Harikrishna Nakshatri

  • 11677 Citations
  • 55 h-Index
1988 …2020

Research output per year

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Publications

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2020

Breast Heterogeneity: Obstacles to Developing Universal Biomarkers of Breast Cancer Initiation and Progression

Dirks, R. C., Burney, H. N., Anjanappa, M., Sandusky, G. E., Hao, Y., Liu, Y., Schmidt, M. C. & Nakshatri, H., Jul 2020, In : Journal of the American College of Surgeons. 231, 1, p. 85-96 12 p.

Research output: Contribution to journalArticle

Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion

Fan, Y., Jalali, A., Chen, A., Zhao, X., Liu, S., Teli, M., Guo, Y., Li, F., Li, J., Siegel, A., Yang, L., Liu, J., Na, S., Agarwal, M., Robling, A. G., Nakshatri, H., Li, B. Y. & Yokota, H., Dec 1 2020, In : Bone Research. 8, 1, 9.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer

Ni, Y., Schmidt, K. R., Werner, B. A., Koenig, J. K., Guldner, I. H., Schnepp, P. M., Tan, X., Jiang, L., Host, M., Sun, L., Howe, E. N., Wu, J., Littlepage, L. E., Nakshatri, H. & Zhang, S., Dec 1 2019, In : Nature communications. 10, 1, 2860.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Dual TGFb/BMP pathway inhibition enables expansion and characterization of multiple epithelial cell types of the normal and cancerous breast

Prasad, M., Kumar, B., Bhat-Nakshatri, P., Anjanappa, M., Sandusky, G., Miller, K. D., Storniolo, A. M. & Nakshatri, H., Jul 1 2019, In : Molecular Cancer Research. 17, 7, p. 1556-1570 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Flower isoforms promote competitive growth in cancer

Madan, E., Pelham, C. J., Nagane, M., Parker, T. M., Canas-Marques, R., Fazio, K., Shaik, K., Yuan, Y., Henriques, V., Galzerano, A., Yamashita, T., Pinto, M. A. F., Palma, A. M., Camacho, D., Vieira, A., Soldini, D., Nakshatri, H., Post, S. R., Rhiner, C., Yamashita, H. & 7 others, Accardi, D., Hansen, L. A., Carvalho, C., Beltran, A. L., Kuppusamy, P., Gogna, R. & Moreno, E., Aug 8 2019, In : Nature. 572, 7768, p. 260-264 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Genetic ancestry–dependent differences in breast cancer–induced field defects in the tumor-adjacent normal breast

Nakshatri, H., Kumar, B., Burney, H. N., Cox, M. L., Jacobsen, M., Sandusky, G. E., D'Souza-Schorey, C. & Storniolo, A. M. V., 2019, In : Clinical Cancer Research. 25, 9, p. 2848-2859 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

An effective epigenetic-PARP inhibitor combination therapy for breast and ovarian cancers independent of BRCA mutations

Pulliam, N., Fang, F., Ozes, A. R., Tang, J., Adewuyi, A., Keer, H., Lyons, J., Baylin, S. B., Matei, D., Nakshatri, H., Rassool, F. V., Miller, K. D. & Nephew, K. P., Jul 1 2018, In : Clinical Cancer Research. 24, 13, p. 3163-3175 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

A system for detecting high impact-low frequency mutations in primary tumors and metastases

Anjanappa, M., Hao, Y., Simpson, E. R., Bhat-Nakshatri, P., Nelson, J. B., Tersey, S. A., Mirmira, R. G., Cohen-Gadol, A. A., Saadatzadeh, M. R., Li, L., Fang, F., Nephew, K. P., Miller, K. D., Liu, Y. & Nakshatri, H., Jan 11 2018, In : Oncogene. 37, 2, p. 185-196 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Attraction and Compaction of Migratory Breast Cancer Cells by Bone Matrix Proteins through Tumor-Osteocyte Interactions

Chen, A., Wang, L., Liu, S., Wang, Y., Liu, Y., Wang, M., Nakshatri, H., Li, B. Y. & Yokota, H., Dec 1 2018, In : Scientific reports. 8, 1, 5420.

Research output: Contribution to journalArticle

4 Scopus citations

Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis

Padua, M. B., Bhat-Nakshatri, P., Anjanappa, M., Prasad, M. S., Hao, Y., Rao, X., Liu, S., Wan, J., Liu, Y., McElyea, K., Jacobsen, M., Sandusky, G., Althouse, S., Perkins, S. & Nakshatri, H., May 2 2018, In : Breast Cancer Research. 20, 1, 35.

