Harikrishna Nakshatri

  • 11806 Citations
  • 56 h-Index
1988 …2020

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Publications

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2-Methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells

Bhati, R., Gökmen-Polar, Y., Sledge, G. W., Fan, C., Nakshatri, H., Ketelsen, D., Borchers, C. H., Dial, M. J., Patterson, C. & Klauber-DeMore, N., Jan 15 2007, In : Cancer Research. 67, 2, p. 702-708 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Activity and enhancer binding factors for BK virus regulatory elements in differentiating embryonal carcinoma cells

Nakshatri, H., Pater, M. M. & Pater, A., Jul 1991, In : Virology. 183, 1, p. 374-380 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Activity and enhancer binding factors for jc virus regulatory elements in differentiating embryonal carcinoma cells

Nakshatri, H., Pater, A. & Pater, M. M., Aug 1990, In : Virology. 177, 2, p. 784-789 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

AKT alters genome-wide estrogen receptor α binding and impacts estrogen signaling in breast cancer

Bhat-Nakshatri, P., Wang, G., Appaiah, H., Luktuke, N., Carroll, J. S., Geistlinger, T. R., Brown, M., Badve, S., Liu, Y. & Nakshatri, H., Dec 1 2008, In : Molecular and cellular biology. 28, 24, p. 7487-7503 17 p.

Research output: Contribution to journalArticle

68 Scopus citations

A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples

Riley, C. P., Zhang, X., Nakshatri, H., Schneider, B., Regnier, F. E., Adamec, J. & Buck, C., May 27 2011, In : Journal of Translational Medicine. 9, 80.

Research output: Contribution to journalArticle

12 Scopus citations

Amplified in breast cancer 1 expression in breast cancer

Thorat, M. A., Turbin, D., Morimiya, A., Leung, S., Zhang, Q., Jeng, M. H., Huntsman, D. G., Nakshatri, H. & Badve, S., Dec 1 2008, In : Histopathology. 53, 6, p. 634-641 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

An effective epigenetic-PARP inhibitor combination therapy for breast and ovarian cancers independent of BRCA mutations

Pulliam, N., Fang, F., Ozes, A. R., Tang, J., Adewuyi, A., Keer, H., Lyons, J., Baylin, S. B., Matei, D., Nakshatri, H., Rassool, F. V., Miller, K. D. & Nephew, K. P., Jul 1 2018, In : Clinical Cancer Research. 24, 13, p. 3163-3175 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain

Avraham, H. K., Jiang, S., Fu, Y., Nakshatri, H., Ovadia, H. & Avraham, S., Feb 1 2014, In : Journal of Pathology. 232, 3, p. 369-381 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Antimyeloma effects of a sesquiterpene lactone parthenolide

Suvannasankha, A., Crean, C. D., Shanmugam, R., Farag, S. S., Abonour, R., Boswell, H. S. & Nakshatri, H., Mar 15 2008, In : Clinical Cancer Research. 14, 6, p. 1814-1822 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
128 Scopus citations

ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer

Chen, D., Bhat-Nakshatri, P., Goswami, C., Badve, S. & Nakshatri, H., Sep 15 2013, In : Cancer Research. 73, 18, p. 5821-5833 13 p.

Research output: Contribution to journalArticle

58 Scopus citations

A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter

Smith, W. C., Nakshatri, H., Leroy, P., Rees, J. & Chambon, P., 1991, In : EMBO Journal. 10, 8, p. 2223-2230 8 p.

Research output: Contribution to journalArticle

182 Scopus citations

A system for detecting high impact-low frequency mutations in primary tumors and metastases

Anjanappa, M., Hao, Y., Simpson, E. R., Bhat-Nakshatri, P., Nelson, J. B., Tersey, S. A., Mirmira, R. G., Cohen-Gadol, A. A., Saadatzadeh, M. R., Li, L., Fang, F., Nephew, K. P., Miller, K. D., Liu, Y. & Nakshatri, H., Jan 11 2018, In : Oncogene. 37, 2, p. 185-196 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Attraction and Compaction of Migratory Breast Cancer Cells by Bone Matrix Proteins through Tumor-Osteocyte Interactions

Chen, A., Wang, L., Liu, S., Wang, Y., Liu, Y., Wang, M., Nakshatri, H., Li, B. Y. & Yokota, H., Dec 1 2018, In : Scientific reports. 8, 1, 5420.

