Hal Broxmeyer

  • 40712 Citations
  • 97 h-Index
1973 …2021

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

Filter
Article
2020

Impact of COVID-19 and Future Emerging Viruses on Hematopoietic Cell Transplantation and Other Cellular Therapies

Broxmeyer, H. E. & Parker, G. C., May 15 2020, In : Stem cells and development. 29, 10, p. 625-626 2 p.

Research output: Contribution to journalArticle

Open Access

The IL-33 Receptor/ST2 acts as a positive regulator of functional mouse bone marrow hematopoietic stem and progenitor cells

Capitano, M. L., Griesenauer, B., Guo, B., Cooper, S., Paczesny, S. & Broxmeyer, H. E., Sep 2020, In : Blood Cells, Molecules, and Diseases. 84, 102435.

Research output: Contribution to journalArticle

2019

CD166 Engagement Augments Mouse and Human Hematopoietic Progenitor Function via Activation of Stemness and Cell Cycle Pathways

Zhang, J., Ghosh, J., Mohamad, S. F., Zhang, C., Huang, X., Capitano, M. L., Gunawan, A. M., Cooper, S., Guo, B., Cai, Q., Broxmeyer, H. E. & Srour, E. F., Oct 1 2019, In : STEM CELLS. 37, 10, p. 1319-1330 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression

Ni, F., Yu, W. M., Li, Z., Graham, D. K., Jin, L., Kang, S., Rossi, M. R., Li, S., Broxmeyer, H. E. & Qu, C. K., Mar 1 2019, In : Nature Metabolism. 1, 3, p. 390-403 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Chen, S., Wang, Q., Yu, H., Capitano, M. L., Vemula, S., Nabinger, S. C., Gao, R., Yao, C., Kobayashi, M., Geng, Z., Fahey, A., Henley, D., Liu, S. Z., Barajas, S., Cai, W., Wolf, E. R., Ramdas, B., Cai, Z., Gao, H., Luo, N. & 12 others, Sun, Y., Wong, T. N., Link, D. C., Liu, Y., Boswell, H. S., Mayo, L. D., Huang, G., Kapur, R., Yoder, M. C., Broxmeyer, H. E., Gao, Z. & Liu, Y., Dec 1 2019, In : Nature communications. 10, 1, 5649.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling

Capitano, M. L., Mor-Vaknin, N., Saha, A. K., Cooper, S., Legendre, M., Guo, H., Contreras-Galindo, R., Kappes, F., Sartor, M. A., Lee, C. T., Huang, X., Markovitz, D. M. & Broxmeyer, H. E., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2555-2570 16 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

AMD3100 ameliorates cigarette smoke-induced emphysema-like manifestations in mice

Barwinska, D., Oueini, H., Poirier, C., Albrecht, M. E., Bogatcheva, N. V., Justice, M. J., Saliba, J., Schweitzer, K. S., Broxmeyer, H. E., March, K. L. & Petrache, I., Sep 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 315, 3, p. L382-L386

Research output: Contribution to journalArticle

3 Scopus citations

Antagonism of PPAR-γ 3 signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis

Guo, B., Huang, X., Lee, M. R., Lee, S. A. & Broxmeyer, H. E., Mar 1 2018, In : Nature Medicine. 24, 3, p. 360-367 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Combinations of antioxidants and/or of epigenetic enzyme inhibitors allow for enhanced collection of mouse bone marrow hematopoietic stem cells in ambient air

Cai, Q., Capitano, M., Huang, X., Guo, B., Cooper, S. & Broxmeyer, H. E., Jul 2018, In : Blood Cells, Molecules, and Diseases. 71, p. 23-28 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Fractalkine induces angiogenic potential in CX3CR1-expressing monocytes

Park, Y., Lee, J., Kwak, J. Y., Noh, K., Yim, E., Kim, H. K., Kim, Y. J., Broxmeyer, H. E. & Kim, J. A., Jan 2018, In : Journal of Leukocyte Biology. 103, 1, p. 53-66 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

m6A reader suppression bolsters HSC expansion

Huang, X. & Broxmeyer, H. E., Sep 1 2018, In : Cell Research. 28, 9, p. 875-876 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

MiR-9 controls chemotactic activity of cord blood CD34+ cells by repressing CXCR4 expression

Ha, T. W., Kang, H. S., Kim, T. H., Kwon, J. H., Kim, H. K., Ryu, A., Jeon, H., Han, J., Broxmeyer, H. E., Hwang, Y., Lee, Y. K. & Lee, M. R., Nov 1 2018, In : International Journal of Stem Cells. 11, 2, p. 187-195 9 p.

