Hal Broxmeyer

  • 41168 Citations
  • 99 h-Index
1973 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

Filter
Article
2013

Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on shp2 phosphatase function

Broxmeyer, H. E., Etienne-Julan, M., Gotoh, A., Braun, S. E., Lu, L., Cooper, S., Feng, G. S., Li, X. J. & Chan, R. J., Mar 15 2013, In : Stem cells and development. 22, 6, p. 998-1006 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies

Farag, S. S., Srivastava, S., Messina-Graham, S., Schwartz, J., Robertson, M. J., Abonour, R., Cornetta, K., Wood, L., Secrest, A., Strother, R. M., Jones, D. R. & Broxmeyer, H. E., Apr 1 2013, In : Stem Cells and Development. 22, 7, p. 1007-1015 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation

Yu, W. M., Liu, X., Shen, J., Jovanovic, O., Pohl, E. E., Gerson, S. L., Finkel, T., Broxmeyer, H. E. & Qu, C. K., Jan 3 2013, In : Cell Stem Cell. 12, 1, p. 62-74 13 p.

Research output: Contribution to journalArticle

143 Scopus citations
9 Scopus citations

Preamble

Broxmeyer, H., Mar 1 2013, In : Unknown Journal. 9781447141716, p. xi-xiii

Research output: Contribution to journalArticle

SIMPL Enhancement of Tumor Necrosis Factor-α Dependent p65-MED1 Complex Formation Is Required for Mammalian Hematopoietic Stem and Progenitor Cell Function

Zhao, W., Breese, E., Bowers, A., Hoggatt, J., Pelus, L. M., Broxmeyer, H. E., Goebl, M. & Harrington, M. A., Apr 22 2013, In : PLoS ONE. 8, 4, e61123.

Research output: Contribution to journalArticle

6 Scopus citations

Spontaneously differentiated GATA6-positive human embryonic stem cells represent an important cellular step in human embryonic development; They are not just an artifact of in vitro culture

Lee, J. H., Hong, K. S., Mantel, C., Broxmeyer, H. E., Lee, M. R. & Kim, K. S., Oct 15 2013, In : Stem Cells and Development. 22, 20, p. 2706-2713 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012

5-aminoimidazole-4-carboxyamide ribonucleoside induces G 1/S arrest and nanog downregulation via p53 and enhances erythroid differentiation

Chae, H. D., Lee, M. R. & Broxmeyer, H. E., Feb 1 2012, In : STEM CELLS. 30, 2, p. 140-149 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors

Broxmeyer, H. E., Srour, E. F., Cooper, S., Wallace, C. T., Hangoc, G. & Youn, B. S., Jan 15 2012, In : Blood Cells, Molecules, and Diseases. 48, 1, p. 25-29 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

A ROSy future for metabolic regulation of HSC division

Broxmeyer, H. E. & Mantel, C., Sep 1 2012, In : Nature Medicine. 18, 9, p. 1334-1336 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing gata3 function

Sawant, D. V., Sehra, S., Nguyen, E. T., Jadhav, R., Englert, K., Shinnakasu, R., Hangoc, G., Broxmeyer, H. E., Nakayama, T., Perumal, N. B., Kaplan, M. H. & Dent, A. L., Nov 15 2012, In : Journal of Immunology. 189, 10, p. 4759-4769 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

CD1d expression on and regulation of murine hematopoietic stem and progenitor cells

Broxmeyer, H. E., Christopherson, K., Hangoc, G., Cooper, S., Mantel, C., Renukaradhya, G. J. & Brutkiewicz, R. R., Jun 14 2012, In : Blood. 119, 24, p. 5731-5741 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cyclin dependent kinase inhibitors differentially modulate synergistic cytokine responsiveness of hematopoietic progenitor cells

Broxmeyer, H. E., Franklin, D. S., Cooper, S., Hangoc, G. & Mantel, C., Jul 1 2012, In : Stem cells and development. 21, 10, p. 1597-1603 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

DEK regulates hematopoietic stem engraftment and progenitor cell proliferation

Broxmeyer, H. E., Kappes, F., Mor-Vaknin, N., Legendre, M., Kinzfogl, J., Cooper, S., Hangoc, G. & Markovitz, D. M., Jun 10 2012, In : Stem Cells and Development. 21, 9, p. 1449-1454 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis

Broxmeyer, H. E., Hoggatt, J., O'leary, H. A., Mantel, C., Chitteti, B. R., Cooper, S., Messina-Graham, S., Hangoc, G., Farag, S., Rohrabaugh, S. L., Ou, X., Speth, J., Pelus, L. M., Srour, E. F. & Campbell, T. B., Dec 1 2012, In : Nature Medicine. 18, 12, p. 1786-1796 11 p.

