Janice Froehlich

  • 2479 Citations
  • 29 h-Index
1976 …2018
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Publications 1976 2018

  • 2479 Citations
  • 29 h-Index
  • 62 Article
  • 1 Chapter
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Article
2018
3 Citations (Scopus)

Co-Administration of Low-Dose Naltrexone and Bupropion Reduces Alcohol Drinking in Alcohol-Preferring (P) Rats

Nicholson, E. R., Dilley, J. E. & Froehlich, J., Jan 1 2018, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Bupropion
Naltrexone
Alcohol Drinking
Rats
Alcohols
2017
5 Citations (Scopus)

A Combination of Naltrexone + Varenicline Retards the Expression of a Genetic Predisposition Toward High Alcohol Drinking

Froehlich, J., Fischer, S. M., Nicholson, E. R., Dilley, J. E., Filosa, N. J., Smith, T. N. & Rademacher, L. C., 2017, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Naltrexone
Genetic Predisposition to Disease
Alcohol Drinking
Alcohols
Drug therapy
1 Citation (Scopus)

Alcohol Drinking and Blood Alcohol Concentration Revisited

Dilley, J. E., Nicholson, E. R., Fischer, S. M., Zimmer, R. & Froehlich, J., Jan 1 2017, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Alcohol Drinking
Blood
Alcohols
Blood Alcohol Content
Rats
10 Citations (Scopus)

Prazosin Prevents Increased Anxiety Behavior That Occurs in Response to Stress During Alcohol Deprivations

Rasmussen, D. D., Kincaid, C. L. & Froehlich, J., Jan 1 2017, In : Alcohol and alcoholism (Oxford, Oxfordshire). 52, 1, p. 5-11 7 p.

Research output: Contribution to journalArticle

Prazosin
Anxiety
Alcohols
Alcohol Drinking
Rats
2 Citations (Scopus)

The Effects of Long-Term Varenicline Administration on Ethanol and Sucrose Seeking and Self-Administration in Male P Rats

Czachowski, C. L., Froehlich, J. & Delory, M., Jan 1 2017, (Accepted/In press) In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Self Administration
Sucrose
Rats
Ethanol
Therapeutics
8 Citations (Scopus)

Varenicline Reduces Alcohol Intake During Repeated Cycles of Alcohol Reaccess Following Deprivation in Alcohol-Preferring (P) Rats

Froehlich, J., Nicholson, E. R., Dilley, J. E., Filosa, N. J., Rademacher, L. C. & Smith, T. N., Aug 1 2017, In : Alcoholism: Clinical and Experimental Research. 41, 8, p. 1510-1517 8 p.

Research output: Contribution to journalArticle

Rats
Alcohols
Varenicline
Alcohol Abstinence
Alcohol Drinking
2016
9 Citations (Scopus)

Combining Varenicline (Chantix) with Naltrexone Decreases Alcohol Drinking More Effectively Than Does Either Drug Alone in a Rodent Model of Alcoholism

Froehlich, J., Fischer, S. M., Dilley, J. E., Nicholson, E. R., Smith, T. N., Filosa, N. J. & Rademacher, L. C., Sep 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 9, p. 1961-1970 10 p.

Research output: Contribution to journalArticle

Naltrexone
Alcohol Drinking
Alcoholism
Rodentia
Alcohols
2015
10 Citations (Scopus)
Naltrexone
Prazosin
Alcohol Drinking
Alcoholism
Rats
16 Citations (Scopus)

Prazosin Reduces Alcohol Intake in an Animal Model of Alcohol Relapse

Froehlich, J., Hausauer, B., Fischer, S., Wise, B. & Rasmussen, D. D., Aug 1 2015, In : Alcoholism: Clinical and Experimental Research. 39, 8, p. 1538-1546 9 p.

