Harm HogenEsch

  • 5275 Citations
  • 43 h-Index
1987 …2019
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Publications 1987 2019

2019
1 Citation (Scopus)

Corn-derived alpha-D-glucan nanoparticles as adjuvant for intramuscular and intranasal immunization in pigs

Dhakal, S., Lu, F., Ghimire, S., Renu, S., Lakshmanappa, Y. S., Hogshead, B. T., Ragland, D., HogenEsch, H. & Renukaradhya, G. J., Feb 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 16, p. 226-235 10 p.

Research output: Contribution to journalArticle

Immunization
Viruses
Nanoparticles
Zea mays
Swine
2 Citations (Scopus)

Formulation of aluminum hydroxide adjuvant with TLR agonists poly(I:C) and CpG enhances the magnitude and avidity of the humoral immune response

Lu, F., Mosley, Y. Y. C., Carmichael, B., Brown, D. D. & HogenEsch, H., Jan 1 2019, In : Vaccine.

Research output: Contribution to journalArticle

Aluminum Hydroxide
polyinosinic-polycytidylic acid
aluminum hydroxide
Toll-Like Receptors
Humoral Immunity

Genetic variation in the magnitude and longevity of the igg subclass response to a diphtheria-tetanus-acellular pertussis (dtap) vaccine in mice

Mosley, Y. Y. C., Radder, J. E. & Esch, H. H., Dec 2019, In : Vaccines. 7, 4, 124.

Research output: Contribution to journalArticle

Open Access
Diphtheria-Tetanus-acellular Pertussis Vaccines
Immunoglobulin G
Vaccines
Inbred C3H Mouse
Antigens
2018
16 Citations (Scopus)

Mucosal immunity and protective efficacy of intranasal inactivated influenza vaccine is improved by chitosan nanoparticle delivery in pigs

Dhakal, S., Renu, S., Ghimire, S., Lakshmanappa, Y. S., Hogshead, B. T., Feliciano-Ruiz, N., Lu, F., HogenEsch, H., Krakowka, S., Lee, C. W. & Renukaradhya, G. J., May 2 2018, In : Frontiers in Immunology. 9, MAY, 934.

Research output: Contribution to journalArticle

Mucosal Immunity
Inactivated Vaccines
Influenza Vaccines
Chitosan
Nanoparticles
18 Citations (Scopus)

Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want

HogenEsch, H., O’Hagan, D. T. & Fox, C. B., Dec 1 2018, In : npj Vaccines. 3, 1, 51.

Research output: Contribution to journalReview article

Aluminum
Vaccines
Vaccine Potency
Excipients
Ligands
5 Citations (Scopus)

Profiling of epidermal lipids in a mouse model of dermatitis: Identification of potential biomarkers

Franco, J., Ferreira, C., Paschoal Sobreira, T. J., Sundberg, J. P. & HogenEsch, H., Apr 1 2018, In : PLoS One. 13, 4, e0196595.

Research output: Contribution to journalArticle

Dermatitis
Biomarkers
dermatitis
ceramides
biomarkers
1 Citation (Scopus)

Training mouse pathologists: 16th annual workshop on the pathology of mouse models of human disease

Sundberg, J. P., Boyd, K., HogenEsch, H., Nikitin, A. Y., Treuting, P. M. & Ward, J. M., Jan 31 2018, In : Lab Animal. 47, 2, p. 38-40 3 p.

Research output: Contribution to journalLetter

human diseases
animal models
Pathology
Education
mice
2017
10 Citations (Scopus)

Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells

Lu, F., Mosley, Y. Y. C., Rodriguez Rosales, R. J., Carmichael, B. E., Elesela, S., Yao, Y. & HogenEsch, H., Dec 1 2017, In : npj Vaccines. 2, 1, 7.

Research output: Contribution to journalArticle

Dendritic Cells
Ovalbumin
Antigens
Injections
Nanoparticles
3 Citations (Scopus)

Differences in innate IFNγ and IL-17 responses to Bordetella pertussis between BALB/c and C57BL/6 mice: role of γδT cells, NK cells, and dendritic cells

Mosley, Y. Y. C., Lu, F. & HogenEsch, H., Oct 19 2017, (Accepted/In press) In : Immunologic Research. p. 1-11 11 p.

