Irina Petrache

  • 8221 Citations
  • 39 h-Index
19992020

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2020

Cigarette smoke exposure impairs β-cell function through activation of oxidative stress and ceramide accumulation

Tong, X., Chaudhry, Z., Lee, C. C., Bone, R. N., Kanojia, S., Maddatu, J., Sohn, P., Weaver, S. A., Robertson, M. A., Petrache, I., Evans-Molina, C. & Kono, T., Jul 2020, In : Molecular Metabolism. 37, 100975.

Research output: Contribution to journalArticle

Open Access

Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension

Tseng, V., Ni, K., Allawzi, A., Prohaska, C., Hernandez-Lagunas, L., Elajaili, H., Cali, V., Midura, R., Hascall, V., Triggs-Raine, B., Petrache, I., Hart, C. M. & Nozik-Grayck, E., Dec 1 2020, In : Scientific reports. 10, 1, 280.

Research output: Contribution to journalArticle

Open Access

MicroRNA-126-3p Inhibits Angiogenic Function of Human Lung Microvascular Endothelial Cells via LAT1 (L-Type Amino Acid Transporter 1)-Mediated mTOR (Mammalian Target of Rapamycin) Signaling

Cao, D., Mikosz, A. M., Ringsby, A. J., Anderson, K. C., Beatman, E. L., Koike, K. & Petrache, I., 2020, (Accepted/In press) In : Arteriosclerosis, thrombosis, and vascular biology. p. 1195-1206 12 p.

Research output: Contribution to journalArticle

Nicotine-free e-cigarette vapor exposure stimulates Il6 and mucin production in human primary small airway epithelial cells

Gellatly, S., Pavelka, N., Crue, T., Schweitzer, K. S., Day, B. J., Min, E., Numata, M., Voelker, D. R., Scruggs, A., Petrache, I. & Chu, H. W., 2020, In : Journal of Inflammation Research. 13, p. 175-185 11 p.

Research output: Contribution to journalArticle

Open Access

Optimization of combined measures of airway physiology and cardiovascular hemodynamics in mice

Kopf, K. W., Harral, J. W., Staker, E. A., Summers, M. E., Petrache, I., Kheyfets, V., Irwin, D. C. & Majka, S. M., Jan 1 2020, In : Pulmonary Circulation. 10, 1

Research output: Contribution to journalArticle

Open Access
2019

Bronchoalveolar lavage fluid from copd patients reveals more compounds associated with disease than matched plasma

Halper-Stromberg, E., Gillenwater, L., Cruickshank-Quinn, C., O’neal, W. K., Reisdorph, N., Petrache, I., Zhuang, Y., Labaki, W. W., Curtis, J. L., Wells, J., Rennard, S., Pratte, K. A., Woodruff, P., Stringer, K. A., Kechris, K. & Bowler, R. P., Aug 2019, In : Metabolites. 9, 8, 157.

Research output: Contribution to journalArticle

Open Access

Intravascular heavy chain-modification of hyaluronan during endotoxic shock

Ni, K., Gill, A., Cao, D., Koike, K., Schweitzer, K. S., Garantziotis, S. & Petrache, I., Mar 2019, In : Biochemistry and Biophysics Reports. 17, p. 114-121 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mesenchymal regulation of the microvascular niche in chronic lung diseases

Majka, S. M., Rojas, M., Petrache, I. & Foronjy, R. F., Oct 2019, In : Comprehensive Physiology. 9, 4, p. 1431-1441 11 p.

Research output: Contribution to journalArticle

Open Access

Role of glucosylceramide in lung endothelial cell fate and emphysema

Koike, K., Berdyshev, E. V., Mikosz, A. M., Bronova, I. A., Bronoff, A. S., Jung, J. P., Beatman, E. L., Ni, K., Cao, D., Scruggs, A. K., Serban, K. A. & Petrache, I., Nov 1 2019, In : American journal of respiratory and critical care medicine. 200, 9, p. 1113-1125 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice

Koike, K., Beatman, E. L., Schweitzer, K. S., Justice, M. J., Mikosz, A. M., Ni, K., Clauss, M. A. & Petrache, I., Mar 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 316, 3, p. L558-L566

Research output: Contribution to journalArticle

2 Scopus citations
2018

AMD3100 ameliorates cigarette smoke-induced emphysema-like manifestations in mice

Barwinska, D., Oueini, H., Poirier, C., Albrecht, M. E., Bogatcheva, N. V., Justice, M. J., Saliba, J., Schweitzer, K. S., Broxmeyer, H. E., March, K. L. & Petrache, I., Sep 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 315, 3, p. L382-L386

Research output: Contribution to journalArticle

3 Scopus citations

Bioactive sphingolipids in the pathogenesis of chronic obstructive pulmonary disease

Koike, K., Berdyshev, E. V., Bowler, R. P., Scruggs, A. K., Cao, D., Schweitzer, K. S., Serban, K. A. & Petrache, I., Dec 2018, In : Annals of the American Thoracic Society. 15, p. S249-S252

Research output: Contribution to journalArticle

4 Scopus citations

Cigarette Smoking Impairs Adipose Stromal Cell Vasculogenic Activity and Abrogates Potency to Ameliorate Ischemia

Barwinska, D., Traktuev, D. O., Merfeld-Clauss, S., Cook, T. G., Lu, H., Petrache, I. & March, K. L., Jun 2018, In : STEM CELLS. 36, 6, p. 856-867 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Data Descriptor: A prototypic small molecule database for bronchoalveolar lavage-based metabolomics

Walmsley, S., Cruickshank-Quinn, C., Quinn, K., Zhang, X., Petrache, I., Bowler, R. P., Reisdorph, R. & Reisdorph, N., Apr 17 2018, In : Scientific Data. 5, 180060.

Research output: Contribution to journalArticle

2 Scopus citations

Effects of Household Air Pollution in Malawi and Human Immunodeficiency Virus Status on Respiratory Symptoms and Inflammation, Injury, and Repair Markers

Kim, C., Jary, H., Mortimer, K., Schweitzer, K. S., Curran-Everett, D., Gordon, S. & Petrache, I., Apr 1 2018, In : Annals of the American Thoracic Society. 15, 2, p. S132-S133

Research output: Contribution to journalArticle

Hypoxia upregulates estrogen receptor β in pulmonary artery endothelial cells in α HIF-1a-dependent manner

Frump, A. L., Selej, M., Wood, J. A., Albrecht, M., Yakubov, B., Petrache, I. & Lahm, T., Jul 2018, In : American journal of respiratory cell and molecular biology. 59, 1, p. 114-126 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Impact of HIV infection on α1-antitrypsin in the lung

Stephenson, S. E., Wilson, C. L., Crothers, K., Attia, E. F., Wongtrakool, C., Petrache, I. & Schnapp, L. M., Apr 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 314, 4, p. L583-L592

Research output: Contribution to journalArticle

4 Scopus citations

Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy

Justice, M. J., Bronova, I., Schweitzer, K. S., Poirier, C., Blum, J. S., Berdyshev, E. V. & Petrache, I., 2018, In : Journal of Lipid Research. 59, 4, p. 596-606 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD

Cruickshank-Quinn, C. I., Jacobson, S., Hughes, G., Powell, R. L., Petrache, I., Kechris, K., Bowler, R. & Reisdorph, N., Dec 1 2018, In : Scientific reports. 8, 1, 17132.

Research output: Contribution to journalArticle

13 Scopus citations

Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury

Ni, K., Gill, A., Tseng, V., Mikosz, A. M., Koike, K., Beatman, E. L., Xu, C. Y., Cao, D., Gally, F., Mould, K. J., Serban, K. A., Schweitzer, K. S., March, K. L., Janssen, W. J., Nozik-Grayck, E., Garantziotis, S. & Petrache, I., May 31 2018, In : Respiratory Research. 19, 1, 107.

Research output: Contribution to journalArticle

5 Scopus citations

Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure

Mizumura, K., Justice, M. J., Schweitzer, K. S., Krishnan, S., Bronova, I., Berdyshev, E. V., Hubbard, W. C., Pewzner-Jung, Y., Futerman, A. H., Choi, A. M. K. & Petrache, I., Apr 2018, In : FASEB Journal. 32, 4, p. 1880-1890 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

The Role of IGSF3 in Cell Adhesion, Proliferation, and Cell Migration

Schweitzer, K., Ni, K., Jacobson, S., Bronova, I., Berdyshev, E., Bowler, R. & Petrache, I., Dec 1 2018, In : Annals of the American Thoracic Society. 15, 4, p. S291

Research output: Contribution to journalArticle

2017

Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure

Serban, K. A., Petrusca, D. N., Mikosz, A., Poirier, C., Lockett, A. D., Saint, L., Justice, M. J., Twigg, H. L., Campos, M. A. & Petrache, I., Apr 2017, In : PloS one. 12, 4, e0176073.

Research output: Contribution to journalArticle

13 Scopus citations

An official American thoracic society workshop report: Obesity and metabolism an emerging frontier in lung health and disease

Suratt, B. T., Ubags, N. D. J., Rastogi, D., Tantisira, K. G., Marsland, B. J., Petrache, I., Allen, J. B., Bates, J. H. T., Holguin, F., McCormack, M. C., Michelakis, E. D., Black, S. M., Jain, M., Mora, A. L., Natarajan, V., Miller, Y. I., Fessler, M. B., Birukov, K. G., Summer, R. S. & Shore, S. A., Jun 2017, In : Annals of the American Thoracic Society. 14, 6, p. 1050-1059 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma

Miller, M. A., Danhorn, T., Cruickshank-Quinn, C. I., Leach, S. M., Jacobson, S., Strand, M. J., Reisdorph, N. A., Bowler, R. P., Petrache, I. & Kechris, K., Jun 2017, In : PloS one. 12, 6, e0178281.

Research output: Contribution to journalArticle

11 Scopus citations

High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension

Brown, M. B., Neves, E., Long, G., Graber, J., Gladish, B., Wiseman, A., Owens, M., Fisher, A. J., Presson, R. G., Petrache, I., Kline, J. & Lahm, T., 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 312, 2, p. R197-R210

Research output: Contribution to journalArticle

18 Scopus citations

Metabolomic similarities between bronchoalveolar lavage fluid and plasma in humans and mice

Cruickshank-Quinn, C., Powell, R., Jacobson, S., Kechris, K., Bowler, R. P., Petrache, I. & Reisdorph, N., Dec 1 2017, In : Scientific reports. 7, 1, 5108.

Research output: Contribution to journalArticle

8 Scopus citations

Oncostatin M and TNF-α Induce Alpha-1 Antitrypsin Production in Undifferentiated Adipose Stromal Cells

Ni, K., Umair Mukhtar Mian, M., Meador, C., Gill, A., Barwinska, D., Cao, D., Justice, M. J., Jiang, D., Schaefer, N., Schweitzer, K. S., Chu, H. W., March, K. L. & Petrache, I., Oct 15 2017, In : Stem Cells and Development. 26, 20, p. 1468-1476 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Alpha-1 antitrypsin and lung cell apoptosis

Serban, K. A. & Petrache, I., Apr 1 2016, In : Annals of the American Thoracic Society. 13, p. S146-S149

Research output: Contribution to journalArticle

9 Scopus citations

Alpha-1 antitrypsin investigations using animal models of emphysema

Ni, K., Serban, K. A., Batra, C. & Petrache, I., Aug 1 2016, In : Annals of the American Thoracic Society. 13, p. S311-S316

Research output: Contribution to journalArticle

5 Scopus citations

Ceramide Signaling and Metabolism in Pathophysiological States of the Lung

Petrache, I. & Berdyshev, E. V., Feb 10 2016, In : Annual Review of Physiology. 78, p. 463-480 18 p.

Research output: Contribution to journalArticle

28 Scopus citations

Pulmonary retention of adipose stromal cells following intravenous delivery is markedly altered in the presence of ARDS

Lu, H., Cook, T., Poirier, C., Merfeld-Clauss, S., Petrache, I., March, K. L. & Bogatcheva, N. V., Jan 1 2016, In : Cell Transplantation. 25, 9, p. 1635-1643 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Structural and functional characterization of endothelial microparticles released by cigarette smoke

Serban, K. A., Rezania, S., Petrusca, D. N., Poirier, C., Cao, D., Justice, M. J., Patel, M., Tsvetkova, I., Kamocki, K., Mikosz, A., Schweitzer, K. S., Jacobson, S., Cardoso, A., Carlesso, N., Hubbard, W. C., Kechris, K., Dragnea, B., Berdyshev, E. V., McClintock, J. & Petrache, I., Aug 17 2016, In : Scientific reports. 6, 31596.

Research output: Contribution to journalArticle

39 Scopus citations

Widespread activation of immunity and pro-inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange

Crothers, K., Petrache, I., Wongtrakool, C., Lee, P. J., Schnapp, L. M. & Gharib, S. A., Apr 1 2016, In : Physiological reports. 4, 8, e12756.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Conditioned media from adipose stromal cells limit lipopolysaccharide-induced lung injury, endothelial hyperpermeability and apoptosis

Lu, H., Poirier, C., Cook, T., Traktuev, D. O., Merfeld-Clauss, S., Lease, B., Petrache, I., March, K. L. & Bogatcheva, N. V., Feb 21 2015, In : Journal of Translational Medicine. 13, 1, 67.

Research output: Contribution to journalArticle

15 Scopus citations

Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures

Schweitzer, K. S., Chen, S. X., Law, S., Van Demark, M., Poirier, C., Justice, M. J., Hubbard, W. C., Kim, E. S., Lai, X., Wang, M., Kranz, W. D., Carroll, C. J., Ray, B. D., Bittman, R., Goodpaster, J. & Petrache, I., Jul 15 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 2, p. L175-L187

Research output: Contribution to journalArticle

115 Scopus citations

Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6

Xie, J., Broxmeyer, H. E., Feng, D., Schweitzer, K. S., Yi, R., Cook, T. G., Chitteti, B. R., Barwinska, D., Traktuev, D. O., Van Demark, M. J., Justice, M. J., Ou, X., Srour, E. F., Prockop, D. J., Petrache, I. & March, K. L., Feb 1 2015, In : STEM CELLS. 33, 2, p. 468-478 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Impact of alginate-producing Pseudomonas aeruginosa on alveolar macrophage apoptotic cell clearance

McCaslin, C. A., Petrusca, D. N., Poirier, C., Serban, K. A., Anderson, G. G. & Petrache, I., Jan 1 2015, In : Journal of Cystic Fibrosis. 14, 1, p. 70-77 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Neonatal hyperoxic lung injury favorably alters adult right ventricular remodeling response to chronic hypoxia exposure

Goss, K. N., Cucci, A. R., Fisher, A. J., Albrecht, M., Frump, A., Tursunova, R., Gao, Y., Brown, M. B., Petrache, I., Tepper, R. S., Ahlfeld, S. K. & Lahm, T., Jan 1 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 8, p. L797-L806

Research output: Contribution to journalArticle

20 Scopus citations

Novel assessment of haemodynamic kinetics with acute exercise in a rat model of pulmonary arterial hypertension

Brown, M. B., Chingombe, T. J., Zinn, A. B., Reddy, J. G., Novack, R. A., Cooney, S. A., Fisher, A. J., Presson, R. G., Lahm, T. & Petrache, I., Jun 1 2015, In : Experimental Physiology. 100, 6, p. 742-754 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes

Bowler, R. P., Jacobson, S., Cruickshank, C., Hughes, G. J., Siska, C., Ory, D. S., Petrache, I., Schaffer, J. E., Reisdorph, N. & Kechris, K., Feb 1 2015, In : American journal of respiratory and critical care medicine. 191, 3, p. 275-284 10 p.

