Hyun-Suk Lim

  • 964 Citations
  • 18 h-Index
20022019
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Publications 2002 2019

  • 964 Citations
  • 18 h-Index
  • 39 Article
  • 2 Review article
2019

A solid-phase method for synthesis of dimeric and trimeric ligands: Identification of potent bivalent ligands of 14-3-3σ

Lee, Y., Chung, B., Ko, D. & Lim, H. S., Oct 1 2019, In : Bioorganic Chemistry. 91, 103141.

Research output: Contribution to journalArticle

Solid-Phase Synthesis Techniques
Ligands
Proteins
14-3-3 Proteins
Biological Phenomena

Bridged α-helix mimetic small molecules

Lee, Y., Im, H., Das, S., Oh, M., Lee, J. H., Ham, S. & Lim, H. S., Jan 1 2019, In : Chemical Communications. 55, 88, p. 13311-13314 4 p.

Research output: Contribution to journalArticle

Proteins
Molecules
Conformations
Membrane Proteins

DNA-Encoded Combinatorial Library of Macrocyclic Peptoids

Shin, M. H., Lee, K. J. & Lim, H. S., Jan 1 2019, (Accepted/In press) In : Bioconjugate Chemistry.

Research output: Contribution to journalArticle

Peptoids
DNA
Screening
Proteins
Molecules

Solid-phase synthesis and circular dichroism study of β-abpeptoids

Sable, G. A., Lee, K. J. & Lim, H. S., Jan 5 2019, In : Molecules. 24, 1, 178.

Research output: Contribution to journalArticle

Peptidomimetics
Solid-Phase Synthesis Techniques
Circular Dichroism
oligomers
Oligomers
2018
4 Citations (Scopus)

A Forkhead Box ProteinC2 Inhibitor: Targeting Epithelial-Mesenchymal Transition and Cancer Metastasis

Castaneda, M., Chen, L., Pradhan, L., Li, S., Zein, R., Lee, Y., Lim, H-S., Nam, H. J. & Lee, J., Jan 1 2018, (Accepted/In press) In : ChemBioChem.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Cells
Neoplasm Metastasis
Cadherins
Stem cells
12 Citations (Scopus)

Comparison of Cell Permeability of Cyclic Peptoids and Linear Peptoids

Shin, M. K., Hyun, Y. J., Lee, J. H. & Lim, H-S., Apr 9 2018, In : ACS Combinatorial Science. 20, 4, p. 237-242 6 p.

Research output: Contribution to journalArticle

Peptoids
Rigidity
Peptidomimetics
Amides
Protons
3 Citations (Scopus)

Submonomer Strategy toward Divergent Solid-Phase Synthesis of α-ABpeptoids

Sable, G. A., Lee, K. J., Shin, M. K. & Lim, H-S., May 4 2018, In : Organic Letters. 20, 9, p. 2526-2529 4 p.

Research output: Contribution to journalArticle

Solid-Phase Synthesis Techniques
Alkylation
oligomers
Oligomers
solid phases
2017
10 Citations (Scopus)

Colorectal Cancer Diagnosis Using Enzyme-Sensitive Ratiometric Fluorescence Dye and Antibody-Quantum Dot Conjugates for Multiplexed Detection

Park, Y., Ryu, Y. M., Wang, T., Jung, Y., Kim, S., Hwang, S., Park, J., Bae, D. J., Kim, J., Moon, H., Lim, H. S., Kim, S. Y., Chung, E., Kim, K. H., Kim, S. & Myung, S. J., Jan 1 2017, (Accepted/In press) In : Advanced Functional Materials.

Research output: Contribution to journalArticle

antibodies
Antibodies
Semiconductor quantum dots
enzymes
Coloring Agents
3 Citations (Scopus)

Intracellular and transdermal protein delivery mediated by non-covalent interactions with a synthetic guanidine-rich molecular carrier

Im, J., Das, S., Jeong, D., Kim, C. J., Lim, H-S., Kim, K. H. & Chung, S. K., Aug 7 2017, In : International Journal of Pharmaceutics. 528, 1-2, p. 646-654 9 p.

Research output: Contribution to journalArticle

Guanidine
Proteins
Skin
Microscopy
Carrier Proteins
8 Citations (Scopus)

Screening methods for identifying pharmacological chaperones

Shin, M. H. & Lim, H-S., 2017, In : Molecular BioSystems. 13, 4, p. 638-647 10 p.

Research output: Contribution to journalReview article

Proteostasis Deficiencies
Protein Folding
Pharmacology
Gaucher Disease
Amyloidosis
7 Citations (Scopus)

Targeted Inhibition of the NCOA1/STAT6 Protein-Protein Interaction

Lee, Y., Yoon, H., Hwang, S. M., Shin, M. K., Lee, J. H., Oh, M., Im, S. H., Song, J. & Lim, H-S., Nov 15 2017, In : Journal of the American Chemical Society. 139, 45, p. 16056-16059 4 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 1
STAT6 Transcription Factor
STAT Transcription Factors
Transcription
Transducers
2016
29 Citations (Scopus)

A Chemical Inhibitor of the Skp2/p300 Interaction that Promotes p53-Mediated Apoptosis

Oh, M., Lee, J. H., Moon, H., Hyun, Y. J. & Lim, H-S., Jan 11 2016, In : Angewandte Chemie - International Edition. 55, 2, p. 602-606 5 p.

Research output: Contribution to journalArticle

Cell death
Peptoids
Cells
Apoptosis
Acetylation
8 Citations (Scopus)

Converting One-Face α-Helix Mimetics into Amphiphilic α-Helix Mimetics as Potent Inhibitors of Protein-Protein Interactions

Lee, J. H., Oh, M., Kim, H. S., Lee, H., Im, W. & Lim, H-S., Jan 11 2016, In : ACS Combinatorial Science. 18, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

Proteins
Peptides
Modulators
12 Citations (Scopus)

Oligomers of N-Substituted β2-Homoalanines: Peptoids with Backbone Chirality

Lee, K. J., Lee, W. S., Yun, H., Hyun, Y. J., Seo, C. D., Lee, C. W. & Lim, H-S., Aug 5 2016, In : Organic Letters. 18, 15, p. 3678-3681 4 p.

Research output: Contribution to journalArticle

Peptoids
Chirality
oligomers
chirality
Oligomers
17 Citations (Scopus)

Skp2 inhibitors: Novel anticancer strategies

Lee, Y. & Lim, H-S., Jul 1 2016, In : Current Medicinal Chemistry. 23, 22, p. 2363-2379 17 p.

Research output: Contribution to journalReview article

Acetylation
Neoplasms
Cell Cycle Proteins
Ubiquitin-Protein Ligases
Ubiquitination
2015
28 Citations (Scopus)
Protein Transport
Libraries
Screening
Molecules
Proteins
2014
17 Citations (Scopus)

Design, solid-phase synthesis, and evaluation of a phenyl-piperazine-triazine scaffold as α-helix mimetics

Moon, H., Lee, W. S., Oh, M., Lee, H., Lee, J. H., Im, W. & Lim, H-S., Dec 8 2014, In : ACS Combinatorial Science. 16, 12, p. 695-701 7 p.

Research output: Contribution to journalArticle

Triazines
Solid-Phase Synthesis Techniques
Scaffolds
Proteins
Solubility
18 Citations (Scopus)

Facile method to sequence cyclic peptides/peptoids via one-pot ring-opening/cleavage reaction

Lee, K. J. & Lim, H-S., Nov 7 2014, In : Organic Letters. 16, 21, p. 5710-5713 4 p.

Research output: Contribution to journalArticle

Peptoids
Cyclic Peptides
peptides
cleavage
Sulfides
39 Citations (Scopus)

Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein

Oh, M., Lee, J. H., Wang, W., Lee, H. S., Lee, W. S., Burlak, C., Im, W., Hoang, Q. & Lim, H-S., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 30, p. 11007-11012 6 p.

Research output: Contribution to journalArticle

Synucleins
Myeloid Leukemia
Myeloid Cells
Parkinson Disease
Pharmacology
2013
32 Citations (Scopus)

Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth

Adler, J. J., Heller, B. L., Bringman, L. R., Ranahan, W. P., Cocklin, R. R., Goebl, M., Oh, M., Lim, H-S., Ingham, R. J. & Wells, C., May 24 2013, In : Journal of Biological Chemistry. 288, 21, p. 15181-15193 13 p.

Research output: Contribution to journalArticle

Cell growth
Growth
Proteins
Tumors
Protein Stability
2012
12 Citations (Scopus)

Application of binding free energy calculations to prediction of binding modes and affinities of MDM2 and MDMX inhibitors

Lee, H. S., Jo, S., Lim, H-S. & Im, W., Jul 23 2012, In : Journal of Chemical Information and Modeling. 52, 7, p. 1821-1832 12 p.

Research output: Contribution to journalArticle

Free energy
Molecular Dynamics Simulation
Ligands
energy
Molecular dynamics
15 Citations (Scopus)

Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines

Lee, J. H. & Lim, H-S., Jun 7 2012, In : Organic and Biomolecular Chemistry. 10, 21, p. 4229-4235 7 p.

Research output: Contribution to journalArticle

Solid-Phase Synthesis Techniques
pyrimidines
solid phases
Peptoids
versatility
2011
31 Citations (Scopus)

Design and facile solid-phase synthesis of conformationally constrained bicyclic peptoids

Lee, J. H., Kim, H. S. & Lim, H-S., Oct 7 2011, In : Organic Letters. 13, 19, p. 5012-5015 4 p.

Research output: Contribution to journalArticle

Peptoids
Solid-Phase Synthesis Techniques
solid phases
routes
synthesis
97 Citations (Scopus)

Novel pyrrolopyrimidine-based α-helix mimetics: Cell-permeable inhibitors of protein-protein interactions

Lee, J. H., Zhang, Q., Jo, S., Chai, S. C., Oh, M., Im, W., Lu, H. & Lim, H-S., Feb 2 2011, In : Journal of the American Chemical Society. 133, 4, p. 676-679 4 p.

Research output: Contribution to journalArticle

Proteins
Molecules
Fluorescence Polarization
Scaffolds
Rigidity
35 Citations (Scopus)

Reductively degradable polyester-based block copolymers prepared by facile polycondensation and ATRP: Synthesis, degradation, and aqueous micellization

Nelson-Mendez, A., Aleksanian, S., Oh, M., Lim, H-S. & Oh, J. K., Aug 21 2011, In : Soft Matter. 7, 16, p. 7441-7452 12 p.

Research output: Contribution to journalArticle

Micellization
Polyesters
Atom transfer radical polymerization
polyesters
disulfides
2010
46 Citations (Scopus)

A simple strategy for the construction of combinatorial cyclic peptoid libraries

Lee, J. H., Meyer, A. M. & Lim, H-S., Dec 7 2010, In : Chemical Communications. 46, 45, p. 8615-8617 3 p.

Research output: Contribution to journalArticle

Peptoids
Mass spectrometry
Screening
Throughput
53 Citations (Scopus)

Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates

Lee, J., Udugamasooriya, D. G., Lim, H-S. & Kodadek, T., Apr 2010, In : Nature Chemical Biology. 6, 4, p. 258-260 3 p.

Research output: Contribution to journalArticle

Peptoids
Singlet Oxygen
Photosensitizing Agents
Ruthenium
Protein Binding
2009
6 Citations (Scopus)

Non-proteolytic regulation of p53-mediated transcription through destabilization of the activator-promoter complex by the proteasomal ATPases

Kim, Y. C., Wu, S. Y., Lim, H-S., Chiang, C. M. & Kodadek, T., Dec 11 2009, In : Journal of Biological Chemistry. 284, 50, p. 34522-34530 9 p.

Research output: Contribution to journalArticle

Transcription
Adenosine Triphosphatases
Gene Expression
Gene expression
Yeast
16 Citations (Scopus)

Rapid identification of improved protein ligands using peptoid microarrays

Lim, H-S., Muralidhar Reddy, M., Xiao, X., Wilson, J., Wilson, R., Connell, S. & Kodadek, T., Jul 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 14, p. 3866-3869 4 p.

Research output: Contribution to journalArticle

Peptoids
Click Chemistry
Microarrays
Protein Binding
Ligands
2008
20 Citations (Scopus)

Rapid identification of the pharmacophore in a peptoid inhibitor of the proteasome regulatory particle

Lim, H-S., Archer, C. T., Kim, Y. C., Hutchens, T. & Kodadek, T., 2008, In : Chemical Communications. 9, p. 1064-1066 3 p.

Research output: Contribution to journalArticle

Peptoids
Proteasome Inhibitors
Proteasome Endopeptidase Complex
Lysine
Derivatives
2007
62 Citations (Scopus)

A cell-permeable synthetic transcription factor mimic

Xiao, X., Yu, P., Lim, H-S., Sikder, D. & Kodadek, T., 2007, In : Angewandte Chemie - International Edition. 46, 16, p. 2865-2868 4 p.

Research output: Contribution to journalArticle

Peptoids
Transcription factors
Nylons
Transcription
Polyamides
42 Citations (Scopus)

Design and synthesis of a cell-permeable synthetic transcription factor mimic

Xiao, X., Yu, P., Lim, H-S., Sikder, D. & Kodadek, T., Jul 2007, In : Journal of Combinatorial Chemistry. 9, 4, p. 592-600 9 p.

Research output: Contribution to journalArticle

Peptoids
Artificial Cells
Nylons
Transcription Factor
Transcription Factors
81 Citations (Scopus)

Identification of a peptoid inhibitor of the proteasome 19S regulatory particle

Lim, H-S., Archer, C. T. & Kodadek, T., Jun 27 2007, In : Journal of the American Chemical Society. 129, 25, p. 7750-7751 2 p.

Research output: Contribution to journalArticle

Peptoids
Proteasome Inhibitors
Proteasome Endopeptidase Complex
Protein Unfolding
Complex Mixtures
31 Citations (Scopus)

Periodate-triggered cross-linking reveals Sug2/Rpt4 as the molecular target of a peptoid inhibitor of the 19S proteasome regulatory particle

Lim, H-S., Cai, D., Archer, C. T. & Kodadek, T., Oct 31 2007, In : Journal of the American Chemical Society. 129, 43, p. 12936-12937 2 p.

Research output: Contribution to journalArticle

Peptoids
Proteasome Inhibitors
Proteasome Endopeptidase Complex
Adenosine Triphosphatases
Cross Reactions
2006
18 Citations (Scopus)

Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure-activity relationship

Kanbe, Y., Kim, M. H., Nishimoto, M., Ohtake, Y., Kato, N., Tsunenari, T., Taniguchi, K., Ohizumi, I., Kaiho, S. I., Morikawa, K., Jo, J. C., Lim, H-S. & Kim, H. Y., Jul 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 14, p. 4803-4819 17 p.

Research output: Contribution to journalArticle

Chromans
sulfoxide
Estrogen Receptor Modulators
Structure-Activity Relationship
Derivatives
19 Citations (Scopus)

Discovery of thiochroman derivatives bearing a carboxy-containing side chain as orally active pure antiestrogens

Kanbe, Y., Kim, M. H., Nishimoto, M., Ohtake, Y., Tsunenari, T., Taniguchi, K., Ohizumi, I., Kaiho, S. I., Nabuchi, Y., Kawata, S., Morikawa, K., Jo, J. C., Kwon, H. A., Lim, H-S. & Kim, H. Y., Aug 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 15, p. 4090-4094 5 p.

Research output: Contribution to journalArticle

Bearings (structural)
sulfoxide
Estrogen Receptor Modulators
Derivatives
Pharmacokinetics
11 Citations (Scopus)

Newly discovered orally active pure antiestrogens

Kanbe, Y., Kim, M. H., Nishimoto, M., Ohtake, Y., Yoneya, T., Ohizumi, I., Tsunenari, T., Taniguchi, K., Kaiho, S. I., Nabuchi, Y., Araya, H., Kawata, S., Morikawa, K., Jo, J. C., Kwon, H. A., Lim, H-S. & Kim, H. Y., Sep 15 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 18, p. 4959-4964 6 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Pharmacokinetics
Intestinal Absorption
Scaffolds
Liver
2004
31 Citations (Scopus)

Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors

Lim, H-S., Park, J. J., Ko, K., Lee, M. H. & Chung, S. K., May 17 2004, In : Bioorganic and Medicinal Chemistry Letters. 14, 10, p. 2499-2503 5 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Ligands
Biological Phenomena
Structure-Activity Relationship
sphingosine 1-phosphate
2003
16 Citations (Scopus)

A practical diastereoselective synthesis of β-amino-α-hydroxy carboxylates

Lee, J. M., Lim, H-S., Seo, K. C. & Chung, S. K., Nov 28 2003, In : Tetrahedron Asymmetry. 14, 23, p. 3639-3641 3 p.

Research output: Contribution to journalArticle

carboxylates
amino acids
Amino acids
esters
Esters
25 Citations (Scopus)

Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors

Lim, H-S., Oh, Y. S., Suh, P. G. & Chung, S. K., Jan 2003, In : Bioorganic and Medicinal Chemistry Letters. 13, 2, p. 237-240 4 p.

Research output: Contribution to journalArticle

Stereoisomerism
Biological Phenomena
Ligands
sphingosine 1-phosphate
2002
50 Citations (Scopus)

A short and efficient stereoselective synthesis of all four diastereomers of sphingosine

Lee, J. M., Lim, H-S. & Chung, S. K., Mar 22 2002, In : Tetrahedron Asymmetry. 13, 4, p. 343-347 5 p.

Research output: Contribution to journalArticle

Sphingosines
Sphingosine
Serine
Derivatives
synthesis