H. Boswell

  • 4530 Citations
  • 30 h-Index
1980 …2020

Research output per year

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Publications

  • 4530 Citations
  • 30 h-Index
  • 68 Article
  • 5 Letter
  • 3 Review article
  • 2 Chapter
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Article
2020

Classic and targeted anti-leukaemic agents interfere with the cholesterol biogenesis metagene in acute myeloid leukaemia: Therapeutic implications

Chen, F., Wu, X., Niculite, C., Gilca, M., Petrusca, D., Rogozea, A., Rice, S., Guo, B., Griffin, S., Calin, G. A., Boswell, H. S. & Konig, H., Jul 1 2020, In : Journal of Cellular and Molecular Medicine. 24, 13, p. 7378-7392 15 p.

Research output: Contribution to journalArticle

Open Access
2019

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2019, In : Nature communications. 10, 1, 5649.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Sayar, S., Liu, Y., Gao, R., Zaid, M. A., Cripe, L. D., Weisenbach, J., Sargent, K. J., Nassiri, M., Li, L., Konig, H., Suvannasankha, A., Pan, F., Shanmugam, R., Goswami, C., Kapur, R., Xu, M. & Scott Boswell, H., 2018, In : Oncotarget. 9, 5, p. 5703-5715 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

O'Leary, H. A., Capitano, M., Cooper, S., Mantel, C., Boswell, H. S., Kapur, R., Ramdas, B., Chan, R., Deng, L., Qu, C. K. & Broxmeyer, H. E., Nov 1 2017, In : Leukemia. 31, 11, p. 2468-2478 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Death-associated protein kinase-1 expression and autophagy in chronic lymphocytic leukemia are dependent on activating transcription factor-6 and CCAAT/Enhancer-binding protein-β

Gade, P., Kimball, A. S., DiNardo, A. C., Gangwal, P., Ross, D. D., Boswell, H., Keay, S. K. & Kalvakolanu, D. V., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 22030-22042 13 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner

Wang, L., Zhang, H., Rodriguez, S., Cao, L., Parish, J., Mumaw, C., Zollman, A., Kamoka, M. M., Mu, J., Chen, D. Z., Srour, E. F., Chitteti, B. R., HogenEsch, H., Tu, X., Bellido, T. M., Boswell, H. S., Manshouri, T., Verstovsek, S., Yoder, M. C., Kapur, R. & 2 others, Cardoso, A. A. & Carlesso, N., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

106 Scopus citations

Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis

Chatterjee, A., Ghosh, J., Ramdas, B., Mali, R. S., Martin, H., Kobayashi, M., Vemula, S., Canela, V. H., Waskow, E. R., Visconte, V., Tiu, R. V., Smith, C. C., Shah, N., Bunting, K. D., Boswell, H. S., Liu, Y., Chan, R. J. & Kapur, R., Nov 20 2014, In : Cell Reports. 9, 4, p. 1333-1348 16 p.

Research output: Contribution to journalArticle

30 Scopus citations
2013

The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, S. C., Li, X. J., Ramdas, B., He, Y., Zhang, X., Zeng, L., Richine, B., Bowling, J. D., Fukuda, S., Goenka, S., Liu, Z., Feng, G. S., Yu, M., Sandusky, G. E., Boswell, H. S., Zhang, Z. Y., Kapur, R. & Chan, R. J., Feb 1 2013, In : Leukemia. 27, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

A noncanonical Flt3ITD/NF-κB signaling pathway represses DAPK1 in acute myeloid leukemia

Shanmugam, R., Gade, P., Wilson-Weekes, A., Sayar, H., Suvannasankha, A., Goswami, C., Li, L., Gupta, S., Cardoso, A. A., Al Baghdadi, T., Sargent, K. J., Cripe, L. D., Kalvakolanu, D. V. & Boswell, H. S., Jan 15 2012, In : Clinical Cancer Research. 18, 2, p. 360-369 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R. J., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. S. & Kapur, R., Sep 1 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

59 Scopus citations
2009

Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3

Fukuda, S., Singh, P., Moh, A., Abe, M., Conway, E. M., Scott Boswell, H., Yamaguchi, S., Fu, X. Y. & Pelus, L. M., Nov 20 2009, In : Blood. 114, 2, p. 394-403 10 p.

