Hal Broxmeyer

  • 41695 Citations
  • 99 h-Index
1973 …2020

Research output per year

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Publications

2020

An expanded role for dipeptidyl peptidase 4 in cell regulation

Ropa, J. & Broxmeyer, H. E., Jul 1 2020, In : Current opinion in hematology. 27, 4, p. 215-224 10 p.

Research output: Contribution to journalArticle

Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway (Nature Communications, (2019), 10, 1, (5649), 10.1038/s41467-019-13542-2)

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2020, In : Nature communications. 11, 1, 3856.

Research output: Contribution to journalComment/debate

Open Access

Collection and Processing of Mobilized Mouse Peripheral Blood at Lowered Oxygen Tension Yields Enhanced Numbers of Hematopoietic Stem Cells

Aljoufi, A., Cooper, S. & Broxmeyer, H. E., 2020, (Accepted/In press) In : Stem Cell Reviews and Reports. 16, 5, p. 946-953 8 p.

Research output: Contribution to journalArticle

Cord blood research, banking, and transplantation: achievements, challenges, and perspectives

Mayani, H., Wagner, J. E. & Broxmeyer, H. E., Jan 1 2020, In : Bone marrow transplantation. 55, 1, p. 48-61 14 p.

Research output: Contribution to journalReview article

13 Scopus citations

Effects of Eupalinilide E and UM171, alone and in combination on cytokine stimulated ex-vivo expansion of human cord blood hematopoietic stem cells

Zhang, J., Huang, X., Guo, B., Cooper, S., Capitano, M. L., Johnson, T. C., Siegel, D. R. & Broxmeyer, H. E., Sep 2020, In : Blood Cells, Molecules, and Diseases. 84, 102457.

Research output: Contribution to journalArticle

Enhanced collection of phenotypic and engrafting human cord blood hematopoietic stem cells at 4°C

Broxmeyer, H. E., Cooper, S. & Capitano, M. L., 2020, (Accepted/In press) In : STEM CELLS.

Research output: Contribution to journalArticle

1 Scopus citations

Impact of COVID-19 and Future Emerging Viruses on Hematopoietic Cell Transplantation and Other Cellular Therapies

Broxmeyer, H. E. & Parker, G. C., May 15 2020, In : Stem cells and development. 29, 10, p. 625-626 2 p.

Research output: Contribution to journalComment/debate

Open Access
3 Scopus citations

Pharmacological activation of nitric oxide signaling promotes human hematopoietic stem cell homing and engraftment

Xu, D., Yang, M., Capitano, M., Guo, B., Liu, S., Wan, J., Broxmeyer, H. E. & Huang, X., Jan 1 2020, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalLetter

Open Access

Physioxia enhances T-cell development ex vivo from human hematopoietic stem and progenitor cells

Shin, D. Y., Huang, X., Gil, C. H., Aljoufi, A., Ropa, J. & Broxmeyer, H. E., 2020, (Accepted/In press) In : STEM CELLS.

Research output: Contribution to journalArticle

The IL-33 Receptor/ST2 acts as a positive regulator of functional mouse bone marrow hematopoietic stem and progenitor cells

Capitano, M. L., Griesenauer, B., Guo, B., Cooper, S., Paczesny, S. & Broxmeyer, H. E., Sep 2020, In : Blood Cells, Molecules, and Diseases. 84, 102435.

Research output: Contribution to journalArticle

2 Scopus citations
2019

CD166 Engagement Augments Mouse and Human Hematopoietic Progenitor Function via Activation of Stemness and Cell Cycle Pathways

Zhang, J., Ghosh, J., Mohamad, S. F., Zhang, C., Huang, X., Capitano, M. L., Gunawan, A. M., Cooper, S., Guo, B., Cai, Q., Broxmeyer, H. E. & Srour, E. F., Oct 1 2019, In : STEM CELLS. 37, 10, p. 1319-1330 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression

Ni, F., Yu, W. M., Li, Z., Graham, D. K., Jin, L., Kang, S., Rossi, M. R., Li, S., Broxmeyer, H. E. & Qu, C. K., Mar 1 2019, In : Nature Metabolism. 1, 3, p. 390-403 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Hematopoietic Stem Cell Intracellular Levels of Ca2+ to the Rescue! What Next?

Broxmeyer, H. E., Aug 1 2019, In : Cell Stem Cell. 25, 2, p. 171-173 3 p.

Research output: Contribution to journalShort survey

Long-Overdue Guidelines for the Cord Blood Banking Community

Broxmeyer, H. E., Apr 2019, In : Stem Cells Translational Medicine. 8, 4, p. 320-322 3 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2019, In : Nature communications. 10, 1, 5649.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Past, present, and future efforts to enhance the efficacy of cord blood hematopoietic cell transplantation [version 1; peer review: 3 approved]

Huang, X., Guo, B., Capitano, M. & Broxmeyer, H. E., Oct 31 2019, In : F1000Research. 8, 1833.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations

Phorbol ester induced ex vivo expansion of rigorously-defined phenotypic but not functional human cord blood hematopoietic stem cells: a cautionary tale demonstrating that phenotype does not always recapitulate stem cell function

Chen, Y., Yao, C., Teng, Y., Jiang, R., Huang, X., Liu, S., Wan, J., Broxmeyer, H. E. & Guo, B., Dec 1 2019, In : Leukemia. 33, 12, p. 2962-2966 5 p.

Research output: Contribution to journalLetter

7 Scopus citations

Progress towards improving homing and engraftment of hematopoietic stem cells for clinical transplantation

Huang, X. & Broxmeyer, H. E., Jul 1 2019, In : Current opinion in hematology. 26, 4, p. 266-272 7 p.

Research output: Contribution to journalReview article

5 Scopus citations

Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling

Capitano, M. L., Mor-Vaknin, N., Saha, A. K., Cooper, S., Legendre, M., Guo, H., Contreras-Galindo, R., Kappes, F., Sartor, M. A., Lee, C. T., Huang, X., Markovitz, D. M. & Broxmeyer, H. E., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2555-2570 16 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

AMD3100 ameliorates cigarette smoke-induced emphysema-like manifestations in mice

Barwinska, D., Oueini, H., Poirier, C., Albrecht, M. E., Bogatcheva, N. V., Justice, M. J., Saliba, J., Schweitzer, K. S., Broxmeyer, H. E., March, K. L. & Petrache, I., Sep 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 315, 3, p. L382-L386

Research output: Contribution to journalArticle

5 Scopus citations

Antagonism of PPAR-γ 3 signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis

Guo, B., Huang, X., Lee, M. R., Lee, S. A. & Broxmeyer, H. E., Mar 1 2018, In : Nature Medicine. 24, 3, p. 360-367 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Combinations of antioxidants and/or of epigenetic enzyme inhibitors allow for enhanced collection of mouse bone marrow hematopoietic stem cells in ambient air

Cai, Q., Capitano, M., Huang, X., Guo, B., Cooper, S. & Broxmeyer, H. E., Jul 2018, In : Blood Cells, Molecules, and Diseases. 71, p. 23-28 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cytokine/Receptor Families and Signal Transduction

Shaheen, M. & Broxmeyer, H. E., Jan 1 2018, Hematology: Basic Principles and Practice. Elsevier Inc., p. 163-175 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Enhancement of stem cell engraftment on a WHIM

Broxmeyer, H. E., Aug 1 2018, In : Journal of Clinical Investigation. 128, 8, p. 3240-3242 3 p.

Research output: Contribution to journalReview article

Enhancing human cord blood hematopoietic stem cell engraftment by targeting nuclear hormone receptors

Guo, B., Huang, X. & Broxmeyer, H. E., Jul 1 2018, In : Current opinion in hematology. 25, 4, p. 245-252 8 p.

Research output: Contribution to journalReview article

5 Scopus citations

Erratum: The HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation (Science Translational Medicine (2018) 10:471 (eaaw2634) DOI:10.1126/scitranslmed.3009443)

Berg, J. M., Smith, O. M., Weber, D. J., Gracon, A. S. A., Ripsch, M. S., Fisher, A. J., Cheon, B. M., Pandya, P. H., Vittal, R., Capitano, M. L., Kim, Y., Allette, Y. M., Riley, A. A., McCarthy, B. P., Territo, P. R., Hutchins, G. D., Broxmeyer, H. E., Sandusky, G. E., White, F. A. & Wilkes, D., Dec 12 2018, In : Science translational medicine. 10, 471, eaaw2634.

Research output: Contribution to journalComment/debate

Fractalkine induces angiogenic potential in CX3CR1-expressing monocytes

Park, Y., Lee, J., Kwak, J. Y., Noh, K., Yim, E., Kim, H. K., Kim, Y. J., Broxmeyer, H. E. & Kim, J. A., Jan 2018, In : Journal of Leukocyte Biology. 103, 1, p. 53-66 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53

Chen, S., Gao, R., Yao, C., Kobayashi, M., Liu, S. Z., Yoder, M. C., Broxmeyer, H., Kapur, R., Boswell, H. S., Mayo, L. D. & Liu, Y., Mar 1 2018, In : Leukemia. 32, 3, p. 850-854 5 p.

Research output: Contribution to journalLetter

10 Scopus citations

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil

Huang, X., Trinh, T., Aljoufi, A. & Broxmeyer, H. E., Jun 1 2018, In : Current Stem Cell Reports. 4, 2, p. 149-157 9 p.

Research output: Contribution to journalReview article

12 Scopus citations

m6A reader suppression bolsters HSC expansion

Huang, X. & Broxmeyer, H. E., Sep 1 2018, In : Cell Research. 28, 9, p. 875-876 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

MiR-9 controls chemotactic activity of cord blood CD34+ cells by repressing CXCR4 expression

Ha, T. W., Kang, H. S., Kim, T. H., Kwon, J. H., Kim, H. K., Ryu, A., Jeon, H., Han, J., Broxmeyer, H. E., Hwang, Y., Lee, Y. K. & Lee, M. R., Nov 1 2018, In : International Journal of Stem Cells. 11, 2, p. 187-195 9 p.

