Hal Broxmeyer

  • 41168 Citations
  • 99 h-Index
1973 …2020

Research output per year

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Publications

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2008

SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

Han, M. K., Song, E. K., Guo, Y., Ou, X., Mantel, C. & Broxmeyer, H. E., Mar 6 2008, In : Cell Stem Cell. 2, 3, p. 241-251 11 p.

Research output: Contribution to journalArticle

268 Scopus citations

Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow

Singh, P., Yao, Y., Weliver, A., Broxmeyer, H. E., Hong, S. C. & Chang, C. H., Apr 1 2008, In : STEM CELLS. 26, 4, p. 1009-1016 8 p.

Research output: Contribution to journalArticle

46 Scopus citations
2007

Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice

Broxmeyer, H. E., Sehra, S., Cooper, S., Toney, L. M., Kusam, S., Aloor, J. J., Marchal, C. C., Dinauer, M. C. & Dent, A. L., Aug 1 2007, In : Molecular and cellular biology. 27, 15, p. 5275-5285 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

A naturally occurring splice variant of CXCL12/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities

Altenburg, J. D., Broxmeyer, H. E., Jin, Q., Cooper, S., Basu, S. & Alkhatib, G., Aug 1 2007, In : Journal of virology. 81, 15, p. 8140-8148 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

A role for natural killer T cells and CD1d molecules in counteracting suppression of hematopoiesis in mice induced by infection with murine cytomegalovirus

Broxmeyer, H. E., Dent, A., Cooper, S., Hangoc, G., Wang, Z. Y., Du, W., Gervay-Haque, J., Sriram, V., Renukaradhya, G. J. & Brutkiewicz, R. R., Apr 1 2007, In : Experimental Hematology. 35, 4 SUPPL., p. 87-93 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: A source of karyotpic instability

Mantel, C., Guo, Y., Man, R. L., Kim, M. K., Han, M. K., Shibayama, H., Fukuda, S., Yoder, M. C., Pelus, L. M., Kim, K. S. & Broxmeyer, H. E., May 15 2007, In : Blood. 109, 10, p. 4518-4527 10 p.

Research output: Contribution to journalArticle

102 Scopus citations

Depsipeptide (FK228) preferentially induces apoptosis in BCR/ABL-expressing cell lines and cells from patients with chronic myelogenous leukemia in blast crisis

Okabe, S., Tauchi, T., Nakajima, A., Sashida, G., Gotoh, A., Broxmeyer, H. E., Ohyashiki, J. H. & Ohyashiki, K., Jun 1 2007, In : Stem Cells and Development. 16, 3, p. 503-514 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Enhanced green fluorescent protein is a nearly ideal long-term expression tracer for hematopoietic stem cells, whereas DsRed-Express fluorescent protein is not

Tao, W., Evans, B. G., Yao, J., Cooper, S., Cornetta, K., Ballas, C. B., Hangoc, G. & Broxmeyer, H. E., Mar 1 2007, In : STEM CELLS. 25, 3, p. 670-678 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte-derived dendritic cells to CCL19 and CXCL12

Li, G., Basu, S., Han, M. K., Kim, Y. J. & Broxmeyer, H. E., Apr 15 2007, In : Blood. 109, 8, p. 3173-3176 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice

Campbell, T. B., Hangoc, G., Liu, Y., Pollok, K. & Broxmeyer, H. E., Jun 1 2007, In : Stem Cells and Development. 16, 3, p. 347-353 7 p.

Research output: Contribution to journalArticle

93 Scopus citations

Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells

Ito, S., Mantel, C. R., Han, M. K., Basu, S., Fukuda, S., Cooper, S. & Broxmeyer, H. E., Mar 1 2007, In : Blood. 109, 5, p. 1923-1930 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: Implications of p53 mutation or isoform expression on breast cancer cell invasion

Mehta, S. A., Christopherson, K. W., Bhat-Nakshatri, P., Goulet, R. J., Broxmeyer, H. E., Kopelovich, L. & Nakshatri, H., May 17 2007, In : Oncogene. 26, 23, p. 3329-3337 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

Protein phosphatase 2A plays an important role in stromal cell-derived factor-1/CXC chemokine ligand 12-mediated migration and adhesion of CD34 + cells

Basu, S., Ray, N. T., Atkinson, S. J. & Broxmeyer, H. E., Sep 1 2007, In : Journal of Immunology. 179, 5, p. 3075-3085 11 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31

Broxmeyer, H. E., Li, J., Hangoc, G., Cooper, S., Tao, W., Mantel, C., Graham-Evans, B., Ghilardi, N. & de Sauvage, F. J., Apr 1 2007, In : Experimental Hematology. 35, 4 SUPPL., p. 78-86 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

SDF-1/CXCL12 enhances in vitro replating capacity of murine and human multipotential and macrophage progenitor cells

Broxmeyer, H. E., Mejia, J. A. H., Hangoc, G., Barese, C., Dinauer, M. & Cooper, S., Aug 1 2007, In : Stem Cells and Development. 16, 4, p. 589-596 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl

Chen, J., Yu, W. M., Daino, H., Broxmeyer, H. E., Druker, B. J. & Qu, C. K., Jan 15 2007, In : Blood. 109, 2, p. 778-785 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

TGF-β combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors

Li, G., Abediankenari, S., Kim, Y. J., Campbell, T. B., Ito, S., Graham-Evans, B., Cooper, S. & Broxmeyer, H. E., Oct 15 2007, In : Blood. 110, 8, p. 2872-2879 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells

Kang, S. G., Lim, H. W., Andrisani, O. M., Broxmeyer, H. E. & Kim, C. H., Sep 15 2007, In : Journal of Immunology. 179, 6, p. 3724-3733 10 p.

Research output: Contribution to journalArticle

Open Access
237 Scopus citations
2006
4 Scopus citations

Cord Blood Stem and Progenitor Cells

Broxmeyer, H., Srour, E., Orschell, C., Ingram, D., Cooper, S., Plett, P. A., Mead, L. E. & Yoder, M., 2006, In : Methods in Enzymology. 419, p. 439-473 35 p.

Research output: Contribution to journalArticle

61 Scopus citations

Enhanced functional response to CXCL12/SDF-1 through retroviral overexpression of CXCR4 on M07e cells: Implications for hematopoietic stem cell transplantation

Porecha, N. K., English, K., Hangoc, G., Broxmeyer, H. E. & Christopherson, K. W., Jun 1 2006, In : Stem Cells and Development. 15, 3, p. 325-333 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
52 Scopus citations

Regulation of trafficking receptor expression in human Forkhead Box P3 + regulatory T cells

Lim, H. W., Broxmeyer, H. E. & Kim, C. H., Jul 15 2006, In : Journal of Immunology. 177, 2, p. 840-851 12 p.

Research output: Contribution to journalArticle

Open Access
131 Scopus citations
22 Scopus citations

Synergistic inhibition in vivo of bone marrow myeloid progenitors by myelosuppressive chemokines and chemokine-accelerated recovery of progenitors after treatment of mice with Ara-C

Broxmeyer, H. E., Pelus, L. M., Kim, C. H., Hangoc, G., Cooper, S. & Hromas, R., Aug 1 2006, In : Experimental Hematology. 34, 8, p. 1069-1077 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2005

Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose administration of AMD3100, a CXCR4 antagonist

Liles, W. C., Rodger, E., Broxmeyer, H. E., Dehner, C., Badel, K., Calandra, G., Christensen, J., Wood, B., Price, T. H. & Dale, D. C., Mar 1 2005, In : Transfusion. 45, 3, p. 295-300 6 p.

Research output: Contribution to journalArticle

193 Scopus citations

BCL-6 negatively regulates macrophage proliferation by suppressing autocrine IL-6 production

Yu, R. Y. L., Wang, X., Pixley, F. J., Yu, J. J., Dent, A. L., Broxmeyer, H. E., Stanley, E. R. & Ye, B. H., Feb 15 2005, In : Blood. 105, 4, p. 1777-1784 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Biology of cord blood cells and future prospects for enchanced clinical benefit

Broxmeyer, H. E., Jan 1 2005, In : Cytotherapy. 7, 3, p. 209-218 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Expansion of bone marrow progenitors and mobilization of multilineage progenitor cells associated with one-per-cycle administration of the long-acting growth factors pegfilgrastim and darbepoetin alfa with chemotherapy

Vadhan-Raj, S., Bueso-Ramos, C. E., Hangoc, G., Christopherson, K., Collard, M. & Broxmeyer, H. E., Mar 1 2005, In : Journal of Supportive Oncology. 3, 2 SUPPL. 1, p. 22-23 2 p.

Research output: Contribution to journalArticle

Flt3 ligand and the Flt3 receptor regulate hematopoietic cell migration by modulating the SDF-1α(CXCL12)/CXCR4 axis

Fukuda, S., Broxmeyer, H. E. & Pelus, L. M., Apr 15 2005, In : Blood. 105, 8, p. 3117-3126 10 p.

Research output: Contribution to journalArticle

90 Scopus citations

Identification of a human B-cell/myeloid common progenitor by the absence of CXCR4

Hou, Y. H., Srour, E. F., Ramsey, H., Dahl, R., Broxmeyer, H. E. & Hromas, R., May 1 2005, In : Blood. 105, 9, p. 3488-3492 5 p.

Research output: Contribution to journalArticle

32 Scopus citations

Identification of a massive reserve of hematopoietic progenitors in mice

Broxmeyer, H. E., Cooper, S., Lasky, L. A. & De Sauvage, F., Apr 1 2005, In : Stem Cells and Development. 14, 2, p. 105-110 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
Open Access
78 Scopus citations

Modulation of cord blood CD8+ T-cell effector differentiation by TGF-β1 and 4-1BB costimulation

Kim, Y. J., Stringfield, T. M., Chen, Y. & Broxmeyer, H. E., Jan 1 2005, In : Blood. 105, 1, p. 274-281 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Neisseria gonorrhoeae enhances infection of dendritic cells by HIV type 1

Zhang, J., Li, G., Bafica, A., Pantelic, M., Zhang, P., Broxmeyer, H., Liu, Y., Wetzler, L., He, J. J. & Chen, T., Jun 15 2005, In : Journal of Immunology. 174, 12, p. 7995-8002 8 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations

Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist

Broxmeyer, H. E., Orschell, C. M., Clapp, D. W., Hangoc, G., Cooper, S., Plett, P. A., Liles, W. C., Li, X., Graham-Evans, B., Campbell, T. B., Calandra, G., Bridger, G., Dale, D. C. & Srour, E. F., Apr 18 2005, In : Journal of Experimental Medicine. 201, 8, p. 1307-1318 12 p.

Research output: Contribution to journalArticle

809 Scopus citations

SDF-1/CXCL12 enhances survival and chemotaxis of murine embryonic stem cells and production of primitive and definitive hematopoietic progenitor cells

Guo, Y., Hangoc, G., Bian, H., Pelus, L. M. & Broxmeyer, H. E., Oct 1 2005, In : STEM CELLS. 23, 9, p. 1324-1332 9 p.

Research output: Contribution to journalArticle

111 Scopus citations
20 Scopus citations

Stromal cell-derived factor-1α/CXCL12-induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1

Okabe, S., Fukuda, S., Kim, Y. J., Niki, M., Pelus, L. M., Ohyashiki, K., Pandolfi, P. P. & Broxmeyer, H. E., Jan 15 2005, In : Blood. 105, 2, p. 474-480 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Transforming growth factor-β1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12

Basu, S. & Broxmeyer, H. E., Jul 15 2005, In : Blood. 106, 2, p. 485-493 9 p.

Research output: Contribution to journalArticle

38 Scopus citations
2004

Comparative proteomic analysis of human CD34+ stem/progenitor cells and mature CD15+ myeloid cells

Tao, W., Wang, M., Voss, E. D., Cocklin, R. R., Smith, J. A., Cooper, S. H. & Broxmeyer, H. E., Jan 1 2004, In : STEM CELLS. 22, 6, p. 1003-1014 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e

Joo, E. K., Broxmeyer, H. E., Kwon, H. J., Ho, B. K., Jin, S. K., Jong, S. L., Choe, Y. K., In, S. C., Pyung, K. M. & Lee, Y., Oct 1 2004, In : Stem Cells and Development. 13, 5, p. 563-570 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
15 Scopus citations

Modulation of hematopoietic stem cell homing and engraftment by CD26

Christopherson, K. W., Hangoc, G., Mantel, C. R. & Broxmeyer, H. E., Aug 13 2004, In : Science. 305, 5686, p. 1000-1003 4 p.

Research output: Contribution to journalArticle

405 Scopus citations
2003

CD26 is essential for normal G-CSF-induced progenitor cell mobilization as determined by CD26-/- mice

Christopherson, K. W., Cooper, S., Hangoc, G. & Broxmeyer, H. E., Nov 2003, In : Experimental Hematology. 31, 11, p. 1126-1134 9 p.

Research output: Contribution to journalArticle

101 Scopus citations

Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells

Christopherson, K. W., Cooper, S. & Broxmeyer, H. E., Jun 15 2003, In : Blood. 101, 12, p. 4680-4686 7 p.

Research output: Contribution to journalArticle

166 Scopus citations

Chemokine/chemokine receptor nomenclature

Bacon, K., Baggiolini, M., Broxmeyer, H., Horuk, R., Lindley, I., Mantovani, A., Matsushima, K., Murphy, P., Nomiyama, H., Oppenheim, J., Rot, A., Schall, T., Tsang, M., Thorpe, R., Van Damme, J., Wadhwa, M., Yoshie, O., Zlotnik, A. & Zoon, K., Jan 7 2003, In : Cytokine. 21, 1, p. 48-49 2 p.

Research output: Contribution to journalArticle

98 Scopus citations

Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines

Kaplan, M. H., Chang, H. C., Cooper, S., Lee, Y. & Broxmeyer, H. E., Aug 1 2003, In : Journal of Hematotherapy and Stem Cell Research. 12, 4, p. 401-408 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of leukotactin-1 on the protection in vivo of myeloid progenitor cells against cytotoxic chemotherapeutics

Kim, W. Y., Broxmeyer, H. E., Han, I. S., Park, D. H., Lee, K. M., Vinay, D. S. & Kwon, B. S., Feb 1 2003, In : Journal of Hematotherapy and Stem Cell Research. 12, 1, p. 107-113 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis

Freie, B., Li, X., Ciccone, S. L. M., Nawa, K., Cooper, S., Vogelweid, C., Schantz, L., Haneline, L. S., Orazi, A., Broxmeyer, H. E., Lee, S. H. & Clapp, D. W., Dec 1 2003, In : Blood. 102, 12, p. 4146-4152 7 p.

Research output: Contribution to journalArticle

51 Scopus citations