Jennifer Wessel

  • 1874 Citations
  • 22 h-Index
20042020

Research output per year

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Publications

2020

Barriers to Weight Management among Overweight and Obese Firefighters

Muegge, C. M., Zollinger, T. W., Song, Y., Wessel, J., Monahan, P. O. & Moffatt, S. M., Jan 1 2020, In : Journal of Occupational and Environmental Medicine. 62, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

2019

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Broad Genomics Platform, DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES & AMP-T2D-GENES, Jun 6 2019, In : Nature. 570, 7759, p. 71-76 6 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program

TOPMed Diabetes Working Group, TOPMed Hematology Working Group, TOPMed Hemostasis Working Group & National Heart, Lung, and Blood Institute TOPMed Consortium, Oct 3 2019, In : American Journal of Human Genetics. 105, 4, p. 706-718 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Maternal lipid profile differs by gestational diabetes physiologic subtype

Layton, J., Powe, C., Allard, C., Battista, M. C., Doyon, M., Bouchard, L., Perron, P., Wessel, J. & Hivert, M. F., Feb 2019, In : Metabolism: Clinical and Experimental. 91, p. 39-42 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct & ReproGen Consortium, Mar 1 2019, In : Nature genetics. 51, 3, p. 452-469 18 p.

Research output: Contribution to journalArticle

17 Scopus citations

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x)

CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC-InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators & Understanding Society Scientific Group, Jul 1 2019, In : Nature genetics. 51, 7, p. 1191-1192 2 p.

Research output: Contribution to journalComment/debate

Open Access

The Continuing Evolution of Precision Health in Type 2 Diabetes: Achievements and Challenges

Lin, Y. & Wessel, J., Apr 1 2019, In : Current Diabetes Reports. 19, 4, 16.

Research output: Contribution to journalReview article

1 Scopus citations
2018

Excess mortality among Indiana firefighters, 1985-2013

Muegge, C. M., Zollinger, T., Song, Y., Wessel, J., Monahan, P. O. & Moffatt, S. M., Dec 1 2018, In : American Journal of Industrial Medicine. 61, 12, p. 961-967 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 379 others, Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Böger, C. A., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Cook, J. P., Corley, J., Corominas Galbany, J., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Angelantonio, E., Drenos, F., Du, M., Dubé, M. P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A. E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H. J., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, A. R., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J. H., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimäki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K. H., Lin, L. A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, C. T., Liu, D. J., Liu, Y., Lo, K. S., Lophatananon, A., Lotery, A. J., Loukola, A., Luan, JA., Lubitz, S. A., Lyytikäinen, L. P., Männistö, S., Marenne, G., Mazul, A. L., McCarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Olde Loohuis, L. M., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Polderman, T. J., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renström, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H. H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J. C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., Van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Velez Edwards, D. R., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Völker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Waterworth, D. M., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., Jan 1 2018, In : Nature genetics. 50, 1, p. 26-35 10 p.

Research output: Contribution to journalArticle

90 Scopus citations

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article

ExomeBP Consortium, MAGIC Consortium & GIANT Consortium, Apr 1 2018, In : Nature genetics. 50, 4, p. 559-571 13 p.

