Hanying Chen

  • Assistant Research Professor of Medicine, Cardiology
  • 2493 Citations
  • 26 h-Index
20022019

Research output per year

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Publications

  • 2493 Citations
  • 26 h-Index
  • 43 Article
  • 2 Comment/debate
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Article
2019

Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12

Pan, Z., Ai, T., Chang, P. C., Liu, Y., Liu, J., Maruyama, M., Homsi, M., Fishbein, M. C., Rubart, M., Lin, S. F., Xiao, D., Chen, H., Chen, P. S., Shou, W. & Li, B. Y., Feb 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 2, p. H371-H379

Research output: Contribution to journalArticle

1 Scopus citations

BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways

Qu, X., Liu, Y., Cao, D., Chen, L. J., Liu, Z., Ji, H., Chen, Y., Zhang, W., Zhu, P., Xiao, D., Li, X., Shou, W. & Chen, H., Dec 27 2019, In : Journal of Biological Chemistry. 294, 52, p. 19877-19888 12 p.

Research output: Contribution to journalArticle

2018

Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation

del Monte-Nieto, G., Ramialison, M., Adam, A. A. S., Wu, B., Aharonov, A., D’uva, G., Bourke, L. M., Pitulescu, M. E., Chen, H., de la Pompa, J. L., Shou, W., Adams, R. H., Harten, S. K., Tzahor, E., Zhou, B. & Harvey, R. P., Jan 1 2018, In : Nature. 557, 7705, p. 439-471 33 p.

Research output: Contribution to journalArticle

27 Scopus citations

Potential Common Pathogenic Pathways for the Left Ventricular Noncompaction Cardiomyopathy (LVNC)

Liu, Y., Chen, H. & Shou, W., Aug 1 2018, In : Pediatric Cardiology. 39, 6, p. 1099-1106 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Protein phosphatase 5 and the tumor suppressor p53 down-regulate each other’s activities in mice

Wang, J., Shen, T., Zhu, W., Dou, L., Gu, H., Zhang, L., Yang, Z., Chen, H., Zhou, Q., Sánchez, E. R., Field, L. J., Mayo, L. D., Xie, Z., Xiao, D., Lin, X., Shou, W. & Yong, W., Nov 23 2018, In : Journal of Biological Chemistry. 293, 47, p. 18218-18229 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Profiling analysis of long non-coding RNAs in early postnatal mouse hearts

Sun, X., Han, Q., Luo, H., Pan, X., Ji, Y., Yang, Y., Chen, H., Wang, F., Lai, W., Guan, X., Zhang, Q., Tang, Y., Chu, J., Yu, J., Shou, W., Deng, Y. & Li, X., Mar 7 2017, In : Scientific Reports. 7, 43485.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Critical roles of STAT3 in β-adrenergic functions in the heart

Zhang, W., Qu, X., Chen, B., Snyder, M., Wang, M., Li, B., Tang, Y., Chen, H., Zhu, W., Zhan, L., Yin, N., Li, D., Xie, L., Liu, Y., Zhang, J. J., Fu, X-Y., Rubart, M., Song, L. S., Huang, X. Y. & Shou, W., Jan 5 2016, In : Circulation. 133, 1, p. 48-61 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Unique expression of angiotensin type-2 receptor in sex-specific distribution of myelinated ah-type baroreceptor neuron contributing to sex-dimorphic neurocontrol of circulation

Liu, Y., Zhou, J. Y., Zhou, Y. H., Wu, D., He, J. L., Han, L. M., Liang, X. B., Wang, L. Q., Lu, X. L., Chen, H., Qiao, G. F., Shou, W. & Li, B. Y., Apr 1 2016, In : Hypertension. 67, 4, p. 783-791 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

KCa1.1 β4-subunits are not responsible for iberiotoxin-resistance in baroreceptor neurons in adult male rats

Xu, W. X., Ban, T., Wang, L. Q., Zhao, M., Yin, L., Li, G., Chen, H., Schield, J., Qiao, G. F., Yan, J. L. & Li, B. Y., Jan 15 2015, In : International Journal of Cardiology. 178, p. 184-187 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Na+-induced Ca2++ influx through reverse mode of Na+-Ca2++ exchanger in mouse ventricular cardiomyocyte

Yan, Z. Y., Ban, T., Fan, Y., Chen, W. R., Sun, H. L., Chen, H., Qiao, Q. F. & Li, B. Y., Jan 1 2015, In : Oncotarget. 6, 27, p. 23272-23280 9 p.