Research output: Contribution to journalArticle

Prazosin
Animals
Animal Models
Alcohols
Recurrence
2014
18 Citations (Scopus)
Adrenergic Antagonists
Prazosin
Propranolol
Alcohol Drinking
Alcohols
10 Citations (Scopus)

The α2-adrenergic receptor agonist, clonidine, reduces alcohol drinking in alcohol-preferring (P) rats

Rasmussen, D. D., Alexander, L., Malone, J., Federoff, D. & Froehlich, J., Sep 1 2014, In : Alcohol. 48, 6, p. 543-549 7 p.

Research output: Contribution to journalArticle

Adrenergic Agonists
Clonidine
Alcohol Drinking
Rats
alcohol
2013
30 Citations (Scopus)

Combining naltrexone and prazosin in a single oral medication decreases alcohol drinking more effectively than does either drug alone

Froehlich, J., Hausauer, B. J. & Rasmussen, D. D., Oct 2013, In : Alcoholism: Clinical and Experimental Research. 37, 10, p. 1763-1770 8 p.

Research output: Contribution to journalArticle

Naltrexone
Prazosin
Alcohol Drinking
Alcohols
Pharmaceutical Preparations
25 Citations (Scopus)

Prazosin reduces alcohol drinking throughout prolonged treatment and blocks the initiation of drinking in rats selectively bred for high alcohol intake

Froehlich, J., Hausauer, B. J., Federoff, D. L., Fischer, S. M. & Rasmussen, D. D., Sep 2013, In : Alcoholism: Clinical and Experimental Research. 37, 9, p. 1552-1560 9 p.

Research output: Contribution to journalArticle

Prazosin
Alcohol Drinking
Drinking
Rats
Alcohols
2012
29 Citations (Scopus)

Effects of Prazosin, an α1-Adrenergic Receptor Antagonist, on the Seeking and Intake of Alcohol and Sucrose in Alcohol-Preferring (P) Rats

Verplaetse, T. L., Rasmussen, D. D., Froehlich, J. & Czachowski, C. L., May 2012, In : Alcoholism: Clinical and Experimental Research. 36, 5, p. 881-886 6 p.

Research output: Contribution to journalArticle

Adrenergic Antagonists
Prazosin
Sucrose
Rats
Alcohols
2011
13 Citations (Scopus)

Alcohol Induces Liver Neoplasia in a Novel Alcohol-Preferring Rat Model

Yip-Schneider, M., Doyle, C. J., Mckillop, I. H., Wentz, S. C., Brandon-Warner, E., Matos, J. M., Sandrasegaran, K., Saxena, R., Hennig, M. E., Wu, H., Waters, J. A., Klein, P. J., Froehlich, J. & Schmidt, C., Dec 2011, In : Alcoholism: Clinical and Experimental Research. 35, 12, p. 2216-2225 10 p.

Research output: Contribution to journalArticle

Liver
Rats
Alcohols
Water
Neoplasms
4 Citations (Scopus)

Imaging of alcohol-induced dopamine release in rats: Preliminary findings with [11C]raclopride PET

Sullivan, J. M., Risacher, S. L., Normandin, M. D., Yoder, K., Froehlich, J. & Morris, E. D., Sep 2011, In : Synapse. 65, 9, p. 929-937 9 p.

Research output: Contribution to journalArticle

Raclopride
Positron-Emission Tomography
Dopamine
Alcohols
Corpus Striatum
2010
8 Citations (Scopus)

What aspects of human alcohol use disorders can be modeled using selectively bred rat lines

Froehlich, J., Jun 2010, In : Substance Use and Misuse. 45, 11, p. 1727-1741 15 p.

Research output: Contribution to journalArticle

alcohol
Alcohols
Alcohol Drinking
Alcoholism
tolerance
2009
7 Citations (Scopus)

Effects of forced alcohol drinking on alcohol-water choice in three pairs of rat lines selectively bred for differences in alcohol preference

Timberlake, W., Leffel, J. K., Chester, J. A. & Froehlich, J., Mar 2009, In : Alcohol. 43, 2, p. 105-118 14 p.

