Harikrishna Nakshatri

  • 11854 Citations
  • 56 h-Index
1988 …2020

Research output per year

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Publications

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2005

The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1α/CXCL12

Kishimoto, H., Wang, Z., Bhat-Nakshatri, P., Chang, D., Clarke, R. & Nakshatri, H., Oct 1 2005, In : Carcinogenesis. 26, 10, p. 1706-1715 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer

Sweeney, C. J., Mehrotra, S., Sadaria, M. R., Kumar, S., Shortle, N. H., Roman, Y., Sheridan, C., Campbell, R. A., Murry, D. J., Badve, S. & Nakshatri, H., Jun 2005, In : Molecular cancer therapeutics. 4, 6, p. 1004-1012 9 p.

Research output: Contribution to journalArticle

132 Scopus citations
2006

CD44+/CD24-Breast cancer cells exhibit enhanced invase properties: An early step necessary for metastasis

Sheridan, C., Kishimoto, H., Fuchs, R. K., Mehrotra, S., Bhat-Nakshatri, P., Turner, C. H., Goulet, R., Badve, S. & Nakshatri, H., Oct 24 2006, In : Breast Cancer Research. 8, 5, R59.

Research output: Contribution to journalArticle

691 Scopus citations

Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer

Srirangam, A., Mitra, R., Wang, M., Gorski, J. C., Badve, S., Baldridge, L. A., Hamilton, J., Kishimoto, H., Hawes, J., Li, L., Orschell, C. M., Srour, E. F., Blum, J. S., Donner, D., Sledge, G. W., Nakshatri, H. & Potter, D. A., Mar 15 2006, In : Clinical Cancer Research. 12, 6, p. 1883-1896 14 p.

Research output: Contribution to journalArticle

72 Scopus citations

Negative regulation of MHC class II gene expression by CXCR4

Sheridan, C., Sadaria, M., Bhat-Nakshatri, P., Goulet, R., Edenberg, H. J., McCarthy, B. P., Chang, C. H., Srour, E. F. & Nakshatri, H., Aug 1 2006, In : Experimental Hematology. 34, 8, p. 1085-1092 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Restoring chemotherapy and hormonetherapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model

Shanmugam, R., Jayaprakasan, V., Gokmen-Polar, Y., Kelich, S., Miller, K. D., Yip-Schneider, M., Cheng, L., Bhat-Nakshatri, P., Sledge, G. W., Nakshatri, H., Zheng, Q. H., Miller, M. A., DeGrado, T., Hutchins, G. D. & Sweeney, C. J., Oct 1 2006, In : Prostate. 66, 14, p. 1498-1511 14 p.

Research output: Contribution to journalArticle

46 Scopus citations
2007

2-Methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells

Bhati, R., Gökmen-Polar, Y., Sledge, G. W., Fan, C., Nakshatri, H., Ketelsen, D., Borchers, C. H., Dial, M. J., Patterson, C. & Klauber-DeMore, N., Jan 15 2007, In : Cancer Research. 67, 2, p. 702-708 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Effect of Celecoxib and Novel Agent LC-1 in a Hamster Model of Lung Cancer

Vegeler, R. C., Yip-Schneider, M. T., Ralstin, M., Wu, H., Crooks, P. A., Neelakantan, S., Nakshatri, H., Sweeney, C. J. & Schmidt, C. M., Nov 1 2007, In : Journal of Surgical Research. 143, 1, p. 169-176 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase

Satpathy, M., Cao, L., Pincheira, R., Emerson, R., Bigsby, R., Nakshatri, H. & Matei, D., Aug 1 2007, In : Cancer Research. 67, 15, p. 7194-7202 9 p.

Research output: Contribution to journalArticle

80 Scopus citations

FOXA1 expression in breast cancer - Correlation with luminal subtype A and survival

Badve, S., Turbin, D., Thorat, M. A., Morimiya, A., Nielsen, T. O., Perou, C. M., Dunn, S., Huntsman, D. G. & Nakshatri, H., Aug 1 2007, In : Clinical Cancer Research. 13, 15, p. 4415-4421 7 p.

Research output: Contribution to journalArticle

164 Scopus citations

Identity profiling of cell surface markers by multiplex gold nanorod probes

Yu, C., Nakshatri, H. & Irudayaraj, J., Aug 1 2007, In : Nano Letters. 7, 8, p. 2300-2306 7 p.