Research output: Contribution to journalArticle

5 Scopus citations

Effects of a checkpoint kinase inhibitor, AZD7762, on tumor suppression and bone remodeling

Wang, L., Wang, Y., Chen, A., Jalali, A., Liu, S., Guo, Y., Na, S., Nakshatri, H., Li, B. Y. & Yokota, H., Sep 2018, In : International journal of oncology. 53, 3, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model

Liu, S., Liu, Y., Minami, K., Chen, A., Wan, Q., Yin, Y., Gan, L., Xu, A., Matsuura, N., Koizumi, M., Liu, Y., Na, S., Li, J., Nakshatri, H., Li, B. Y. & Yokota, H., 2018, In : Oncotarget. 9, 10, p. 9364-9378 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells

Janganati, V., Ponder, J., Balasubramaniam, M., Bhat-Nakshatri, P., Bar, E. E., Nakshatri, H., Jordan, C. T. & Crooks, P. A., Sep 5 2018, In : European Journal of Medicinal Chemistry. 157, p. 562-581 20 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mutational landscape of RNA-binding proteins in human cancers

Neelamraju, Y., Gonzalez-Perez, A., Bhat-Nakshatri, P., Nakshatri, H. & Janga, S. C., Jan 2 2018, In : RNA Biology. 15, 1, p. 115-129 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

Normal breast-derived epithelial cells with luminal and intrinsic subtype-enriched gene expression document interindividual differences in their differentiation Cascade

Kumar, B., Prasad, M., Bhat-Nakshatri, P., Anjanappa, M., Kalra, M., Marino, N., Storniolo, A. M., Rao, X., Liu, S., Wan, J., Liu, Y. & Nakshatri, H., Sep 1 2018, In : Cancer Research. 78, 17, p. 5107-5123 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Osteocyte-driven downregulation of snail restrains effects of Drd2 inhibitors on mammary tumor cells

Liu, S., Fan, Y., Chen, A., Jalali, A., Minami, K., Ogawa, K., Nakshatri, H., Li, B. Y. & Yokota, H., Jul 15 2018, In : Cancer Research. 78, 14, p. 3865-3876 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Individualized breast cancer characterization through single-cell analysis of tumor and adjacent normal cells

Anjanappa, M., Cardoso, A., Cheng, L., Mohamad, S., Gunawan, A., Rice, S., Dong, Y., Li, L., Sandusky, G. E., Srour, E. F. & Nakshatri, H., May 15 2017, In : Cancer Research. 77, 10, p. 2759-2769 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Inflammation-associated microRNA changes in circulating exosomes of heart failure patients

Beg, F., Wang, R., Saeed, Z., Devaraj, S., Masoor, K. & Nakshatri, H., Dec 19 2017, In : BMC Research Notes. 10, 1, 751.

Research output: Contribution to journalArticle

9 Scopus citations

Inhibitory Effects of Dopamine Receptor D 1 Agonist on Mammary Tumor and Bone Metastasis

Minami, K., Liu, S., Liu, Y., Chen, A., Wan, Q., Na, S., Li, B. Y., Matsuura, N., Koizumi, M., Yin, Y., Gan, L., Xu, A., Li, J., Nakshatri, H. & Yokota, H., Apr 4 2017, In : Scientific reports. 7, 45686.

Research output: Contribution to journalArticle

11 Scopus citations

Microfluidic channel for characterizing normal and breast cancer cells

Truongvo, T. N., Kennedy, R. M., Chen, H., Chen, A., Berndt, A., Agarwal, M., Zhu, L., Nakshatri, H., Wallace, J., Na, S., Yokota, H. & Ryu, J. E., Feb 15 2017, In : Journal of Micromechanics and Microengineering. 27, 3, 035017.

Research output: Contribution to journalArticle

10 Scopus citations

Pharmacological dual inhibition of tumor and tumor-induced functional limitations in a transgenic model of breast cancer

Wang, R., Bhat-Nakshatri, P., Padua, M. B., Prasad, M. S., Anjanappa, M., Jacobson, M., Finnearty, C., Sefcsik, V., McElyea, K., Redmond, R., Sandusky, G., Penthala, N., Crooks, P. A., Liu, J., Zimmers, T. & Nakshatri, H., Dec 2017, In : Molecular cancer therapeutics. 16, 12, p. 2747-2758 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

RareVar: A Framework for Detecting Low-Frequency Single-Nucleotide Variants

Hao, Y., Xuei, X., Li, L., Nakshatri, H., Edenberg, H. J. & Liu, Y., Jul 1 2017, In : Journal of Computational Biology. 24, 7, p. 637-646 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Reduction in Migratory Phenotype in a Metastasized Breast Cancer Cell Line via Downregulation of S100A4 and GRM3

