Heather O'Hagan

  • 1134 Citations
  • 15 h-Index
20012019
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Publications 2001 2019

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2019

DNA methyltransferase inhibition reduces inflammation-induced colon tumorigenesis

Maiuri, A. R., Savant, S. S., Podicheti, R., Rusch, D. B. & O’Hagan, H. M., Dec 2 2019, In : Epigenetics. 14, 12, p. 1209-1223 15 p.

Research output: Contribution to journalArticle

Methyltransferases
Colon
Carcinogenesis
Inflammation
DNA
2 Citations (Scopus)

JAK2 regulates mismatch repair protein-mediated epigenetic alterations in response to oxidative damage

Ding, N., Miller, S. A., Savant, S. S. & O'Hagan, H., Jan 1 2019, (Accepted/In press) In : Environmental and Molecular Mutagenesis.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Polycomb Repressive Complex 2
Epigenomics
Reactive Oxygen Species
Inflammation
1 Citation (Scopus)

Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 mediates antiestrogen resistance in human breast cancer cells

Pulliam, N., Tang, J., Wang, W., Fang, F., Sood, R., O'Hagan, H., Miller, K., Clarke, R. & Nephew, K., Jan 1 2019, In : Cancers. 11, 1, 43.

Research output: Contribution to journalArticle

Open Access
Estrogen Receptor Modulators
Estrogen Receptor alpha
Tamoxifen
Adenosine Diphosphate
Estrogen Receptors
2018
3 Citations (Scopus)

Epigenetic targeting of adipocytes inhibits high-grade serous ovarian cancer cell migration and invasion

Tang, J., Pulliam, N., Ozeş, A., Buechlein, A., Ding, N., Keer, H., Rusch, D., O'Hagan, H., Sharon Stack, M. & Nephew, K., Aug 1 2018, In : Molecular Cancer Research. 16, 8, p. 1226-1240 15 p.

Research output: Contribution to journalArticle

Adipocytes
Epigenomics
Ovarian Neoplasms
Cell Movement
Tumor Microenvironment
2017
43 Citations (Scopus)

Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations

Vaz, M., Hwang, S. Y., Kagiampakis, I., Phallen, J., Patil, A., O'Hagan, H., Murphy, L., Zahnow, C. A., Gabrielson, E., Velculescu, V. E., Easwaran, H. P. & Baylin, S. B., Sep 11 2017, In : Cancer Cell. 32, 3, p. 360-376 17 p.

Research output: Contribution to journalArticle

Oncogenes
Epigenomics
Smoke
Tobacco Products
Epithelial Cells
9 Citations (Scopus)

Mismatch repair proteins initiate epigenetic alterations during inflammation-driven tumorigenesis

Maiuri, A. R., Peng, M., Sriramkumar, S., Kamplain, C. M., DeStefano Shields, C. E., Sears, C. L. & O'Hagan, H., Jul 1 2017, In : Cancer Research. 77, 13, p. 3467-3478 12 p.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Epigenomics
Carcinogenesis
Inflammation
Proteins
1 Citation (Scopus)
Epigenomics
DNA Damage
Chronic Disease
Inflammation
Chromatin
2016
22 Citations (Scopus)

Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage

Ding, N., Bonham, E. M., Hannon, B. E., Amick, T. R., Baylin, S. B. & O'Hagan, H., Jun 1 2016, In : Journal of Molecular Cell Biology. 8, 3, p. 244-254 11 p.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Methyltransferases
DNA Damage
DNA
Epigenomics
20 Citations (Scopus)

Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment

Destefano Shields, C. E., Van Meerbeke, S. W., Housseau, F., Wang, H., Huso, D. L., Casero, R. A., O'Hagan, H. & Sears, C. L., Jul 1 2016, In : Journal of Infectious Diseases. 214, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

Cefoxitin
Bacteroides fragilis
Colon
Carcinogenesis
Interleukin-17
2015
13 Citations (Scopus)

Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer

Calmon, M. F., Jeschke, J., Zhang, W., Dhir, M., Siebenkäs, C., Herrera, A., Tsai, H. C., O'Hagan, H., Pappou, E. P., Hooker, C. M., Fu, T., Schuebel, K. E., Gabrielson, E., Rahal, P., Herman, J. G., Baylin, S. B. & Ahuja, N., Jan 1 2015, In : Epigenetics. 10, 7, p. 622-632 11 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Gene Silencing
Epigenomics
Breast Neoplasms
Phenotype
2013
39 Citations (Scopus)

Frequent inactivation of Cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines

Jeschke, J., O'Hagan, H., Zhang, W., Vatapalli, R., Calmon, M. F., Danilova, L., Nelkenbrecher, C., Van Neste, L., Bijsmans, I. T. G. W., Van Engeland, M., Gabrielson, E., Schuebel, K. E., Winterpacht, A., Baylin, S. B., Herman, J. G. & Ahuja, N., Jun 15 2013, In : Clinical Cancer Research. 19, 12, p. 3201-3211 11 p.

