Gary Hutchins

  • 9806 Citations
  • 56 h-Index
1982 …2020

Research output per year

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Publications

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Article
2020

[68Ga]Ga-P16-093 as a PSMA-Targeted PET Radiopharmaceutical for Detection of Cancer: Initial Evaluation and Comparison with [68Ga]Ga-PSMA-11 in Prostate Cancer Patients Presenting with Biochemical Recurrence

Green, M. A., Hutchins, G. D., Bahler, C. D., Tann, M., Mathias, C. J., Territo, W., Sims, J., Polson, H., Alexoff, D., Eckelman, W. C., Kung, H. F. & Fletcher, J. W., Jun 1 2020, In : Molecular Imaging and Biology. 22, 3, p. 752-763 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2 Scopus citations
2019

Synthesis and initial in vitro characterization of a new P2X7R radioligand [18F]IUR-1602

Gao, M., Wang, M., Glick-Wilson, B. E., Meyer, J. A., Peters, J. S., Territo, P. R., Green, M. A., Hutchins, G. D., Zarrinmayeh, H. & Zheng, Q. H., Feb 2019, In : Applied Radiation and Isotopes. 144, p. 10-18 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis and in vitro biological evaluation of new P2X7R radioligands [ 11 C]halo-GSK1482160 analogs

Gao, M., Wang, M., Meyer, J. A., Territo, P. R., Hutchins, G. D., Zarrinmayeh, H. & Zheng, Q. H., Jun 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 12, p. 1476-1480 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection vs. Insulin Alone in Type 2 Diabetes

Mather, K., Considine, R., Hamilton, L., Patel, N. A., Mathias, C., Territo, W., Goodwill, A. G., Tune, J., Green, M. & Hutchins, G., Sep 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 9, p. 3456-3465 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis and preliminary biological evaluation of a novel P2X7R radioligand [18F]IUR-1601

Gao, M., Wang, M., Glick-Wilson, B. E., Meyer, J. A., Peters, J. S., Territo, P. R., Green, M. A., Hutchins, G. D., Zarrinmayeh, H. & Zheng, Q. H., May 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 9, p. 1603-1609 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
2017

Characterization of 11C-GSK1482160 for Targeting the P2X7 receptor as a biomarker for neuroinflammation

Territo, P., Meyer, J. A., Peters, J. S., Riley, A. A., McCarthy, B. P., Gao, M., Min, W., Green, M., Zheng, Q-H. & Hutchins, G., Mar 1 2017, In : Journal of Nuclear Medicine. 58, 3, p. 458-465 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Development of a novel magnetic resonance imaging acquisition and analysis workflow for the quantification of shock wave lithotripsy-induced renal hemorrhagic injury

Handa, R. K., Territo, P. R., Blomgren, P. M., Persohn, S. A., Lin, C., Johnson, C. D., Jiang, L., Connors, B. A. & Hutchins, G. D., Oct 1 2017, In : Urolithiasis. 45, 5, p. 507-513 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model

Allen, M. R., McNerny, E., Aref, M., Organ, J. M., Newman, C. L., McGowan, B., Jang, T., Burr, D. B., Brown, D. M., Hammond, M., Territo, P. R., Lin, C., Persohn, S., Jiang, L., Riley, A. A., McCarthy, B. P., Hutchins, G. D. & Wallace, J. M., Aug 1 2017, In : PloS one. 12, 8, e0181750.

Research output: Contribution to journalArticle

1 Scopus citations

Estimation of radiation dosimetry for 68Ga-HBED-CC (PSMA-11) in patients with suspected recurrence of prostate cancer

Green, M. A., Eitel, J. A., Fletcher, J. W., Mathias, C. J., Tann, M. A., Territo, W., Polson, H., Hutchins, G. D., Gardner, T. & Koch, M. O., Mar 1 2017, In : Nuclear Medicine and Biology. 46, p. 32-35 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
9 Scopus citations
8 Scopus citations

Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor

Wang, M., Gao, M., Meyer, J. A., Peters, J. S., Zarrinmayeh, H., Territo, P. R., Hutchins, G. D. & Zheng, Q. H., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 14, p. 3835-3844 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Assessment of myocardial metabolic flexibility and work efficiency in human type 2 diabetes using 16-[18F]fluoro-4-thiapalmitate, a novel PET fatty acid tracer

Mather, K. J., Hutchins, G. D., Perry, K., Territo, W., Chisholm, R., Acton, A., Glick-Wilson, B., Considine, R. V., Moberly, S. & DeGrado, T. R., Jan 1 2016, In : American Journal of Physiology - Endocrinology and Metabolism. 310, 6, p. E452-E460

Research output: Contribution to journalArticle

24 Scopus citations

Differential dopamine function in fibromyalgia

Albrecht, D. S., MacKie, P. J., Kareken, D. A., Hutchins, G. D., Chumin, E. J., Christian, B. T. & Yoder, K. K., Sep 1 2016, In : Brain Imaging and Behavior. 10, 3, p. 829-839 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Measurement of cardiovascular function using a novel view-sharing PET reconstruction method and tracer kinetic analysis

Territo, P., Riley, A. A., McCarthy, B. P. & Hutchins, G., Dec 1 2016, In : EJNMMI Physics. 3, 1, 24.

Research output: Contribution to journalArticle

2 Scopus citations

Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney

Hato, T., Friedman, A. N., Mang, H., Plotkin, Z., Dube, S., Hutchins, G. D., Territo, P. R., McCarthy, B. P., Riley, A. A., Pichumani, K., Malloy, C. R., Harris, R. A., Daghe, P. C. & Sutton, T. A., Apr 15 2016, In : American Journal of Physiology - Renal Physiology. 310, 8, p. F717-F725

Research output: Contribution to journalArticle

11 Scopus citations

Preclinical Evidence for the Use of Sunitinib Malate in the Treatment of Plexiform Neurofibromas

Ferguson, M. J., Rhodes, S. D., Jiang, L., Li, X., Yuan, J., Yang, X., Zhang, S., Vakili, S. T., Territo, P., Hutchins, G., Yang, F. C., Ingram, D. A., Clapp, D. W. & Chen, S., Feb 1 2016, In : Pediatric Blood and Cancer. 63, 2, p. 206-213 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation

Gehlhausen, J. R., Park, S. J., Hickox, A. E., Shew, M., Staser, K., Rhodes, S. D., Menon, K., Lajiness, J. D., Mwanthi, M., Yang, X., Yuan, J., Territo, P., Hutchins, G., Nalepa, G., Yang, F-C., Conway, S. J., Heinz, M. G., Stemmer-Rachamimov, A., Yates, C. W. & Clapp, D. W., Jan 1 2015, In : Human molecular genetics. 24, 1, p. 1-8 8 p., ddu414.

Research output: Contribution to journalArticle

31 Scopus citations

Comparison of standardized uptake values with volume of distribution for quantitation of [11C]PBR28 brain uptake

Yoder, K. K., Territo, P. R., Hutchins, G. D., Hannestad, J., Morris, E. D., Gallezot, J. D., Normandin, M. D. & Cosgrove, K. P., Mar 1 2015, In : Nuclear Medicine and Biology. 42, 3, p. 305-308 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP

Ramanan, V. K., Risacher, S. L., Nho, K., Kim, S., Shen, L., McDonald, B. C., Yoder, K. K., Hutchins, G. D., West, J. D., Tallman, E. F., Gao, S., Foroud, T. M., Farlow, M. R., De Jager, P. L., Bennett, D. A., Aisen, P. S., Petersen, R. C., Jack, C. R., Toga, A. W., Green, R. C. & 3 others, Jagust, W. J., Weiner, M. W. & Saykin, A. J., Oct 1 2015, In : Brain. 138, 10, p. 3076-3088 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

In Vivo UTE-MRI Reveals Positive Effects of Raloxifene on Skeletal-Bound Water in Skeletally Mature Beagle Dogs

Allen, M. R., Territo, P. R., Lin, C., Persohn, S., Jiang, L., Riley, A. A., McCarthy, B. P., Newman, C. L., Burr, D. B. & Hutchins, G. D., Aug 1 2015, In : Journal of Bone and Mineral Research. 30, 8, p. 1441-1444 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Synthesis of [11C]GSK1482160 as a new PET agent for targeting P2X7 receptor

Gao, M., Wang, M., Green, M. A., Hutchins, G. D. & Zheng, Q. H., May 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 9, p. 1965-1970 6 p.