Research output: Contribution to journalArticle

124 Scopus citations

Dynamic expression of specific miRNAs during erythroid differentiation of human embryonic stem cells

Jin, H. L., Kim, J. S., Kim, Y. J., Kim, S. J., Broxmeyer, H. E. & Kim, K. S., Aug 1 2012, In : Molecules and Cells. 34, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

22 Scopus citations
14 Scopus citations

Mouse hematopoietic cell-targeted STAT3 deletion: Stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype

Mantel, C., Messina-Graham, S., Moh, A., Cooper, S., Hangoc, G., Fu, X. Y. & Broxmeyer, H. E., Sep 27 2012, In : Blood. 120, 13, p. 2589-2599 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells

Liu, Y., Lee, M. R., Timani, K., He, J. J. & Broxmeyer, H. E., Apr 10 2012, In : Stem Cells and Development. 21, 6, p. 829-833 5 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking

Schweitzer, K. S., Johnstone, B. H., Garrison, J., Rush, N. I., Cooper, S., Traktuev, D. O., Feng, D., Adamowicz, J. J., Van Demark, M., Fisher, A. J., Kamocki, K., Brown, M. B., Presson, R. G., Broxmeyer, H. E., March, K. L. & Petrache, I., Jan 15 2011, In : American journal of respiratory and critical care medicine. 183, 2, p. 215-225 11 p.

Research output: Contribution to journalArticle

118 Scopus citations

Ex vivo rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice

Rohrabaugh, S. L., Campbell, T. B., Hangoc, G. & Broxmeyer, H. E., Apr 15 2011, In : Blood Cells, Molecules, and Diseases. 46, 4, p. 318-320 3 p.

Research output: Contribution to journalArticle

28 Scopus citations

Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5-year cryopreserved cord blood

Broxmeyer, H. E., Lee, M. R., Hangoc, G., Cooper, S., Prasain, N., Kim, Y. J., Mallett, C., Ye, Z., Witting, S., Cornetta, K., Cheng, L. & Yoder, M. C., May 5 2011, In : Blood. 117, 18, p. 4773-4777 5 p.

Research output: Contribution to journalArticle

102 Scopus citations

Insights into the biology of cord blood stem/progenitor cells

Broxmeyer, H. E., Apr 1 2011, In : Cell Proliferation. 44, SUPPL. 1, p. 55-59 5 p.

Research output: Contribution to journalArticle

21 Scopus citations
4 Scopus citations

Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells

Kinzfogl, J., Hangoc, G. & Broxmeyer, H. E., Jul 21 2011, In : Blood. 118, 3, p. 565-575 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
14 Scopus citations

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells

Dar, A., Schajnovitz, A., Lapid, K., Kalinkovich, A., Itkin, T., Ludin, A., Kao, W. M., Battista, M., Tesio, M., Kollet, O., Cohen, N. N., Margalit, R., Buss, E. C., Baleux, F., Oishi, S., Fujii, N., Larochelle, A., Dunbar, C. E., Broxmeyer, H. E., Frenette, P. S. & 1 others, Lapidot, T., Aug 2011, In : Leukemia. 25, 8, p. 1286-1296 11 p.

Research output: Contribution to journalArticle

137 Scopus citations

SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse

Ou, X., Chae, H. D., Wang, R. H., Shelley, W. C., Cooper, S., Taylor, T., Kim, Y. J., Deng, C. X., Yoder, M. C. & Broxmeyer, H. E., Jan 13 2011, In : Blood. 117, 2, p. 440-450 11 p.

Research output: Contribution to journalArticle

72 Scopus citations
65 Scopus citations

STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis

Kaplan, M. H., Glosson, N. L., Stritesky, G. L., Yeh, N., Kinzfogl, J., Rohrabaugh, S. L., Goswami, R., Pham, D., Levy, D. E., Brutkiewicz, R. R., Blum, J. S., Cooper, S., Hangoc, G. & Broxmeyer, H. E., Jun 9 2011, In : Blood. 117, 23, p. 6198-6201 4 p.

Research output: Contribution to journalArticle

26 Scopus citations
21 Scopus citations

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC

Liu, Y., Timani, K., Mantel, C., Fan, Y., Hangoc, G., Cooper, S., He, J. J. & Broxmeyer, H. E., May 26 2011, In : Blood. 117, 21, p. 5643-5651 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2010

Diversifying biomedical training: A synergistic intervention

Gibau, G. S., Foertsch, J., Blum, J., Brutkiewicz, R., Queener, S., Roman, A., Rhodes, S., Sturek, M., Wilkes, D. & Broxmeyer, H., Dec 1 2010, In : Journal of Women and Minorities in Science and Engineering. 16, 3, p. 215-235 21 p.

Research output: Contribution to journalArticle

10 Scopus citations

Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling

Gluckman, E., Broxmeyer, H. E., Auerbach, A. D., Friedman, H. S., Douglas, G. W., Devergie, A., Esperou, H., Thierry, D., Socie, G., Lehn, P., Cooper, S., English, D., Kurtzberg, J., Bard, J. & Boyse, E. A., Dec 1 2010, In : Cellular Therapy and Transplantation. 2, 7

Research output: Contribution to journalArticle

Muscle-derived Gr1dimCD11b+ cells enhance neovascularization in an ischemic hind limb mouse model

Kim, J. A., March, K., Chae, H. D., Johnstone, B., Park, S. J., Cook, T., Merfeld-Clauss, S. & Broxmeyer, H. E., Sep 2 2010, In : Blood. 116, 9, p. 1623-1626 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

New Approaches for Improving Engraftment after Cord Blood Transplantation

Rocha, V. & Broxymeyer, H., Jan 2010, In : Biology of Blood and Marrow Transplantation. 16, 1, p. S126-S132

Research output: Contribution to journalArticle

Open Access
70 Scopus citations

Toll-like receptor 2 mediates proliferation, survival, NF-κB translocation, and cytokine mRNA expression in LIF-maintained mouse embryonic stem cells

Taylor, T., Kim, Y. J., Ou, X., Derbigny, W. & Broxmeyer, H. E., Sep 1 2010, In : Stem Cells and Development. 19, 9, p. 1333-1341 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity

Ha, S. P., Klemen, N. D., Kinnebrew, G. H., Brandmaier, A. G., Marsh, J., Hangoc, G., Palmer, D. C., Restifo, N. P., Cornetta, K., Broxmeyer, H. E. & Touloukian, C. E., Dec 1 2010, In : Journal of Clinical Investigation. 120, 12, p. 4273-4288 16 p.

Research output: Contribution to journalArticle

20 Scopus citations

Umbilical Cord Transplantation: Epilogue

Broxmeyer, H. E., Jan 1 2010, In : Seminars in Hematology. 47, 1, p. 97-103 7 p.

Research output: Contribution to journalArticle

33 Scopus citations
51 Scopus citations
2009

CCR5 ligands modulate CXCL12-induced chemotaxis, adhesion, and Akt phosphorylation of human cord blood CD34+ cells

Basu, S. & Broxmeyer, H. E., Dec 1 2009, In : Journal of Immunology. 183, 11, p. 7478-7488 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation

Campbell, T. B., Basu, S., Hangoc, G., Tao, W. & Broxmeyer, H. E., Nov 19 2009, In : Blood. 114, 16, p. 3392-3401 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis

Stumpo, D. J., Broxmeyer, H. E., Ward, T., Cooper, S., Hangoc, G., Yang, J. C., Shelley, W. C., Richfield, E. K., Ray, M. K., Yoder, M. C., Aplan, P. D. & Blackshear, P. J., Nov 20 2009, In : Blood. 114, 12, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

82 Scopus citations
2008

4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells

Kim, Y. J., Han, M. K. & Broxmeyer, H. E., Feb 12 2008, In : Blood. 111, 3, p. 1378-1386 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice

Pulliam, A. C., Hobson, M. J., Ciccone, S. L., Li, Y., Chen, S., Srour, E. F., Yang, F. C., Broxmeyer, H. E. & Clapp, D. W., Sep 1 2008, In : Experimental Hematology. 36, 9, p. 1084-1090 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

A noncytotoxic DsRed variant for whole-cell labeling

Strack, R. L., Strongin, D. E., Bhattacharyya, D., Tao, W., Berman, A., Broxmeyer, H. E., Keenan, R. J. & Glick, B. S., Oct 27 2008, In : Nature Methods. 5, 11, p. 955-957 3 p.

Research output: Contribution to journalArticle

118 Scopus citations

Cells enter a unique intermediate 4N stage, not 4N-G1, after aborted mitosis

Mantel, C., Guo, Y., Man, R. L., Myung, K. H., Rohrabough, S., Kye, S. K. & Broxmeyer, H. E., Feb 15 2008, In : Cell Cycle. 7, 4, p. 484-492 9 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34+ NOD/SCID-repopulating cells

Liu, Y., Hangoc, G., Campbell, T. B., Goodman, M., Tao, W., Pollok, K., Srour, E. F. & Broxmeyer, H. E., Aug 1 2008, In : Experimental Hematology. 36, 8, p. 947-956 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mouse hematopoietic stem cells, unlike human and mouse embryonic stem cells, exhibit checkpoint-apoptosis coupling

Rohrabaugh, S., Mantel, C. & Broxmeyer, H. E., Oct 1 2008, In : Stem Cells and Development. 17, 5, p. 1017-1020 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: Effects associated with Stat3/Survivin

Guo, Y., Mantel, C., Hromas, R. A. & Broxmeyer, H. E., Jan 1 2008, In : STEM CELLS. 26, 1, p. 30-34 5 p.

Research output: Contribution to journalArticle

78 Scopus citations