G. David Roodman

  • 23000 Citations
  • 79 h-Index
1975 …2020
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Publications 1975 2019

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Article
1998
2 Citations (Scopus)

Pagetic osteoclasts formed in vitro: Absence of paracrystalline inclusions

Roodman, G. D., Ohsaki, Y., Miller, M. M., Demulder, A., Hosking, D., Singer, F. R. & McManus, L. M., Apr 1998, In : Journal of Submicroscopic Cytology and Pathology. 30, 2, p. 315-327 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Nucleocapsid
Distemper
Bone and Bones
Intranuclear Inclusion Bodies
1 Citation (Scopus)

Paget's Disease of Bone

Roodman, G. D., 1998, In : Advances in Organ Biology. 5, C, p. 661-675 15 p.

Research output: Contribution to journalArticle

Bone
1997
12 Citations (Scopus)

Cokeromyces recurvatus infection in a bone marrow transplant recipient

Tsai, T. W., Hammond, L. A., Rinaldi, M., Martin, K., Tio, F., Maples, J., Freytes, C. O. & Roodman, G. D., Feb 1 1997, In : Bone Marrow Transplantation. 19, 3, p. 301-302 2 p.

Research output: Contribution to journalArticle

Diarrhea
Bone Marrow
Infection
Transplants
Transplant Recipients
131 Citations (Scopus)

Genetic linkage of Paget disease of the bone to chromosome 18q

Cody, J. D., Singer, F. R., Roodman, G. D., Otterund, B., Lewis, T. B., Leppert, M. & Leach, R. J., Nov 1997, In : American Journal of Human Genetics. 61, 5, p. 1117-1122 6 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Genetic Linkage
Chromosomes
Osteoclasts
Intranuclear Inclusion Bodies
141 Citations (Scopus)

Mechanisms of bone lesions in multiple myeloma and lymphoma

Roodman, G. D., Oct 15 1997, In : Cancer. 80, 8 SUPPL., p. 1557-1563 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Lymphoma
Bone and Bones
Parathyroid Hormone-Related Protein
Adult T Cell Leukemia Lymphoma
46 Citations (Scopus)

Tumor necrosis factor enhances parathyroid hormone-related protein- induced hypercalcemia and bone resorption without inhibiting: Bone formation in vivo

Uy, H. L., Mundy, G. R., Boyce, B. F., Story, B. M., Dunstan, C. R., Yin, J. J., Roodman, G. D. & Guise, T., 1997, In : Cancer Research. 57, 15, p. 3194-3199 6 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Hypercalcemia
Bone Resorption
Osteogenesis
Cricetulus
1996
8 Citations (Scopus)

Absence of paramyxo virus transcripts in juvenile Paget bone disease.

Whyte, M. P., Leelawattana, R., Reddy, S. V. & Roodman, G. D., Jul 1996, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 11, 7, p. 1041 1 p.

Research output: Contribution to journalArticle

Respirovirus
Osteitis Deformans
Viral RNA
Viruses
Bone and Bones
438 Citations (Scopus)

Advances in bone biology: The osteoclast

Roodman, G. D., 1996, In : Endocrine Reviews. 17, 4, p. 308-332 25 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone and Bones
Bone Resorption
Hormones
Cytokines
266 Citations (Scopus)
Biological Models
Bone Remodeling
Diphosphonates
Calcitonin
Osteoclasts
2 Citations (Scopus)

Assignment of matrix metalloproteinase 9 (Mmp9) to mouse Chromosome 2 bands H1-H2

DuPont, B. R., Linn, R., Knight, C. B., Roodman, G. D., Sakaguchi, A. Y., Lalley, P. A., Fournier, R. E. K. & Leach, R. J., 1996, In : Cytogenetics and Cell Genetics. 74, 1-2, p. 118-119 2 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Cytokine Regulation of Bone Cell Differentiation

