Hal Broxmeyer

  • 41168 Citations
  • 99 h-Index
1973 …2020

Research output per year

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Publications

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Article
1998

Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity

Youn, B. S., Zhang, S., Broxmeyer, H. E., Antol, K., Fraser, M. J., Hangoc, G. & Kwon, B. S., Jun 18 1998, In : Biochemical and Biophysical Research Communications. 247, 2, p. 217-222 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Leukemia inhibitory factor and steel factor regulate Tie message stability in CD34+ cells from human umbilical cord blood

Ge, Y., Broxmeyer, H. E. & Lu, L., Mar 1 1998, In : In Vivo. 12, 2, p. 149-153 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac(-/-) mice

Haneline, L. S., Broxmeyer, H. E., Cooper, S., Hangoc, G., Carreau, M., Buchwald, M. & Clapp, D. W., Jun 1 1998, In : Blood. 91, 11, p. 4092-4098 7 p.

Research output: Contribution to journalArticle

143 Scopus citations
35 Scopus citations
6 Scopus citations
1997

A coiled-coil tetramerization domain of BCR-ABL is essential for the interactions of SH2-containing signal transduction molecules

Tauchi, T., Miyazawa, K., Feng, G. S., Broxmeyer, H. E. & Toyama, K., Jan 25 1997, In : Journal of Biological Chemistry. 272, 2, p. 1389-1394 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Altered hematopoiesis, behavior, and sexual function in μ opioid receptor-deficient mice

Tian, M., Broxmeyer, H. E., Fan, Y., Lai, Z., Zhang, S., Aronica, S., Cooper, S., Bigsby, R. M., Steinmetz, R., Engle, S. J., Mestek, A., Pollock, J. D., Lehman, M. N., Jansen, H. T., Ying, M., Stambrook, P. J., Tischfield, J. A. & Yu, L., Apr 21 1997, In : Journal of Experimental Medicine. 185, 8, p. 1517-1522 6 p.

Research output: Contribution to journalArticle

149 Scopus citations

Antitumor activity and immunotherapeutic properties of Flt3-ligand in a murine breast cancer model

Chen, K., Braun, S., Lyman, S., Fan, Y., Traycoff, C. M., Wiebke, E. A., Gaddy, J., Sledge, G., Broxmeyer, H. E. & Cornetta, K., Aug 15 1997, In : Cancer Research. 57, 16, p. 3511-3516 6 p.

Research output: Contribution to journalArticle

108 Scopus citations

Biology and mechanisms of action of synergistically stimulated myeloid progenitor cell proliferation and suppression by chemokines

Broxmeyer, H. E., Mantel, C. R. & Aronica, S. M., Dec 1 1997, In : Stem Cells. 15, SUPPL. 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cloning and characterization of Exodus, a novel β-chemokine

Hromas, R., Gray, P. W., Chantry, D., Godiska, R., Krathwohl, M., Fife, K., Bell, G. I., Takeda, J., Aronica, S., Gordon, M., Cooper, S., Broxmeyer, H. E. & Klemsz, M. J., May 1 1997, In : Blood. 89, 9, p. 3315-3322 8 p.

Research output: Contribution to journalArticle

164 Scopus citations

Cord blood CD16+56- cells with low lytic activity are possible precursors of mature natural killer cells

Gaddy, J. & Broxmeyer, H. E., Sep 15 1997, In : Cellular Immunology. 180, 2, p. 132-142 11 p.

Research output: Contribution to journalArticle

95 Scopus citations
40 Scopus citations
76 Scopus citations
57 Scopus citations

Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1

Gao, J. L., Wynn, T. A., Chang, Y., Lee, E. J., Broxmeyer, H. E., Cooper, S., Tiffany, H. L., Westphal, H., Kwon-Chung, J. & Murphy, P. M., Jun 2 1997, In : Journal of Experimental Medicine. 185, 11, p. 1959-1968 10 p.

Research output: Contribution to journalArticle

368 Scopus citations

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice

Boring, L., Gosling, J., Chensue, S. W., Kunkel, S. L., Farese, R. V., Broxmeyer, H. E. & Charo, I. F., Nov 15 1997, In : Journal of Clinical Investigation. 100, 10, p. 2552-2561 10 p.

Research output: Contribution to journalArticle

Open Access
790 Scopus citations

Interferon-inducible protein 10 as a possible factor in the pathogenesis of cutaneous T-cell lymphomas

Sarris, A. H., Daliani, D., Ulmer, R., Crow, M., Broxmeyer, H. E., Reiss, M., Karasavvas, N., Zelenetz, A. D., Pugh, W., Cabanillas, F., Deisseroth, A. B. & Duvic, M., Mar 18 1997, In : Clinical Cancer Research. 3, 2, p. 169-177 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Isolation and characterization of exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension

Hromas, R., Kim, C. H., Klemsz, M., Krathwohl, M., Fife, K., Cooper, S., Schnizlein-Bick, C. & Broxmeyer, H. E., Dec 1 1997, In : Journal of Immunology. 159, 6, p. 2554-2558 5 p.

Research output: Contribution to journalArticle

122 Scopus citations
25 Scopus citations

Molecular Cloning of Leukotactin-1: A Novel Human β-Chemokine, a Chemoattractant for Neutrophils, Monocytes, and Lymphocytes, and a Potent Agonist at CC Chemokine Receptors 1 and 3

Youn, B. S., Zhang, S. M., Lee, E. K., Park, D. H., Broxmeyer, H. E., Murphy, P. M., Locati, M., Pease, J. E., Kim, K. K., Antol, K. & Kwon, B. S., Dec 1 1997, In : Journal of Immunology. 159, 11, p. 5201-5205 5 p.

Research output: Contribution to journalArticle

93 Scopus citations

Retrovirally mediated gene transfer of Arg22 and Tyr22 forms of dihydrofolate reductase into the hematopoietic cell line K562: A comparison of methotrexate resistance

Braun, S. E., Mclvor, R. S., Davidson, A. S., Hanna, M., Traycoff, C. M., Berebetsky, D. A., Gonin, R., Broxmeyer, H. E. & Cornetta, K., Dec 1 1997, In : Cancer Gene Therapy. 4, 1, p. 26-32 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Retroviral mediated gene transfer of Flt3 ligand enhances proliferation and MAP kinase activity of AML5 cells

Braun, S. E., Aronica, S. M., Ge, Y., Takahira, H., Etienne-Julan, M., Lu, L., Minden, M. D., Lyman, S. D. & Broxmeyer, H. E., Feb 17 1997, In : Experimental Hematology. 25, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Steel factor enhances integrin-mediated tyrosine phosphorylation of focal adhesion kinase (pp125(FAK)) and paxillin

Takahira, H., Gotoh, A., Ritchie, A. & Broxmeyer, H. E., Mar 11 1997, In : Blood. 89, 5, p. 1574-1584 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Stem cell heterogeneity: (Discussion)

Eaves, A., Moore, M. A. S., Lansdorp, P. M., Spangrude, G. J., Broxmeyer, H. E., Lemischka, I. R., Quesenberry, P. J., Papayannopoulou, T., Torok-Storb, B. & Hoffman, R., Jan 1 1997, In : STEM CELLS. 15, SUPPL. 1, p. 217-220 4 p.

Research output: Contribution to journalArticle

Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with cancer

Vadhan-Raj, S., Murray, L. J., Bueso-Ramos, C., Patel, S., Reddy, S. P., Hoots, W. K., Johnston, T., Papadopoulous, N. E., Hittelman, W. N., Johnston, D. A., Yang, T. A., Paton, V. E., Cohen, R. L., Hellmann, S. D., Benjamin, R. S. & Broxmeyer, H. E., May 1 1997, In : Annals of internal medicine. 126, 9, p. 673-681 9 p.

Research output: Contribution to journalArticle

189 Scopus citations
20 Scopus citations

Thrombopoietin upregulates the promoter conformation of p53 in a proliferation-independent manner coincident with a decreased expression of Bax: Potential mechanisms for survival enhancing effects

Ritchie, A., Gotoh, A., Gaddy, J., Braun, S. E. & Broxmeyer, H. E., Dec 1 1997, In : Blood. 90, 11, p. 4394-4402 9 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Up-regulation of Tie gene expression by leukemia inhibitory factor and steel factor in CD34+ cells from human umbilical cord blood

Ge, Y., Li, Z. H., Yung, Y. P., Ratzkin, B. J., Broxmeyer, H. E. & Lu, L., Oct 1 1997, In : Journal of Leukocyte Biology. 62, 4, p. 510-516 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

What are the current limitations for HSC transduction? How can we overcome them? (Discussion)

Nienhuis, A., Moore, M. A. S., Dick, J. E., Stamatoyannopoulos, G., Lemischka, I. R., Torok-Storb, B., Spangrude, G. J., Papayannopoulou, T., Flugel, R. M., Orlic, D., Broxmeyer, H. E., Quesenberry, P. J., Lansdorp, P. M. & Sharkis, S. J., Dec 3 1997, In : STEM CELLS. 15, SUPPL. 1, p. 255-263 9 p.

Research output: Contribution to journalArticle

What characterizes the earliest stem cell? What is true for human stem cells? (Discussion)

Papayannopoulou, T., Eaves, C., Dick, J. E., Lansdorp, P. M., Zanjani, E. D., Hoffman, R., Sharkis, S. J., Kanz, L., Torok-Storb, B., Spangrude, G. J., Moore, M. A. S. & Broxmeyer, H. E., Dec 3 1997, In : STEM CELLS. 15, SUPPL. 1, p. 213-215 3 p.

Research output: Contribution to journalArticle

1996

A pathogenetic role for TNFα in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency

Taylor, G. A., Carballo, E., Lee, D. M., Lai, W. S., Thompson, M. J., Patel, D. D., Schenkman, D. I., Gilkeson, G. S., Broxmeyer, H. E., Haynes, B. F. & Blackshear, P. J., May 1996, In : Immunity. 4, 5, p. 445-454 10 p.

Research output: Contribution to journalArticle

569 Scopus citations

A phase i trial of subcutaneous (SC) BB-10010 in breast. Cancer patients (PTS) receiving high-dose cyclophosphamide (C)

Gordon, M. S., McCaskill-Stevens, W. J. & Broxmeyer, H. E., Dec 1 1996, In : Experimental Hematology. 24, 9, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations
3 Scopus citations

Curative effect of split low dosage total-body irradiation on murine AIDS Induced by friend virus: The results and the possible mechanism

Shen, R. N., Lu, L., Kaiser, H. E. & Broxmeyer, H. E., Dec 1 1996, In : In Vivo. 10, 2, p. 191-200 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Flt3-ligand production by human bone marrow stromal cells

Lisovsky, M., Braun, S. E., Ge, Y., Takahira, H., Lu, L., Savchenko, V. G., Lyman, S. D. & Broxmeyer, H. E., Jun 1996, In : Leukemia. 10, 6, p. 1012-1018 7 p.

Research output: Contribution to journalArticle

87 Scopus citations

Flt3 ligand prolongs survival of CD34+++ human umbilical cord blood myeloid progenitors in serum-depleted culture medium

Takahira, H., Lyman, S. D. & Broxmeyer, H. E., Mar 1996, In : Annals of Hematology. 72, 3, p. 131-135 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Hematopoietic defects in mice lacking the sialomucin CD34

Cheng, J., Baumhueter, S., Cacalano, G., Carver-Moore, K., Thibodeaux, H., Thomas, R., Broxmeyer, H. E., Cooper, S., Hague, N., Moore, M. & Lasky, L. A., Jan 15 1996, In : Blood. 87, 2, p. 479-490 12 p.

Research output: Contribution to journalArticle

Open Access
165 Scopus citations
8 Scopus citations

Interferon-inducible protein-10 and the pathogenesis of cutaneous T-cell lymphomas

Sarris, A. H., Daliani, D., Ulmer, R., Crow, M., Broxmeyer, H. E., Pugh, W., Reiss, M., Cabanillas, F., Deisseroth, A. B. & Duvic, M., Jan 1 1996, In : Leukemia and Lymphoma. 24, 1-2, p. 103-110 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Involvement of interleukin (IL) 8 receptor in negative regulation of myeloid progenitor cells in vivo: Evidence from mice lacking the murine IL-8 receptor homologue

Broxmeyer, H. E., Cooper, S., Cacalano, G., Hague, N. L., Bailish, E. & Moore, M. W., Nov 1 1996, In : Journal of Experimental Medicine. 184, 5, p. 1825-1832 8 p.

Research output: Contribution to journalArticle

Open Access
85 Scopus citations

Involvement of p21(cip-1) and p27(kip-1) in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21(cip-1) in the maintenance of stem/progenitor cells in vivo

Mantel, C., Luo, Z., Canfield, J., Braun, S., Deng, C. & Broxmeyer, H. E., Nov 15 1996, In : Blood. 88, 10, p. 3710-3719 10 p.

Research output: Contribution to journalArticle

97 Scopus citations

Low levels of erythroid and myeloid progenitors in thrombopoietin- and c- mpl-deficient mice

Carver-Moore, K., Broxmeyer, H. E., Luoh, S. M., Cooper, S., Peng, J., Burstein, S. A., Moore, M. W. & De Sauvage, F. J., Aug 1 1996, In : Blood. 88, 3, p. 803-808 6 p.

Research output: Contribution to journalArticle

244 Scopus citations

Macrophage-stimulating protein, a ligand for the RON receptor protein tyrosine kinase, suppresses myeloid progenitor cell proliferation and synergizes with vascular endothelial cell growth factor and members of the chemokine family

Broxmeyer, H. E., Cooper, S., Li, Z. H., Lu, L., Sarris, A., Wang, M. H., Chang, M. S., Donner, D. B. & Leonard, E. J., Jul 1 1996, In : Annals of Hematology. 73, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Murine AIDS cured by low dosage total body irradiation

Shen, R. N., Lu, L., Kaiser, H. E. & Broxmeyer, H. E., Dec 1 1996, In : Advances in experimental medicine and biology. 407, p. 451-458 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Recovery and characterization of CD34+ cord blood cells after cryopreservation

Lu, L., Li, Z. H. & Broxmeyer, H. E., Dec 1 1996, In : In Vivo. 10, 2, p. 229-232 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Regulation of egr-1 gene expression by retinoic acid in a human growth factor-dependent cell line

Horie, M., Sakamoto, K. M. & Broxmeyer, H. E., Jun 1996, In : International Journal of Hematology. 63, 4, p. 303-309 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Retroviral transfer of the recombinant human erythropoietin receptor gene into single hematopoietic stem/progenitor cells from human cord blood increases the number of erythropoietin-dependent erythroid colonies

Lu, L., Ge, Y., Li, Z. H., Keeble, W., Kabat, D., Bagby, G. C., Broxmeyer, H. E. & Hoatlin, M. E., Jan 15 1996, In : Blood. 87, 2, p. 525-534 10 p.

Research output: Contribution to journalArticle

20 Scopus citations