Research output: Contribution to journalArticle

77 Scopus citations
5 Scopus citations
2017

A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk

Manning, A., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., Grarup, N., Rivas, M. A., Mahajan, A., Locke, A. E., Cingolani, P., Pers, T. H., Viñuela, A., Brown, A. A., Wu, Y., Flannick, J., Fuchsberger, C., Gamazon, E. R., Gaulton, K. J., Im, H. K. & 243 others, Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimäki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B. R., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., Depristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., de Angelis, M. H., Maguire, J., Neale, B. M., Poplin, R., Purcell, S., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., Varga, T. V., Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Hale, D. E., Fowler, S. P., Arya, R., Defronzo, R. A., Abboud, H. E., Syvänen, A. C., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Mägi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Müller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S. T., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J. Y., Han, B. G., Käräjämäki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., E Mel Ander, O. L., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., U, J. L., Khor, C. C., Chia, K. S., Lim, W. Y., Cheng, C. Y., Chan, E., Shyong Tai, E., Aung, T., Linneberg, A., Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Na Kravi C, J., Jørgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Kat, K. H., Farmer, A. J., Frayling, T. M., O’rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stan?cáková, A., Barroso, I., Bharadwaj, D., Chan, J., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Antero Kesaniemi, Y., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jørgensen, T., Hansen, T., Pedersen, O., Kuusisto, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M., Jul 1 2017, In : Diabetes. 66, 7, p. 2019-2032 14 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya

Temu, T. M., Lane, K. A., Shen, C., Ng’ang’a, L., Akwanalo, C. O., Chen, P. S., Emonyi, W., Heckbert, S. R., Koech, M. M., Manji, I., Vatta, M., Velazquez, E. J., Wessel, J., Kimaiyo, S., Inui, T. S. & Bloomfield, G. S., Sep 2017, In : PloS one. 12, 9, e0185204.

Research output: Contribution to journalArticle

6 Scopus citations

Exome-wide association study of plasma lipids in >300,000 individuals

Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Angelantonio, E. DI., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 207 others, Boehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M. P., Ebeling, T., Eiriksdottir, G., Esko, T., Farmaki, A. E., Feitosa, M. F., Ferrario, M., Ferrieres, J., Ford, I., Fornage, M., Franks, P. W., Frayling, T. M., Frikke-Schmidt, R., Fritsche, L. G., Frossard, P., Fuster, V., Ganesh, S. K., Gao, W., Garcia, M. E., Gieger, C., Giulianini, F., Goodarzi, M. O., Grallert, H., Grarup, N., Groop, L., Grove, M. L., Gudnason, V., Hansen, T., Harris, T. B., Hayward, C., Hirschhorn, J. N., Holmen, O. L., Huffman, J., Huo, Y., Hveem, K., Jabeen, S., Jackson, A. U., Jakobsdottir, J., Jarvelin, M. R., Jensen, G. B., Jørgensen, M. E., Jukema, J. W., Justesen, J. M., Kamstrup, P. R., Kanoni, S., Karpe, F., Kee, F., Khera, A. V., Klarin, D., Koistinen, H. A., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T., Langenberg, C., Langsted, A., Launer, L. J., Lauritzen, T., MLiewald, D. C., Lin, L. A., Linneberg, A., Loos, R. J. F., Lu, Y., Lu, X., Mägi, R., Malarstig, A., Manichaikul, A., Manning, A. K., Mäntyselkä, P., Marouli, E., Masca, N. G. D., Maschio, A., Meigs, J. B., Melander, O., Metspalu, A., Morris, A. P., Morrison, A. C., Mulas, A., Müller-Nurasyid, M., Munroe, P. B., Neville, M. J., Nielsen, S. F., Nielsen, J. B., Nordestgaard, B. G., Ordovas, J. M., Mehran, R., O'Donnell, C. J., Orho-Melander, M., Molony, C. M., Muntendam, P., Padmanabhan, S., Palmer, C. N. A., Pasko, D., Patel, A. P., Pedersen, O., Perola, M., Peters, A., Pisinger, C., Pistis, G., Polasek, O., Poulter, N., Psaty, B. M., Rader, D. J., Rasheed, A., Rauramaa, R., Reilly, D. F., Reiner, A. P., Renström, F., Rich, S. S., Ridker, P. M., Rioux, J. D., Robertson, N. R., Roden, D. M., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sanna, S., Sattar, N., Schmidt, E. M., Scott, R. A., Sever, P., Sevilla, R. S., Shaffer, C. M., Sim, X., Sivapalaratnam, S., Small, K. S., Smith, A. V., Smith, B. H., Somayajula, S., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stirrups, K. E., Stitziel, N., Strauch, K., Stringham, H. M., Surendran, P., Tada, H., Tall, A. R., Tang, H., Tardif, J. C., Taylor, K. D., Trompet, S., Tsao, P. S., Tuomilehto, J., Tybjaerg-Hansen, A., Zuydam, N. R. V., Varbo, A., Varga, T. V., Virtamo, J., Waldenberger, M., Wang, N., Wareham, N. J., Warren, H. R., Weeke, P. E., Weinstock, J., Wessel, J., Wilson, J. G., Wilson, P. W. F., Xu, M., Yaghootkar, H., Young, R., Zeggini, E., Zhang, H., Zheng, N. S., Zhang, W., Zhang, Y., Zhou, W., Zhou, Y., Zoledziewska, M., Howson, J. M. M., Danesh, J., McCarthy, M. I., Cowan, C. A., Abecasis, G., Deloukas, P., Musunuru, K., Willer, C. J. & Kathiresan, S., Dec 1 2017, In : Nature genetics. 49, 12, p. 1758-1766 9 p.