Research output: Contribution to journalArticle

Alcohol Drinking
Rats
alcohol
Alcohols
water
51 Citations (Scopus)

The α1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats

Rasmussen, D. D., Alexander, L. L., Raskind, M. A. & Froehlich, J., Feb 2009, In : Alcoholism: Clinical and Experimental Research. 33, 2, p. 264-272 9 p.

Research output: Contribution to journalArticle

Adrenergic Antagonists
Prazosin
Alcohol Drinking
Rats
Alcohols
2006
15 Citations (Scopus)

Decreased reward during acute alcohol withdrawal in rats selectively bred for low alcohol drinking

Chester, J. A., Rausch, E. J., June, H. L. & Froehlich, J., Apr 2006, In : Alcohol. 38, 3, p. 165-172 8 p.

Research output: Contribution to journalArticle

Reward
Alcohol Drinking
withdrawal
reward
Rats
2005
17 Citations (Scopus)
Acoustics
Alcohol Drinking
Rats
Alcohols
Water
36 Citations (Scopus)

NtPET: A new application of PET Imaging for characterizing the kinetics of endogenous neurotransmitter release

Morris, E. D., Yoder, K., Wang, C., Normandin, M. D., Zheng, Q-H., Mock, B., Muzic, R. F. & Froehlich, J., Oct 2005, In : Molecular Imaging. 4, 4, p. 473-489 17 p.

Research output: Contribution to journalArticle

Neurotransmitter Agents
Dopamine
Imaging techniques
Kinetics
Dopamine D3 Receptors
2004
31 Citations (Scopus)
Genetic Predisposition to Disease
Acoustics
Alcohol Drinking
Rats
Alcohols
62 Citations (Scopus)

Effects of Stress on Alcohol Consumption in Rats Selectively Bred for High or Low Alcohol Drinking

Chester, J. A., Blose, A. M., Zweifel, M. & Froehlich, J., Mar 2004, In : Alcoholism: Clinical and Experimental Research. 28, 3, p. 385-393 9 p.

Research output: Contribution to journalArticle

Alcohol Drinking
Rats
Alcohols
Nylons
Genetic Predisposition to Disease
42 Citations (Scopus)
Rats
Alcohols
Water
Acoustics
Alcohol Drinking
5 Citations (Scopus)

Pain Thresholds in Alcohol Preferring and Non-preferring Rats: Diurnal and Repeated Trial Line Differences

Kimpel, M. W., Brown, M. M. & Froehlich, J., Dec 2003, In : Alcoholism: Clinical and Experimental Research. 27, 12, p. 1921-1928 8 p.

Research output: Contribution to journalArticle

Pain Threshold
Rats
Alcohols
Light
Tail
29 Citations (Scopus)

Preclinical and clinical studies on naltrexone: What have they taught each other?

Froehlich, J., O'Malley, S., Hyytiä, P., Davidson, D. & Farren, C., Mar 1 2003, In : Alcoholism: Clinical and Experimental Research. 27, 3, p. 533-539 7 p.

Research output: Contribution to journalArticle

Naltrexone
Alcohols
Alcoholism
Alcohol Drinking
Aptitude
2002
28 Citations (Scopus)
Rats
Alcohols
Association reactions
Phenotype
Alcohol Drinking
2001
15 Citations (Scopus)

Effects of acamprosate on sensitization to the locomotor-stimulant effects of alcohol in mice selectively bred for high and low alcohol preference

Chester, J. A., Grahame, N. J., Li, T. K., Lumeng, L. & Froehlich, J., 2001, In : Behavioural Pharmacology. 12, 6-7, p. 535-543 9 p.