Chen, A., Wang, L., Li, B. Y., Sherman, J., Ryu, J. E., Hamamura, K., Liu, Y., Nakshatri, H. & Yokota, H., Dec 1 2017, In : Scientific reports. 7, 1, 3459.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Distinct effects of adipose-derived stem cells and adipocytes on normal and cancer cell hierarchy

Anjanappa, M., Burnett, R., Zieger, M. A., Merfeld-Clauss, S., Wooden, W., March, K., Tholpady, S. & Nakshatri, H., Jan 1 2016, In : Molecular Cancer Research. 14, 7, p. 660-671 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Molecular insights of pathways resulting from two common PIK3CA mutations in breast cancer

Bhat-Nakshatri, P., Goswami, C. P., Badve, S., Magnani, L., Lupien, M. & Nakshatri, H., Jul 1 2016, In : Cancer Research. 76, 13, p. 3989-4001 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Statistical modeling for sensitive detection of low-frequency single nucleotide variants

Hao, Y., Zhang, P., Xuei, X., Nakshatri, H., Edenberg, H. J., Li, L. & Liu, Y., Aug 22 2016, In : BMC genomics. 17, 514.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Essential components of cancer education

Welch, D. R., Antalis, T. M., Burnstein, K., Vona-Davis, L., Jensen, R. A., Nakshatri, H., Riegel, A. T., Spitz, D. R., Watson, D. K. & Weiner, G. J., Dec 15 2015, In : Cancer Research. 75, 24, p. 5202-5205 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ethnicity-dependent and -independent heterogeneity in healthy normal breast hierarchy impacts tumor characterization

Nakshatri, H., Anjanappa, M. & Bhat-Nakshatri, P., Aug 27 2015, In : Scientific reports. 5, 13526.

Research output: Contribution to journalArticle

23 Scopus citations

HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance

Jin, K., Park, S., Teo, W. W., Korangath, P., Cho, S. S., Yoshida, T., Győrffy, B., Goswami, C. P., Nakshatri, H., Cruz, L. A., Zhou, W., Ji, H., Su, Y., Ekram, M., Wu, Z., Zhu, T., Polyak, K. & Sukumar, S., Sep 1 2015, In : Cancer Discovery. 5, 9, p. 944-959 16 p.

Research output: Contribution to journalArticle

39 Scopus citations

Nf-kB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT

Nakshatri, H., Appaiah, H. N., Anjanappa, M., Gilley, D., Tanaka, H., Badve, S., Crooks, P. A., Mathews, W., Sweeney, C. & Bhat-Nakshatri, P., Jan 1 2015, In : Cell Death and Disease. 6, 1, e1608.

Research output: Contribution to journalArticle

24 Scopus citations

Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells

Burnett, R. M., Craven, K. E., Krishnamurthy, P., Goswami, C. P., Badve, S., Crooks, P., Mathews, W. P., Bhat-Nakshatri, P. & Nakshatri, H., 2015, In : Oncotarget. 6, 14, p. 12682-12696 15 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

TFAP2C expression in breast cancer: correlation with overall survival beyond 10 years of initial diagnosis

Perkins, S. M., Bales, C., Vladislav, T., Althouse, S., Miller, K. D., Sandusky, G., Badve, S. & Nakshatri, H., Aug 31 2015, In : Breast Cancer Research and Treatment. 152, 3, p. 519-531 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
2014

Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain

Avraham, H. K., Jiang, S., Fu, Y., Nakshatri, H., Ovadia, H. & Avraham, S., Feb 1 2014, In : Journal of Pathology. 232, 3, p. 369-381 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle

Chen, D., Goswami, C. P., Burnett, R. M., Anjanappa, M., Bhat-Nakshatri, P., Muller, W. & Nakshatri, H., Aug 15 2014, In : Cancer Research. 74, 16, p. 4270-4281 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

PROGgeneV2: Enhancements on the existing database

Goswami, C. P. & Nakshatri, H., Dec 17 2014, In : BMC Cancer. 14, 1, 970.

Research output: Contribution to journalArticle

168 Scopus citations

The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes

Loganathan, J., Jiang, J., Smith, A., Jedinak, A., Thyagarajan-Sahu, A., Sandusky, G. E., Nakshatri, H. & Sliva, D., Jun 2014, In : International journal of oncology. 45, 6, p. 2009-2015 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
2013

ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer

Chen, D., Bhat-Nakshatri, P., Goswami, C., Badve, S. & Nakshatri, H., Sep 15 2013, In : Cancer Research. 73, 18, p. 5821-5833 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression

Shah, N., Jin, K., Cruz, L. A., Park, S., Sadik, H., Cho, S., Goswami, C. P., Nakshatri, H., Gupta, R., Chang, H. Y., Zhang, Z., Cimino-Mathews, A., Cope, L., Umbricht, C. & Sukumar, S., Sep 1 2013, In : Cancer Research. 73, 17, p. 5449-5458 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity

Bhat-Nakshatri, P., Goswami, C. P., Badve, S., Sledge, G. W. & Nakshatri, H., Sep 9 2013, In : Scientific reports. 3, 2530.

Research output: Contribution to journalArticle

45 Scopus citations

Interplay between estrogen receptor and AKT in Estradiol-induced alternative splicing

Bhat-Nakshatri, P., Song, E. K., Collins, N. R., Uversky, V. N., Dunker, A. K., O'Malley, B. W., Geistlinger, T. R., Carroll, J. S., Brown, M. & Nakshatri, H., Jun 13 2013, In : BMC Medical Genomics. 6, 1, 21.

Research output: Contribution to journalArticle

13 Scopus citations

PROGgene: Gene expression based survival analysis web application for multiple cancers

Goswami, C. P. & Nakshatri, H., Oct 28 2013, In : Journal of Clinical Bioinformatics. 3, 1, 22.

Research output: Contribution to journalArticle

91 Scopus citations
2012

Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

Choi, M. R., Bardhan, R., Stanton-Maxey, K. J., Badve, S., Nakshatri, H., Stantz, K. M., Cao, N., Halas, N. J. & Clare, S. E., Dec 1 2012, In : Cancer Nanotechnology. 3, 1-6, p. 47-54 8 p.

Research output: Contribution to journalArticle

88 Scopus citations

FOXA1 is an independent prognostic marker for ER-positive breast cancer

Mehta, R. J., Jain, R. K., Leung, S., Choo, J., Nielsen, T., Huntsman, D., Nakshatri, H. & Badve, S., Feb 2012, In : Breast Cancer Research and Treatment. 131, 3, p. 881-890 10 p.

Research output: Contribution to journalArticle

77 Scopus citations
2011

A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples

Riley, C. P., Zhang, X., Nakshatri, H., Schneider, B., Regnier, F. E., Adamec, J. & Buck, C., May 27 2011, In : Journal of Translational Medicine. 9, 80.

Research output: Contribution to journalArticle

12 Scopus citations

A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species

Shanmugam, R., Kusumanchi, P., Appaiah, H., Cheng, L., Crooks, P., Neelakantan, S., Peat, T., Klaunig, J., Matthews, W., Nakshatri, H. & Sweeney, C. J., May 1 2011, In : International Journal of Cancer. 128, 10, p. 2481-2494 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22

Patel, J. B., Appaiah, H. N., Burnett, R. M., Bhat-Nakshatri, P., Wang, G., Mehta, R., Badve, S., Thomson, M. J., Hammond, S., Steeg, P., Liu, Y. & Nakshatri, H., Mar 17 2011, In : Oncogene. 30, 11, p. 1290-1301 12 p.

Research output: Contribution to journalArticle

89 Scopus citations

High-level expression of forkhead-box protein A1 in metastatic prostate cancer

Jain, R. K., Mehta, R. J., Nakshatri, H., Idrees, M. T. & Badve, S. S., Apr 1 2011, In : Histopathology. 58, 5, p. 766-772 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients

Appaiah, H. N., Goswami, C. P., Mina, L. A., Badve, S., Sledge, G. W., Liu, Y. & Nakshatri, H., Sep 13 2011, In : Breast Cancer Research. 13, 5, R86.

Research output: Contribution to journalArticle

57 Scopus citations

Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis

Wang, F., Li, J., Sinn, A. L., Knabe, W. E., Khanna, M., Jo, I., Silver, J. M., Oh, K., Li, L., Sandusky, G. E., Sledge, G. W., Nakshatri, H., Jones, D. R., Pollok, K. E. & Meroueh, S. O., Oct 27 2011, In : Journal of Medicinal Chemistry. 54, 20, p. 7193-7205 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
2010

A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFκB and generating reactive oxygen species

Shanmugam, R., Kusumanchi, P., Cheng, L., Crooks, P., Neelakantan, S., Matthews, W., Nakshatri, H. & Sweeney, C. J., Jul 1 2010, In : Prostate. 70, 10, p. 1074-1086 13 p.

Research output: Contribution to journalArticle

51 Scopus citations