Hal Broxmeyer

  • 41168 Citations
  • 99 h-Index
1973 …2020

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1989

Preclinical and clinical studies with the hematopoietic colony-stimulating factors and related interleukins

Broxmeyer, H. E. & Vadhan-Raj, S., Sep 1 1989, In : Immunologic Research. 8, 3, p. 185-201 17 p.

Research output: Contribution to journalArticle

21 Scopus citations

Recombinant human colony stimulating factor-granulocyte/macrophage and -granulocyte, but not macrophage induce the development of a respiratory burst in primary human myeloid leukemic cells in vitro

Geissler, K., Tricot, G., Grimm, G., Siostrzonek, P. & Broxmeyer, H., Sep 1 1989, In : Blut. 59, 3, p. 226-230 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Stimulation of nonclonal hematopoiesis and suppression of the neoplastic clone after treatment with recombinant human granulocyte-macrophage colony-stimulating factor in a patient with therapy-related myelodysplastic syndrome

Vadhan-Raj, S., Broxmeyer, H. E., Spitzer, G., LeMaistre, A., Hultman, S., Ventura, G., Tigaud, J. D., Cork, M. A., Trujilo, J. M., Gutterman, J. U. & Hittelman, W. N., Jan 1 1989, In : Blood. 74, 5, p. 1491-1498 8 p.

Research output: Contribution to journalArticle

54 Scopus citations
12 Scopus citations

Suppressive effects in vivo of purified recombinant human H-subunit (acidic) ferritin on murine myelopoiesis

Broxmeyer, H. E., Williams, D. E., Geissler, K., Hangoc, G., Cooper, S., Bicknell, D. C., Levi, S. & Arosio, P., Jan 1 1989, In : Blood. 73, 1, p. 74-79 6 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations
30 Scopus citations
1988

Acicid isoferritin stimulates differentiation of normal granulomonocytic progenitors

Guimaraes, J. E. T. E., Berney, J. J., Broxmeyer, H. E., Hoffbrand, A. V. & Francis, G. E., Jan 1 1988, In : Leukemia. 2, 7, p. 466-471 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Correlation between CSF-1 responsiveness and expression of (CSF-1 receptor) c-fms in purified murine granulocyte-macrophage progenitor cells (CFU-GM)

Bicknell, D. C., Williams, D. E. & Broxmeyer, H. E., Jan 1 1988, In : Experimental Hematology. 16, 1, p. 88-91 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Correlation between CSF-1 responsiveness and expression of (CSF-1 receptor) c-fms in purified murine granulocyte-macrophage progenitor cells (CFU-GM)

Bicknell, D. C., Williams, D. E. & Broxmeyer, H. E., Jan 1 1988, In : Experimental Hematology. 16, 3, p. 240-243 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Curative Effect of Split Low Dosage Total-Body Irradiation on Mice Infected with the Polycythemia-inducing Strain of the Friend Virus Complex

Shen, R. N., Hornback, N. B., Lu, L., Young, P., Brahmi, Z. & Broxmeyer, H. E., May 1988, In : Cancer Research. 48, 9, p. 2399-2403 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of Whole-Body Hyperthermia and Cyclophosphamide on Natural Killer Cell Activity in Murine Erythroleukemia

Shen, R. N., Hornback, N. B., Shidnia, H., Lu, L., Broxmeyer, H. E. & Brahmi, Z., Aug 15 1988, In : Cancer Research. 48, 16, p. 4561-4563 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Effects of Hematopoietic Suppressor Molecules on the in Vitro Proliferation of Purified Murine Granulocyte-Macrophage Progenitor Cells

Williams, D. E., Cooper, S. & Broxmeyer, H. E., Jan 1 1988, In : Cancer Research. 48, 6, p. 1548-1550 3 p.

Research output: Contribution to journalArticle

21 Scopus citations
33 Scopus citations
32 Scopus citations

Growth characteristics of marrow hematopoietic progenitor/precursor cells from patients on a phase I clinical trial with purified recombinant human granulocyte-macrophage colony-stimulating factor

Broxmeyer, H. E., Cooper, S., Williams, D. E., Hangoc, G., Gutterman, J. U. & Vadhan-Raj, S., Jan 1 1988, In : Experimental Hematology. 16, 7, p. 594-602 9 p.

Research output: Contribution to journalArticle

57 Scopus citations
Open Access
16 Scopus citations
15 Scopus citations

Recombinant human tumor necrosis factors α and β stimulate fibroblasts to produce hemopoietic growth factors in vitro

Zucali, J. R., Broxmeyer, H. E., Gross, M. A. & Dinarello, C. A., Jan 1 1988, In : Journal of Immunology. 140, 3, p. 840-844 5 p.

