Heather O'Hagan

  • 1213 Citations
  • 16 h-Index
20012019

Research output per year

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Publications

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Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress

Klibanov, S. A., O'Hagan, H. M. & Ljungman, M., Jun 23 2001, In : Journal of cell science. 114, 10, p. 1867-1873 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations

Vaz, M., Hwang, S. Y., Kagiampakis, I., Phallen, J., Patil, A., O'Hagan, H. M., Murphy, L., Zahnow, C. A., Gabrielson, E., Velculescu, V. E., Easwaran, H. P. & Baylin, S. B., Sep 11 2017, In : Cancer Cell. 32, 3, p. 360-376.e6

Research output: Contribution to journalArticle

57 Scopus citations

DNA methyltransferase inhibition reduces inflammation-induced colon tumorigenesis

Maiuri, A. R., Savant, S. S., Podicheti, R., Rusch, D. B. & O’Hagan, H. M., Dec 2 2019, In : Epigenetics. 14, 12, p. 1209-1223 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

O'Hagan, H. M., Mohammad, H. P. & Baylin, S. B., Aug 1 2008, In : PLoS Genetics. 4, 8, e1000155.

Research output: Contribution to journalArticle

228 Scopus citations

Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs

O'Hagan, H. M. & Ljungman, M., Jul 15 2004, In : Experimental Cell Research. 297, 2, p. 548-559 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer

Calmon, M. F., Jeschke, J., Zhang, W., Dhir, M., Siebenkäs, C., Herrera, A., Tsai, H. C., O’Hagan, H. M., Pappou, E. P., Hooker, C. M., Fu, T., Schuebel, K. E., Gabrielson, E., Rahal, P., Herman, J. G., Baylin, S. B. & Ahuja, N., Jan 1 2015, In : Epigenetics. 10, 7, p. 622-632 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Epigenetic targeting of adipocytes inhibits high-grade serous ovarian cancer cell migration and invasion

Tang, J., Pulliam, N., Ozeş, A., Buechlein, A., Ding, N., Keer, H., Rusch, D., O'Hagan, H., Sharon Stack, M. & Nephew, K. P., Aug 2018, In : Molecular Cancer Research. 16, 8, p. 1226-1240 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Frequent inactivation of Cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines

Jeschke, J., O'Hagan, H. M., Zhang, W., Vatapalli, R., Calmon, M. F., Danilova, L., Nelkenbrecher, C., Van Neste, L., Bijsmans, I. T. G. W., Van Engeland, M., Gabrielson, E., Schuebel, K. E., Winterpacht, A., Baylin, S. B., Herman, J. G. & Ahuja, N., Jun 15 2013, In : Clinical Cancer Research. 19, 12, p. 3201-3211 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus

Galigniana, M. D., Harrell, J. M., O'Hagen, H. M., Ljungman, M. & Pratt, W. B., May 21 2004, In : Journal of Biological Chemistry. 279, 21, p. 22483-22489 7 p.

Research output: Contribution to journalArticle

118 Scopus citations

Induction of serl5 and 1ys382 modifications of p53 by blockage of transcription elongation

Ljungman, M., O'hagan, H. M. & Paulsen, M. T., Sep 20 2001, In : Oncogene. 20, 42, p. 5964-5971 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

JAK2 regulates mismatch repair protein-mediated epigenetic alterations in response to oxidative damage

Ding, N., Miller, S. A., Savant, S. S. & O'Hagan, H. M., May 2019, In : Environmental and Molecular Mutagenesis. 60, 4, p. 308-319 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mismatch repair proteins initiate epigenetic alterations during inflammation-driven tumorigenesis

Maiuri, A. R., Peng, M., Sriramkumar, S., Kamplain, C. M., DeStefano Shields, C. E., Sears, C. L. & O'Hagan, H., Jul 1 2017, In : Cancer Research. 77, 13, p. 3467-3478 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage

Ding, N., Bonham, E. M., Hannon, B. E., Amick, T. R., Baylin, S. B. & O'Hagan, H. M., Jun 1 2016, In : Journal of Molecular Cell Biology. 8, 3, p. 244-254 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2

O'Hagan, H. M. & Ljungman, M., Jul 15 2004, In : Oncogene. 23, 32, p. 5505-5512 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

O'Hagan, HM., Wang, W., Sen, S., DeStefano Shields, C., Lee, SS., Zhang, YW., Clements, EG., Cai, Y., Van Neste, L., Easwaran, H., Casero, RA., Sears, CL. & Baylin, SB., Nov 15 2011, In : Cancer Cell. 20, 5, p. 606-619 14 p.

Research output: Contribution to journalArticle

281 Scopus citations
18 Scopus citations

Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 mediates antiestrogen resistance in human breast cancer cells

Pulliam, N., Tang, J., Wang, W., Fang, F., Sood, R., O'Hagan, H., Miller, K., Clarke, R. & Nephew, K., Jan 1 2019, In : Cancers. 11, 1, 43.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation

Mohammad, H. P., Cai, Y., McGarvey, K. M., Easwaran, H., Van Neste, L., Ohm, J. E., O'Hagan, H. M. & Baylin, S. B., Aug 1 2009, In : Cancer Research. 69, 15, p. 6322-6330 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment

Destefano Shields, C. E., Van Meerbeke, S. W., Housseau, F., Wang, H., Huso, D. L., Casero, R. A., O'Hagan, H. M. & Sears, C. L., Jul 1 2016, In : Journal of Infectious Diseases. 214, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

RPA and ATR link transcriptional stress to p53

Derheimer, F. A., O'Hagan, H. M., Krueger, H. M., Hanasoge, S., Paulsen, M. T. & Ljungman, M., Jul 31 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 31, p. 12778-12783 6 p.

Research output: Contribution to journalArticle

89 Scopus citations