Alsina, M., Guise, T. & Roodman, G. D., 1996, In : Vitamins and Hormones. 52, C, p. 63-98 36 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteoblasts
Cell Division
Cell Differentiation
Cytokines
78 Citations (Scopus)
Nucleocapsid
Measles virus
Osteoclasts
Blood Cells
Granulocyte-Macrophage Progenitor Cells
80 Citations (Scopus)

Development of an in vivo model of human multiple myeloma bone disease

Alsina, M., Boyce, B., Devlin, R. D., Anderson, J. L., Craig, F., Mundy, G. R. & Roodman, G. D., Feb 15 1996, In : Blood. 87, 4, p. 1495-1501 7 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Bone
Bone and Bones
Hypercalcemia
22 Citations (Scopus)

Inhibition of tartrate-resistant acid phosphatase gene expression by hemin and protoporphyrin IX. Identification of a hemin-responsive inhibitor of transcription

Reddy, S. V., Alcantara, O., Roodman, G. D. & Boldt, D. H., Sep 15 1996, In : Blood. 88, 6, p. 2288-2297 10 p.

Research output: Contribution to journalArticle

Hemin
Heroin
Transcription
Acid Phosphatase
Gene expression
143 Citations (Scopus)

Interleukin-6: A potential mediator of the massive osteolysis in patients with Gorham-Stout disease

Devlin, R. D., Bone, H. G. & Roodman, G. D., 1996, In : Journal of Clinical Endocrinology and Metabolism. 81, 5, p. 1893-1897 5 p.

Research output: Contribution to journalArticle

Essential Osteolysis
Interleukin-6
Serum
Bone
Osteoclasts
35 Citations (Scopus)

Paget's disease and osteoclast biology

Roodman, G. D., Sep 1996, In : Bone. 19, 3, p. 209-212 4 p.

Research output: Contribution to journalArticle

Osteoclasts

Rutologous hematopoietic stem cell transplantation for poof prognosis low grade lymphoka

Frevets, C. O., Vukelia, S., Castro, D. J., Boldt, D., Roodman, G. D., Hilesbeck, S., Adkins, D., Bachier, C., Craig, F., Clare, N., Weismare, A. & Lemaistre, C. F., 1996, In : Experimental Hematology. 24, 9, p. 1140 1 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Drug Therapy
Stem Cells
1995
8 Citations (Scopus)

An in vivo model of human multiple myeloma bone disease

Alsina, M., Boyce, B. F., Mundy, G. R. & Roodman, G. D., 1995, In : Stem Cells. 13, SUPPL. 2, p. 48-50 3 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Hypercalcemia
Bone and Bones
Severe Combined Immunodeficiency
853 Citations (Scopus)

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

Hughes, D. E., Wright, K. R., Uy, H. L., Sasaki, A., Yoneda, T., Roodman, G. D., Mundy, G. R. & Boyce, B. F., 1995, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 10, 10, p. 1478-1487 10 p.

Research output: Contribution to journalArticle

Diphosphonates
Osteoclasts
Apoptosis
Bone Resorption
pamidronate
98 Citations (Scopus)
Nucleocapsid
Measles virus
Viruses
Bone Marrow Cells
Osteoclasts
15 Citations (Scopus)

Characterization of the 5′-flanking region of the human tartrate-resistant acid phosphatase (TRAP) gene

Reddy, S. V., Kuzhandaivelu, N., Acosta, L. G. & Roodman, G. D., 1995, In : Bone. 16, 5, p. 587-593 7 p.

Research output: Contribution to journalArticle

5' Flanking Region
Genes
Introns
Gene Expression
Tartrate-Resistant Acid Phosphatase
70 Citations (Scopus)

Characterization of the mouse tartrate-resistant acid phosphatase (TRAP) gene promoter

Reddy, S. V., Hundley, J. E., Windle, J. J., Alcantara, O., Linn, R., Leach, R. J., Boldt, D. H. & Roodman, G. D., 1995, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 10, 4, p. 601-606 6 p.