Research output: Contribution to journalArticle

138 Scopus citations

MOZ and MOZ-CBP cooperate with NF-κB to activate transcription from NF-κB-dependent promoters

Chan, E. M., Chan, R. J., Comer, E. M., Goulet, R. J., Crean, C. D., Brown, Z. D., Fruehwald, A. M., Yang, Z., Boswell, H. S., Nakshatri, H. & Gabig, T. G., Dec 1 2007, In : Experimental Hematology. 35, 12, p. 1782-1792 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: Implications of p53 mutation or isoform expression on breast cancer cell invasion

Mehta, S. A., Christopherson, K. W., Bhat-Nakshatri, P., Goulet, R. J., Broxmeyer, H. E., Kopelovich, L. & Nakshatri, H., May 17 2007, In : Oncogene. 26, 23, p. 3329-3337 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement of ZEB-1 and ZEB-2

Chua, H. L., Bhat-Nakshatri, P., Clare, S. E., Morimiya, A., Badve, S. & Nakshatri, H., Feb 1 2007, In : Oncogene. 26, 5, p. 711-724 14 p.

Research output: Contribution to journalArticle

429 Scopus citations

Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-κB and split-dose repair

Mendonca, M. S., Chin-Sinex, H., Gomez-Millan, J., Datzman, N., Hardacre, M., Comerford, K., Nakshatri, H., Nye, M., Benjamin, L., Mehta, S., Patino, F. & Sweeney, C., Dec 1 2007, In : Radiation research. 168, 6, p. 689-697 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo

Yip-Schneider, M. T., Wu, H., Ralstin, M., Yiannoutsos, C., Crooks, P. A., Neelakantan, S., Noble, S., Nakshatri, H., Sweeney, C. J. & Schmidt, C. M., Jun 1 2007, In : Molecular cancer therapeutics. 6, 6, p. 1736-1744 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

The platelet-derived growth factor receptor α is destabilized by geldanamycins in cancer cells

Matei, D., Satpathy, M., Cao, L., Lai, Y. C., Nakshatri, H. & Donner, D. B., Jan 5 2007, In : Journal of Biological Chemistry. 282, 1, p. 445-453 9 p.

Research output: Contribution to journalArticle

54 Scopus citations
2008

AKT alters genome-wide estrogen receptor α binding and impacts estrogen signaling in breast cancer

Bhat-Nakshatri, P., Wang, G., Appaiah, H., Luktuke, N., Carroll, J. S., Geistlinger, T. R., Brown, M., Badve, S., Liu, Y. & Nakshatri, H., Dec 1 2008, In : Molecular and cellular biology. 28, 24, p. 7487-7503 17 p.

Research output: Contribution to journalArticle

68 Scopus citations

Amplified in breast cancer 1 expression in breast cancer

Thorat, M. A., Turbin, D., Morimiya, A., Leung, S., Zhang, Q., Jeng, M. H., Huntsman, D. G., Nakshatri, H. & Badve, S., Dec 1 2008, In : Histopathology. 53, 6, p. 634-641 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Antimyeloma effects of a sesquiterpene lactone parthenolide

Suvannasankha, A., Crean, C. D., Shanmugam, R., Farag, S. S., Abonour, R., Boswell, H. S. & Nakshatri, H., Mar 15 2008, In : Clinical Cancer Research. 14, 6, p. 1814-1822 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Forkhead box A1 expression in breast cancer is associated with luminal subtype and good prognosis

Thorat, M. A., Marchio, C., Morimiya, A., Savage, K., Nakshatri, H., Reis-Filho, J. S. & Badve, S., Mar 1 2008, In : Journal of clinical pathology. 61, 3, p. 327-332 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover

Prasad, N. K., Tandon, M., Badve, S., Snyder, P. W. & Nakshatri, H., Jan 1 2008, In : Carcinogenesis. 29, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Striatin-3γ inhibits estrogen receptor activity by recruiting a protein phosphatase

Tan, B., Long, X., Nakshatri, H., Nephew, K. P. & Bigsby, R. M., May 2008, In : Journal of Molecular Endocrinology. 40, 5-6, p. 199-210 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
75 Scopus citations
2009

Epithelial-to-mesenchymal transition and ovarian tumor progression induced by tissue transglutaminase