Research output: Contribution to journalArticle

6 Scopus citations

A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species

Shanmugam, R., Kusumanchi, P., Appaiah, H., Cheng, L., Crooks, P., Neelakantan, S., Peat, T., Klaunig, J., Matthews, W., Nakshatri, H. & Sweeney, C. J., May 1 2011, In : International Journal of Cancer. 128, 10, p. 2481-2494 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFκB and generating reactive oxygen species

Shanmugam, R., Kusumanchi, P., Cheng, L., Crooks, P., Neelakantan, S., Matthews, W., Nakshatri, H. & Sweeney, C. J., Jul 1 2010, In : Prostate. 70, 10, p. 1074-1086 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4

Stewart, M. J., Dipple, K. M., Estonius, M., Nakshatri, H., Everett, L. M. & Crabb, D. W., Aug 20 1998, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1399, 2-3, p. 181-186 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Breast Heterogeneity: Obstacles to Developing Universal Biomarkers of Breast Cancer Initiation and Progression

Dirks, R. C., Burney, H. N., Anjanappa, M., Sandusky, G. E., Hao, Y., Liu, Y., Schmidt, M. C. & Nakshatri, H., Jul 2020, In : Journal of the American College of Surgeons. 231, 1, p. 85-96 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle

Chen, D., Goswami, C. P., Burnett, R. M., Anjanappa, M., Bhat-Nakshatri, P., Muller, W. & Nakshatri, H., Aug 15 2014, In : Cancer Research. 74, 16, p. 4270-4281 12 p.

Research output: Contribution to journalArticle

20 Scopus citations
57 Scopus citations

CD44+/CD24-Breast cancer cells exhibit enhanced invase properties: An early step necessary for metastasis

Sheridan, C., Kishimoto, H., Fuchs, R. K., Mehrotra, S., Bhat-Nakshatri, P., Turner, C. H., Goulet, R., Badve, S. & Nakshatri, H., Oct 24 2006, In : Breast Cancer Research. 8, 5, R59.

Research output: Contribution to journalArticle

689 Scopus citations

Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells

Hromas, R., Broxmeyer, H. E., Kim, C., Nakshatri, H., Christopherson, K., Azam, M. & Hou, Y. H., Feb 24 1999, In : Biochemical and Biophysical Research Communications. 255, 3, p. 703-706 4 p.

Research output: Contribution to journalArticle

143 Scopus citations

CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency

Cohen, P. S., Nakshatri, H., Dennis, J., Caragine, T., Bianchi, M., Cerami, A. & Tracey, K. J., Apr 30 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 9, p. 3967-3971 5 p.

Research output: Contribution to journalArticle

97 Scopus citations

Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth

Nakshatri, H., Bhat-Nakshatri, P., Martin, D. A., Goulet, R. J. & Sledge, G. W., Jul 1997, In : Molecular and cellular biology. 17, 7, p. 3629-3639 11 p.

Research output: Contribution to journalArticle

Open Access
692 Scopus citations

Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22

Patel, J. B., Appaiah, H. N., Burnett, R. M., Bhat-Nakshatri, P., Wang, G., Mehta, R., Badve, S., Thomson, M. J., Hammond, S., Steeg, P., Liu, Y. & Nakshatri, H., Mar 17 2011, In : Oncogene. 30, 11, p. 1290-1301 12 p.

Research output: Contribution to journalArticle

89 Scopus citations

Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production

Starnes, T., Robertson, M. J., Sledge, G., Kelich, S., Nakshatri, H., Broxmeyer, H. E. & Hromas, R., Oct 15 2001, In : Journal of Immunology. 167, 8, p. 4137-4140 4 p.