Research output: Contribution to journalArticle

58 Scopus citations
Open Access
138 Scopus citations

Stimulation of hematopoiesis in patients with bone marrow failure and in patients with malignancy by recombinant human granulocyte-macrophage colony-stimulating factor

Vadhan-Raj, S., Buescher, S., LeMaistre, A., Keating, M., Walters, R., Ventura, C., Hittelman, W., Broxmeyer, H. E. & Gutterman, J. U., Jan 1 1988, In : Blood. 72, 1, p. 134-141 8 p.

Research output: Contribution to journalArticle

94 Scopus citations

Stimulation of Myelopoiesis in Patients with Aplastic Anemia by Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

Vadhan-Raj, S., Buescher, S., Broxmeyer, H. E., Lemaistre, A., Lepe-Zuniga, J. L., Ventura, G., Jeha, S., Horwitz, L. J., Trujillo, J. M., Gillis, S., Hittelman, W. N. & Gutterman, J. U., Dec 22 1988, In : New England Journal of Medicine. 319, 25, p. 1628-1634 7 p.

Research output: Contribution to journalArticle

133 Scopus citations

Synergistic effects of purified recombinant human and murine B cell growth factor-1/IL-4 on colony formation in vitro by hematopoietic progenitor cells: Multiple actions

Broxmeyer, H. E., Lu, L., Cooper, S., Tushinski, R., Mochizuki, D., Rubin, B. Y., Gillis, S. & Williams, D. E., Dec 1 1988, In : Journal of Immunology. 141, 11, p. 3852-3862 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Temporal adaptation of neutrophil oxidative responsiveness to n-formyl-methionyl-leucyl-phenylalanine. Acceleration by granulocyte-macrophage colony stimulating factor

English, D., Broxmeyer, H. E., Gabig, T. G., Akard, L. P., Williams, D. E. & Hoffman, R., Jan 1 1988, In : Journal of Immunology. 141, 7, p. 2400-2406 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

The production of myeloid blood cells and their regulation during health and disease

Broxmeyer, H. E., Williams, D. E. & Gentile, P. S., 1988, In : Critical Reviews in Oncology and Hematology. 8, 3, p. 173-226 54 p.

Research output: Contribution to journalArticle

61 Scopus citations
1987
73 Scopus citations

Characterization of hematopoietic stem and progenitor cells

Williams, D. E., Lu, L. & Broxmeyer, H. E., Dec 1 1987, In : Immunologic Research. 6, 4, p. 294-304 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Comparative effects in vivo of recombinant murine interleukin 3, natural murine colony-stimulating factor-1, and recombinant murine granulocyte-macrophage colony-stimulating factor on myelopoiesis in mice

Broxmeyer, H. E., Williams, D. E., Cooper, S., Shadduck, R. K., Gillis, S., Waheed, A., Urdal, D. L. & Bicknell, D. C., Jan 1 1987, In : Journal of Clinical Investigation. 79, 3, p. 721-730 10 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations

Effects of purified iron-saturated human lactoferrin on spleen morphology in mice infected with Friend virus complex

Chen, L. T., Lu, L. & Broxmeyer, H. E., Jan 1 1987, In : American Journal of Pathology. 126, 2, p. 285-292 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effects of Recombinant Human Granulocyte–Macrophage Colony-Stimulating Factor in Patients with Myelodysplastic Syndromes

Vadhan-Raj, S., Keating, M., Lemaistre, A., Hittelman, W. N., McCredie, K., Trujillo, J. M., Broxmeyer, H. E., Henney, C. & Gutterman, J. U., Dec 17 1987, In : New England Journal of Medicine. 317, 25, p. 1545-1552 8 p.

Research output: Contribution to journalArticle

433 Scopus citations

Interactions between purified murine colony-stimulating factors (natural CSF-1, recombinant GM-CSF, and recombinant IL-3) on the in vitro proliferation of purified murine granulocyte-macrophage progenitor cells

Williams, D. E., Straneva, J. E., Cooper, S., Shadduck, R. K., Waheed, A., Gillis, S., Urdal, D. & Broxmeyer, H. E., Dec 1 1987, In : Experimental Hematology. 15, 10, p. 1007-1012 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Modulation of Friend virus infectivity in vivo by administration of purified preparations of human lactoferrin and recombinant murine interleukin-3 to mice

Hangoc, G., Lu, L., Oliff, A., Gillis, S., Hu, W., Bicknell, D. C., Williams, D. & Broxmeyer, H. E., Dec 1 1987, In : Leukemia. 1, 11, p. 762-764 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Prostaglandin E acts at two levels to enhance colony formation in vitro by erythroid (BFU-E) progenitor cells

