Harikrishna Nakshatri

  • 11854 Citations
  • 56 h-Index
1988 …2020

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Publications

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2014

Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain

Avraham, H. K., Jiang, S., Fu, Y., Nakshatri, H., Ovadia, H. & Avraham, S., Feb 1 2014, In : Journal of Pathology. 232, 3, p. 369-381 13 p.

Research output: Contribution to journalArticle

48 Scopus citations

Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle

Chen, D., Goswami, C. P., Burnett, R. M., Anjanappa, M., Bhat-Nakshatri, P., Muller, W. & Nakshatri, H., Aug 15 2014, In : Cancer Research. 74, 16, p. 4270-4281 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

PROGgeneV2: Enhancements on the existing database

Goswami, C. P. & Nakshatri, H., Dec 17 2014, In : BMC Cancer. 14, 1, 970.

Research output: Contribution to journalArticle

183 Scopus citations

The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes

Loganathan, J., Jiang, J., Smith, A., Jedinak, A., Thyagarajan-Sahu, A., Sandusky, G. E., Nakshatri, H. & Sliva, D., Jun 2014, In : International journal of oncology. 45, 6, p. 2009-2015 7 p.

Research output: Contribution to journalArticle

36 Scopus citations
2015

Essential components of cancer education

Welch, D. R., Antalis, T. M., Burnstein, K., Vona-Davis, L., Jensen, R. A., Nakshatri, H., Riegel, A. T., Spitz, D. R., Watson, D. K. & Weiner, G. J., Dec 15 2015, In : Cancer Research. 75, 24, p. 5202-5205 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ethnicity-dependent and -independent heterogeneity in healthy normal breast hierarchy impacts tumor characterization

Nakshatri, H., Anjanappa, M. & Bhat-Nakshatri, P., Aug 27 2015, In : Scientific reports. 5, 13526.

Research output: Contribution to journalArticle

23 Scopus citations

HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance

Jin, K., Park, S., Teo, W. W., Korangath, P., Cho, S. S., Yoshida, T., Győrffy, B., Goswami, C. P., Nakshatri, H., Cruz, L. A., Zhou, W., Ji, H., Su, Y., Ekram, M., Wu, Z., Zhu, T., Polyak, K. & Sukumar, S., Sep 1 2015, In : Cancer Discovery. 5, 9, p. 944-959 16 p.

Research output: Contribution to journalArticle

41 Scopus citations

Nf-kB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT

Nakshatri, H., Appaiah, H. N., Anjanappa, M., Gilley, D., Tanaka, H., Badve, S., Crooks, P. A., Mathews, W., Sweeney, C. & Bhat-Nakshatri, P., Jan 1 2015, In : Cell Death and Disease. 6, 1, e1608.

Research output: Contribution to journalArticle

27 Scopus citations

Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells

Burnett, R. M., Craven, K. E., Krishnamurthy, P., Goswami, C. P., Badve, S., Crooks, P., Mathews, W. P., Bhat-Nakshatri, P. & Nakshatri, H., 2015, In : Oncotarget. 6, 14, p. 12682-12696 15 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

TFAP2C expression in breast cancer: correlation with overall survival beyond 10 years of initial diagnosis

Perkins, S. M., Bales, C., Vladislav, T., Althouse, S., Miller, K. D., Sandusky, G., Badve, S. & Nakshatri, H., Aug 31 2015, In : Breast Cancer Research and Treatment. 152, 3, p. 519-531 13 p.

Research output: Contribution to journalArticle

16 Scopus citations
2016

Distinct effects of adipose-derived stem cells and adipocytes on normal and cancer cell hierarchy

Anjanappa, M., Burnett, R., Zieger, M. A., Merfeld-Clauss, S., Wooden, W., March, K., Sunil, T. & Nakshatri, H., Jan 1 2016, In : Molecular Cancer Research. 14, 7, p. 660-671 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Molecular insights of pathways resulting from two common PIK3CA mutations in breast cancer

Bhat-Nakshatri, P., Goswami, C. P., Badve, S., Magnani, L., Lupien, M. & Nakshatri, H., Jul 1 2016, In : Cancer Research. 76, 13, p. 3989-4001 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Statistical modeling for sensitive detection of low-frequency single nucleotide variants

Hao, Y., Zhang, P., Xuei, X., Nakshatri, H., Edenberg, H. J., Li, L. & Liu, Y., Aug 22 2016, In : BMC genomics. 17, 514.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Individualized breast cancer characterization through single-cell analysis of tumor and adjacent normal cells

Anjanappa, M., Cardoso, A., Cheng, L., Mohamad, S., Gunawan, A., Rice, S., Dong, Y., Li, L., Sandusky, G. E., Srour, E. F. & Nakshatri, H., May 15 2017, In : Cancer Research. 77, 10, p. 2759-2769 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Inflammation-associated microRNA changes in circulating exosomes of heart failure patients

Beg, F., Wang, R., Saeed, Z., Devaraj, S., Masoor, K. & Nakshatri, H., Dec 19 2017, In : BMC Research Notes. 10, 1, 751.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibitory Effects of Dopamine Receptor D 1 Agonist on Mammary Tumor and Bone Metastasis

Minami, K., Liu, S., Liu, Y., Chen, A., Wan, Q., Na, S., Li, B. Y., Matsuura, N., Koizumi, M., Yin, Y., Gan, L., Xu, A., Li, J., Nakshatri, H. & Yokota, H., Apr 4 2017, In : Scientific reports. 7, 45686.