Research output: Contribution to journalArticle

40 Scopus citations
2008

Antimyeloma effects of a sesquiterpene lactone parthenolide

Suvannasankha, A., Crean, C. D., Shanmugam, R., Farag, S. S., Abonour, R., Boswell, H. S. & Nakshatri, H., Mar 15 2008, In : Clinical Cancer Research. 14, 6, p. 1814-1822 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2007

MOZ and MOZ-CBP cooperate with NF-κB to activate transcription from NF-κB-dependent promoters

Chan, E. M., Chan, R. J., Comer, E. M., Goulet, R. J., Crean, C. D., Brown, Z. D., Fruehwald, A. M., Yang, Z., Boswell, H. S., Nakshatri, H. & Gabig, T. G., Dec 1 2007, In : Experimental Hematology. 35, 12, p. 1782-1792 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2006

Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation

Hartman, A. D., Wilson-Weekes, A., Suvannasankha, A., Burgess, G. S., Phillips, C. A., Hincher, K. J., Cripe, L. D. & Boswell, H. S., Oct 1 2006, In : Experimental Hematology. 34, 10, p. 1360-1376 17 p.

Research output: Contribution to journalArticle

26 Scopus citations
2002

P21waf-1-Chk1 pathway monitors G1 phase microtubule integrity and is crucial for restriction point transition.

Mantel, C. R., Gelfano, V. M., Kim, Y. J., McDaniel, A., Lee, Y., Boswell, H. S. & Broxmeyer, H. E., Jan 1 2002, In : Cell cycle (Georgetown, Tex.). 1, 5, p. 327-336 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): Signaling to multidrug-efflux and hyperproliferation

Cripe, L. D., Gelfanov, V. M., Smith, E. A., Spigel, D. R., Phillips, C. A., Gabig, T. G., Jung, S. H., Fyffe, J., Hartman, A. D., Kneebone, P., Mercola, D., Burgess, G. S. & Boswell, H. S., Jan 1 2002, In : Leukemia. 16, 5, p. 799-812 14 p.

Research output: Contribution to journalArticle

48 Scopus citations
2001

Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: Cooperation of akt with raf/erk leads to p65 nuclear factor kB-mediated antiapoptosis involving c-IAP2

Gelfanov, V. M., Burgess, G. S., Litz-Jackson, S., King, A. J., Marshall, M. S., Nakshatri, H. & Scott Boswell, H., Oct 15 2001, In : Blood. 98, 8, p. 2508-2517 10 p.

Research output: Contribution to journalArticle

36 Scopus citations
2000

Paclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by IκBα super-repressor and parthenolide

Patel, N. M., Nozaki, S., Shortle, N. H., Bhat-Nakshatri, P., Newton, T. R., Rice, S., Gelfanov, V., Boswell, S. H., Goulet, R. J., Sledge, G. W. & Nakshatri, H., Aug 24 2000, In : Oncogene. 19, 36, p. 4159-4169 11 p.

Research output: Contribution to journalArticle

Open Access
248 Scopus citations
1999

Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells

Rizzo, M. T., Regazzi, E., Garau, D., Akard, L., Dugan, M., Boswell, H. S., Rizzoli, V. & Carlo-Stella, C., Oct 1 1999, In : Cancer Research. 59, 19, p. 5047-5053 7 p.

Research output: Contribution to journalArticle

55 Scopus citations
1998

Regulation of the c-jun gene in p210 BCR-ABL transformed cells corresponds with activity of JNK, the c-jun N-terminal kinase

Burgess, G. S., Williamson, E. A., Cripe, L. D., Litz-Jackson, S., Bhatt, J. A., Stanley, K., Stewart, M. J., Kraft, A. S., Nakshatri, H. & Boswell, H. S., Oct 1 1998, In : Blood. 92, 7, p. 2450-2460 11 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations
1997

Cyclic AMP negatively controls c-myc transcription and G1 cell cycle progression in p210 BCR-ABL transformed cells: Inhibitory activity exerted through cyclin D1 and cdk4

Williamson, E. A., Burgess, G. S., Eder, P., Litz-Jackson, S. & Boswell, H. S., Jan 1 1997, In : Leukemia. 11, 1, p. 73-85 13 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

High incidence of c-jun kinase activity in 2/relapsed acute leukemia: role in mrp-mediated drug resistance?

Cripe, L. D., Burgess, O. S., Tanzer, L., Kneebpne, P., Williamson, E. A., Kraft, A. S., Moore, R. E. & Boswell, H. S., Dec 1 1997, In : Experimental Hematology. 25, 8, 1 p.