Research output: Contribution to journalArticle

Sex- and afferent-specific differences in histamine receptor expression in vagal afferents of rats: A potential mechanism for sexual dimorphism in prevalence and severity of asthma

Li, J. N., Li, X. L., He, J., Wang, J. X., Zhao, M., Liang, X. B., Zhao, S. Y., Ma, M. N., Liu, Y., Wang, Y. B., Chen, H., Qiao, G. F. & Li, B. Y., Sep 1 2015, In : Neuroscience. 303, p. 166-177 12 p.

Research output: Contribution to journalArticle

13 Scopus citations
2014

Alternations of cardiac IK1 and Ito from FKBP12.6 transgenic mouse heart and potential impact of cardiac hypertrophy

Xu, B., Zhu, J. X., Huo, R., Yan, Z. Y., Hee, J. L., Deng, L., Wang, J. X., He, J., Qiao, G. F., Chen, H. & Li, B. Y., Oct 20 2014, In : International Journal of Cardiology. 176, 3, p. 1017-1020 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fine tuning of calcium on membrane excitation of baroreceptor neurons in rats

Huo, R., Xu, W. X., Han, L. M., He, J. L., Liu, Y., Lu, X. L., Liu, S. Z., Yuan, M., Chen, H., Yan, J. L., Qiao, G. F. & Li, B. Y., Jul 1 2014, In : International Journal of Cardiology. 174, 3, p. 883-887 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Phosphatase of regenerating Liver 2 (PRL2) deficiency impairs kit Signaling and Spermatogenesis

Dong, Y., Zhang, L., Bai, Y., Zhou, H. M., Campbell, A. M., Chen, H., Yong, W., Zhang, W., Zeng, Q., Shou, W. & Zhang, Z. Y., Feb 7 2014, In : Journal of Biological Chemistry. 289, 6, p. 3799-3810 12 p.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development

Chen, H., Ridgway, J. B., Sai, T., Lai, J., Warming, S., Chen, H., Roose-Girma, M., Zhang, G., Shou, W. & Yan, M., Jul 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 29, p. 11887-11892 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity

Chen, H., Zhang, W., Sun, X., Yoshimoto, M., Chen, Z., Zhu, W., Liu, J., Shen, Y., Yong, W., Li, D., Zhang, J., Lin, Y., Li, B., VanDusen, N. J., Snider, P., Schwartz, R. J., Conway, S. J., Field, L. J., Yoder, M. C., Firulli, A. B. & 3 others, Carlesso, N., Towbin, J. A. & Shou, W., May 1 2013, In : Development (Cambridge). 140, 9, p. 1946-1957 12 p.

Research output: Contribution to journalArticle

45 Scopus citations
65 Scopus citations

Myocardial Mycn is essential for mouse ventricular wall morphogenesis

Harmelink, C., Peng, Y., DeBenedittis, P., Chen, H., Shou, W. & Jiao, K., Jan 1 2013, In : Developmental Biology. 373, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (phosphatase and tensin homologue deleted on chromosome 10) and activating Akt protein

Dong, Y., Zhang, L., Zhang, S., Bai, Y., Chen, H., Sun, X., Yong, W., Li, W., Colvin, S. C., Rhodes, S. J., Shou, W. & Zhang, Z. Y., Sep 14 2012, In : Journal of Biological Chemistry. 287, 38, p. 32172-32179 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity

Song, W., Xiao, Y., Chen, H., Ashpole, N. M., Piekarz, A. D., Ma, P., Hudmon, A., Cummins, T. R. & Shou, W., Oct 1 2012, In : Journal of Physiology. 590, 20, p. 5123-5139 17 p.