Research output: Contribution to journalArticle

141 Scopus citations

Methodological standards for meta-analyses and qualitative systematic reviews of cardiac prevention and treatment studies a scientific statement from the American Heart Association

Rao, G., Lopez-Jimenez, F., Boyd, J., D'Amico, F., Durant, N. H., Hlatky, M. A., Howard, G., Kirley, K., Masi, C., Powell-Wiley, T. M., Solomonides, A. E., West, C. P. & Wessel, J., Sep 1 2017, In : Circulation. 136, 10, p. e172-e194

Research output: Contribution to journalArticle

56 Scopus citations

Rare and low-frequency coding variants alter human adult height

MAGIC Investigators, The EPIC-InterAct Consortium, EPIC-CVD Consortium, CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium & ReproGen Consortium, Feb 9 2017, In : Nature. 542, 7640, p. 186-190 5 p.

Research output: Contribution to journalArticle

218 Scopus citations

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

Li, M., Li, Y., Weeks, O., Mijatovic, V., Teumer, A., Huffman, J. E., Tromp, G., Fuchsberger, C., Gorski, M., Lyytikäinen, L. P., Nutile, T., Sedaghat, S., Sorice, R., Tin, A., Yang, Q., Ahluwalia, T. S., Arking, D. E., Bihlmeyer, N. A., Böger, C. A., Carroll, R. J. & 136 others, Chasman, D. I., Cornelis, M. C., Dehghan, A., Faul, J. D., Feitosa, M. F., Gambaro, G., Gasparini, P., Giulianini, F., Heid, I., Huang, J., Imboden, M., Jackson, A. U., Jeff, J., Jhun, M. A., Katz, R., Kifley, A., Kilpeläinen, T. O., Kumar, A., Laakso, M., Li-Gao, R., Lohman, K., Lu, Y., Mägi, R., Malerba, G., Mihailov, E., Mohlke, K. L., Mook-Kanamori, D. O., Robino, A., Ruderfer, D., Salvi, E., Schick, U. M., Schulz, C. A., Smith, A. V., Smith, J. A., Traglia, M., Yerges-Armstrong, L. M., Zhao, W., Goodarzi, M. O., Kraja, A. T., Liu, C., Wessel, J., Boerwinkle, E., Borecki, I. B., Bork-Jensen, J., Bottinger, E. P., Braga, D., Brandslund, I., Brody, J. A., Campbell, A., Carey, D. J., Christensen, C., Coresh, J., Crook, E., Curhan, G. C., Cusi, D., De Boer, I. H., De Vries, A. P. J., Denny, J. C., Devuyst, O., Dreisbach, A. W., Endlich, K., Esko, T., Franco, O. H., Fulop, T., Gerhard, G. S., Glümer, C., Gottesman, O., Grarup, N., Gudnason, V., Hansen, T., Harris, T. B., Hayward, C., Hocking, L., Hofman, A., Hu, F. B., Husemoen, L. L. N., Jackson, R. D., Jørgensen, T., Jørgensen, M. E., Kähönen, M., Kardia, S. L. R., König, W., Kooperberg, C., Kriebel, J., Launer, L. J., Lauritzen, T., Lehtimäki, T., Levy, D., Linksted, P., Linneberg, A., Liu, Y., Loos, R. J. F., Lupo, A., Meisinger, C., Melander, O., Metspalu, A., Mitchell, P., Nauck, M., Nürnberg, P., Orho-Melander, M., Parsa, A., Pedersen, O., Peters, A., Peters, U., Polasek, O., Porteous, D., Probst-Hensch, N. M., Psaty, B. M., Qi, L., Raitakari, O. T., Reiner, A. P., Rettig, R., Ridker, P. M., Rivadeneira, F., Rossouw, J. E., Schmidt, F., Siscovick, D., Soranzo, N., Strauch, K., Toniolo, D., Turner, S. T., Uitterlinden, A. G., Ulivi, S., Velayutham, D., Völker, U., Völzke, H., Waldenberger, M., Wang, J. J., Weir, D. R., Witte, D., Kuivaniemi, H., Fox, C. S., Franceschini, N., Goessling, W., Köttgen, A. & Chu, A. Y., Mar 2017, In : Journal of the American Society of Nephrology. 28, 3, p. 981-994 14 p.