Research output: Contribution to journalArticle

1996

A calcium requirement for jnk activation contributes to c-jun hyperexpression by P210 BCR-ABL

Williamson, E. A., Stewart, M. J., Litz-Jackson, S., Burgess, G. S., Rizzo, M. T., Kraft, A. S. & Boswell, H. S., Dec 1 1996, In : Experimental Hematology. 24, 9, 1 p.

Research output: Contribution to journalArticle

Forced over-expression of the myeloid zinc finger gene MZF-1 inhibits apoptosis and promotes oncogenesis in interleukin-3-dependent FDCP.1 cells

Hromas, R., Boswell, S., Shen, R. N., Burgess, G., Davidson, A., Cornetta, K., Sutton, J. & Robertson, K., Jun 1996, In : Leukemia. 10, 6, p. 1049-1050 2 p.

Research output: Contribution to journalArticle

23 Scopus citations

Role for PI-3-Kinase in C-MYC expression by P210 BCR-ABL

Williamen, E. A., Burgess, G. S., Rizzo, M. T., Litz-Jackson, S., Kraft, A. S. & Boswell, H. S., Dec 1 1996, In : Experimental Hematology. 24, 9, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Steel factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines

Gotoh, A., Takahira, H., Mantel, C., Litz-Jackson, S., Boswell, H. S. & Broxmeyer, H. E., Jul 1 1996, In : Blood. 88, 1, p. 138-145 8 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations
1995

Adeno-associated virus 2-mediated gene transfer and functional expression of the human granulocyte-macrophage colony-stimulating factor

Luo, F., Zhou, S. Z., Cooper, S., Munshi, N. C., Scott Boswell, H., Broxmeyer, H. E. & Srivastava, A., 1995, In : Experimental Hematology. 23, 12, p. 1261-1267 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

AP-1/c-jun and c-myc regulation during megakaryocytic differentiation of a human bi-potential growth-factor-dependent cell line

Derigs, H. G., Morgan, D. A., Hoffman, R., Litz, S. L., Srour, E. F., Brandt, J. E. & Boswell, H. S., Jan 1 1995, In : Platelets. 6, 1, p. 24-30 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Arachidonic acid induces c-jun gene expression in stromal cells stimulated by interleukin-1 and tumor necrosis factor-α: Evidence for a tyrosine- kinase-dependent process

Rizzo, M. T., Boswell, H. S., Mangoni, L., Carlo-Stella, C. & Rizzoli, V., 1995, In : Blood. 86, 8, p. 2967-2975 9 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

Role for E2F1 in p210 BCR-ABL downstream regulation of c-myc transcription initiation. Studies in murine myeloid cells

Stewart, M. J., Litz-Jackson, S., Burgess, G. S., Williamson, E. A., Leibowitz, D. S. & Boswell, H. S., Sep 1995, In : Leukemia. 9, 9, p. 1499-1507 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Tyrosine phosphorylation and activation of focal adhesion kinase (p125(FAK)) by BCR-ABL oncoprotein

Gotoh, A., Miyazawa, K., Ohyashiki, K., Tauchi, T., Boswell, H. S., Broxmeyer, H. E. & Toyama, K., Jan 1 1995, In : Experimental Hematology. 23, 11, p. 1153-1159 7 p.

Research output: Contribution to journalArticle

76 Scopus citations
1994
133 Scopus citations

Granulocyte-macrophage colony-stimulating factor expression is regulated at transcriptional and posttranscriptional levels in a murine bone marrow stromal cell line

Derigs, H. G., Reifel-Miller, A., Kaushansky, K., Hromas, R. A. & Boswell, H. S., Jan 1 1994, In : Experimental Hematology. 22, 9, p. 924-932 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
17 Scopus citations
1993

LIF mRNA expression is transcriptionally regulated in murine bone marrow stromal cells

Derigs, H. G. & Boswell, H. S., Apr 1993, In : Leukemia. 7, 4, p. 630-634 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mutant H-ras over-expression inhibits a random apoptotic nuclease in myeloid leukemia cells

Moore, J., Boswell, S., Hoffman, R., Burgess, G. & Hromas, R., Aug 1993, In : Leukemia Research. 17, 8, p. 703-709 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells

Mandanas, R. A., Leibowitz, D. S., Gharehbaghl, K., Tauchi, T., Burgess, G. S., Miyazawa, K., Jayaram, H. N. & Boswell, H. S., 1993, In : Blood. 82, 6, p. 1838-1847 10 p.