Research output: Contribution to journalArticle

miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., Jan 1 2018, In : Oncotarget. 9, 4, p. 4823-4832 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment

Huang, X., Guo, B., Liu, S., Wan, J. & Broxmeyer, H. E., Dec 1 2018, In : Nature communications. 9, 1, 2741.

Research output: Contribution to journalArticle

16 Scopus citations

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim

Hu, P., Nebreda, A. R., Hanenberg, H., Kinnebrew, G. H., Ivan, M., Yoder, M. C., Filippi, M. D., Broxmeyer, H. E. & Kapur, R., Dec 1 2018, In : Nature communications. 9, 1, 3518.

Research output: Contribution to journalArticle

5 Scopus citations

Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-b1 secretion and hematopoiesis in mice

Capitano, M., Zhao, L., Cooper, S., Thorsheim, C., Suzuki, A., Huang, X., Dent, A. L., Marks, M. S., Abrams, C. S. & Broxmeyer, H. E., Sep 6 2018, In : Blood. 132, 10, p. 1027-1038 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

O'Leary, H. A., Capitano, M., Cooper, S., Mantel, C., Boswell, H. S., Kapur, R., Ramdas, B., Chan, R., Deng, L., Qu, C. K. & Broxmeyer, H. E., Nov 1 2017, In : Leukemia. 31, 11, p. 2468-2478 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment

Guo, B., Huang, X., Cooper, S. & Broxmeyer, H. E., Apr 1 2017, In : Nature Medicine. 23, 4, p. 424-428 5 p.

Research output: Contribution to journalArticle

34 Scopus citations

High-dose sitagliptin for systemic inhibition of dipeptidylpeptidase-4 to enhance engraftment of single cord umbilical cord blood transplantation

Farag, S. S., Nelson, R., Cairo, M. S., O'Leary, H. A., Zhang, S., Huntley, C., Delgado, D., Schwartz, J., Zaid, M. A., Abonour, R., Robertson, M. & Broxmeyer, H., Jan 1 2017, In : Oncotarget. 8, 66, p. 110350-110357 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Metabolome Profiling of Partial and Fully Reprogrammed Induced Pluripotent Stem Cells

Park, S. J., Lee, S. A., Prasain, N., Bae, D., Kang, H., Ha, T., Kim, J. S., Hong, K. S., Mantel, C., Moon, S. H., Broxmeyer, H. & Lee, M. R., May 15 2017, In : Stem Cells and Development. 26, 10, p. 734-742 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Parkinson disease-associated LRRK2 G2019s transgene disrupts marrow myelopoiesis and peripheral Th17 response

Park, J., Lee, J. W., Cooper, S. C., Broxmeyer, H. E., Cannon, J. R. & Kim, C. H., Oct 2017, In : Journal of Leukocyte Biology. 102, 4, p. 1093-1102 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression

Huang, X., Lee, M. R., Cooper, S., Hangoc, G., Hong, K. S., Chung, H. M. & Broxmeyer, H. E., Jan 1 2016, In : Leukemia. 30, 1, p. 144-153 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Erythropoietin modulation is associated with improved homing and engraftment after umbilical cord blood transplantation

Aljitawi, O. S., Paul, S., Ganguly, A., Lin, T. L., Ganguly, S., Vielhauer, G., Capitano, M. L., Cantilena, A., Lipe, B., Mahnken, J. D., Wise, A., Berry, A., Singh, A. K., Shune, L., Lominska, C., Abhyankar, S., Allin, D., Laughlin, M., McGuirk, J. P. & Broxmeyer, H., Dec 22 2016, In : Blood. 128, 25, p. 3000-3010 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Glucose-independent acetate metabolism promotes melanoma cell survival and tumor growth

Lakhter, A. J., Hamilton, J., Konger, R., Broustovetski, N., Broxmeyer, H. & Naidu, S., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 21869-21879 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Golgi Associated HIF1a Serves as a Reserve in Melanoma Cells

Lakhter, A. J., Lahm, T., Broxmeyer, H. E. & Naidu, S. R., Apr 1 2016, In : Journal of Cellular Biochemistry. 117, 4, p. 853-859 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

Dong, L., Yu, W. M., Zheng, H., Loh, M. L., Bunting, S. T., Pauly, M., Huang, G., Zhou, M., Broxmeyer, H., Scadden, D. T. & Qu, C. K., Nov 10 2016, In : Nature. 539, 7628, p. 304-308 5 p.

