Janice Blum

  • 10992 Citations
  • 44 h-Index
1980 …2019

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2019

Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes

Ocaña, G. J., Sims, E. K., Watkins, R. A., Ragg, S., Mather, K. J., Oram, R. A., Mirmira, R. G., DiMeglio, L. A., Blum, J. S. & Evans-Molina, C., Jan 2019, In : PloS one. 14, 1, e0208456.

Research output: Contribution to journalArticle

2 Scopus citations

Proinsulin secretion is a persistent feature of type 1 diabetes

Sims, E. K., Bahnson, H. T., Nyalwidhe, J., Haataja, L., Davis, A. K., Speake, C., DiMeglio, L. A., Blum, J., Morris, M. A., Mirmira, R. G., Nadler, J., Mastracci, T. L., Marcovina, S., Qian, W. J., Yi, L., Swensen, A. C., Yip-Schneider, M., Schmidt, C. M., Considine, R. V., Arvan, P. & 2 others, Greenbaum, C. J. & Evans-Molina, C., Feb 1 2019, In : Diabetes care. 42, 2, p. 258-264 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
2018

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

Vecchio, F., Lo Buono, N., Stabilini, A., Nigi, L., Dufort, M. J., Geyer, S., Rancoita, P. M., Cugnata, F., Mandelli, A., Valle, A., Leete, P., Mancarella, F., Linsley, P. S., Krogvold, L., Herold, K. C., Larsson, H. E., Richardson, S. J., Morgan, N. G., Dahl-Jørgensen, K., Sebastiani, G. & 82 others, Dotta, F., Bosi, E., Bianconi, E., Bonfanti, R., Bonura, C., De Pellegrin, M., Frontino, G., Grogan, P., Laurenzi, A., Meschi, F., Ragogna, F., Rigamonti, A., Greenbaum, C. J., Atkinson, M., Baidal, D., Becker, D., Bingley, P., Buckner, J., Clements, M., Colman, P., DiMeglio, L., Gitelman, S., Goland, R., Gottlieb, P., Knip, M., Krischer, J., Lernmark, A., Moore, W., Moran, A., Muir, A., Palmer, J., Peakman, M., Philipson, L., Raskin, P., Redondo, M., Rodriguez, H., Russell, W., Spain, L., Schatz, D. A., Sosenko, J., Wentworth, J., Wherrett, D., Wilson, D., Winter, W., Ziegler, A., Anderson, M., Antinozzi, P., Benoist, C., Blum, J., Bourcier, K., Chase, P., Clare-Salzler, M., Clynes, R., Eisenbarth, G., Fathman, C. G., Grave, G., Hering, B., Insel, R., Kaufman, F., Kay, T., Leschek, E., Mahon, J., Marks, J. B., Nanto-Salonen, K., Nepom, G., Orban, T., Parkman, R., Pescovitz, M., Peyman, J., Pugliese, A., Roep, B., Roncarolo, M., Savage, P., Simell, O., Sherwin, R., Siegelman, M., Skyler, J. S., Steck, A., Thomas, J., Trucco, M., Wagner, J. & Battaglia, M., Sep 20 2018, In : JCI Insight. 3, 18, e122146.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: A pilot study

Walline, C. C., Blum, J. S., Linton, T., Mangiacarne, D. & Liangpunsakul, S., Jan 1 2018, In : Journal of Investigative Medicine. 66, 5, p. 953-956 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy

Justice, M. J., Bronova, I., Schweitzer, K. S., Poirier, C., Blum, J. S., Berdyshev, E. V. & Petrache, I., 2018, In : Journal of Lipid Research. 59, 4, p. 596-606 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Melanoma LAMP-2C modulates tumor growth and autophagy

Pérez, L., Sinn, A. L., Sandusky, G. E., Pollok, K. E. & Blum, J. S., Aug 29 2018, In : Frontiers in Cell and Developmental Biology. 6, AUG, 101.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90α

Ocaña, G. J., Pérez, L., Guindon, L., Deffit, S. N., Evans-Molina, C., Thurmond, D. & Blum, J. S., Jun 2017, In : Immunology. 151, 2, p. 198-210 13 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Critical role of PPARγ in myeloid-derived suppressor cellstimulated cancer cell proliferation and metastasis

Zhao, T., Du, H., Blum, J. S. & Yan, C., 2016, In : Oncotarget. 7, 2, p. 1529-1543 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Elevations in the fasting serum Proinsulin-to-C-peptide ratio precede the onset of type 1 diabetes

Sims, E. K., Chaudhry, Z., Watkins, R., Syed, F., Blum, J., Ouyang, F., Perkins, S. M., Mirmira, R. G., Sosenko, J., DiMeglio, L. A. & Evans-Molina, C., Sep 1 2016, In : Diabetes care. 39, 9, p. 1519-1526 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Hypoxia-inducible factor-1α regulates CD55 in airway epithelium

Pandya, P. H., Fisher, A. J., Mickler, E. A., Temm, C. J., Lipking, K. P., Gracon, A., Rothhaar, K., Sandusky, G. E., Murray, M., Pollok, K., Renbarger, J., Blum, J. S., Lahm, T. & Wilkes, D. S., Dec 2016, In : American journal of respiratory cell and molecular biology. 55, 6, p. 889-898 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Immunogenicity of Therapeutic Protein Aggregates

Moussa, E. M., Panchal, J. P., Moorthy, B. S., Blum, J., Joubert, M. K., Narhi, L. O. & Topp, E. M., Feb 1 2016, In : Journal of Pharmaceutical Sciences. 105, 2, p. 417-430 14 p.

Research output: Contribution to journalArticle

163 Scopus citations

LAMP-2C inhibits MHC class II presentation of cytoplasmic antigens by disrupting chaperone-mediated autophagy

Pérez, L., McLetchie, S., Gardiner, G. J., Deffit, S. N., Zhou, D. & Blum, J. S., Mar 15 2016, In : Journal of Immunology. 196, 6, p. 2457-2465 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Physical Characterization and Innate Immunogenicity of Aggregated Intravenous Immunoglobulin (IGIV) in an In Vitro Cell-Based Model

Moussa, E. M., Kotarek, J., Blum, J. S., Marszal, E. & Topp, E. M., Jul 1 2016, In : Pharmaceutical Research. 33, 7, p. 1736-1751 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes

Watkins, R. A., Evans-Molina, C., Terrell, J. K., Day, K. H., Guindon, L., Restrepo, I. A., Mirmira, R., Blum, J. & DiMeglio, L., Feb 1 2016, In : Translational Research. 168, p. 96-106.e1

Research output: Contribution to journalArticle

28 Scopus citations

The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positivity and type 1 diabetes among TrialNet Pathway to Prevention participants

Meah, F. A., DiMeglio, L. A., Greenbaum, C. J., Blum, J. S., Sosenko, J. M., Pugliese, A., Geyer, S., Xu, P. & Evans-Molina, C., Jun 1 2016, In : Diabetologia. 59, 6, p. 1186-1195 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Elevation of c-MYC disrupts HLA class II-mediated immune recognition of human B cell tumors

God, J. M., Cameron, C., Figueroa, J., Amria, S., Hossain, A., Kempkes, B., Bornkamm, G. W., Stuart, R. K., Blum, J. S. & Haque, A., Feb 15 2015, In : Journal of Immunology. 194, 4, p. 1434-1445 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Elevations in circulating methylated and unmethylated preproinsulin DNA in new-onset type 1 diabetes

Fisher, M. M., Watkins, R. A., Blum, J., Evans-Molina, C., Chalasani, N., Dimeglio, L. A., Mather, K. J., Tersey, S. A. & Mirmira, R. G., Nov 2015, In : Diabetes. 64, 11, p. 3867-3872 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Hyper-responsive Toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts

Mcletchie, S., Volpp, B. D., Dinauer, M. C. & Blum, J. S., Dec 1 2015, In : Immunology. 146, 4, p. 595-606 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Literature-based discovery of salivary biomarkers for type 2 diabetes mellitus

Srinivasan, M., Blackburn, C., Mohamed, M., Sivagami, A. V. & Blum, J., May 14 2015, In : Biomarker Insights. 10, p. 39-45 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Literature-based discovery of salivary biomarkers for type 2 diabetes mellitus

Srinivasan, M., Blackburn, C., Mohamed, M., Sivagami, A. V. & Blum, J., May 14 2015, In : Biomarker Insights. 10, p. 39-45 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Macronutrient deprivation modulates antigen trafficking and immune recognition through HSC70 accessibility

Deffit, S. N. & Blum, J. S., Feb 15 2015, In : Journal of Immunology. 194, 4, p. 1446-1453 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Pyruvate protects pathogenic spirochetes from H2O2 killing

Troxel, B., Zhang, J. J., Bourret, T. J., Zeng, M. Y., Blum, J., Gherardini, F., Hassan, H. M. & Yang, X. F., Jan 2 2014, In : PloS one. 9, 1, e84625.