Research output: Contribution to journalArticle

Cysteine Dioxygenase
Anthracyclines
Breast Neoplasms
DNA Methylation
Reactive Oxygen Species
2011
270 Citations (Scopus)

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

O'Hagan, H., Wang, W., Sen, S., DeStefano Shields, C., Lee, SS., Zhang, YW., Clements, EG., Cai, Y., Van Neste, L., Easwaran, H., Casero, RA., Sears, CL. & Baylin, SB., Nov 15 2011, In : Cancer Cell. 20, 5, p. 606-619 14 p.

Research output: Contribution to journalArticle

CpG Islands
Methyltransferases
DNA Methylation
Hydrogen Peroxide
DNA
2009
60 Citations (Scopus)

Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation

Mohammad, H. P., Cai, Y., McGarvey, K. M., Easwaran, H., Van Neste, L., Ohm, J. E., O'Hagan, H. & Baylin, S. B., Aug 1 2009, In : Cancer Research. 69, 15, p. 6322-6330 9 p.

Research output: Contribution to journalArticle

DNA
Genes
Neoplasms
Gene Silencing
Epigenomics
2008
222 Citations (Scopus)

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

O'Hagan, H., Mohammad, H. P. & Baylin, S. B., Aug 2008, In : PLoS Genetics. 4, 8, e1000155.

Research output: Contribution to journalArticle

CpG Islands
methylation
Gene Silencing
gene silencing
DNA methylation
2007
86 Citations (Scopus)

RPA and ATR link transcriptional stress to p53

Derheimer, F. A., O'Hagan, H., Krueger, H. M., Hanasoge, S., Paulsen, M. T. & Ljungman, M., Jul 31 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 31, p. 12778-12783 6 p.

Research output: Contribution to journalArticle

Replication Protein A
DNA Damage
RNA Polymerase II
Phosphorylation
Cell Nucleus Active Transport
2004
17 Citations (Scopus)

Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs

O'Hagan, H. & Ljungman, M., Jul 15 2004, In : Experimental Cell Research. 297, 2, p. 548-559 12 p.

Research output: Contribution to journalArticle

Nuclear Export Signals
Cell Nucleus Active Transport
Messenger RNA
Microinjections
Proteins
116 Citations (Scopus)

Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus

Galigniana, M. D., Harrell, J. M., O'Hagan, H., Ljungman, M. & Pratt, W. B., May 21 2004, In : Journal of Biological Chemistry. 279, 21, p. 22483-22489 7 p.

Research output: Contribution to journalArticle

Immunophilins
Dyneins
Peptidylprolyl Isomerase
Cytoplasmic Dyneins
Tumor Suppressor Protein p53
31 Citations (Scopus)

Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2

O'Hagan, H. & Ljungman, M., Jul 15 2004, In : Oncogene. 23, 32, p. 5505-5512 8 p.

Research output: Contribution to journalArticle

Dichlororibofuranosylbenzimidazole
Cell Nucleus Active Transport
Phosphotransferases
Down-Regulation
Phosphorylation
18 Citations (Scopus)
Ionizing Radiation
Phosphorylation
Cell Nucleus Active Transport
Oncogenes
Transcriptional Activation
2001
69 Citations (Scopus)

Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress

Klibanov, S. A., O'Hagan, H. & Ljungman, M., 2001, In : Journal of Cell Science. 114, 10, p. 1867-1873 7 p.

Research output: Contribution to journalArticle

Dichlororibofuranosylbenzimidazole
Proteasome Endopeptidase Complex
Proteins
Genes
Proteasome Inhibitors
57 Citations (Scopus)

Induction of serl5 and 1ys382 modifications of p53 by blockage of transcription elongation

Ljungman, M., O'Hagan, H. & Paulsen, M. T., Sep 20 2001, In : Oncogene. 20, 42, p. 5964-5971 8 p.

Research output: Contribution to journalArticle

DNA Repair-Deficiency Disorders
Dichlororibofuranosylbenzimidazole
Nucleic Acid Synthesis Inhibitors
Camptothecin
RNA Polymerase II