Shao, M., Cao, L., Shen, C., Satpathy, M., Chelladurai, B., Bigsby, R. M., Nakshatri, H. & Matei, D., Dec 15 2009, In : Cancer Research. 69, 24, p. 9192-9201 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

Estradiol-regulated microRNAs control estradiol response in breast cancer cells

Bhat-Nakshatri, P., Wang, G., Collins, N. R., Thomson, M. J., Geistlinger, T. R., Carroll, J. S., Brown, M., Hammond, S., Srour, E. F., Liu, Y. & Nakshatri, H., 2009, In : Nucleic acids research. 37, 14, p. 4850-4861 12 p.

Research output: Contribution to journalArticle

243 Scopus citations

Intrinsic subtype-associated changes in the plasma proteome in breast cancer

Nakshatri, H., Qi, G., You, J., Kerry, B., Schneider, B., Zon, R., Buck, C., Regnier, F. & Wang, M., Dec 2009, In : Proteomics - Clinical Applications. 3, 11, p. 1305-1313 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

NF-κB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy

Wu, J. M., Sheng, H., Saxena, R., Skill, N. J., Bhat-Nakshatri, P., Yu, M., Nakshatri, H. & Maluccio, M. A., Jun 18 2009, In : Cancer Letters. 278, 2, p. 145-155 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Obesity potentiates the growth and dissemination of pancreatic cancer

Zyromski, N. J., Mathur, A., Pitt, H. A., Wade, T. E., Wang, S., Nakshatri, P., Swartz-Basile, D. A. & Nakshatri, H., Aug 2009, In : Surgery. 146, 2, p. 258-263 6 p.

Research output: Contribution to journalArticle

86 Scopus citations
2010

A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFκB and generating reactive oxygen species

Shanmugam, R., Kusumanchi, P., Cheng, L., Crooks, P., Neelakantan, S., Matthews, W., Nakshatri, H. & Sweeney, C. J., Jul 1 2010, In : Prostate. 70, 10, p. 1074-1086 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

Expression of forkhead-box protein A1, a marker of luminal A type breast cancer, parallels low Oncotype DX 21-gene recurrence scores

Ademuyiwa, F. O., Thorat, M. A., Jain, R. K., Nakshatri, H. & Badve, S., Feb 1 2010, In : Modern Pathology. 23, 2, p. 270-275 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

ITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative breast cancer

Appaiah, H., Bhat-Nakshatri, P., Mehta, R., Thorat, M., Badve, S. & Nakshatri, H., Sep 15 2010, In : Cancer Biology and Therapy. 10, 6, p. 600-614 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Loss of ERα and FOXA1 expression in a progression model of luminal type breast cancer: Insights from PyMT transgenic mouse model

McCune, K., Mehta, R., Thorat, M. A., Badve, S. & Nakshatri, H., Nov 2010, In : Oncology reports. 24, 5, p. 1233-1239 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
20 Scopus citations

Prognostic impact of ALDH1 in breast cancer: A story of stem cells and tumor microenvironment

Resetkova, E., Reis-Filho, J. S., Jain, R. K., Mehta, R., Thorat, M. A., Nakshatri, H. & Badve, S., Aug 1 2010, In : Breast Cancer Research and Treatment. 123, 1, p. 97-108 12 p.

Research output: Contribution to journalArticle

135 Scopus citations

SLUG/SNAI2 and Tumor Necrosis Factor Generate Breast Cells With CD44+/CD24- Phenotype

Bhat-Nakshatri, P., Appaiah, H., Ballas, C., Pick-Franke, P., Goulet, R., Badve, S., Srour, E. F. & Nakshatri, H., Aug 6 2010, In : BMC Cancer. 10, 411.

Research output: Contribution to journalArticle

117 Scopus citations

Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: Potential clinical implications

Badve, S., Collins, N. R., Bhat-Nakshatri, P., Turbin, D., Leung, S., Thorat, M., Dunn, S. E., Geistlinger, T. R., Carroll, J. S., Brown, M., Bose, S., Teitell, M. A. & Nakshatri, H., May 2010, In : American Journal of Pathology. 176, 5, p. 2139-2149 11 p.