Research output: Contribution to journalArticle

14 Scopus citations

Microfluidic channel for characterizing normal and breast cancer cells

Truongvo, T. N., Kennedy, R. M., Chen, H., Chen, A., Berndt, A., Agarwal, M., Zhu, L., Nakshatri, H., Wallace, J., Na, S., Yokota, H. & Ryu, J. E., Feb 15 2017, In : Journal of Micromechanics and Microengineering. 27, 3, 035017.

Research output: Contribution to journalArticle

10 Scopus citations

Pharmacological dual inhibition of tumor and tumor-induced functional limitations in a transgenic model of breast cancer

Wang, R., Bhat-Nakshatri, P., Padua, M. B., Prasad, M. S., Anjanappa, M., Jacobson, M., Finnearty, C., Sefcsik, V., McElyea, K., Redmond, R., Sandusky, G., Penthala, N., Crooks, P. A., Liu, J., Zimmers, T. & Nakshatri, H., Dec 2017, In : Molecular cancer therapeutics. 16, 12, p. 2747-2758 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

RareVar: A Framework for Detecting Low-Frequency Single-Nucleotide Variants

Hao, Y., Xuei, X., Li, L., Nakshatri, H., Edenberg, H. J. & Liu, Y., Jul 1 2017, In : Journal of Computational Biology. 24, 7, p. 637-646 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Reduction in Migratory Phenotype in a Metastasized Breast Cancer Cell Line via Downregulation of S100A4 and GRM3

Chen, A., Wang, L., Li, B. Y., Sherman, J., Ryu, J. E., Hamamura, K., Liu, Y., Nakshatri, H. & Yokota, H., Dec 1 2017, In : Scientific reports. 7, 1, 3459.

Research output: Contribution to journalArticle

11 Scopus citations
2018

An effective epigenetic-PARP inhibitor combination therapy for breast and ovarian cancers independent of BRCA mutations

Pulliam, N., Fang, F., Ozes, A. R., Tang, J., Adewuyi, A., Keer, H., Lyons, J., Baylin, S. B., Matei, D., Nakshatri, H., Rassool, F. V., Miller, K. D. & Nephew, K. P., Jul 1 2018, In : Clinical Cancer Research. 24, 13, p. 3163-3175 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

A system for detecting high impact-low frequency mutations in primary tumors and metastases

Anjanappa, M., Hao, Y., Simpson, E. R., Bhat-Nakshatri, P., Nelson, J. B., Tersey, S. A., Mirmira, R. G., Cohen-Gadol, A. A., Saadatzadeh, M. R., Li, L., Fang, F., Nephew, K. P., Miller, K. D., Liu, Y. & Nakshatri, H., Jan 11 2018, In : Oncogene. 37, 2, p. 185-196 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Attraction and Compaction of Migratory Breast Cancer Cells by Bone Matrix Proteins through Tumor-Osteocyte Interactions

Chen, A., Wang, L., Liu, S., Wang, Y., Liu, Y., Wang, M., Nakshatri, H., Li, B. Y. & Yokota, H., Dec 1 2018, In : Scientific reports. 8, 1, 5420.

Research output: Contribution to journalArticle

6 Scopus citations

Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis

Padua, M. B., Bhat-Nakshatri, P., Anjanappa, M., Prasad, M. S., Hao, Y., Rao, X., Liu, S., Wan, J., Liu, Y., McElyea, K., Jacobsen, M., Sandusky, G., Althouse, S., Perkins, S. & Nakshatri, H., May 2 2018, In : Breast Cancer Research. 20, 1, 35.

Research output: Contribution to journalArticle

5 Scopus citations

Effects of a checkpoint kinase inhibitor, AZD7762, on tumor suppression and bone remodeling

Wang, L., Wang, Y., Chen, A., Jalali, A., Liu, S., Guo, Y., Na, S., Nakshatri, H., Li, B. Y. & Yokota, H., Sep 2018, In : International journal of oncology. 53, 3, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model

Liu, S., Liu, Y., Minami, K., Chen, A., Wan, Q., Yin, Y., Gan, L., Xu, A., Matsuura, N., Koizumi, M., Liu, Y., Na, S., Li, J., Nakshatri, H., Li, B. Y. & Yokota, H., 2018, In : Oncotarget. 9, 10, p. 9364-9378 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells

Janganati, V., Ponder, J., Balasubramaniam, M., Bhat-Nakshatri, P., Bar, E. E., Nakshatri, H., Jordan, C. T. & Crooks, P. A., Sep 5 2018, In : European Journal of Medicinal Chemistry. 157, p. 562-581 20 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mutational landscape of RNA-binding proteins in human cancers