Research output: Contribution to journalArticle

82 Scopus citations

MiR-31/SDHA Axis Regulates Reprogramming Efficiency through Mitochondrial Metabolism

Lee, M. R., Mantel, C., Lee, S. A., Moon, S. H. & Broxmeyer, H. E., Jul 12 2016, In : Stem Cell Reports. 7, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Modulation of Hematopoietic Chemokine Effects in Vitro and in Vivo by DPP-4/CD26

Broxmeyer, H. E., Capitano, M., Campbell, T. B., Hangoc, G. & Cooper, S., Apr 15 2016, In : Stem Cells and Development. 25, 8, p. 575-585 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

SDF-1/CXCL12 modulates mitochondrial respiration of immature blood cells in a bi-phasic manner

Messina-Graham, S. & Broxmeyer, H., May 1 2016, In : Blood Cells, Molecules, and Diseases. 58, p. 13-18 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J. T., Feb 11 2016, In : Oncogene. 35, 6, p. 783-792 10 p.

Research output: Contribution to journalArticle

51 Scopus citations
2015

Ames hypopituitary dwarf mice demonstrate imbalanced myelopoiesis between bone marrow and spleen

Capitano, M. L., Chitteti, B. R., Cooper, S., Srour, E. F., Bartke, A. & Broxmeyer, H. E., Jun 1 2015, In : Blood Cells, Molecules, and Diseases. 55, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cutting edge: Progesterone directly upregulates vitamin D receptor gene expression for efficient regulation of T cells by calcitriol

Thangamani, S., Kim, M., Son, Y., Huang, X., Kim, H., Lee, J. H., Cho, J., Ulrich, B., Broxmeyer, H. E. & Kim, C. H., Feb 1 2015, In : Journal of Immunology. 194, 3, p. 883-886 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

Mantel, C. R., O'Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S., Hangoc, G., Brustovetsky, N., Srour, E. F., Lee, M. R., Messina-Graham, S., Haas, D. M., Falah, N., Kapur, R., Pelus, L. M., Bardeesy, N., Fitamant, J., Ivan, M., Kim, K. S. & Broxmeyer, H. E., Jun 18 2015, In : Cell. 161, 7, p. 1553-1565 13 p.

Research output: Contribution to journalArticle

118 Scopus citations

Expansion of prostate epithelial progenitor cells after inflammation of the mouse prostate

Wang, L., Zoetemelk, M., Chitteti, B. R., Ratliff, T. L., Myers, J. D., Srour, E. F., Broxmeyer, H. & Jerde, T. J., Jun 15 2015, In : American Journal of Physiology - Renal Physiology. 308, 12, p. F1421-F1430

Research output: Contribution to journalArticle

7 Scopus citations

Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6

Xie, J., Broxmeyer, H. E., Feng, D., Schweitzer, K. S., Yi, R., Cook, T. G., Chitteti, B. R., Barwinska, D., Traktuev, D. O., Van Demark, M. J., Justice, M. J., Ou, X., Srour, E. F., Prockop, D. J., Petrache, I. & March, K. L., Feb 1 2015, In : STEM CELLS. 33, 2, p. 468-478 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis

Liu, Y., Huang, X., Timani, K. A., Broxmeyer, H. E. & He, J. J., Sep 1 2015, In : Stem Cells and Development. 24, 17, p. 2009-2017 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mild heat treatment primes human CD34+ cord blood cells for migration toward SDF-1α and enhances engraftment in an NSG mouse model

Capitano, M. L., Hangoc, G., Cooper, S. & Broxmeyer, H. E., Jun 1 2015, In : STEM CELLS. 33, 6, p. 1975-1984 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation

Zeng, Y., Broxmeyer, H. E., Staser, K., Chitteti, B. R., Park, S. J., Hahn, S., Cooper, S., Sun, Z., Jiang, L., Yang, X., Yuan, J., Kosoff, R., Sandusky, G., Srour, E. F., Chernoff, J. & Clapp, D. W., May 1 2015, In : STEM CELLS. 33, 5, p. 1630-1641 12 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014

CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche

Chitteti, B. R., Kobayashi, M., Cheng, Y., Zhang, H., Poteat, B. A., Broxmeyer, H. E., Pelus, L. M., Hanenberg, H., Zollman, A., Kamocka, M. M., Carlesso, N., Cardoso, A. A., Kacena, M. A. & Srour, E. F., Jul 24 2014, In : Blood. 124, 4, p. 519-529 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells

Prasain, N., Lee, M. R., Vemula, S., Meador, J. L., Yoshimoto, M., Ferkowicz, M. J., Fett, A., Gupta, M., Rapp, B. M., Saadatzadeh, M. R., Ginsberg, M., Elemento, O., Lee, Y., Voytik-Harbin, S. L., Chung, H. M., Hong, K. S., Reid, E., O'Neill, C. L., Medina, R. J., Stitt, A. W. & 4 others, Murphy, M., Rafii, S., Broxmeyer, H. & Yoder, M., 2014, In : Nature Biotechnology. 32, 11, p. 1151-1157 7 p.

Research output: Contribution to journalArticle

106 Scopus citations

Hyperbaric oxygen improves engraftment of ex-vivo expanded and gene transduced human CD34+ cells in a murine model of umbilical cord blood transplantation

Aljitawi, O. S., Xiao, Y., Eskew, J. D., Parelkar, N. K., Swink, M., Radel, J., Lin, T. L., Kimler, B. F., Mahnken, J. D., McGuirk, J. P., Broxmeyer, H. E. & Vielhauer, G., Jan 1 2014, In : Blood Cells, Molecules, and Diseases. 52, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
20 Scopus citations

Modelling the sitagliptin effect on dipeptidyl peptidase-4 activity in adults with haematological malignancies after umbilical cord blood haematopoietic cell transplantation

Vélez De Mendizábal, N., Strother, R. M., Farag, S. S., Broxmeyer, H. E., Messina-Graham, S., Chitnis, S. D. & Bies, R. R., Mar 1 2014, In : Clinical Pharmacokinetics. 53, 3, p. 247-259 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Nonmarrow hematopoiesis occurs in a hyaluronic-acid-rich node and duct system in mice

Hwang, S., Lee, S. J., Park, S. H., Chitteti, B. R., Srour, E. F., Cooper, S., Hangoc, G., Broxmeyer, H. E. & Kwon, B. S., Nov 1 2014, In : Stem cells and development. 23, 21, p. 2661-2671 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress

Ou, X., Lee, M. R., Huang, X., Messina-Graham, S. & Broxmeyer, H. E., May 2014, In : STEM CELLS. 32, 5, p. 1183-1194 12 p.

Research output: Contribution to journalArticle

149 Scopus citations

The HMGB1-RAGE axis mediates traumaticbrain injury - Induced pulmonary dysfunction in lung transplantation

Weber, D. J., Gracon, A. S. A., Ripsch, M. S., Fisher, A. J., Cheon, B. M., Pandya, P. H., Vittal, R., Capitano, M. L., Kim, Y., Allette, Y. M., Riley, A. A., McCarthy, B. P., Territo, P. R., Hutchins, G. D., Broxmeyer, H. E., Sandusky, G. E., White, F. A. & Wilkes, D. S., Sep 3 2014, In : Science translational medicine. 6, 252, 252ra124.

Research output: Contribution to journalArticle

50 Scopus citations
2013
15 Scopus citations

C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells

Liu, Y., Timani, K., Ou, X., Broxmeyer, H. E. & He, J. J., Mar 1 2013, In : Stem Cells and Development. 22, 5, p. 689-694 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming

Lee, M. R., Prasain, N., Chae, H. D., Kim, Y. J., Mantel, C., Yoder, M. C. & Broxmeyer, H. E., Apr 1 2013, In : STEM CELLS. 31, 4, p. 666-681 16 p.

Research output: Contribution to journalArticle

66 Scopus citations