Research output: Contribution to journalArticle

Genes
Iron
Iron-Binding Proteins
5' Flanking Region
Heroin
19 Citations (Scopus)

Characterization of the osteoclast vacuolar H+-ATPase B-subunit

Bartkiewicz, M., Hernando, N., Reddy, S. V., Roodman, G. D. & Baron, R., 1995, In : Gene. 160, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

Vacuolar Proton-Translocating ATPases
Osteoclasts
Protein Isoforms
Chickens
Messenger RNA
37 Citations (Scopus)

Development and characterization of a human marrow stromal cell line that enhances osteoclast-like cell formation

Takahashi, S., Reddy, S. V., Dallas, M., Devlin, R., Chou, J. Y. & Roodman, G. D., 1995, In : Endocrinology. 136, 4, p. 1441-1449 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Stromal Cells
Bone Marrow
Cell Line
Simian virus 40
105 Citations (Scopus)

Downregulation of calcitonin receptor mRNA expression by calcitonin during human osteoclast-like cell differentiation

Takahashi, S., Goldring, S., Katz, M., Hilsenbeck, S., Williams, R. & Roodman, G. D., Jan 1995, In : Journal of Clinical Investigation. 95, 1, p. 167-171 5 p.

Research output: Contribution to journalArticle

Calcitonin Receptors
Calcitonin
Osteoclasts
Cell Differentiation
Down-Regulation
33 Citations (Scopus)

Effects of parathyroid hormone (PTH)-related protein and PTH on osteoclasts and osteoclast precursors in vivo

Uy, H. L., Guise, T., De La Mata, J., Taylor, S. D., Story, B. M., Dallas, M. R., Boyce, B. F., Mundy, G. R. & Roodman, G. D., Aug 1995, In : Endocrinology. 136, 8, p. 3207-3212 6 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Osteoclasts
Parathyroid Hormone
Granulocyte-Macrophage Progenitor Cells
Hypercalcemia
211 Citations (Scopus)

Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo

De La Mata, J., Uy, H. L., Guise, T., Story, B., Boyce, B. F., Mundy, G. R. & Roodman, G. D., 1995, In : Journal of Clinical Investigation. 95, 6, p. 2846-2852 7 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Hypercalcemia
Bone Resorption
Interleukin-6
Osteoclasts
40 Citations (Scopus)

Osteoclast function in Paget's disease and multiple myeloma

Roodman, G. D., 1995, In : Bone. 17, 2 SUPPL. 1

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Interleukin-6
Bone Marrow
Bone Resorption
41 Citations (Scopus)

Targeting simian virus 40 T antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation and apoptosis of osteoclasts

Boyce, B. F., Wright, K., Reddy, S. V., Koop, B. A., Story, B., Devlin, R., Leach, R. J., Roodman, G. D. & Windle, J. L., 1995, In : Endocrinology. 136, 12, p. 5751-5759 9 p.

Research output: Contribution to journalArticle

Simian virus 40
Viral Tumor Antigens
Osteoclasts
Transgenic Mice
Apoptosis
42 Citations (Scopus)
Osteoclasts
Interleukin-1
Granulocyte-Macrophage Progenitor Cells
Bone Density Conservation Agents
Bone Remodeling
1994
4 Citations (Scopus)

Biology of the osteoclast in Paget's disease

Roodman, G. D., 1994, In : Seminars in Arthritis and Rheumatism. 23, 4, p. 235-236 2 p.

Research output: Contribution to journalArticle

Viral Inclusion Bodies
Osteitis Deformans
Osteoclasts
Cell Division
Interleukin-6
83 Citations (Scopus)

Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption

Takahashi, S., Reddy, S. V., Chirgwin, J., Devlin, R., Haipek, C., Anderson, J. & Roodman, G. D., Nov 18 1994, In : Journal of Biological Chemistry. 269, 46, p. 28696-28701 6 p.