Research output: Contribution to journalArticle

Alcohols
Aptitude
Locomotion
acamprosate
Drug-Seeking Behavior
14 Citations (Scopus)

Induction of steady-state blood alcohol levels: Application to the study of within-session alcohol tolerance in rats

Froehlich, J., Stewart, R. B., Li, T. K., Mosemiller, A. K., McCullough, D. E., Ho, M. C. & Kisner, J. M., 2001, In : Alcoholism: Clinical and Experimental Research. 25, 3, p. 370-376 7 p.

Research output: Contribution to journalArticle

Rats
Blood
Alcohols
Clamping devices
Blood Alcohol Content
2000
58 Citations (Scopus)

Analysis of heritability of hormonal responses to alcohol in twins: Beta-endorphin as a potential biomarker of genetic risk for alcoholism

Froehlich, J., Zink, R. W., Li, T. K. & Christian, J. C., Mar 2000, In : Alcoholism: Clinical and Experimental Research. 24, 3, p. 265-277 13 p.

Research output: Contribution to journalArticle

beta-Endorphin
Biomarkers
Alcoholism
Alcohols
Hormones
24 Citations (Scopus)

Naltrexone and alcohol drinking in mice lacking β-endorphin by site-directed mutagenesis

Grahame, N. J., Mosemiller, A. K., Low, M. J. & Froehlich, J., 2000, In : Pharmacology Biochemistry and Behavior. 67, 4, p. 759-766 8 p.

Research output: Contribution to journalArticle

Endorphins
Mutagenesis
Naltrexone
Site-Directed Mutagenesis
Alcohol Drinking
1999
20 Citations (Scopus)

Naloxone retards the expression of a genetic predisposition toward alcohol drinking

Badia-Elder, N. E., Mosemiller, A. K., Elder, R. L. & Froehlich, J., 1999, In : Psychopharmacology. 144, 3, p. 205-212 8 p.

Research output: Contribution to journalArticle

Genetic Predisposition to Disease
Naloxone
Alcohol Drinking
Alcohols
Food
64 Citations (Scopus)

The δ2-opioid receptor antagonist naltriben reduces motivated responding for ethanol

June, H. L., McCane, S. R., Zink, R. W., Portoghese, P. S., Li, T. K. & Froehlich, J., 1999, In : Psychopharmacology. 147, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Saccharin
Ethanol
Naloxone
Alcohols
1998
59 Citations (Scopus)

Contribution of the opioid system to alcohol aversion and alcohol drinking behavior

Froehlich, J., Badia-Elder, N. E., Zink, R. W., McCullough, D. E. & Portoghese, P. S., 1998, In : Journal of Pharmacology and Experimental Therapeutics. 287, 1, p. 284-292 9 p.

Research output: Contribution to journalArticle

Drinking Behavior
Alcohol Drinking
naltrindole
Opioid Analgesics
Alcohols
91 Citations (Scopus)

Effect of Mu opioid receptor blockade on alcohol intake in rats bred for high alcohol drinking

Krishnan-Sarin, S., Wand, G. S., Li, X. W., Portoghese, P. S. & Froehlich, J., Mar 1998, In : Pharmacology Biochemistry and Behavior. 59, 3, p. 627-635 9 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Alcohol Drinking
Rats
beta-funaltrexamine
Alcohols
60 Citations (Scopus)

Enhanced sensitivity of the nucleus accumbens proenkephalin system to alcohol in rats selectively bred for alcohol preference

Li, X. W., Li, T. K. & Froehlich, J., May 25 1998, In : Brain Research. 794, 1, p. 35-47 13 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
Alcohols
Messenger RNA
Alcohol Drinking
Drinking Behavior
22 Citations (Scopus)
Paraventricular Hypothalamic Nucleus
Vasopressins
Alcohol Drinking
Arginine Vasopressin
Rats
1997
33 Citations (Scopus)

Adenylyl cyclase signal transduction and alcohol-induced sedation

Froehlich, J. & Wand, G. S., Dec 1997, In : Pharmacology Biochemistry and Behavior. 58, 4, p. 1021-1030 10 p.