Research output: Contribution to journalArticle

17 Scopus citations
2016

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

CHD Exome+ Consortium, CARDIOGRAM Exome Consortium & GERAD-EC Consortium, Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), Jun 1 2016, In : Science translational medicine. 8, 341, 341ra76.

Research output: Contribution to journalArticle

45 Scopus citations

A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans

Clapham, K. R., Chu, A. Y., Wessel, J., Natarajan, P., Flannick, J., Rivas, M. A., Sartori, S., Mehran, R., Baber, U., Fuster, V., Scott, R. A., Rader, D. J., Boehnke, M., McCarthy, M. I., Altshuler, D. M., Kathiresan, S. & Peloso, G. M., Jan 28 2016, In : BMC Endocrine Disorders. 16, 1, 7.

Research output: Contribution to journalArticle

5 Scopus citations

Factors Motivating Individuals to Consider Genetic Testing for Type 2 Diabetes Risk Prediction

Wessel, J., Gupta, J. & De Groot, M., Jan 1 2016, In : PloS one. 11, 1, e0147071.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Genetic mutations in African patients with atrial fibrillation: Rationale and design of the Study of Genetics of Atrial Fibrillation in an African Population (SIGNAL)

Bloomfield, G. S., Temu, T. M., Akwanalo, C. O., Chen, P. S., Emonyi, W., Heckbert, S. R., Koech, M. M., Manji, I., Shen, C., Vatta, M., Velazquez, E. J., Wessel, J., Kimaiyo, S. & Inui, T. S., Sep 1 2015, In : American Heart Journal. 170, 3, p. 455-464.e5

Research output: Contribution to journalArticle

5 Scopus citations

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Wessel, J., Chu, A. Y., Willems, S. M., Wang, S., Yaghootkar, H., Brody, J. A., Dauriz, M., Hivert, M. F., Raghavan, S., Lipovich, L., Hidalgo, B., Fox, K., Huffman, J. E., An, P., Lu, Y., Rasmussen-Torvik, L. J., Grarup, N., Ehm, M. G., Li, L., Baldridge, A. S. & 184 others, Stančáková, A., Abrol, R., Besse, C., Boland, A., Bork-Jensen, J., Fornage, M., Freitag, D. F., Garcia, M. E., Guo, X., Hara, K., Isaacs, A., Jakobsdottir, J., Lange, L. A., Layton, J. C., Li, M., Hua Zhao, J., Meidtner, K., Morrison, A. C., Nalls, M. A., Peters, M. J., Sabater-Lleal, M., Schurmann, C., Silveira, A., Smith, A. V., Southam, L., Stoiber, M. H., Strawbridge, R. J., Taylor, K. D., Varga, T. V., Allin, K. H., Amin, N., Aponte, J. L., Aung, T., Barbieri, C., Bihlmeyer, N. A., Boehnke, M., Bombieri, C., Bowden, D. W., Burns, S. M., Chen, Y., Chen, Y. D., Cheng, C. Y., Correa, A., Czajkowski, J., Dehghan, A., Ehret, G. B., Eiriksdottir, G., Escher, S. A., Farmaki, A. E., Frånberg, M., Gambaro, G., Giulianini, F., Goddard, W. A., Goel, A., Gottesman, O., Grove, M. L., Gustafsson, S., Hai, Y., Hallmans, G., Heo, J., Hoffmann, P., Ikram, M. K., Jensen, R. A., Jørgensen, M. E., Jørgensen, T., Karaleftheri, M., Khor, C. C., Kirkpatrick, A., Kraja, A. T., Kuusisto, J., Lange, E. M., Lee, I. T., Lee, W. J., Leong, A., Liao, J., Liu, C., Liu, Y., Lindgren, C. M., Linneberg, A., Malerba, G., Mamakou, V., Marouli, E., Maruthur, N. M., Matchan, A., McKean-Cowdin, R., McLeod, O., Metcalf, G. A., Mohlke, K. L., Muzny, D. M., Ntalla, I., Palmer, N. D., Pasko, D., Peter, A., Rayner, N. W., Renström, F., Rice, K., Sala, C. F., Sennblad, B., Serafetinidis, I., Smith, J. A., Soranzo, N., Speliotes, E. K., Stahl, E. A., Stirrups, K., Tentolouris, N., Thanopoulou, A., Torres, M., Traglia, M., Tsafantakis, E., Javad, S., Yanek, L. R., Zengini, E., Becker, D. M., Bis, J. C., Brown, J. B., Adrienne Cupples, L., Hansen, T., Ingelsson, E., Karter, A. J., Lorenzo, C., Mathias, R. A., Norris, J. M., Peloso, G. M., Sheu, W. H. H., Toniolo, D., Vaidya, D., Varma, R., Wagenknecht, L. E., Boeing, H., Bottinger, E. P., Dedoussis, G., Deloukas, P., Ferrannini, E., Franco, O. H., Franks, P. W., Gibbs, R. A., Gudnason, V., Hamsten, A., Harris, T. B., Hattersley, A. T., Hayward, C., Hofman, A., Jansson, J. H., Langenberg, C., Launer, L. J., Levy, D., Oostra, B. A., O'Donnell, C. J., O'Rahilly, S., Padmanabhan, S., Pankow, J. S., Polasek, O., Province, M. A., Rich, S. S., Ridker, P. M., Rudan, I., Schulze, M. B., Smith, B. H., Uitterlinden, A. G., Walker, M., Watkins, H., Wong, T. Y., Zeggini, E., Laakso, M., Borecki, I. B., Chasman, D. I., Pedersen, O., Psaty, B. M., Shyong Tai, E., Van Duijn, C. M., Wareham, N. J., Waterworth, D. M., Boerwinkle, E., Linda Kao, W. H., Florez, J. C., Loos, R. J. F., Wilson, J. G., Frayling, T. M., Siscovick, D. S., Dupuis, J., Rotter, J. I., Meigs, J. B., Scott, R. A. & Goodarzi, M. O., Feb 2015, In : Nature communications. 6, 5897.

Research output: Contribution to journalArticle

102 Scopus citations
2014

Genetic Testing and Type 2 Diabetes Risk Awareness

de Groot, M. & Wessel, J., Jul 2014, In : The Diabetes Educator. 40, 4, p. 427-433 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2012

Genome-wide meta-analyses of smoking behaviors in African Americans

David, S. P., Hamidovic, A., Chen, G. K., Bergen, A. W., Wessel, J., Kasberger, J. L., Brown, W. M., Petruzella, S., Thacker, E. L., Kim, Y., Nalls, M. A., Tranah, G. J., Sung, Y. J., Ambrosone, C. B., Arnett, D., Bandera, E. V., Becker, D. M., Becker, L., Berndt, S. I., Bernstein, L. & 59 others, Blot, W. J., Broeckel, U., Buxbaum, S. G., Caporaso, N., Casey, G., Chanock, S. J., Deming, S. L., Diver, W. R., Eaton, C. B., Evans, D. S., Evans, M. K., Fornage, M., Franceschini, N., Harris, T. B., Henderson, B. E., Hernandez, D. G., Hitsman, B., Hu, J. J., Hunt, S. C., Ingles, S. A., John, E. M., Kittles, R., Kolb, S., Kolonel, L. N., Le Marchand, L., Liu, Y., Lohman, K. K., McKnight, B., Millikan, R. C., Murphy, A., Neslund-Dudas, C., Nyante, S., Press, M., Psaty, B. M., Rao, D. C., Redline, S., Rodriguez-Gil, J. L., Rybicki, B. A., Signorello, L. B., Singleton, A. B., Smoller, J., Snively, B., Spring, B., Stanford, J. L., Strom, S. S., Swan, G. E., Taylor, K. D., Thun, M. J., Wilson, A. F., Witte, J. S., Yamamura, Y., Yanek, L. R., Yu, K., Zheng, W., Ziegler, R. G., Zonderman, A. B., Jorgenson, E., Haiman, C. A. & Furberg, H., 2012, In : Translational psychiatry. 2, e119.

Research output: Contribution to journalArticle

75 Scopus citations

Varenicline for smoking cessation: Nausea severity and variation in nicotinic receptor genes

Swan, G. E., Javitz, H. S., Jack, L. M., Wessel, J., Michel, M., Hinds, D. A., Stokowksi, R. P., Mcclure, J. B., Catz, S. L., Richards, J., Zbikowski, S. M., Deprey, M., Mcafee, T., Conti, D. V. & Bergen, A. W., Aug 1 2012, In : Pharmacogenomics Journal. 12, 4, p. 349-358 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

Environmental and genetic contributions to indicators of oral malodor in twins

Bretz, W. A., Biesbrock, A., Corby, P. M., Corby, A. L., Bretz, W. G., Wessel, J. & Schork, N. J., Dec 1 2011, In : Twin Research and Human Genetics. 14, 6, p. 568-572 5 p.

Research output: Contribution to journalArticle

Naturally occurring variations in the human cholinesterase genes: Heritability and association with cardiovascular and metabolic traits

Valle, A. M., Radić, Z., Rana, B. K., Mahboubi, V., Wessel, J., Shih, P. A. B., Rao, F., O'Connor, D. T. & Taylor, P., Jul 2011, In : Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2010

Human tyrosine hydroxylase natural allelic variation: Influence on autonomic function and hypertension

Rao, F., Zhang, K., Zhang, L., Rana, B. K., Wessel, J., Fung, M. M., Rodriguez-Flores, J. L., Taupenot, L., Ziegler, M. G. & O’Connor, D. T., Nov 2010, In : Cellular and Molecular Neurobiology. 30, 8, p. 1391-1394 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Presymptomatic risk assessment for chronic non-communicable diseases

Padhukasahasram, B., Halperin, E., Wessel, J., Thomas, D. J., Silver, E., Trumbower, H., Cargill, M. & Stephan, D. A., Dec 1 2010, In : PloS one. 5, 12, e14338.

Research output: Contribution to journalArticle

11 Scopus citations

Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence

Wessel, J., McDonald, S. M., Hinds, D. A., Stokowski, R. P., Javitz, H. S., Kennemer, M., Krasnow, R., Dirks, W., Hardin, J., Pitts, S. J., Michel, M., Jack, L., Ballinger, D. G., McClure, J. B., Swan, G. E. & Bergen, A. W., Nov 1 2010, In : Neuropsychopharmacology. 35, 12, p. 2392-2402 11 p.

Research output: Contribution to journalArticle

53 Scopus citations
2009

CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response

Beitelshees, A. L., Navare, H., Wang, D., Gong, Y., Wessel, J., Moss, J. I., Langaee, T. Y., Cooper-DeHoff, R. M., Sadee, W., Pepine, C. J., Schork, N. J. & Johnson, J. A., Aug 1 2009, In : Circulation: Cardiovascular Genetics. 2, 4, p. 362-370 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: Influence on heritable autonomic traits in twin pairs

Rana, B. K., Wessel, J., Mahboubi, V., Rao, F., Haeller, J., Gayen, J. R., Eskin, E., Valle, A. M., Das, M., Mahata, S. K., Taupenot, L., Stridsberg, M., Talley, T. T., Ziegler, M. G., Smith, D. W., Schork, N. J., O'Connor, D. T. & Taylor, P., Nov 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 419-428 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample

Hardin, J., He, Y., Javitz, H. S., Wessel, J., Krasnow, R. E., Tildesley, E., Hops, H., Swan, G. E. & Bergen, A. W., Dec 1 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 12, p. 3399-3406 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
2008

Adrenergic polymorphism and the human stress response

Rao, F., Zhang, L., Wessel, J., Zhang, K., Wen, G., Kennedy, B. P., Rana, B. K., Das, M., Rodriguez-Flores, J. L., Smith, D. W., Cadman, P. E., Salem, R. M., Mahata, S. K., Schork, N. J., Taupenot, L., Ziegler, M. G. & O'Connor, D. T., Dec 2008, Stress, Neurotransmitters, and Hormones Neuroendocrine and Genetic Mechanisms. Blackwell Publishing Inc., p. 282-296 15 p. (Annals of the New York Academy of Sciences; vol. 1148).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

DNA Sequence-Based Phenotypic Association Analysis

Schork, N. J., Wessel, J. & Malo, N., Mar 20 2008, Genetic Dissection of Complex Traits. Rao, D. C. & Gu, C. (eds.). p. 195-217 23 p. (Advances in Genetics; vol. 60).

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations

Evidence for a heritable unidimensional symptom factor underlying obsessionality

Mathews, C. A., Greenwood, T., Wessel, J., Azzam, A., Garrido, H., Chavira, D. A., Chandavarkar, U., Bagnarello, M., Stein, M. & Schork, N. J., Sep 5 2008, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 147, 6, p. 676-685 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inheritance of occlusal topography: a twin study.

Su, C. Y., Corby, P. M., Elliot, M. A., Studen-Pavlovich, D. A., Ranalli, D. N., Rosa, B., Wessel, J., Schork, N. J., Hart, T. C. & Bretz, W. A., Mar 2008, In : European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry. 9, 1, p. 19-24 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2007

Accommodating pathway information in expression quantitative trait locus analysis

Wessel, J., Zapala, M. A. & Schork, N. J., Jul 1 2007, In : Genomics. 90, 1, p. 132-142 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension

Wen, G., Wessel, J., Zhou, W., Ehret, G. B., Rao, F., Stridsberg, M., Mahata, S. K., Gent, P. M., Das, M., Cooper, R. S., Chakravarti, A., Zhou, H., Schork, N. J., O'Connor, D. T. & Hamilton, B. A., Jul 15 2007, In : Human molecular genetics. 16, 14, p. 1752-1764 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

C-reactive protein, an 'intermediate phenotype' for inflammation: Human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/β-adrenergic pathway loci

Wessel, J., Moratorio, G., Rao, F., Mahata, M., Zhang, L., Greene, W., Rana, B. K., Kennedy, B. P., Khandrika, S., Huang, P., Lillie, E. O., Shih, P. A. B., Smith, D. W., Wen, G., Hamilton, B. A., Ziegler, M. G., Witztum, J. L., Schork, N. J., Schmid-Schönbein, G. W. & O'Connor, D. T., Feb 1 2007, In : Journal of Hypertension. 25, 2, p. 329-343 15 p.

Research output: Contribution to journalArticle

75 Scopus citations

Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk

Zhang, L., Rao, F., Zhang, K., Khandrika, S., Das, M., Vaingankar, S. M., Bao, X., Rana, B. K., Smith, D. W., Wessel, J., Salem, R. M., Rodriguez-Flores, J. L., Mahata, S. K., Schork, N. J., Ziegler, M. G. & O'Connor, D. T., Sep 4 2007, In : Journal of Clinical Investigation. 117, 9, p. 2658-2671 14 p.

Research output: Contribution to journalArticle

68 Scopus citations

Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding

Mathews, C. A., Nievergelt, C. M., Azzam, A., Garrido, H., Chavira, D. A., Wessel, J., Bagnarello, M., Reus, V. I. & Schork, N. J., Mar 5 2007, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 144, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Heritability of oral microbial species in caries-active and caries-free twins

Corby, P. M. A., Bretz, W. A., Hart, T. C., Schork, N. J., Wessel, J., Lyons-Weiler, J. & Paster, B. J., Dec 2007, In : Twin Research and Human Genetics. 10, 6, p. 821-828 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Powerful designs for genetic association studies that consider twins and sibling pairs with discordant genotypes

Wessel, J., Schork, A. J., Tiwari, H. K. & Schork, N. J., Nov 1 2007, In : Genetic epidemiology. 31, 7, p. 789-796 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Renal albumin excretion: Twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism

Rao, F., Wessel, J., Wen, G., Zhang, L., Rana, B. K., Kennedy, B. P., Greenwood, T. A., Salem, R. M., Chen, Y., Khandrika, S., Hamilton, B. A., Smith, D. W., Holstein-Rathlou, N. H., Ziegler, M. G., Schork, N. J. & O'Connor, D. T., May 1 2007, In : Hypertension. 49, 5, p. 1015-1031 17 p.

Research output: Contribution to journalArticle

35 Scopus citations

Single nucleotide polymorphism discovery and haplotype analysis of Ca2+-dependent K+ channel beta-1 subunit

Gong, Y., Beitelshees, A. L., Wessel, J., Langaee, T. Y., Schork, N. J. & Johnson, J. A., Apr 1 2007, In : Pharmacogenetics and Genomics. 17, 4, p. 267-275 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: Discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo

Rao, F., Zhang, L., Wessel, J., Zhang, K., Wen, G., Kennedy, B. P., Rana, B. K., Das, M., Rodriguez-Flores, J. L., Smith, D. W., Cadman, P. E., Salem, R. M., Mahata, S. K., Schork, N. J., Taupenot, L., Ziegler, M. G. & O'Connor, D. T., Aug 1 2007, In : Circulation. 116, 9, p. 993-1006 14 p.

Research output: Contribution to journalArticle

72 Scopus citations
2006

Generalized genomic distance-based regression methodology for multilocus association analysis

Wessel, J. & Schork, N. J., Nov 2006, In : American Journal of Human Genetics. 79, 5, p. 792-806 15 p.

Research output: Contribution to journalArticle

120 Scopus citations

Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: Role of heredity

Seasholtz, T. M., Wessel, J., Rao, F., Rana, B. K., Khandrika, S., Kennedy, B. P., Lillie, E. O., Ziegler, M. G., Smith, D. W., Schork, N. J., Brown, J. H. & O'Connor, D. T., May 1 2006, In : Hypertension. 47, 5, p. 937-947 11 p.

Research output: Contribution to journalArticle

68 Scopus citations