Research output: Contribution to journalArticle

Bordetella pertussis
Interleukin-17
Inbred C57BL Mouse
Natural Killer Cells
Dendritic Cells
2 Citations (Scopus)

Evaluation of the Potency, Neutralizing Antibody Response, and Stability of a Recombinant Fusion Protein Vaccine for Streptococcus pyogenes

Burlet, E., HogenEsch, H., Dunham, A. & Morefield, G., Mar 10 2017, (Accepted/In press) In : AAPS Journal. p. 1-7 7 p.

Research output: Contribution to journalArticle

Recombinant Fusion Proteins
Streptococcus pyogenes
Neutralizing Antibodies
Streptococcus
Antibody Formation
3 Citations (Scopus)

Genome-wide association mapping of the antibody response to diphtheria, tetanus and acellular pertussis vaccine in mice

Mosley, Y. Y. C., Radder, J. E., Berndt, A. & HogenEsch, H., 2017, In : Journal of Infectious Diseases. 215, 3, p. 466-474 9 p.

Research output: Contribution to journalArticle

Diphtheria-Tetanus-acellular Pertussis Vaccines
Antibody Formation
Genome
Immunoglobulin G
Acellular Vaccines
2 Citations (Scopus)

Loss of FAS/FASL signalling does not reduce apoptosis in Sharpin null mice

Potter, C. S., Silva, K. A., Kennedy, V. E., Stearns, T. M., HogenEsch, H. & Sundberg, J. P., 2017, (Accepted/In press) In : Experimental Dermatology.

Research output: Contribution to journalArticle

Apoptosis
Skin
Dermatitis
Phenotype
Mutation
7 Citations (Scopus)

Preclinical safety study of a recombinant Streptococcus pyogenes vaccine formulated with aluminum adjuvant

HogenEsch, H., Dunham, A., Burlet, E., Lu, F., Mosley, Y. Y. C. & Morefield, G., Feb 1 2017, In : Journal of Applied Toxicology. 37, 2, p. 222-230 9 p.

Research output: Contribution to journalArticle

Streptococcus pyogenes
Aluminum
Vaccines
Safety
Injections
2 Citations (Scopus)

Selection of a suitable reference gene for quantitative gene expression in mouse lymph nodes after vaccination

Mosley, Y. Y. C. & HogenEsch, H., Dec 6 2017, In : BMC Research Notes. 10, 1, 689.

Research output: Contribution to journalArticle

Gene expression
Vaccination
Genes
Lymph Nodes
Gene Expression

Training mouse pathologists: 15 years of workshops on the pathology of mouse models of human disease

Sundberg, J. P., Boyd, K., HogenEsch, H., Nikitin, A. Y., Treuting, P. M. & Ward, J. M., Apr 19 2017, In : Lab Animal. 46, 5, p. 204-206 3 p.

Research output: Contribution to journalLetter

2016
3 Citations (Scopus)

Angiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis

HogenEsch, H., Sola, M., Stearns, T. M., Silva, K. A., Kennedy, V. E. & Sundberg, J. P., Dec 1 2016, In : Experimental and Molecular Pathology. 101, 3, p. 303-307 5 p.

Research output: Contribution to journalArticle

Dermatitis
Skin
Inflammation
Blood vessels
Blood Vessels
43 Citations (Scopus)

Chronically elevated levels of short-chain fatty acids induce T Cell-mediated ureteritis and hydronephrosis

Park, J., Goergen, C. J., HogenEsch, H. & Kim, C. H., Mar 1 2016, In : Journal of Immunology. 196, 5, p. 2388-2400 13 p.

Research output: Contribution to journalArticle

Volatile Fatty Acids
Hydronephrosis
T-Lymphocytes
Kidney
Regulatory T-Lymphocytes
3 Citations (Scopus)

Dermal lymphatic dilation in a mouse model of alopecia areata

Sundberg, J. P., Pratt, C. H., Silva, K. A., Kennedy, V. E., Stearns, T. M., Sundberg, B. A., King, L. E. & HogenEsch, H., Apr 1 2016, In : Experimental and Molecular Pathology. 100, 2, p. 332-336 5 p.

Research output: Contribution to journalArticle

Alopecia Areata
Dilatation
Skin
CD44 Antigens
Lymphatic Vessels
2015
32 Citations (Scopus)

Dendrimer-like alpha-d-glucan nanoparticles activate dendritic cells and are effective vaccine adjuvants

Lu, F., Mencia, A., Bi, L., Taylor, A., Yao, Y. & HogenEsch, H., Apr 28 2015, In : Journal of Controlled Release. 204, p. 51-59 9 p., 7587.