Research output: Contribution to journalArticle

Signal transduction
Adenylyl Cyclases
Signal Transduction
Rats
Alcohols
22 Citations (Scopus)

Comparison of rats selectively bred for high and low ethanol intake in a forced-swim-test model of depression: Effects of desipramine

Godfrey, C. D., Froehlich, J., Stewart, R. B., Li, T. K. & Murphy, J. M., Oct 1997, In : Physiology and Behavior. 62, 4, p. 729-733 5 p.

Research output: Contribution to journalArticle

Desipramine
Ethanol
Alcohol Drinking
Depression
Alcohols
51 Citations (Scopus)

Opioid peptides

Froehlich, J., 1997, In : Alcohol Research and Health. 21, 2, p. 132-136 5 p.

Research output: Contribution to journalArticle

Opioid Peptides
Alcohols
Alcohol Drinking
Neurotransmitter Agents
Neurons
17 Citations (Scopus)

Quantitative comparison of mu opioid receptor mRNA in selected CNS regions of alcohol naive rats selectively bred for high and low alcohol drinking

Gong, J., Li, X. W., Lai, Z., Froehlich, J. & Yu, L., May 9 1997, In : Neuroscience Letters. 227, 1, p. 9-12 4 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Alcohol Drinking
Central Nervous System
Alcohols
Messenger RNA
1996
80 Citations (Scopus)

Genetic differences in tolerance and sensitization to the sedative/hypnotic effects of alcohol

Kurtz, D. L., Stewart, R. B., Zweifel, M., Li, T. K. & Froehlich, J., Mar 1996, In : Pharmacology Biochemistry and Behavior. 53, 3, p. 585-591 7 p.

Research output: Contribution to journalArticle

Hypnotics and Sedatives
Alcohols
Rats
Righting Reflex
Injections
50 Citations (Scopus)

The neurobiology of ethanol-opioid interactions in ethanol reinforcement

Froehlich, J. & Wand, G., 1996, In : Alcoholism: Clinical and Experimental Research. 20, 8 SUPPL.

Research output: Contribution to journalArticle

delta Opioid Receptor
Opioid Peptides
Neurobiology
Alcohol Drinking
Opioid Analgesics
1995
70 Citations (Scopus)

Genetic factors in alcohol self-administration

Froehlich, J., 1995, In : Journal of Clinical Psychiatry. 56, 9, p. 15-23 9 p.

Research output: Contribution to journalArticle

Self Administration
Alcohol Drinking
Alcohols
Drinking Behavior
Opioid Analgesics
95 Citations (Scopus)

The delta2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference

Krishnan-Sarin, S., Portoghese, P. S., Li, T. K. & Froehlich, J., 1995, In : Pharmacology Biochemistry and Behavior. 52, 1, p. 153-159 7 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Rats
Alcohols
naltrindole
Opioid Receptors
120 Citations (Scopus)

The delta opioid receptor antagonist naltrindole attenuates both alcohol and saccharin intake in rats selectively bred for alcohol preference

Krishnan-Sarin, S., Jing, S. L., Kurtz, D. L., Zweifel, M., Portoghese, P. S., Li, T. K. & Froehlich, J., Jul 1995, In : Psychopharmacology. 120, 2, p. 177-185 9 p.

Research output: Contribution to journalArticle

naltrindole
Saccharin
delta Opioid Receptor
Narcotic Antagonists
Alcohols
1994
67 Citations (Scopus)

Opioid involvement in alcohol drinking

Froehlich, J. & Li, T. K., 1994, In : Annals of the New York Academy of Sciences. 739, p. 156-167 12 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Alcohol Drinking
Opioid Analgesics
Alcohols
Alcoholism
1993
58 Citations (Scopus)
Opioid Peptides
Alcoholism
Narcotic Antagonists
Alcohols
Alcohol Drinking