Hal Broxmeyer

  • 41168 Citations
  • 99 h-Index
1973 …2020

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2000
89 Scopus citations

Hal E. Broxmeyer, Ph.D.

Broxmeyer, H. E., Oct 2000, In : Journal of hematotherapy & stem cell research. 9, 5, p. 597-605 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Interleukin-11 enhancement of VLA-5 mediated adhesion of CD34+ cells from cord blood to fibronectin is associated with the PI-3 kinase pathway

Wang, L. S., Liu, H. J., Broxmeyer, H. E. & Lu, L., Mar 1 2000, In : In Vivo. 14, 2, p. 331-337 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
Open Access
4 Scopus citations

Macrophage migration inhibitory factor release by macrophages after ingestion of Plasmodium chabaudi-infected erythrocytes: Possible role in the pathogenesis of malarial anemia

Martiney, J. A., Sherry, B., Metz, C. N., Espinoza, M., Ferrer, A. S., Calandra, T., Broxmeyer, H. E. & Bucala, R., Apr 1 2000, In : Infection and immunity. 68, 4, p. 2259-2267 9 p.

Research output: Contribution to journalArticle

106 Scopus citations

Megakaryocytic maturation is regulated by maintaining a balance against cytokine induced-cell proliferation: Steel factor retards thrombopoietin-induced megakaryocytic differentiation while synergistically stimulating mitogenesis

Miyazawa, K., Nishimaki, J., Katagiri, T., Yaguchi, M., Iwase, O., Gotoh, A., Tauchi, T., Kawanishi, Y., Toyama, K., Ohyashiki, K., Ishibashi, T. & Broxmeyer, H. E., Jan 1 2000, In : Hematology. 5, 3, p. 233-246 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer

Vadhan-Raj, S., Verschraegen, C. F., Bueso-Ramos, C., Broxmeyer, H. E., Kudelka, A. P., Freedman, R. S., Edwards, C. L., Gershenson, D., Jones, D., Ashby, M. & Kavanagh, J. J., Mar 7 2000, In : Annals of internal medicine. 132, 5, p. 364-368 5 p.

Research output: Contribution to journalArticle

130 Scopus citations
9 Scopus citations

The CC chemokine CKβ-11/MIP-3β/ELC/exodus 3 mediates tumor rejection of murine breast cancer cells through NK cells

Braun, S. E., Chen, K., Foster, R. G., Kim, C. H., Hromas, R., Kaplan, M. H., Broxmeyer, H. E. & Cornetta, K., Apr 15 2000, In : Journal of Immunology. 164, 8, p. 4025-4031 7 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations

The Exodus subfamily of CC chemotrines inhibits the proliferation of chronic myelogenous leukemia progenitors

Hromas, R., Cripe, L., Hangoc, G., Cooper, S. & Broxmeyer, H. E., Feb 15 2000, In : Blood. 95, 4, p. 1506-1508 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

Transduction of human IL-9 receptor cDNA into TF1 cells induces IL-9 dependency and erythroid differentiation

Xiao, M., Luo, Z., Mantel, C., Broxmeyer, H. E. & Lu, L., Mar 30 2000, In : Journal of Hematotherapy and Stem Cell Research. 9, 1, p. 77-82 6 p.

Research output: Contribution to journalArticle

1999

Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses

Kim, C. H., Qu, C. K., Hangoc, G., Cooper, S., Anzai, N., Feng, G. S. & Broxmeyer, H. E., Sep 6 1999, In : Journal of Experimental Medicine. 190, 5, p. 681-690 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

A human factor-dependent cell line simulates cobblestone formation under human bone marrow stromal cells in vitro

Mantel, C. R., Balduini, A. & Broxmeyer, H. E., Jan 1 1999, In : Annals of the New York Academy of Sciences. 872, p. 399-401 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Altered responsiveness to chemokines due to targeted disruption of SHIP

Kim, C. H., Hangoc, G., Cooper, S., Helgason, C. D., Yew, S., Humphries, R. K., Krystal, G. & Broxmeyer, H. E., Dec 1999, In : Journal of Clinical Investigation. 104, 12, p. 1751-1759 9 p.

Research output: Contribution to journalArticle

Open Access
91 Scopus citations

Amphotropic retrovirus transduction of hematopoietic stem cells

Orlic, D., Girard, L. J., Anderson, S. M., Barrette, S., Broxmeyer, H. E. & Bodine, D. M., Jan 1 1999, In : Annals of the New York Academy of Sciences. 872, p. 115-124 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

CCR7 ligands, SLC/6Ckine/Exodus2/TCA4 and CKβ-11/MIP-3β/ELC, are chemoattractants for CD56+CD16- NK cells and late stage lymphoid progenitors

Kim, C. H., Pelus, L. M., Appelbaum, E., Johanson, K., Anzai, N. & Broxmeyer, H. E., May 1 1999, In : Cellular Immunology. 193, 2, p. 226-235 10 p.

Research output: Contribution to journalArticle

85 Scopus citations

Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells

Hromas, R., Broxmeyer, H. E., Kim, C., Nakshatri, H., Christopherson, K., Azam, M. & Hou, Y. H., Feb 24 1999, In : Biochemical and Biophysical Research Communications. 255, 3, p. 703-706 4 p.

Research output: Contribution to journalArticle

141 Scopus citations

Differential in vitro maturation of hematopoietic stem cells from wild-type and immunoglobulin transgenic mice

Jayne, J. A., Reid, S., Braun, S. E. & Broxmeyer, H. E., Dec 1 1999, In : Cytokines, Cellular and Molecular Therapy. 5, 4, p. 195-204 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dominant myelopoietic effector functions mediated by chemokine receptor CCR1

Broxmeyer, H. E., Cooper, S., Hangoc, G., Gao, J. L. & Murphy, P. M., Jun 21 1999, In : Journal of Experimental Medicine. 189, 12, p. 1987-1992 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors

Broxmeyer, H. E., Kim, C. H., Cooper, S. H., Hangoc, G., Hromas, R. & Pelus, L. M., Jan 1 1999, In : Annals of the New York Academy of Sciences. 872, p. 142-163 22 p.

Research output: Contribution to journalArticle

81 Scopus citations

Enhanced myeloid progenitor cell cycling and apoptosis in mice lacking the chemokine receptor, CCR2

Reid, S., Ritchie, A., Boring, L., Gosling, J., Cooper, S., Hangoc, G., Charo, I. F. & Broxmeyer, H. E., Mar 1 1999, In : Blood. 93, 5, p. 1524-1533 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Flt3 ligand antitumor activity in a murine breast cancer model: A comparison with granulocyte-macrophage colony-stimulating factor and a potential mechanism of action

Braun, S. E., Chen, K., Blazar, B. R., Orchard, P. J., Sledge, G., Robertson, M. J., Broxmeyer, H. E. & Cornetta, K., Sep 1 1999, In : Human gene therapy. 10, 13, p. 2141-2151 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells

Zhang, S., Mantel, C. & Broxmeyer, H. E., Jan 1 1999, In : Journal of Leukocyte Biology. 65, 3, p. 372-380 9 p.

Research output: Contribution to journalArticle

94 Scopus citations

H-Ras is involved in the inside-out signaling pathway of interleukin-3- induced integrin activation

Shibayama, H., Anzai, N., Braun, S. E., Fukuda, S., Mantel, C. & Broxmeyer, H. E., Mar 1 1999, In : Blood. 93, 5, p. 1540-1548 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extension

Hromas, R., Broxmeyer, H. E., Kim, C., Christopherson, K. & Hou, Y. H., May 19 1999, In : Biochemical and Biophysical Research Communications. 258, 3, p. 737-740 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Modulation of integrin function in hematopoietic progenitor cells by CD43 engagement: Possible involvement of protein tyrosine kinase and phospholipase C-γ

Anzai, N., Gotoh, A., Shibayama, H. & Broxmeyer, H. E., May 15 1999, In : Blood. 93, 10, p. 3317-3326 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

p21(cip-1/waf-1) deficiency causes deformed nuclear architecture, centriole overduplication, polyploidy, and relaxed microtubule damage checkpoints in human hematopoietic cells

Mantel, C., Braun, S. E., Reid, S., Henegariu, O., Liu, L., Hangoc, G. & Broxmeyer, H. E., Feb 15 1999, In : Blood. 93, 4, p. 1390-1398 9 p.

Research output: Contribution to journalArticle

113 Scopus citations
68 Scopus citations

Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities

Broxmeyer, H. E. & Kim, C. H., Jul 1999, In : Experimental Hematology. 27, 7, p. 1113-1123 11 p.

Research output: Contribution to journalArticle

123 Scopus citations
24 Scopus citations

SDF-1 suppresses cytokine-induced adhesion of human haemopoietic progenitor cells to immobilized fibronectin

Gotoh, A., Reid, S., Miyazawa, K. & Broxmeyer, H. E., Aug 2 1999, In : British journal of haematology. 106, 1, p. 171-174 4 p.

Research output: Contribution to journalArticle

14 Scopus citations
57 Scopus citations

TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9- 6/CCR9 as a specific receptor

Youn, B. S., Kim, C. H., Smith, F. O. & Broxmeyer, H. E., Oct 1 1999, In : Blood. 94, 7, p. 2533-2536 4 p.

Research output: Contribution to journalArticle

66 Scopus citations
2 Scopus citations

The proteasome regulates caspase-dependent and caspase-independent protease cascades during apoptosis of MO7e hematopoietic progenitor cells

Li-Wha, W., Reid, S., Ritchie, A., Broxmeyer, H. E. & Donner, D. B., Feb 1999, In : Blood Cells, Molecules, and Diseases. 25, 1, p. 20-29 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Thrombopoietin-induced conformational change in p53 lies downstream of the p44/p42 mitogen activated protein kinase cascade in the human growth factor-dependent cell line M07e

Ritchie, A., Braun, S. E., He, J. & Broxmeyer, H. E., Feb 18 1999, In : Oncogene. 18, 7, p. 1465-1477 13 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Umbilical cord blood collection, storage and transplantation: Issues and recommendations for expectant parents and patients

Smith, F. O., Kurtzberg, J., Karson, E. M., Howe, C. W. S., Wilfond, B., Broxmeyer, H. E., Mastroianni, A. C., Gross, S. & Sugarmanj, J., Dec 1 1999, In : Cancer Research, Therapy and Control. 10, 3, p. 217-226 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
1998
Open Access
40 Scopus citations

A positive effect of p21(cip1/waf1) in the colony formation from murine myeloid progenitor cells as assessed by retroviral-mediated gene transfer

Braun, S. E., Mantel, C., Rosenthal, M., Cooper, S., Liu, L., Robertson, K. A., Hromas, R. & Broxmeyer, H. E., Jun 1998, In : Blood Cells, Molecules and Diseases. 24, 2, p. 138-148 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells

Qu, C. K., Yu, W. M., Azzarelli, B., Cooper, S., Broxmeyer, H. E. & Feng, G. S., Jan 1 1998, In : Molecular and cellular biology. 18, 10, p. 6075-6082 8 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations

Characterization of CKβ8 and CKβ8-1: Two alternatively spliced forms of human β-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1

Youn, B. S., Zhang, S. M., Broxmeyer, H. E., Cooper, S., Antol, K., Fraser, M. & Kwon, B. S., May 1 1998, In : Blood. 91, 9, p. 3118-3126 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Ckβ-11/macrophage inflammatory protein-3β/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells

Kim, C. H., Pelus, L. M., White, J. R., Applebaum, E., Johanson, K. & Broxmeyer, H. E., Mar 1 1998, In : Journal of Immunology. 160, 5, p. 2418-2424 7 p.

Research output: Contribution to journalArticle

101 Scopus citations
3 Scopus citations

Differential chemotactic behavior of developing T cells in response to thymic chemokines

Kim, C. H., Pelus, L. M., White, J. R. & Broxmeyer, H. E., Jun 23 1998, In : Blood. 91, 12, p. 4434-4443 10 p.

Research output: Contribution to journalArticle

152 Scopus citations

Identification of human and mouse hematopoietic stem cell populations expressing high levels of mRNA encoding retrovirus receptors

Orlic, D., Girard, L. J., Anderson, S. M., Pyle, L. C., Yoder, M. C., Broxmeyer, H. E. & Bodine, D. M., May 1 1998, In : Blood. 91, 9, p. 3247-3254 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Interleukin-3 and Flt3-ligand induce adhesion of Baf3/Flt3 precursor B- lymphoid cells to fibronectin via activation of VLA-4 and VLA-5

Shibayama, H., Anzai, N., Ritchie, A., Zhang, S., Mantel, C. & Broxmeyer, H. E., Jul 10 1998, In : Cellular Immunology. 187, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
Open Access
346 Scopus citations

Involvement of H-ras in erythroid differentiation of TF1 and human umbilical cord blood CD34+++ cells

Ge, Y., Li, Z. H., Marshall, M. S., Broxmeyer, H. E. & Lu, L., Jun 1998, In : Blood Cells, Molecules and Diseases. 24, 2, p. 124-136 13 p.

Research output: Contribution to journalArticle

9 Scopus citations