Research output: Contribution to journalArticle

Dendrimers
Glucans
Nanoparticles
Dendritic Cells
Vaccines
2 Citations (Scopus)

The pathogenesis of chronic eosinophilic esophagitis in SHARPIN-deficient mice

Chien, S. J., Silva, K. A., Kennedy, V. E., HogenEsch, H. & Sundberg, J. P., Dec 1 2015, In : Experimental and Molecular Pathology. 99, 3, p. 460-467 8 p.

Research output: Contribution to journalArticle

Eosinophilic Esophagitis
Interleukin-13
Interleukin-4
Chemokine CCL24
Chemokine CCL11
2014
35 Citations (Scopus)

Chronic proliferative dermatitis in Sharpin null mice: Development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling

Potter, C. S., Wang, Z., Silva, K. A., Kennedy, V. E., Stearns, T. M., Burzenski, L., Shultz, L. D., HogenEsch, H. & Sundberg, J. P., Jan 21 2014, In : PLoS One. 9, 1, e85666.

Research output: Contribution to journalArticle

Dermatitis
T-cells
Interleukin-13
dermatitis
Interleukin-4
14 Citations (Scopus)

Development of a recombinant fusion protein vaccine formulation to protect against Streptococcus pyogenes

Morefield, G., Touhey, G., Lu, F., Dunham, A. & HogenEsch, H., 2014, In : Vaccine. 32, 30, p. 3810-3815 6 p.

Research output: Contribution to journalArticle

recombinant fusion proteins
Recombinant Fusion Proteins
Streptococcus pyogenes
Vaccines
vaccines
102 Citations (Scopus)

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner

Wang, L., Zhang, H., Rodriguez, S., Cao, L., Parish, J., Mumaw, C., Zollman, A., Kamocka, M., Mu, J., Chen, D. Z., Srour, E., Chitteti, B. R., HogenEsch, H., Tu, X., Bellido, T., Boswell, H., Manshouri, T., Verstovsek, S., Yoder, M., Kapur, R. & 2 others, Cardoso, A. A. & Carlesso, N., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

Hematopoiesis
Bone Marrow
Cytokines
Myeloproliferative Disorders
MicroRNAs
10 Citations (Scopus)

The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis

Chun, K., Li, B., Dobrota, E., Tate, C., Lee, J. H., Khan, S., Haneline, L., HogenEsch, H. & Skalnik, D. G., Dec 3 2014, In : PLoS One. 9, 12, e113745.

Research output: Contribution to journalArticle

hematopoiesis
Hematopoiesis
Epigenomics
epigenetics
Fingers

The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis

Chun, K. T., Li, B., Dobrota, E., Tate, C., Lee, J. H., Khan, S., Haneline, L., HogenEsch, H. & Skalnik, D. G., 2014, In : PLoS One. 9, 12, p. e113745

Research output: Contribution to journalArticle

hematopoiesis
Hematopoiesis
Epigenomics
epigenetics
Fingers
2013
10 Citations (Scopus)

Control of antigen-binding to aluminum adjuvants and the immune response with a novel phosphonate linker

Lu, F., Boutselis, I., Borch, R. F. & HogenEsch, H., Sep 13 2013, In : Vaccine. 31, 40, p. 4362-4367 6 p.

Research output: Contribution to journalArticle

phosphonates
Aluminum Hydroxide
Organophosphonates
Aluminum
aluminum hydroxide
42 Citations (Scopus)

Kinetics of the inflammatory response following intramuscular injection of aluminum adjuvant

Lu, F. & HogenEsch, H., Aug 20 2013, In : Vaccine. 31, 37, p. 3979-3986 8 p.

Research output: Contribution to journalArticle

injection site
Intramuscular Injections
intramuscular injection
Aluminum
adjuvants
7 Citations (Scopus)

Loss of Function of the Mouse Sharpin Gene Results in Peyer's Patch Regression

Seymour, R., Shirley, B. J., HogenEsch, H., Shultz, L. D. & Sundberg, J. P., Feb 12 2013, In : PLoS One. 8, 2, e55224.

Research output: Contribution to journalArticle

Peyer's Patches
Peyer's patches
Bone
Genes
mice
2012
5 Citations (Scopus)

A NUP98-HOXD13 leukemic fusion gene leads to impaired class switch recombination and antibody production

Puthiyaveetil, A. G., Heid, B., Reilly, C. M., HogenEsch, H. & Caudell, D. L., Aug 2012, In : Experimental Hematology. 40, 8, p. 622-633 12 p.