Research output: Contribution to journalArticle

13 Scopus citations

The role of FK506-binding proteins 12 and 12.6 in regulating cardiac function

Li, B. Y., Chen, H., Maruyama, M., Zhang, W., Zhang, J., Pan, Z. W., Rubart, M., Chen, P. S. & Shou, W., Aug 1 2012, In : Pediatric Cardiology. 33, 6, p. 988-994 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis

Li, D., Hallett, M. A., Zhu, W., Rubart, M., Liu, Y., Yang, Z., Chen, H., Haneline, L. S., Chan, R. J., Schwartz, R. J., Field, L. J., Atkinson, S. J. & Shou, W., Jan 15 2011, In : Development. 138, 2, p. 303-315 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice

Maruyama, M., Li, B. Y., Chen, H., Xu, X., Song, L. S., Guatimosim, S., Zhu, W., Yong, W., Zhang, W., Bu, G., Lin, S. F., Fishbein, M. C., Lederer, W. J., Schild, J. H., Field, L. J., Rubart, M., Chen, P. S. & Shou, W., Apr 29 2011, In : Circulation research. 108, 9, p. 1042-1052 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy

Li, D., Liu, Y., Maruyama, M., Zhu, W., Chen, H., Zhang, W., Reuter, S., Lin, S. F., Haneline, L. S., Field, L. J., Chen, P. S. & Shou, W., Dec 2011, In : Human molecular genetics. 20, 23, p. 4582-4596 15 p., ddr392.

Research output: Contribution to journalArticle

53 Scopus citations

Tbx20 transcription factor is a downstream mediator for bone morphogenetic protein-10 in regulating cardiac ventricular wall development and function

Zhang, W., Chen, H., Wang, Y., Yong, W., Zhu, W., Liu, Y., Wagner, G. R., Payne, R. M., Field, L. J., Xin, H., Cai, C. L. & Shou, W., Oct 21 2011, In : Journal of Biological Chemistry. 286, 42, p. 36820-36829 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release

Liu, Y., Chen, H., Ji, G., Li, B., Mohler, P. J., Zhu, Z., Yong, W., Chen, Z., Xu, X., Xin, H. & Shou, W., Dec 1 2011, In : Assay and Drug Development Technologies. 9, 6, p. 620-627 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2010

Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis

Chen, H., Yong, W., Hinds, T. D., Yang, Z., Zhou, Y., Sanchez, E. R. & Shou, W., Sep 3 2010, In : Journal of Biological Chemistry. 285, 36, p. 27776-27784 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
2009

Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathway

Zhu, W., Soonpaa, M. H., Chen, H., Shen, W., Payne, R. M., Liechty, E. A., Caldwell, R. L., Shou, W. & Field, L. J., Jan 13 2009, In : Circulation. 119, 1, p. 99-106 8 p.

Research output: Contribution to journalArticle

128 Scopus citations

Analysis of ventricular hypertrabeculation and noncompaction using genetically engineered mouse models

Chen, H., Zhang, W., Li, D., Cordes, T. M., Mark Payne, R. & Shou, W., Jul 1 2009, In : Pediatric Cardiology. 30, 5, p. 626-634 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia

Zhang, W., Chan, R. J., Chen, H., Yang, Z., He, Y., Zhang, X., Luo, Y., Yin, F., Moh, A., Miller, L. C., Payne, R. M., Zhang, Z. Y., Fu, X. Y. & Shou, W., Aug 14 2009, In : Journal of Biological Chemistry. 284, 33, p. 22353-22363 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Smad7 is required for the development and function of the heart

Chen, Q., Chen, H., Zheng, D., Kuang, C., Fang, H., Zou, B., Zhu, W., Bu, G., Jin, T., Wang, Z., Zhang, X., Chen, J., Field, L. J., Rubart, M., Shou, W. & Chen, Y., Jan 2 2009, In : Journal of Biological Chemistry. 284, 1, p. 292-300 9 p.

Research output: Contribution to journalArticle

78 Scopus citations
2008

Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mtor-mediated signaling and cardiac function

Shen, W. H., Chen, Z., Shi, S., Chen, H., Zhu, W., Penner, A., Bu, G., Li, W., Boyle, D. W., Rubart, M., Field, L. J., Abraham, R., Liechty, E. A. & Shou, W., May 16 2008, In : Journal of Biological Chemistry. 283, 20, p. 13842-13849 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Endocardial Brg1 Represses ADAMTS1 to Maintain the Microenvironment for Myocardial Morphogenesis

Stankunas, K., Hang, C. T., Tsun, Z. Y., Chen, H., Lee, N. V., Wu, J. I., Shang, C., Bayle, J. H., Shou, W., Iruela-Arispe, M. L. & Chang, C. P., Feb 12 2008, In : Developmental Cell. 14, 2, p. 298-311 14 p.