Research output: Contribution to journalArticle

Annexin A2
Cloning
Osteoclasts
Bone Resorption
Organism Cloning
58 Citations (Scopus)
Giant Cell Tumor of Bone
Giant Cells
Bone Resorption
Interleukin-6
Bone and Bones
60 Citations (Scopus)

Multinucleated cells formed in vitro from Paget's bone marrow express viral antigens

Mills, B. G., Frausto, A., Singer, F. R., Ohsaki, Y., Demulder, A. & Roodman, G. D., 1994, In : Bone. 15, 4, p. 443-448 6 p.

Research output: Contribution to journalArticle

Viral Antigens
Osteoclasts
Bone Marrow
Measles
Viruses
7 Citations (Scopus)

Phase I trial of dacarbazine with cyclophosphamide, carmustine, etoposide, and autologous stem-cell transplantation in patients with lymphoma and multiple myeloma

Adkins, D. R., Salzman, D., Boldt, D., Kuhn, J., Irvin, R., Roodman, G. D., Lyons, R., Smith, L., Freytes, C. O. & LeMaistre, C. F., Sep 1994, In : Journal of Clinical Oncology. 12, 9, p. 1890-1901 12 p.

Research output: Contribution to journalArticle

Carmustine
Dacarbazine
Stem Cell Transplantation
Etoposide
Multiple Myeloma
32 Citations (Scopus)

Transcriptional regulation of the tartrate-resistant acid phosphatase (TRAP) gene by iron

Alcantara, O., Reddy, S. V., Roodman, G. D. & Boldt, D. H., 1994, In : Biochemical Journal. 298, 2, p. 421-425 5 p.

Research output: Contribution to journalArticle

Acid Phosphatase
Iron
Genes
Luciferases
5' Flanking Region
1993
76 Citations (Scopus)

5-Lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices

Gallwitz, W. E., Mundy, G. R., Lee, C. H., Qiao, M., Roodman, G. D., Raftery, M., Gaskell, S. J. & Bonewald, L., May 15 1993, In : Journal of Biological Chemistry. 268, 14, p. 10087-10094 8 p.

Research output: Contribution to journalArticle

Arachidonate 5-Lipoxygenase
Osteoclasts
Metabolites
Arachidonic Acid
Bone
63 Citations (Scopus)

Abnormalities in osteoclast precursors and marrow accessory cells in Paget's disease

Demulder, A., Takahashi, S., Singer, F. R., Hosking, D. J. & Roodman, G. D., Nov 1993, In : Endocrinology. 133, 5, p. 1978-1982 5 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone Marrow
Granulocyte-Macrophage Progenitor Cells
Calcitriol
CD34 Antigens
7 Citations (Scopus)

A phase I clinical and pharmacological profile of dacarbazine with autologous bone marrow transplantation in patients with solid tumors

Adkins, D. R., Irvin, R., Kuhn, J., Boldt, D. H., Roodman, G. D., Salzman, D., Freytes, C., Von Hoff, D. D. & LeMaistre, C. F., Jun 1993, In : Investigational New Drugs. 11, 2-3, p. 169-179 11 p.

Research output: Contribution to journalArticle

Dacarbazine
Autologous Transplantation
Bone Marrow Transplantation
Pharmacology
Neoplasms
14 Citations (Scopus)

Assignment of the Mouse Tartrate-Resistant Acid Phosphatase Gene (Acp5) to Chromosome 9

Grimes, R., Reddy, S. V., Leach, R. J., Scarcez, T., Roodman, G. D., Sakaguchi, A. Y., Lalley, P. A. & Windle, J. J., Feb 1993, In : Genomics. 15, 2, p. 421-422 2 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 9
Hybrid Cells
Human Chromosomes
Osteoclasts
Bone Resorption
13 Citations (Scopus)

Cellular interactions in hemopoietic progenitor cell homing: A review

Hardy, C. L., Minguell, J. J., Roodman, G. D., Greenberger, J. S. & Allen, T. D., Mar 1993, In : Scanning Microscopy. 7, 1, p. 333-341 9 p.