Research output: Contribution to journalArticle

miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., 2018, In : Oncotarget. 9, 4, p. 4823-4832 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment

Huang, X., Guo, B., Liu, S., Wan, J. & Broxmeyer, H. E., Dec 1 2018, In : Nature communications. 9, 1, 2741.

Research output: Contribution to journalArticle

19 Scopus citations

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

Hu, P., Nebreda, A. R., Hanenberg, H., Kinnebrew, G. H., Ivan, M., Yoder, M. C., Filippi, M. D., Broxmeyer, H. E. & Kapur, R., Dec 1 2018, In : Nature communications. 9, 1, 3518.

Research output: Contribution to journalArticle

6 Scopus citations

Peripheral Blood Stem Cell Mobilization: a Look Ahead

Pelus, L. M. & Broxmeyer, H. E., Dec 1 2018, In : Current Stem Cell Reports. 4, 4, p. 273-281 9 p.

Research output: Contribution to journalReview article

7 Scopus citations

Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-b1 secretion and hematopoiesis in mice

Capitano, M., Zhao, L., Cooper, S., Thorsheim, C., Suzuki, A., Huang, X., Dent, A. L., Marks, M. S., Abrams, C. S. & Broxmeyer, H. E., Sep 6 2018, In : Blood. 132, 10, p. 1027-1038 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

A role for intracellular and extracellular DEK in regulating hematopoiesis

Capitano, M. L. & Broxmeyer, H. E., Jul 1 2017, In : Current opinion in hematology. 24, 4, p. 300-306 7 p.

Research output: Contribution to journalReview article

3 Scopus citations

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

O'Leary, H. A., Capitano, M., Cooper, S., Mantel, C., Boswell, H. S., Kapur, R., Ramdas, B., Chan, R., Deng, L., Qu, C. K. & Broxmeyer, H. E., Nov 1 2017, In : Leukemia. 31, 11, p. 2468-2478 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Erythropoietin in umbilical cord blood transplantation: defining the role and implications

Aljitawi, O. S., Laughlin, M. & Broxmeyer, H., Aug 3 2017, In : Expert Review of Hematology. 10, 8, p. 675-677 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Generating autologous hematopoietic cells from human-induced pluripotent stem cells through ectopic expression of transcription factors

Hwang, Y., Broxmeyer, H. E. & Lee, M. R., Jul 1 2017, In : Current opinion in hematology. 24, 4, p. 283-288 6 p.

Research output: Contribution to journalReview article

5 Scopus citations

Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment

Guo, B., Huang, X., Cooper, S. & Broxmeyer, H. E., Apr 1 2017, In : Nature Medicine. 23, 4, p. 424-428 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

High-dose sitagliptin for systemic inhibition of dipeptidylpeptidase-4 to enhance engraftment of single cord umbilical cord blood transplantation

Farag, S. S., Nelson, R., Cairo, M. S., O'Leary, H. A., Zhang, S., Huntley, C., Delgado, D., Schwartz, J., Zaid, M. A., Abonour, R., Robertson, M. & Broxmeyer, H., 2017, In : Oncotarget. 8, 66, p. 110350-110357 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Metabolome Profiling of Partial and Fully Reprogrammed Induced Pluripotent Stem Cells

Park, S. J., Lee, S. A., Prasain, N., Bae, D., Kang, H., Ha, T., Kim, J. S., Hong, K. S., Mantel, C., Moon, S. H., Broxmeyer, H. & Lee, M. R., May 15 2017, In : Stem Cells and Development. 26, 10, p. 734-742 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Parkinson disease-associated LRRK2 G2019s transgene disrupts marrow myelopoiesis and peripheral Th17 response

Park, J., Lee, J. W., Cooper, S. C., Broxmeyer, H. E., Cannon, J. R. & Kim, C. H., Oct 2017, In : Journal of Leukocyte Biology. 102, 4, p. 1093-1102 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression

Huang, X., Lee, M. R., Cooper, S., Hangoc, G., Hong, K. S., Chung, H. M. & Broxmeyer, H. E., Jan 1 2016, In : Leukemia. 30, 1, p. 144-153 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Cord Blood Hematopoietic Cell Transplantation

Broxmeyer, H. E., Farag, S. S. & Rocha, V., Jan 1 2016, Thomas' Hematopoietic Cell Transplantation: Fifth Edition. Wiley-Blackwell, Vol. 1-2. p. 437-455 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

CXCL12/SDF-1 and Hematopoiesis

Capitano, M. L. & Broxmeyer, H. E., Jan 1 2016, Functional Cell Biology. Elsevier Inc., Vol. 3. p. 624-631 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Enhancing the efficacy of engraftment of cord blood for hematopoietic cell transplantation

Broxmeyer, H. E., Jun 1 2016, In : Transfusion and Apheresis Science. 54, 3, p. 364-372 9 p.

Research output: Contribution to journalReview article

19 Scopus citations

Erratum: Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo (Oncogene (2016) 35 (783-792) DOI:10.1038/onc.2015.215)

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J. T., Feb 11 2016, In : Oncogene. 35, 6, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations