Bones
Bone Neoplasms
Breast Neoplasms
Prostate
331 Citations (Scopus)

Myeloma management guidelines: A consensus report from the Scientific Advisors of the International Myeloma Foundation

Durie, B. G. M., Kyle, R. A., Belch, A., Bensinger, W., Blade, J., Boccadoro, M., Child, J. A., Comenzo, R., Djulbegovic, B., Fantl, D., Gahrton, G., Harousseau, J. L., Hungria, V., Joshua, D., Ludwig, H., Mehta, J., Morales, A. R., Morgan, G., Nouel, A., Oken, M. & 9 others, Powles, R., Roodman, G. D., San Miquel, J., Shimizu, K., Singhal, S., Sirohi, B., Sonneveld, P., Tricot, G. & Van Ness, B., 2003, In : Hematology Journal. 4, 6, p. 379-398 20 p.

Research output: Contribution to journalArticle

Guidelines
Expert Testimony
Therapeutics
Internet
Databases
1 Citation (Scopus)

Recent developments in Paget's disease

Roodman, G. D., May 2003, In : Advanced Studies in Medicine. 3, 5, p. 286-292 7 p.

Research output: Contribution to journalArticle

Skeleton
Alkaline Phosphatase
Bone and Bones
Diphosphonates
Osteoclasts
55 Citations (Scopus)

Role of stromal-derived cytokines and growth factors in bone metastasis

Roodman, G. D., Feb 1 2003, In : Cancer. 97, 3 SUPPL., p. 733-738 6 p.

Research output: Contribution to journalArticle

Intercellular Signaling Peptides and Proteins
Cytokines
Neoplasm Metastasis
Bone and Bones
Bone Development

Summary - Bone resorption session

Roodman, G. D., Dec 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 4, p. 292-294 3 p.

Research output: Contribution to journalArticle

Bone Resorption
2002
80 Citations (Scopus)

Human bone marrow myeloma cells express RANKL [2] (multiple letters)

Sezer, O., Heider, U., Jakob, C., Eucker, J., Possinger, K. & Roodman, G. D., Jan 1 2002, In : Journal of Clinical Oncology. 20, 1, p. 353-354 2 p.

Research output: Contribution to journalArticle

Receptor Activator of Nuclear Factor-kappa B
RANK Ligand
Myeloma Proteins
Membrane Glycoproteins
Multiple Myeloma
68 Citations (Scopus)

Multiple myeloma.

Anderson, K. C., Shaughnessy, J. D., Barlogie, B., Harousseau, J. L. & Roodman, G. D., 2002, In : Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. p. 214-240 27 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Transplantation
Bone Diseases
Cell Communication
Therapeutics
104 Citations (Scopus)
Multiple Myeloma
Bone Marrow
Osteoclasts
Neoplasms
Stromal Cells