Research output: Contribution to journalArticle

32 Scopus citations
2011

A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples

Riley, C. P., Zhang, X., Nakshatri, H., Schneider, B., Regnier, F. E., Adamec, J. & Buck, C., May 27 2011, In : Journal of Translational Medicine. 9, 80.

Research output: Contribution to journalArticle

12 Scopus citations

A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species

Shanmugam, R., Kusumanchi, P., Appaiah, H., Cheng, L., Crooks, P., Neelakantan, S., Peat, T., Klaunig, J., Matthews, W., Nakshatri, H. & Sweeney, C. J., May 1 2011, In : International Journal of Cancer. 128, 10, p. 2481-2494 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22

Patel, J. B., Appaiah, H. N., Burnett, R. M., Bhat-Nakshatri, P., Wang, G., Mehta, R., Badve, S., Thomson, M. J., Hammond, S., Steeg, P., Liu, Y. & Nakshatri, H., Mar 17 2011, In : Oncogene. 30, 11, p. 1290-1301 12 p.

Research output: Contribution to journalArticle

89 Scopus citations

High-level expression of forkhead-box protein A1 in metastatic prostate cancer

Jain, R. K., Mehta, R. J., Nakshatri, H., Idrees, M. T. & Badve, S. S., Apr 1 2011, In : Histopathology. 58, 5, p. 766-772 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Persistent upregulation of U6:SNORD44 small RNA ratio in the serum of breast cancer patients

Appaiah, H. N., Goswami, C. P., Mina, L. A., Badve, S., Sledge, G. W., Liu, Y. & Nakshatri, H., Sep 13 2011, In : Breast Cancer Research. 13, 5, R86.

Research output: Contribution to journalArticle

59 Scopus citations

Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis

Wang, F., Li, J., Sinn, A. L., Knabe, W. E., Khanna, M., Jo, I., Silver, J. M., Oh, K., Li, L., Sandusky, G. E., Sledge, G. W., Nakshatri, H., Jones, D. R., Pollok, K. E. & Meroueh, S. O., Oct 27 2011, In : Journal of Medicinal Chemistry. 54, 20, p. 7193-7205 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

Choi, M. R., Bardhan, R., Stanton-Maxey, K. J., Badve, S., Nakshatri, H., Stantz, K. M., Cao, N., Halas, N. J. & Clare, S. E., Dec 1 2012, In : Cancer Nanotechnology. 3, 1-6, p. 47-54 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

FOXA1 is an independent prognostic marker for ER-positive breast cancer

Mehta, R. J., Jain, R. K., Leung, S., Choo, J., Nielsen, T., Huntsman, D., Nakshatri, H. & Badve, S., Feb 2012, In : Breast Cancer Research and Treatment. 131, 3, p. 881-890 10 p.

Research output: Contribution to journalArticle

78 Scopus citations
2013

ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer

Chen, D., Bhat-Nakshatri, P., Goswami, C., Badve, S. & Nakshatri, H., Sep 15 2013, In : Cancer Research. 73, 18, p. 5821-5833 13 p.

Research output: Contribution to journalArticle

58 Scopus citations

HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression

Shah, N., Jin, K., Cruz, L. A., Park, S., Sadik, H., Cho, S., Goswami, C. P., Nakshatri, H., Gupta, R., Chang, H. Y., Zhang, Z., Cimino-Mathews, A., Cope, L., Umbricht, C. & Sukumar, S., Sep 1 2013, In : Cancer Research. 73, 17, p. 5449-5458 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity

Bhat-Nakshatri, P., Goswami, C. P., Badve, S., Sledge, G. W. & Nakshatri, H., 2013, In : Scientific reports. 3, 2530.

Research output: Contribution to journalArticle

46 Scopus citations

Interplay between estrogen receptor and AKT in Estradiol-induced alternative splicing

Bhat-Nakshatri, P., Song, E. K., Collins, N. R., Uversky, V. N., Dunker, A. K., O'Malley, B. W., Geistlinger, T. R., Carroll, J. S., Brown, M. & Nakshatri, H., 2013, In : BMC Medical Genomics. 6, 1, 21.

Research output: Contribution to journalArticle

13 Scopus citations

PROGgene: Gene expression based survival analysis web application for multiple cancers

Goswami, C. P. & Nakshatri, H., Oct 28 2013, In : Journal of Clinical Bioinformatics. 3, 1, 22.

Research output: Contribution to journalArticle

95 Scopus citations