Research output: Contribution to journalArticle

25 Scopus citations

Soypeptide lunasin in cytokine immunotherapy for lymphoma

Chang, H. C., Lewis, D., Tung, C. Y., Han, L., Henriquez, S. M. P., Voiles, L., Lupov, I. P., Pelloso, D., Sinn, A. L., Pollok, K. E., De Lumen, B. O., Li, F., Blum, J. S., Srivastava, S. & Robertson, M. J., Mar 2014, In : Cancer Immunology, Immunotherapy. 63, 3, p. 283-295 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy

Walline, C. C., Deffit, S. N., Wang, N., Guindon, L. M., Crotzer, V. L., Liu, J., Hollister, K., Eisenlohr, L. C., Brutkiewicz, R. R., Kaplan, M. H. & Blum, J. S., Apr 2014, In : Immunology. 141, 4, p. 531-539 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Allergic Airway Disease in Mice Alters T and B Cell Responses during an Acute Respiratory Poxvirus Infection

Walline, C. C., Sehra, S., Fisher, A. J., Guindon, L. M., Kratzke, I. M., Montgomery, J. B., Lipking, K. P., Glosson, N. L., Benson, H. L., Sandusky, G. E., Wilkes, D. S., Brutkiewicz, R. R., Kaplan, M. H. & Blum, J. S., Apr 19 2013, In : PloS one. 8, 4, e62222.

Research output: Contribution to journalArticle

5 Scopus citations

Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation

Pham, D., Yu, Q., Walline, C. C., Muthukrishnan, R., Blum, J. S. & Kaplan, M. H., Jul 15 2013, In : Journal of Immunology. 191, 2, p. 902-911 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
17 Scopus citations
2012

Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells

Crotzer, V. L., Matute, J. D., Arias, A. A., Zhao, H., Quilliam, L. A., Dinauer, M. C. & Blum, J. S., Oct 15 2012, In : Journal of Immunology. 189, 8, p. 3800-3804 5 p.

Research output: Contribution to journalArticle

31 Scopus citations

Donor lung derived myeloid and plasmacytoid dendritic cells differentially regulate T cell proliferation and cytokine production

Benson, H. L., Suzuki, H., Lott, J., Fisher, A. J., Walline, C., Heidler, K. M., Brutkiewicz, R., Blum, J. S. & Wilkes, D. S., Mar 20 2012, In : Respiratory Research. 13, 25.

Research output: Contribution to journalArticle

4 Scopus citations

Inhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis

Wu, L., Yan, C., Czader, M., Foreman, O., Blum, J. S., Kapur, R. & Du, H., Jan 5 2012, In : Blood. 119, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

58 Scopus citations
2011
27 Scopus citations

STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis

Kaplan, M. H., Glosson, N. L., Stritesky, G. L., Yeh, N., Kinzfogl, J., Rohrabaugh, S. L., Goswami, R., Pham, D., Levy, D. E., Brutkiewicz, R. R., Blum, J. S., Cooper, S., Hangoc, G. & Broxmeyer, H. E., Jun 9 2011, In : Blood. 117, 23, p. 6198-6201 4 p.

Research output: Contribution to journalArticle

26 Scopus citations
2010

Diversifying biomedical training: A synergistic intervention

Gibau, G. S., Foertsch, J., Blum, J., Brutkiewicz, R., Queener, S., Roman, A., Rhodes, S., Sturek, M., Wilkes, D. & Broxmeyer, H., 2010, In : Journal of Women and Minorities in Science and Engineering. 16, 3, p. 215-235 21 p.

Research output: Contribution to journalArticle

10 Scopus citations

LAMP-2-deficient human B cells exhibit altered MHC class II presentation of exogenous antigens

Crotzer, V. L., Glosson, N., Zhou, D., Nishino, I. & Blum, J. S., Nov 2010, In : Immunology. 131, 3, p. 318-330 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype

Yeh, N., Glosson, N. L., Wang, N., Guindon, L., McKinley, C., Hamada, H., Li, Q., Dutton, R. W., Shrikant, P., Zhou, B., Brutkiewicz, R. R., Blum, J. S. & Kaplan, M. H., Aug 15 2010, In : Journal of Immunology. 185, 4, p. 2089-2098 10 p.

Research output: Contribution to journalArticle

40 Scopus citations
2009

Diminished intracellular invariant chain expression after vaccinia virus infection

Wang, N., Weber, E. & Blum, J. S., Aug 1 2009, In : Journal of Immunology. 183, 3, p. 1542-1550 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

HSP90α and HSP90β isoforms selectively modulate MHC class II antigen presentation in B cells

Houlihan, J. L., Metzler, J. J. & Blum, J. S., Jun 15 2009, In : Journal of Immunology. 182, 12, p. 7451-7458 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Type B insulin resistance developing during interferon-α therapy

Daniel, A. L., Houlihan, J. L., Blum, J. S. & Walsh, J. P., Mar 2009, In : Endocrine Practice. 15, 2, p. 153-157 5 p.

Research output: Contribution to journalArticle

9 Scopus citations
2008

HLA-DM negatively regulates HLA-DR4-restricted collagen pathogenic peptide presentation and T cell recognition

Amria, S., Hajiaghamohseni, L. M., Harbeson, C., Zhao, D., Goldstein, O., Blum, J. S. & Haque, A., Jul 2008, In : European Journal of Immunology. 38, 7, p. 1961-1970 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons

Mann, B. A., Huang, J. H., Li, P., Chang, H. C., Slee, R. B., O'Sullivan, A., Mathur, A., Yeh, N., Klemsz, M. J., Brutkiewicz, R. R., Blum, J. S. & Kaplan, M. H., Jun 2008, In : Journal of Interferon and Cytokine Research. 28, 6, p. 367-379 13 p.

Research output: Contribution to journalArticle

44 Scopus citations
2007

Invariant chain modulates HLA class II protein recycling and peptide presentation in nonprofessional antigen presenting cells

Haque, A., Hajiaghamohseni, L. M., Li, P., Toomy, K. & Blum, J. S., Sep 1 2007, In : Cellular Immunology. 249, 1, p. 20-29 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Suppression of immune responses in collagen-induced arthritis by a rationally designed CD80-binding peptide agent

Srinivasan, M., Eri, R., Zunt, S. L., Summerlin, D. J., Brand, D. D. & Blum, J. S., Feb 2007, In : Arthritis and Rheumatism. 56, 2, p. 498-508 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II

Yao, Y., Li, P., Singh, P., Thiele, A. T., Wilkes, D. S., Renukaradhya, G. J., Brutkiewicz, R. R., Travers, J. B., Luker, G. D., Hong, S. C., Blum, J. S. & Chang, C. H., Apr 1 2007, In : Cellular Immunology. 246, 2, p. 92-102 11 p.

Research output: Contribution to journalArticle

33 Scopus citations
2006

Anti-type V collagen lymphocytes that express IL-17 and IL-23 induce rejection pathology in fresh and well-healed lung transplants

Yoshida, S., Haque, A., Mizobuchi, T., Iwata, T., Chiyo, M., Webb, T. J., Baldridge, L. A., Heidler, K. M., Cummings, O. W., Fujisawa, T., Blum, J. S., Brand, D. D. & Wilkes, D. S., Apr 2006, In : American Journal of Transplantation. 6, 4, p. 724-735 12 p.

Research output: Contribution to journalArticle

142 Scopus citations

Cutting edge: Rho activation and actin polarization are dependent on plexin-A1 in dendritic cells

Eun, S. Y., O'Connor, B. P., Wong, A. W., Van Deventer, H. W., Taxman, D. J., Reed, W., Li, P., Blum, J. S., McKinnon, K. P. & Ting, J. P. Y., Oct 1 2006, In : Journal of Immunology. 177, 7, p. 4271-4275 5 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer

Srirangam, A., Mitra, R., Wang, M., Gorski, J. C., Badve, S., Baldridge, L. A., Hamilton, J., Kishimoto, H., Hawes, J., Li, L., Orschell, C. M., Srour, E. F., Blum, J. S., Donner, D., Sledge, G. W., Nakshatri, H. & Potter, D. A., Mar 15 2006, In : Clinical Cancer Research. 12, 6, p. 1883-1896 14 p.

Research output: Contribution to journalArticle

72 Scopus citations
2005

CD80 binding polyproline helical peptide inhibits T cell activation

Srinivasan, M., Lu, D., Eri, R., Brand, D. D., Haque, A. & Blum, J. S., Mar 18 2005, In : Journal of Biological Chemistry. 280, 11, p. 10149-10155 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Disruption of MHC class II-restricted antigen presentation by vaccinia virus

Li, P., Wang, N., Zhou, D., Yee, C. S. K., Chang, C. H., Brutkiewicz, R. R. & Blum, J. S., Nov 15 2005, In : Journal of Immunology. 175, 10, p. 6481-6488 8 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens

Zhou, D., Li, P., Lin, Y., Lott, J. M., Hislop, A. D., Canaday, D. H., Brutkiewicz, R. R. & Blum, J. S., May 1 2005, In : Immunity. 22, 5, p. 571-581 11 p.

Research output: Contribution to journalArticle

216 Scopus citations
24 Scopus citations