Research output: Contribution to journalArticle

49 Scopus citations
4 Scopus citations
2014

Cerebral hypometabolism and grey matter density in MAPT intron 10 +3 mutation carriers

Deters, K. D., Risacher, S. L., Farlow, M., Unverzagt, F., Kareken, D., Hutchins, G., Yoder, K., Murrell, J. R., Spina, S., Epperson, F., Gao, S., Saykin, A. & Ghetti, B., 2014, In : American Journal of Neurodegenerative Diseases. 3, 3, p. 103-114 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
13 Scopus citations

The HMGB1-RAGE axis mediates traumaticbrain injury - Induced pulmonary dysfunction in lung transplantation

Weber, D. J., Gracon, A. S. A., Ripsch, M. S., Fisher, A. J., Cheon, B. M., Pandya, P. H., Vittal, R., Capitano, M. L., Kim, Y., Allette, Y. M., Riley, A. A., McCarthy, B. P., Territo, P. R., Hutchins, G. D., Broxmeyer, H. E., Sandusky, G. E., White, F. A. & Wilkes, D. S., Sep 3 2014, In : Science translational medicine. 6, 252, 252ra124.

Research output: Contribution to journalArticle

51 Scopus citations

The impact of image reconstruction bias on PET/CT 90Y dosimetry after radioembolization

Tapp, K. N., Lea, W. B., Johnson, M. S., Tann, M., Fletcher, J. W. & Hutchins, G. D., Sep 1 2014, In : Journal of Nuclear Medicine. 55, 9, p. 1452-1458 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013
9 Scopus citations

Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus

Moberly, S. P., Mather, K. J., Berwick, Z. C., Owen, M. K., Goodwill, A. G., Casalini, E. D., Hutchins, G. D., Green, M. A., Ng, Y., Considine, R. V., Perry, K. M., Chisholm, R. L. & Tune, J. D., Jun 14 2013, In : Basic Research in Cardiology. 108, 4, 365.

Research output: Contribution to journalArticle

35 Scopus citations
2012

A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor

Wang, M., Gao, M., Steele, B. L., Glick-Wilson, B. E., Brown-Proctor, C., Shekhar, A., Hutchins, G. D. & Zheng, Q. H., Jul 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 14, p. 4713-4718 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: A phase 2 trial

Robertson, K. A., Nalepa, G., Yang, F-C., Bowers, D. C., Ho, C. Y., Hutchins, G. D., Croop, J. M., Vik, T. A., Denne, S. C., Parada, L. F., Hingtgen, C. M., Walsh, L. E., Yu, M., Pradhan, K. R., Edwards-Brown, M. K., Cohen, M. D., Fletcher, J. W., Travers, J. B., Staser, K. W., Lee, M. W. & 5 others, Sherman, M. R., Davis, C. J., Miller, L. C., Ingram, D. A. & Clapp, D. W., Dec 1 2012, In : The Lancet Oncology. 13, 12, p. 1218-1224 7 p.

Research output: Contribution to journalArticle

113 Scopus citations

Small animal PET imaging

Hutchins, G. D., Miller, M. A., Soon, V. C. & Receveur, T., Sep 11 2012, In : ILAR Journal. 53, 1, p. 54-65 12 p.