Research output: Contribution to journalArticle

Open Access
281 Scopus citations

Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer

Ni, Y., Schmidt, K. R., Werner, B. A., Koenig, J. K., Guldner, I. H., Schnepp, P. M., Tan, X., Jiang, L., Host, M., Sun, L., Howe, E. N., Wu, J., Littlepage, L. E., Nakshatri, H. & Zhang, S., Dec 1 2019, In : Nature communications. 10, 1, 2860.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

Choi, M. R., Bardhan, R., Stanton-Maxey, K. J., Badve, S., Nakshatri, H., Stantz, K. M., Cao, N., Halas, N. J. & Clare, S. E., Dec 1 2012, In : Cancer Nanotechnology. 3, 1-6, p. 47-54 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis

Padua, M. B., Bhat-Nakshatri, P., Anjanappa, M., Prasad, M. S., Hao, Y., Rao, X., Liu, S., Wan, J., Liu, Y., McElyea, K., Jacobsen, M., Sandusky, G., Althouse, S., Perkins, S. & Nakshatri, H., May 2 2018, In : Breast Cancer Research. 20, 1, 35.

Research output: Contribution to journalArticle

5 Scopus citations

Differential effect of anti-apoptotic genes Bcl-xL and c-FLIP on sensitivity of MCF-7 breast cancer cells to paclitaxel and docetaxel

Wang, Z., Goulet, R., Stanton, K. J., Sadaria, M. & Nakshatri, H., May 1 2005, In : Anticancer Research. 25, 3 C, p. 2367-2379 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Differential effect of Nonidet P40 on DNA binding of transcription factors.

Nakshatri, H. & Bhat-Nakshatri, P., Jun 15 1997, In : Analytical biochemistry. 249, 1, p. 103-104 2 p.

Research output: Contribution to journalArticle

8 Scopus citations

Distinct effects of adipose-derived stem cells and adipocytes on normal and cancer cell hierarchy

Anjanappa, M., Burnett, R., Zieger, M. A., Merfeld-Clauss, S., Wooden, W., March, K., Sunil, T. & Nakshatri, H., Jan 1 2016, In : Molecular Cancer Research. 14, 7, p. 660-671 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Dual TGFb/BMP pathway inhibition enables expansion and characterization of multiple epithelial cell types of the normal and cancerous breast

Prasad, M., Kumar, B., Bhat-Nakshatri, P., Anjanappa, M., Sandusky, G., Miller, K. D., Storniolo, A. M. & Nakshatri, H., Jul 1 2019, In : Molecular Cancer Research. 17, 7, p. 1556-1570 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effect of Celecoxib and Novel Agent LC-1 in a Hamster Model of Lung Cancer

Vegeler, R. C., Yip-Schneider, M. T., Ralstin, M., Wu, H., Crooks, P. A., Neelakantan, S., Nakshatri, H., Sweeney, C. J. & Schmidt, C. M., Nov 1 2007, In : Journal of Surgical Research. 143, 1, p. 169-176 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Effects of a checkpoint kinase inhibitor, AZD7762, on tumor suppression and bone remodeling

Wang, L., Wang, Y., Chen, A., Jalali, A., Liu, S., Guo, Y., Na, S., Nakshatri, H., Li, B. Y. & Yokota, H., Sep 2018, In : International journal of oncology. 53, 3, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer

Srirangam, A., Mitra, R., Wang, M., Gorski, J. C., Badve, S., Baldridge, L. A., Hamilton, J., Kishimoto, H., Hawes, J., Li, L., Orschell, C. M., Srour, E. F., Blum, J. S., Donner, D., Sledge, G. W., Nakshatri, H. & Potter, D. A., Mar 15 2006, In : Clinical Cancer Research. 12, 6, p. 1883-1896 14 p.

Research output: Contribution to journalArticle

72 Scopus citations

Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase

Satpathy, M., Cao, L., Pincheira, R., Emerson, R., Bigsby, R., Nakshatri, H. & Matei, D., Aug 1 2007, In : Cancer Research. 67, 15, p. 7194-7202 9 p.