Research output: Contribution to journalArticle

homing
Stem cells
stem cells
Bone
cells
37 Citations (Scopus)

Cloning and characterization of the 5′-flanking region of the mouse tartrate-resistant acid phosphatase gene

Reddy, S. V., Scarcez, T., Windle, J. J., Leach, R. J., Hundley, J. E., Chirgwin, J., Chou, J. Y. & Roodman, G. D., Oct 1993, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 8, 10, p. 1263-1270 8 p.

Research output: Contribution to journalArticle

5' Flanking Region
Organism Cloning
Osteoclasts
Genes
Bone Resorption
25 Citations (Scopus)

Comparison of engraftment and acute GVHD in patients undergoing cryopreserved or fresh allogeneic BMT

Eckardt, J. R., Roodman, G. D., Boldt, D. H., Clark, G. M., Alvarez, R., Page, C., Gaskill, H. & LeMaistre, C. F., 1993, In : Bone Marrow Transplantation. 11, 2, p. 125-131 7 p.

Research output: Contribution to journalArticle

Bone Marrow
Tissue Donors
Platelet Transfusion
Granulocytes
Recurrence
4 Citations (Scopus)

In vitro cytotoxicity of hepsulfam against human tumor cell lines and primary human tumor colony forming units

Marshall, M. V., Marshall, M. H., Degen, D. R., Roodman, G. D., Kuhn, J. G., Ross, M. E. & Von Hoff, D. D., 1993, In : Stem Cells. 11, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Nutritional parameters observed during 28-day infusion of recombinant human tumor necrosis factor-α

Hardin, T. C., Koeller, J. M., Kuhn, J. G., Roodman, G. D. & Von Hoff, D. D., 1993, In : Journal of Parenteral and Enteral Nutrition. 17, 6, p. 541-545 5 p.

Research output: Contribution to journalArticle

tumor necrosis factors
resting energy expenditure
Energy Metabolism
Serum
Indirect Calorimetry
144 Citations (Scopus)

Role of cytokines in the regulation of bone resorption

Roodman, G. D., Feb 1993, In : Calcified Tissue International. 53, 1 Supplement

Research output: Contribution to journalArticle

Osteoclasts
Bone Resorption
Cytokines
Bone Marrow
Bone Remodeling
7 Citations (Scopus)

Tartrate-resistant acid phosphatase gene expression as a facile reporter gene for screening transfection efficiency in mammalian cell cultures

Reddy, S. V., Takahashi, S., Haipek, C., Chirgwin, J. & Roodman, G. D., 1993, In : BioTechniques. 15, 3, p. 444-446 3 p.

Research output: Contribution to journalArticle

Tartrates
Calcium Phosphates
beta-Galactosidase
Acid Phosphatase
Cell culture
1992
34 Citations (Scopus)

Effects of stem cell factor on osteoclast-like cell formation in long-term human marrow cultures

Demulder, A., Suggs, S. V., Zsebo, K. M., Scarcez, T. & Roodman, G. D., Nov 1992, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 7, 11, p. 1337-1344 8 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Osteoclasts
Bone Marrow
Hematopoietic Stem Cells
Mast Cells
6 Citations (Scopus)

Effects of TNF and lymphotoxin on bone cells.

Mundy, G. R., Roodman, G. D., Bonewald, L., Yoneda, T. & Sabatini, M., 1992, In : Immunology series. 56, p. 483-498 16 p.

Research output: Contribution to journalArticle

Lymphotoxin-alpha
Bone Remodeling
Bone Diseases
Osteoclasts
Multiple Myeloma
146 Citations (Scopus)

Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone

Ohsaki, Y., Takahashi, S., Scarcez, T., Demulder, A., Nishihara, T., Williams, R. & Roodman, G. D., Nov 1992, In : Endocrinology. 131, 5, p. 2229-2234 6 p.

Research output: Contribution to journalArticle

Giant Cell Tumor of Bone
Giant Cells
Bone Resorption
Interleukin-6
Osteoclasts