Research output: Contribution to journalArticle

166 Scopus citations
2007

Essential role for co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology

Yong, W., Yang, Z., Periyasamy, S., Chen, H., Yucel, S., Li, W., Lin, L. Y., Wolf, I. M., Cohn, M. J., Baskin, L. S., Sánchez, E. R. & Shou, W., Feb 16 2007, In : Journal of Biological Chemistry. 282, 7, p. 5026-5036 11 p.

Research output: Contribution to journalArticle

108 Scopus citations

Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest

Yong, W., Bao, S., Chen, H., Li, D., Sánchez, E. R. & Shou, W., May 18 2007, In : Journal of Biological Chemistry. 282, 20, p. 14690-14694 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Notch Signaling Is Essential for Ventricular Chamber Development

Grego-Bessa, J., Luna-Zurita, L., del Monte, G., Bolós, V., Melgar, P., Arandilla, A., Garratt, A. N., Zang, H., Mukouyama, Y. S., Chen, H., Shou, W., Ballestar, E., Esteller, M., Rojas, A., Pérez-Pomares, J. M. & de la Pompa, J. L., Mar 1 2007, In : Developmental Cell. 12, 3, p. 415-429 15 p.

Research output: Contribution to journalArticle

300 Scopus citations

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

Li, Y., Yan, J., De, P., Chang, H. C., Yamauchi, A., Christopherson, K. W., Paranavitana, N. C., Peng, X., Kim, C., Munugulavadla, V., Kapur, R., Chen, H., Shou, W., Stone, J. C., Kaplan, M. H., Dinauer, M. C., Durden, D. L. & Quilliam, L. A., Dec 15 2007, In : Journal of Immunology. 179, 12, p. 8322-8331 10 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations
2006

FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform

Yang, Z., Wolf, I. M., Chen, H., Periyasamy, S., Chen, Z., Yong, W., Shi, S., Zhao, W., Xu, J., Srivastava, A., Sánchez, E. R. & Shou, W., Nov 1 2006, In : Molecular Endocrinology. 20, 11, p. 2682-2694 13 p.

Research output: Contribution to journalArticle

99 Scopus citations

Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth

Chen, H., Yong, W., Ren, S., Shen, W., He, Y., Cox, K. A., Zhu, W., Li, W., Soonpaa, M., Payne, R. M., Franco, D., Field, L. J., Rosen, V., Wang, Y. & Shou, W., Sep 15 2006, In : Journal of Biological Chemistry. 281, 37, p. 27481-27491 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2004

Abnormal cardiac development in the absence of heart glycogen

Pederson, B. A., Chen, H., Schroeder, J. M., Shou, W., DePaoli-Roach, A. A. & Roach, P. J., Aug 1 2004, In : Molecular and cellular biology. 24, 16, p. 7179-7187 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

BMP10 is essential for maintaining cardiac growth during murine cardiogenesis

Chen, H., Shi, S., Acosta, L., Li, W., Lu, J., Bao, S., Chen, Z., Yang, Z., Schneider, M. D., Chien, K. R., Conway, S. J., Yoder, M. C., Haneline, L. S., Franco, D. & Shou, W., May 1 2004, In : Development. 131, 9, p. 2219-2231 13 p.

Research output: Contribution to journalArticle

311 Scopus citations

Nkx2-5 pathways and congenital heart disease: Loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block

Pashmforoush, M., Lu, J. T., Chen, H., St. Amand, T., Kondo, R., Pradervand, S., Evans, S. M., Clark, B., Feramisco, J. R., Giles, W., Ho, S. Y., Benson, D. W., Silberbach, M., Shou, W. & Chien, K. R., Apr 30 2004, In : Cell. 117, 3, p. 373-386 14 p.

Research output: Contribution to journalArticle

313 Scopus citations
2002

FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506

Xu, X., Su, B., Barndt, R. J., Chen, H., Xin, H., Yan, G., Chen, L., Cheng, D., Heitman, J., Zhuang, Y., Fleischer, S. & Shou, W., Jun 15 2002, In : Transplantation. 73, 11, p. 1835-1838 4 p.

Research output: Contribution to journalArticle

34 Scopus citations