Research output: Contribution to journalArticle

2011

Assessment of IP injection of [18F]fallypride for behavioral neuroimaging in rats

Yoder, K. K., Mock, B. H., Zheng, Q. H., McCarthy, B. P., Riley, A. A. & Hutchins, G. D., Mar 15 2011, In : Journal of Neuroscience Methods. 196, 1, p. 70-75 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia

Murphy, M. P., Lawson, J. H., Rapp, B. M., Dalsing, M. C., Klein, J., Wilson, M. G., Hutchins, G. D. & March, K. L., Jun 2011, In : Journal of vascular surgery. 53, 6, p. 1565-1574.e1

Research output: Contribution to journalArticle

73 Scopus citations

Positron emission tomography (PET) assessment of renal perfusion

Green, M. A. & Hutchins, G. D., May 1 2011, In : Seminars in Nephrology. 31, 3, p. 291-299 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Regional reproducibility of pulsed arterial spin labeling perfusion imaging at 3T

Wang, Y., Saykin, A. J., Pfeuffer, J., Lin, C., Mosier, K. M., Shen, L., Kim, S. & Hutchins, G. D., Jan 15 2011, In : NeuroImage. 54, 2, p. 1188-1195 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Striatal dopamine transporter availability in unmedicated bipolar disorder

Anand, A., Barkay, G., Dzemidzic, M., Albrecht, D., Karne, H., Zheng, Q. H., Hutchins, G. D., Normandin, M. D. & Yoder, K. K., Jun 1 2011, In : Bipolar Disorders. 13, 4, p. 406-413 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Synthesis of carbon-11-labeled bivalent Β-carbolines as new PET agents for imaging of cholinesterase in Alzheimer's disease

Wang, M., Zheng, D. X., Gao, M., Hutchins, G. D. & Zheng, Q. H., Apr 1 2011, In : Applied Radiation and Isotopes. 69, 4, p. 678-685 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

The first synthesis of [11C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3)

Wang, M., Gao, M., Miller, K. D., Sledge, G. W., Hutchins, G. D. & Zheng, Q. H., Jan 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 1, p. 245-249 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
2010
16 Scopus citations

An improved synthesis of dopamine D2/D3 receptor radioligands [11C]fallypride and [18F]fallypride

Gao, M., Wang, M., Mock, B. H., Glick-Wilson, B. E., Yoder, K. K., Hutchins, G. D. & Zheng, Q. H., Jun 1 2010, In : Applied Radiation and Isotopes. 68, 6, p. 1079-1086 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

Cerebral metabolism in dogs assessed by 18F-FDG PET: A pilot study to understand physiological changes in behavioral disorders in dogs

Irimajiri, M., Miller, M. A., Green, M. A., Jaeger, C. B., Luescher, A. U. & Hutchins, G. D., Jan 1 2010, In : Journal of Veterinary Medical Science. 72, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Facile synthesis of carbon-11-labeled cholesterol-based cationic lipids as new potential PET probes for imaging of gene delivery in cancer

Gao, M., Wang, M., Miller, K. D., Sledge, G. W., Hutchins, G. D. & Zheng, Q. H., Oct 1 2010, In : Steroids. 75, 10, p. 715-720 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Pancreatic cancer: Utility of dynamic contrast-enhanced MR imaging in assessment of antiangiogenic therapy

Akisik, M. F., Sandrasegaran, K., Bu, G., Lin, C., Hutchins, G. D. & Chiorean, E. G., Aug 1 2010, In : Radiology. 256, 2, p. 441-449 9 p.

Research output: Contribution to journalArticle

73 Scopus citations
2 Scopus citations

Role of endogenous ET-1 in the regulation of myocardial blood flow in lean and obese humans

Mather, K. J., Lteif, A. A., Veeneman, E., Fain, R., Giger, S., Perry, K. & Hutchins, G. D., Jan 1 2010, In : Obesity. 18, 1, p. 63-70 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
24 Scopus citations

Synthesis of carbon-11-labeled 4-aryl-4H-chromens as new PET agents for imaging of apoptosis in cancer

Gao, M., Wang, M., Miller, K. D., Hutchins, G. D. & Zheng, Q. H., Jan 1 2010, In : Applied Radiation and Isotopes. 68, 1, p. 110-116 7 p.

Research output: Contribution to journalArticle

22 Scopus citations
3 Scopus citations