Research output: Contribution to journalArticle

Open Access
156 Scopus citations
43 Scopus citations
1992

17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: A potential mechanism for the antiosteoporotic effect of estrogens

Girasole, G., Jilka, R. L., Passeri, G., Boswell, S., Boder, G., Williams, D. C. & Manolagas, S. C., 1992, In : Journal of Clinical Investigation. 89, 3, p. 883-891 9 p.

Research output: Contribution to journalArticle

Open Access
575 Scopus citations

BCR/ABL confers growth factor independence upon a murine myeloid cell line

Mandanas, R. A., Boswell, H. S., Lu, L. & Leibowitz, D., Aug 1992, In : Leukemia. 6, 8, p. 796-800 5 p.

Research output: Contribution to journalArticle

51 Scopus citations

Dissociation of nuclear events on p21 RAS transformation of FDC-P1 myeloid cells: c-jun/AP-1 expression versus c-myc transcription

Litz-Jackson, S., Miller, A. H., Burgess, G. S. & Boswell, H. S., 1992, In : Blood. 79, 9, p. 2404-2414 11 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Oncogene intervention into hematopoietic signaling

Boswell, H. S., Nov 1992, In : The Journal of Laboratory and Clinical Medicine. 120, 5, p. 681-687 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
1991
5 Scopus citations

Interleukin-3 dependent mitogenesis in murine cells involves a predominant non-protein kinase C (pKC) dependent pathway for c-myc transcription. Role of a myc expression vector in rescuing pKC dependent mitogenesis

Nahreini, T. S., Litz-Jackson, S., Burgess, G. S., Helvering, L. M., Manolagas, S. C. & Boswell, H. S., Dec 1991, In : Leukemia. 5, 12, p. 1099-1109 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Requirement for mast cell growth factor for primordial germ cell survival in culture

Dolci, S., Williams, D. E., Ernst, M. K., Resnick, J. L., Brannan, C. I., Lock, L. F., Lyman, S. D., Boswell, H. S. & Donovan, P. J., Jan 1 1991, In : Nature. 352, 6338, p. 809-811 3 p.

Research output: Contribution to journalArticle

399 Scopus citations
1990

A novel mast cell growth factor (MCGF-3) produced by marrow-adherent cells that synergizes with interleukin 3 and interleukin 4

Boswell, H. S., Mochizuki, D. Y., Burgess, G. S., Gillis, S., Walker, E. B., Anderson, D. & Williams, D. E., Sep 10 1990, In : Experimental Hematology. 18, 7, p. 794-800 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

A RAS oncogene imparts growth factor independence to myeloid cells that abnormally regulate protein kinase C: A nonautocrine transformation pathway

Boswell, H. S., Nahreini, T. S., Burgess, G. S., Srivastava, A., Gabig, T. G., Inhorn, L., Srour, E. F. & Harrington, M. A., Jul 2 1990, In : Experimental Hematology. 18, 5, p. 452-460 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Identification of a ligand for the c-kit proto-oncogene

Williams, D. E., Eisenman, J., Baird, A., Rauch, C., Van Ness, K., March, C. J., Park, L. S., Martin, U., Mochizukl, D. Y., Boswell, H. S., Burgess, G. S., Cosman, D. & Lyman, S. D., Oct 5 1990, In : Cell. 63, 1, p. 167-174 8 p.

Research output: Contribution to journalArticle

740 Scopus citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

Anderson, D. M., Lyman, S. D., Baird, A., Wignall, J. M., Eisenman, J., Rauch, C., March, C. J., Boswell, H. S., Gimpel, S. D., Cosman, D. & Williams, D. E., Oct 5 1990, In : Cell. 63, 1, p. 235-243 9 p.

Research output: Contribution to journalArticle

683 Scopus citations

Role for cyclic AMP in the postreceptor control of cytokine-stimulated stromal cell growth factor production

Derigs, H. G., Burgess, G. S., Klingberg, D., Nahreini, T. S., Mochizuki, D. Y., Williams, D. E. & Boswell, H. S., Jul 1990, In : Leukemia. 4, 7, p. 471-479 9 p.

Research output: Contribution to journalArticle

20 Scopus citations