Research output: Contribution to journalArticle

80 Scopus citations

Epithelial-to-mesenchymal transition and ovarian tumor progression induced by tissue transglutaminase

Shao, M., Cao, L., Shen, C., Satpathy, M., Chelladurai, B., Bigsby, R. M., Nakshatri, H. & Matei, D., Dec 15 2009, In : Cancer Research. 69, 24, p. 9192-9201 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

Essential components of cancer education

Welch, D. R., Antalis, T. M., Burnstein, K., Vona-Davis, L., Jensen, R. A., Nakshatri, H., Riegel, A. T., Spitz, D. R., Watson, D. K. & Weiner, G. J., Dec 15 2015, In : Cancer Research. 75, 24, p. 5202-5205 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Estradiol-regulated microRNAs control estradiol response in breast cancer cells

Bhat-Nakshatri, P., Wang, G., Collins, N. R., Thomson, M. J., Geistlinger, T. R., Carroll, J. S., Brown, M., Hammond, S., Srour, E. F., Liu, Y. & Nakshatri, H., 2009, In : Nucleic acids research. 37, 14, p. 4850-4861 12 p.

Research output: Contribution to journalArticle

242 Scopus citations

Ethnicity-dependent and -independent heterogeneity in healthy normal breast hierarchy impacts tumor characterization

Nakshatri, H., Anjanappa, M. & Bhat-Nakshatri, P., Aug 27 2015, In : Scientific reports. 5, 13526.

Research output: Contribution to journalArticle

23 Scopus citations

Expression of forkhead-box protein A1, a marker of luminal A type breast cancer, parallels low Oncotype DX 21-gene recurrence scores

Ademuyiwa, F. O., Thorat, M. A., Jain, R. K., Nakshatri, H. & Badve, S., Feb 1 2010, In : Modern Pathology. 23, 2, p. 270-275 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Flower isoforms promote competitive growth in cancer

Madan, E., Pelham, C. J., Nagane, M., Parker, T. M., Canas-Marques, R., Fazio, K., Shaik, K., Yuan, Y., Henriques, V., Galzerano, A., Yamashita, T., Pinto, M. A. F., Palma, A. M., Camacho, D., Vieira, A., Soldini, D., Nakshatri, H., Post, S. R., Rhiner, C., Yamashita, H. & 7 others, Accardi, D., Hansen, L. A., Carvalho, C., Beltran, A. L., Kuppusamy, P., Gogna, R. & Moreno, E., Aug 8 2019, In : Nature. 572, 7768, p. 260-264 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Forkhead box A1 expression in breast cancer is associated with luminal subtype and good prognosis

Thorat, M. A., Marchio, C., Morimiya, A., Savage, K., Nakshatri, H., Reis-Filho, J. S. & Badve, S., Mar 1 2008, In : Journal of clinical pathology. 61, 3, p. 327-332 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

FOXA1 expression in breast cancer - Correlation with luminal subtype A and survival

Badve, S., Turbin, D., Thorat, M. A., Morimiya, A., Nielsen, T. O., Perou, C. M., Dunn, S., Huntsman, D. G. & Nakshatri, H., Aug 1 2007, In : Clinical Cancer Research. 13, 15, p. 4415-4421 7 p.

Research output: Contribution to journalArticle

163 Scopus citations

FOXA1 is an independent prognostic marker for ER-positive breast cancer

Mehta, R. J., Jain, R. K., Leung, S., Choo, J., Nielsen, T., Huntsman, D., Nakshatri, H. & Badve, S., Feb 2012, In : Breast Cancer Research and Treatment. 131, 3, p. 881-890 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

Functional role of BK virus tumor antigens in transformation

Nakshatri, H., Pater, M. M. & Pater, A., 1988, In : Journal of virology. 62, 12, p. 4613-4621 9 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein

Hromas, R., Busse, T., Carroll, A., Mack, D., Shopnick, R., Zhang, D. E., Nakshatri, H. & Richkind, K., Apr 1 2001, In : Blood. 97, 7, p. 2168-2170 3 p.

Research output: Contribution to journalArticle

33 Scopus citations

Genetic ancestry–dependent differences in breast cancer–induced field defects in the tumor-adjacent normal breast

Nakshatri, H., Kumar, B., Burney, H. N., Cox, M. L., Jacobsen, M., Sandusky, G. E., D'Souza-Schorey, C. & Storniolo, A. M. V., 2019, In : Clinical Cancer Research. 25, 9, p. 2848-2859 12 p.

Research output: Contribution to journalArticle

3 Scopus citations