Lu, L., Pelus, L. M., Piacibello, W., Moore, M. A. S., Hu, W. & Broxmeyer, H. E., Jan 1 1987, In : Experimental Hematology. 15, 7, p. 765-771 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Purification of murine bone-marrow-derived granulocyte-macrophage colony-forming cells

Williams, D. E., Straneva, J. E., Shen, R. N. & Broxmeyer, H. E., Jan 1 1987, In : Experimental Hematology. 15, 3, p. 243-250 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Regulation of early human hematopoietic (BFU-E and CFU-GEMM) progenitor cells in vitro by interleukin 1-induced fibroblast-conditioned medium

Zucali, J. R., Broxmeyer, H. E., Dinarello, C. A., Gross, M. A. & Weiner, R. S., Mar 30 1987, In : Blood. 69, 1, p. 33-37 5 p.

Research output: Contribution to journalArticle

47 Scopus citations
67 Scopus citations
4 Scopus citations

The effects of purified recombinant murine interleukin-3 and/or purified natural murine CSF-1 in vivo on the proliferation of murine high- and low-proliferative potential colony-forming cells: Demonstration of in vivo synergism

Williams, D. E., Hangoc, G., Cooper, S., Boswell, H. S., Shadduck, R. K., Gillis, S., Waheed, A., Urdal, D. & Broxmeyer, H. E., Jan 1 1987, In : Blood. 70, 2, p. 401-403 3 p.

Research output: Contribution to journalArticle

26 Scopus citations

The influence in vivo of murine colony-stimulating factor-1 on myeloid progenitor cells in mice recovering from sublethal dosages of cyclophosphamide

Broxmeyer, H. E., Williams, D. E., Cooper, S., Waheed, A. & Shadduck, R. K., Jun 16 1987, In : Blood. 69, 3, p. 913-918 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
14 Scopus citations

The opposing actions in vivo on murine myelopoiesis of purified preparations of lactoferrin and the colony stimulating factors

Broxmeyer, H. E., Williams, D. E., Hangoc, G., Cooper, S., Gentile, P., Shen, R. N., Ralph, P., Gillis, S. & Bicknell, D. C., Oct 27 1987, In : Blood Cells. 13, 1-2, p. 31-48 18 p.

Research output: Contribution to journalArticle

41 Scopus citations
1986

Activities derived from established human myeloid cell lines reverse the suppression of cell line colony formation by lactoferrin and transferrin

Broxmeyer, H. E., Rubin, B. Y., Berman, E., Juliano, L., Lu, L., Hast, L. J., Cooper, S. & Singer, J. W., Apr 9 1986, In : Experimental Hematology. 14, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Biomolecule‐cell interactions and the regulation of myelopoiesis

Broxmeyer, H. E., 1986, In : The International Journal of Cell Cloning. 4, 5, p. 378-405 28 p.

Research output: Contribution to journalArticle

67 Scopus citations
42 Scopus citations
26 Scopus citations

Gamma interferon induces colony-forming cells of the human monoblast cell line U937 to respond to inhibition by lactoferrin, transferrin, and acidic isoferritins

Broxmeyer, H. E., Piacibello, W., Juliano, L., Platzer, E., Berman, E. & Rubin, B. Y., Apr 9 1986, In : Experimental Hematology. 14, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Human gamma interferon enhances release from phytohemagglutinin-stimulated T4+ lymphocytes of activities that stimulate colony formation by granulocyte-macrophage, erythroid, and multipotential progenitor cells

Piacibello, W., Lu, L., Williams, D., Aglietta, M., Rubin, B. Y., Cooper, S., Wachter, M., Gavosto, F. & Broxmeyer, H. E., Dec 1 1986, In : Blood. 68, 6, p. 1339-1347 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Inducible production of human macrophage growth factor, CSF-1

Ralph, P., Warren, M. K., Lee, M. T., Csejtey, J., Weaver, J. F., Broxmeyer, H. E., Williams, D. E., Stanley, E. R. & Kawasaki, E. S., Jan 1 1986, In : Blood. 68, 3, p. 633-639 7 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations

Monoclonal antibody (II2C) to human lactoferrin inactivates the myelopoietic suppressive effect of human lactoferrin in vitro

Sledge, G. W., Bicknell, D. C., Harris, E. L., Zegarra, G. & Broxmeyer, H. E., Sep 24 1986, In : Experimental Hematology. 14, 5, p. 333-337 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
15 Scopus citations