Research output: Contribution to journalArticle

60 Scopus citations

Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells

Lockett, A. D., Petrusca, D. N., Justice, M. J., Poirier, C., Serban, K. A., Rush, N. I., Kamocka, M., Predescu, D., Predescu, S. & Petrache, I., Aug 18 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 4, p. L425-L434

Research output: Contribution to journalArticle

7 Scopus citations

Space radiation-associated lung injury in a murine model

Christofidou-Solomidou, M., Pietrofesa, R. A., Arguiri, E., Schweitzer, K. S., Berdyshev, E. V., McCarthy, M., Corbitt, A., Alwood, J. S., Yu, Y., Globus, R. K., Solomides, C. C., Ullrich, R. L. & Petrache, I., Jan 1 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 5, p. L416-L428

Research output: Contribution to journalArticle

28 Scopus citations
2014

Active trafficking of alpha 1 antitrypsin across the lung endothelium

Lockett, A. D., Brown, M. B., Santos-Falcon, N., Rush, N. I., Oueini, H., Oberle, A. J., Bolanis, E., Fragoso, M. A., Petrusca, D. N., Serban, K. A., Schweitzer, K. S., Presson, R. G., Campos, M. & Petrache, I., Apr 17 2014, In : PloS one. 9, 4, e93979.

Research output: Contribution to journalArticle

24 Scopus citations

Cathepsin E promotes pulmonary emphysema via mitochondrial fission

Zhang, X., Shan, P., Homer, R., Zhang, Y., Petrache, I., Mannam, P. & Lee, P. J., Jan 1 2014, In : American Journal of Pathology. 184, 10, p. 2730-2741 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Effects of lipid interactions on model vesicle engulfment by alveolar macrophages

Justice, M. J., Petrusca, D. N., Rogozea, A. L., Williams, J. A., Schweitzer, K. S., Petrache, I., Wassall, S. R. & Petrache, H. I., Feb 4 2014, In : Biophysical journal. 106, 3, p. 598-609 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
22 Scopus citations

Loss of cystic fibrosis transmembrane conductance regulator impairs lung endothelial cell barrier function and increases susceptibility to microvascular damage from cigarette smoke

Brown, M. B., Hunt, W. R., Noe, J. E., Rush, N. I., Schweitzer, K. S., Leece, T. C., Moldobaeva, A., Wagner, E. M., Dudek, S. M., Poirier, C., Presson, R. G., Gulbins, E. & Petrache, I., Jun 2014, In : Pulmonary Circulation. 4, 2, p. 260-268 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

MSPrep-Summarization, normalization and diagnostics for processing of mass spectrometry-based metabolomic data

Hughes, G., Cruickshank-Quinn, C., Reisdorph, R., Lutz, S., Petrache, I., Reisdorph, N., Bowler, R. & Kechris, K., Jan 1 2014, In : Bioinformatics. 30, 1, p. 133-134 2 p.

Research output: Contribution to journalArticle

29 Scopus citations

Overexpression of type VI collagen in neoplastic lung tissues

Voiles, L., Lewis, D. E., Han, L., Lupov, I. P., Lin, T. L., Robertson, M. J., Petrache, I. & Chang, H. C., Nov 1 2014, In : Oncology reports. 32, 5, p. 1897-1904 8 p.

Research output: Contribution to journalArticle

9 Scopus citations