Research output: Contribution to journalArticle

Gene Fusion
Genetic Recombination
Antibody Formation
Dinitrophenols
Myelodysplastic Syndromes
28 Citations (Scopus)

Challenges in pre-clinical testing of anti-cancer drugs in cell culture and in animal models

HogenEsch, H. & Nikitin, A. Y., Dec 10 2012, In : Journal of Controlled Release. 164, 2, p. 183-186 4 p.

Research output: Contribution to journalArticle

Animal Models
Cell Culture Techniques
Pharmaceutical Preparations
Neoplasms
Tumor Cell Line
22 Citations (Scopus)

Increased expression of Cxcr3 and its ligands, Cxcl9 and Cxcl10, during the development of alopecia areata in the mouse

McPhee, C. G., Duncan, F. J., Silva, K. A., King, L. E., HogenEsch, H., Roopenian, D. C., Everts, H. B. & Sundberg, J. P., Jun 2012, In : Journal of Investigative Dermatology. 132, 6, p. 1736-1738 3 p.

Research output: Contribution to journalLetter

Ligands
148 Citations (Scopus)

Mechanism of immunopotentiation and safety of aluminum adjuvants

HogenEsch, H., 2012, In : Frontiers in Immunology. 3, JAN, Article 406.

Research output: Contribution to journalArticle

Aluminum
Safety
Adsorption
Dendritic Cells
Antigens
34 Citations (Scopus)

SHARPIN is a key regulator of immune and inflammatory responses

Wang, Z., Potter, C. S., Sundberg, J. P. & HogenEsch, H., Oct 2012, In : Journal of Cellular and Molecular Medicine. 16, 10, p. 2271-2279 9 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
Ubiquitin
Cytokines
Hypereosinophilic Syndrome
Inflammation
24 Citations (Scopus)

SHARPIN is essential for cytokine production, NF-κB signaling, and induction of Th1 differentiation by dendritic cells

Wang, Z., Sokolovska, A., Seymour, R., Sundberg, J. P. & HogenEsch, H., Feb 14 2012, In : PLoS One. 7, 2, e31809.

Research output: Contribution to journalArticle

dendritic cells
Dendritic Cells
cytokines
bone marrow
Cytokines
4 Citations (Scopus)

Training Mouse Pathologists: Ten Years of Workshops on the Pathology of Mouse Models of Human Disease

Sundberg, J. P., HogenEsch, H., Nikitin, A. Y., Treuting, P. M. & Ward, J. M., 2012, In : Toxicologic Pathology. 40, 5, p. 823-825 3 p.

Research output: Contribution to journalArticle

Pathology
Animals
Education
3 Citations (Scopus)

Training Pathologists in Mouse Pathology

Sundberg, J. P., Ward, J. M., HogenEsch, H., Nikitin, A. Y., Treuting, P. M., Macauley, J. B. & Schofield, P. N., Mar 2012, In : Veterinary Pathology. 49, 2, p. 393-397 5 p.

Research output: Contribution to journalArticle

Pathology
mice
Research
job training
Pathologists
2011
17 Citations (Scopus)

Effect of the strength of adsorption of HIV 1 SF162dV2gp140 to aluminum-containing adjuvants on the immune response

Hansen, B., Malyala, P., Singh, M., Sun, Y., Srivastava, I., HogenEsch, H. & Hem, S. L., Aug 2011, In : Journal of Pharmaceutical Sciences. 100, 8, p. 3245-3250 6 p.

Research output: Contribution to journalArticle

Aluminum Hydroxide
Aluminum
Adsorption
HIV-1
HIV Antigens
13 Citations (Scopus)

Formulation of a killed whole cell pneumococcus vaccine - effect of aluminum adjuvants on the antibody and IL-17 response

HogenEsch, H., Dunham, A., Hansen, B., Anderson, K., Maisonneuve, J. F. & Hem, S. L., Jul 29 2011, In : Journal of Immune Based Therapies and Vaccines. 9, 5.

Research output: Contribution to journalArticle

Interleukin-17
Streptococcus pneumoniae
Aluminum
Vaccines
Aluminum Hydroxide
2010
20 Citations (Scopus)

Adverse Vaccinal Events in Dogs and Cats

Moore, G. E. & HogenEsch, H., May 2010, In : Veterinary Clinics of North America - Small Animal Practice. 40, 3, p. 393-407 15 p.

Research output: Contribution to journalReview article

Veterinarians
Pets
Felidae
pets
veterinarians
19 Citations (Scopus)

Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in Sharpin-deficient mice

Renninger, M. L., Seymour, R. E., Whiteley, L. O., Sundberg, J. P. & HogenEsch, H., Mar 2010, In : Experimental Dermatology. 19, 3, p. 252-258 7 p.

Research output: Contribution to journalArticle

Dermatitis
Interleukin-5
Eosinophils
Amine Oxidase (Copper-Containing)
Tenascin
7 Citations (Scopus)

Effect of Ageing on the Immune Response of Dogs to Vaccines

HogenEsch, H. & Thompson, S., Jan 2010, In : Journal of Comparative Pathology. 142, SUPPL. 1

Research output: Contribution to journalArticle

Vaccines
immune response
Dogs
vaccines
dogs
15 Citations (Scopus)

Evaluation of innate immunity and vector toxicity following inoculation of bovine, porcine or human adenoviral vectors in a mouse model

Sharma, A., Bangari, D. S., Tandon, M., HogenEsch, H. & Mittal, S. K., Oct 2010, In : Virus Research. 153, 1, p. 134-142 9 p.

Research output: Contribution to journalArticle

Innate Immunity
Swine
Kupffer Cells
Adenoviridae
Human Adenoviruses
57 Citations (Scopus)
Aluminum
Aluminum Hydroxide
adjuvants
aluminum
vaccination
25 Citations (Scopus)

Preformulation studies-The next advance in aluminum adjuvant-containing vaccines

Hem, S. L., HogenEsch, H., Middaugh, C. R. & Volkin, D. B., Jul 2010, In : Vaccine. 28, 31, p. 4868-4870 3 p.

Research output: Contribution to journalArticle

Aluminum Compounds
Immunologic Adjuvants
Pharmaceutical Chemistry
Aluminum
adjuvants
68 Citations (Scopus)

Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine

Wang, C., Kang, S. G., HogenEsch, H., Love, P. E. & Kim, C. H., May 15 2010, In : Journal of Immunology. 184, 10, p. 5519-5526 8 p.

Research output: Contribution to journalArticle

Th17 Cells
Tropism
Tretinoin
Intestines
Small Intestine
17 Citations (Scopus)

Vascular lesions in pigs experimentally infected with porcine circovirus type 2 serogroup B

Langohr, I. M., Stevenson, G. W., Nelson, E. A., Lenz, S. D., HogenEsch, H., Wei, H. & Pogranichniy, R. M., 2010, In : Veterinary Pathology. 47, 1, p. 140-147 8 p.

Research output: Contribution to journalArticle

Circovirus
vasculitis
Porcine circovirus-2
Vasculitis
blood vessels
2009
36 Citations (Scopus)

Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model

Sharma, A., Bangari, D. S., Tandon, M., Pandey, A., HogenEsch, H. & Mittal, S. K., Mar 30 2009, In : Virology. 386, 1, p. 44-54 11 p.

Research output: Contribution to journalArticle

Swine
Gene Expression
Porcine Adenoviruses
Human Adenoviruses
Adenoviridae
74 Citations (Scopus)

Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis

Rodriguez, S., Chora, A., Goumnerov, B., Mumaw, C., Goebel, W., Fernandez, L., Baydoun, H., HogenEsch, H., Dombkowski, D. M., Karlewicz, C. A., Rice, S., Rahme, L. G. & Carlesso, N., Nov 5 2009, In : Blood. 114, 19, p. 4064-4076 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Sepsis
Neutropenia
Neutrophils
64 Citations (Scopus)

Effect of the strength of adsorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune response

Hansen, B., Belfast, M., Soung, G., Song, L., Egan, P. M., Capen, R., HogenEsch, H., Mancinelli, R. & Hem, S. L., Feb 5 2009, In : Vaccine. 27, 6, p. 888-892 5 p.

Research output: Contribution to journalArticle

Aluminum Hydroxide
aluminum hydroxide
Hepatitis B Surface Antigens
Adsorption
adjuvants

Veterinary pathology and peer review

Cantor, G. H., Caswell, J. L., Crissman, J. W., Gillette, D. M., Gunson, D. E., HogenEsch, H., Kiupel, M., Mense, M. G., Miller, M. A., Rush, L. J., St. Leger, J. A., Schoeb, T. R., Sellers, R. S., Sills, R. C., Swayne, D. E., Thomas, H. C., Ward, J. M. & Alden, C. L., Mar 2009, In : Veterinary Pathology. 46, 2, p. 173-175 3 p.

Research output: Contribution to journalReview article

Veterinary Pathology
Peer Review
peers
mentoring
Teaching