Neelamraju, Y., Gonzalez-Perez, A., Bhat-Nakshatri, P., Nakshatri, H. & Janga, S. C., Jan 2 2018, In : RNA Biology. 15, 1, p. 115-129 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Normal breast-derived epithelial cells with luminal and intrinsic subtype-enriched gene expression document interindividual differences in their differentiation Cascade

Kumar, B., Prasad, M., Bhat-Nakshatri, P., Anjanappa, M., Kalra, M., Marino, N., Storniolo, A. M., Rao, X., Liu, S., Wan, J., Liu, Y. & Nakshatri, H., Sep 1 2018, In : Cancer Research. 78, 17, p. 5107-5123 17 p.

Research output: Contribution to journalArticle

8 Scopus citations

Osteocyte-driven downregulation of snail restrains effects of Drd2 inhibitors on mammary tumor cells

Liu, S., Fan, Y., Chen, A., Jalali, A., Minami, K., Ogawa, K., Nakshatri, H., Li, B. Y. & Yokota, H., Jul 15 2018, In : Cancer Research. 78, 14, p. 3865-3876 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2019

Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer

Ni, Y., Schmidt, K. R., Werner, B. A., Koenig, J. K., Guldner, I. H., Schnepp, P. M., Tan, X., Jiang, L., Host, M., Sun, L., Howe, E. N., Wu, J., Littlepage, L. E., Nakshatri, H. & Zhang, S., Dec 1 2019, In : Nature communications. 10, 1, 2860.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Dual TGFb/BMP pathway inhibition enables expansion and characterization of multiple epithelial cell types of the normal and cancerous breast

Prasad, M., Kumar, B., Bhat-Nakshatri, P., Anjanappa, M., Sandusky, G., Miller, K. D., Storniolo, A. M. & Nakshatri, H., Jul 1 2019, In : Molecular Cancer Research. 17, 7, p. 1556-1570 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Flower isoforms promote competitive growth in cancer

Madan, E., Pelham, C. J., Nagane, M., Parker, T. M., Canas-Marques, R., Fazio, K., Shaik, K., Yuan, Y., Henriques, V., Galzerano, A., Yamashita, T., Pinto, M. A. F., Palma, A. M., Camacho, D., Vieira, A., Soldini, D., Nakshatri, H., Post, S. R., Rhiner, C., Yamashita, H. & 7 others, Accardi, D., Hansen, L. A., Carvalho, C., Beltran, A. L., Kuppusamy, P., Gogna, R. & Moreno, E., Aug 8 2019, In : Nature. 572, 7768, p. 260-264 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Genetic ancestry–dependent differences in breast cancer–induced field defects in the tumor-adjacent normal breast

Nakshatri, H., Kumar, B., Burney, H. N., Cox, M. L., Jacobsen, M., Sandusky, G. E., D'Souza-Schorey, C. & Storniolo, A. M. V., 2019, In : Clinical Cancer Research. 25, 9, p. 2848-2859 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2020

Breast Heterogeneity: Obstacles to Developing Universal Biomarkers of Breast Cancer Initiation and Progression

Dirks, R. C., Burney, H. N., Anjanappa, M., Sandusky, G. E., Hao, Y., Liu, Y., Schmidt, M. C. & Nakshatri, H., Jul 2020, In : Journal of the American College of Surgeons. 231, 1, p. 85-96 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

In vivo modeling of metastatic human highgrade serous ovarian cancer in mice

Kim, O., Park, E. Y., Klinkebie, D. L., Pack, S. D., Shin, Y. H., Abdullaev, Z., Emerson, R. E., Coffey, D. M., Kwon, S. Y., Creighton, C. J., Kwon, S., Chang, E. C., Chiang, T., Yatsenko, A. N., Chien, J., Cheon, D. J., Yang-Hartwich, Y., Nakshatri, H., Nephew, K. P., Behringer, R. R. & 8 others, Fernandez, F. M., Cho, C. H., Vanderhyden, B., Drapkin, R., Bast, R. C., Miller, K. D., Karpf, A. R. & Kim, J., Jun 2020, In : PLoS Genetics. 16, 6, e1008808.

Research output: Contribution to journalArticle

Open Access

regSNPs-ASB: A Computational Framework for Identifying Allele-Specific Transcription Factor Binding From ATAC-seq Data

Xu, S., Feng, W., Lu, Z., Yu, C. Y., Shao, W., Nakshatri, H., Reiter, J. L., Gao, H., Chu, X., Wang, Y. & Liu, Y., Jul 29 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 886.

Research output: Contribution to journalArticle

Open Access

Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion

Fan, Y., Jalali, A., Chen, A., Zhao, X., Liu, S., Teli, M., Guo, Y., Li, F., Li, J., Siegel, A., Yang, L., Liu, J., Na, S., Agarwal, M., Robling, A. G., Nakshatri, H., Li, B. Y. & Yokota, H., Dec 1 2020, In : Bone Research. 8, 1, 9.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations