Jennifer Wessel

  • 1468 Citations
  • 20 h-Index
20042019
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Publications 2004 2019

  • 1468 Citations
  • 20 h-Index
  • 48 Article
  • 1 Conference contribution
  • 1 Comment/debate
  • 1 Review article
2019
13 Citations (Scopus)

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Broad Genomics Platform, DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES & AMP-T2D-GENES, Jun 6 2019, In : Nature. 570, 7759, p. 71-76 6 p.

Research output: Contribution to journalArticle

Open Access
Exome
Type 2 Diabetes Mellitus
Genes
Gene Knockout Techniques
Gene Frequency

Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program

TOPMed Diabetes Working Group, TOPMed Hematology Working Group, TOPMed Hemostasis Working Group & National Heart, Lung, and Blood Institute TOPMed Consortium, Oct 3 2019, In : American Journal of Human Genetics. 105, 4, p. 706-718 13 p.

Research output: Contribution to journalArticle

Precision Medicine
Hispanic Americans
African Americans
Hemoglobins
Gene Frequency
4 Citations (Scopus)

Maternal lipid profile differs by gestational diabetes physiologic subtype

Layton, J., Powe, C., Allard, C., Battista, M. C., Doyon, M., Bouchard, L., Perron, P., Wessel, J. & Hivert, M. F., Feb 1 2019, In : Metabolism: Clinical and Experimental. 91, p. 39-42 4 p.

Research output: Contribution to journalArticle

Gestational Diabetes
Mothers
Lipids
Glucose
Fatty Acids
6 Citations (Scopus)

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

T2D-Genes Consortium, The MAGIC Investigators, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct & ReproGen Consortium, Mar 1 2019, In : Nature genetics. 51, 3, p. 452-469 18 p.

Research output: Contribution to journalArticle

Body Fat Distribution
Homeostasis
Lipids
Fats
Genes

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x)

CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC-InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators & Understanding Society Scientific Group, Jan 1 2019, In : Nature genetics.

Research output: Contribution to journalComment/debate

Open Access
Energy Intake
Energy Metabolism
Body Mass Index
Obesity
Proteins

The Continuing Evolution of Precision Health in Type 2 Diabetes: Achievements and Challenges

Lin, Y. & Wessel, J., Apr 1 2019, In : Current Diabetes Reports. 19, 4, 16.

Research output: Contribution to journalReview article

Type 2 Diabetes Mellitus
Health
Genomics
Public Health
2018

Excess mortality among Indiana firefighters, 1985-2013

Muegge, C. M., Zollinger, T., Song, Y., Wessel, J., Monahan, P. O. & Moffatt, S. M., Dec 1 2018, In : American Journal of Industrial Medicine. 61, 12, p. 961-967 7 p.

Research output: Contribution to journalArticle

Firefighters
Mortality
Death Certificates
Neoplasms
Cardiovascular Diseases
70 Citations (Scopus)

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Turcot, V., Lu, Y., Highland, H. M., Schurmann, C., Justice, A. E., Fine, R. S., Bradfield, J. P., Esko, T., Giri, A., Graff, M., Guo, X., Hendricks, A. E., Karaderi, T., Lempradl, A., Locke, A. E., Mahajan, A., Marouli, E., Sivapalaratnam, S., Young, K. L., Alfred, T. & 380 others, Feitosa, M. F., Masca, N. G. D., Manning, A. K., Medina-Gomez, C., Mudgal, P., Ng, M. C. Y., Reiner, A. P., Vedantam, S., Willems, S. M., Winkler, T. W., Abecasis, G., Aben, K. K., Alam, D. S., Alharthi, S. E., Allison, M., Amouyel, P., Asselbergs, F. W., Auer, P. L., Balkau, B., Bang, L. E., Barroso, I., Bastarache, L., Benn, M., Bergmann, S., Bielak, L. F., Blüher, M., Boehnke, M., Boeing, H., Boerwinkle, E., Wessel, J., Bork-Jensen, J., Bots, M. L., Bottinger, E. P., Bowden, D. W., Brandslund, I., Breen, G., Brilliant, M. H., Broer, L., Brumat, M., Burt, A. A., Butterworth, A. S., Campbell, P. T., Cappellani, S., Carey, D. J., Catamo, E., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Cocca, M., Collins, F. S., Cook, J. P., Corley, J., Corominas Galbany, J., Cox, A. J., Crosslin, D. S., Cuellar-Partida, G., D'Eustacchio, A., Danesh, J., Davies, G., Bakker, P. I. W., Groot, M. C. H., Mutsert, R., Deary, I. J., Dedoussis, G., Demerath, E. W., Heijer, M., Hollander, A. I., Ruijter, H. M., Dennis, J. G., Denny, J. C., Angelantonio, E., Drenos, F., Du, M., Dubé, M. P., Dunning, A. M., Easton, D. F., Edwards, T. L., Ellinghaus, D., Ellinor, P. T., Elliott, P., Evangelou, E., Farmaki, A. E., Farooqi, I. S., Faul, J. D., Fauser, S., Feng, S., Ferrannini, E., Ferrieres, J., Florez, J. C., Ford, I., Fornage, M., Franco, O. H., Franke, A., Franks, P. W., Friedrich, N., Frikke-Schmidt, R., Galesloot, T. E., Gan, W., Gandin, I., Gasparini, P., Gibson, J., Giedraitis, V., Gjesing, A. P., Gordon-Larsen, P., Gorski, M., Grabe, H. J., Grant, S. F. A., Grarup, N., Griffiths, H. L., Grove, M. L., Gudnason, V., Gustafsson, S., Haessler, J., Hakonarson, H., Hammerschlag, A. R., Hansen, T., Harris, K. M., Harris, T. B., Hattersley, A. T., Have, C. T., Hayward, C., He, L., Heard-Costa, N. L., Heath, A. C., Heid, I. M., Helgeland, Ø., Hernesniemi, J., Hewitt, A. W., Holmen, O. L., Hovingh, G. K., Howson, J. M. M., Hu, Y., Huang, P. L., Huffman, J. E., Ikram, M. A., Ingelsson, E., Jackson, A. U., Jansson, J. H., Jarvik, G. P., Jensen, G. B., Jia, Y., Johansson, S., Jørgensen, M. E., Jørgensen, T., Jukema, J. W., Kahali, B., Kahn, R. S., Kähönen, M., Kamstrup, P. R., Kanoni, S., Kaprio, J., Karaleftheri, M., Kardia, S. L. R., Karpe, F., Kathiresan, S., Kee, F., Kiemeney, L. A., Kim, E., Kitajima, H., Komulainen, P., Kooner, J. S., Kooperberg, C., Korhonen, T., Kovacs, P., Kuivaniemi, H., Kutalik, Z., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T. A., Lamparter, D., Lange, E. M., Lange, L. A., Langenberg, C., Larson, E. B., Lee, N. R., Lehtimäki, T., Lewis, C. E., Li, H., Li, J., Li-Gao, R., Lin, H., Lin, K. H., Lin, L. A., Lin, X., Lind, L., Lindström, J., Linneberg, A., Liu, C. T., Liu, D. J., Liu, Y., Lo, K. S., Lophatananon, A., Lotery, A. J., Loukola, A., Luan, JA., Lubitz, S. A., Lyytikäinen, L. P., Männistö, S., Marenne, G., Mazul, A. L., McCarthy, M. I., McKean-Cowdin, R., Medland, S. E., Meidtner, K., Milani, L., Mistry, V., Mitchell, P., Mohlke, K. L., Moilanen, L., Moitry, M., Montgomery, G. W., Mook-Kanamori, D. O., Moore, C., Mori, T. A., Morris, A. D., Morris, A. P., Müller-Nurasyid, M., Munroe, P. B., Nalls, M. A., Narisu, N., Nelson, C. P., Neville, M., Nielsen, S. F., Nikus, K., Njølstad, P. R., Nordestgaard, B. G., Nyholt, D. R., O'Connel, J. R., O'Donoghue, M. L., Olde Loohuis, L. M., Ophoff, R. A., Owen, K. R., Packard, C. J., Padmanabhan, S., Palmer, C. N. A., Palmer, N. D., Pasterkamp, G., Patel, A. P., Pattie, A., Pedersen, O., Peissig, P. L., Peloso, G. M., Pennell, C. E., Perola, M., Perry, J. A., Perry, J. R. B., Pers, T. H., Person, T. N., Peters, A., Petersen, E. R. B., Peyser, P. A., Pirie, A., Polasek, O., Polderman, T. J., Puolijoki, H., Raitakari, O. T., Rasheed, A., Rauramaa, R., Reilly, D. F., Renström, F., Rheinberger, M., Ridker, P. M., Rioux, J. D., Rivas, M. A., Roberts, D. J., Robertson, N. R., Robino, A., Rolandsson, O., Rudan, I., Ruth, K. S., Saleheen, D., Salomaa, V., Samani, N. J., Sapkota, Y., Sattar, N., Schoen, R. E., Schreiner, P. J., Schulze, M. B., Scott, R. A., Segura-Lepe, M. P., Shah, S. H., Sheu, W. H. H., Sim, X., Slater, A. J., Small, K. S., Smith, A. V., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stefansson, K., Steinthorsdottir, V., Stirrups, K. E., Strauch, K., Stringham, H. M., Stumvoll, M., Sun, L., Surendran, P., Swift, A. J., Tada, H., Tansey, K. E., Tardif, J. C., Taylor, K. D., Teumer, A., Thompson, D. J., Thorleifsson, G., Thorsteinsdottir, U., Thuesen, B. H., Tönjes, A., Tromp, G., Trompet, S., Tsafantakis, E., Tuomilehto, J., Tybjaerg-Hansen, A., Tyrer, J. P., Uher, R., Uitterlinden, A. G., Uusitupa, M., Laan, S. W., Duijn, C. M., Leeuwen, N., Van Setten, J., Vanhala, M., Varbo, A., Varga, T. V., Varma, R., Velez Edwards, D. R., Vermeulen, S. H., Veronesi, G., Vestergaard, H., Vitart, V., Vogt, T. F., Völker, U., Vuckovic, D., Wagenknecht, L. E., Walker, M., Wallentin, L., Wang, F., Wang, C. A., Wang, S., Wang, Y., Ware, E. B., Wareham, N. J., Warren, H. R., Wessel, J., Wessel, J., White, H. D., Willer, C. J., Wilson, J. G., Witte, D. R., Wood, A. R., Wu, Y., Yaghootkar, H., Yao, J., Yao, P., Yerges-Armstrong, L. M., Young, R., Zeggini, E., Zhan, X., Zhang, W., Zhao, J. H., Zhao, W., Zhou, W., Zondervan, K. T., Rotter, J. I., Pospisilik, J. A., Rivadeneira, F., Borecki, I. B., Deloukas, P., Frayling, T. M., Lettre, G., North, K. E., Lindgren, C. M., Hirschhorn, J. N. & Loos, R. J. F., Jan 1 2018, In : Nature Genetics. 50, 1, p. 26-35 10 p.

Research output: Contribution to journalArticle

Energy Intake
Energy Metabolism
Body Mass Index
Obesity
Genes
51 Citations (Scopus)

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article

ExomeBP Consortium, MAGIC Consortium & GIANT Consortium, Apr 1 2018, In : Nature Genetics. 50, 4, p. 559-571 13 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Causality
Odds Ratio
Genome
Therapeutics
3 Citations (Scopus)
African Americans
Type 2 Diabetes Mellitus
Insulin Resistance
Reference Values
Homeostasis
2017

A low-frequency inactivating AKT2 variant enriched in the finnish population is associated with fasting insulin levels and type 2 diabetes risk

Manning, A., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., Grarup, N., Rivas, M. A., Mahajan, A., Locke, A. E., Cingolani, P., Pers, T. H., Viñuela, A., Brown, A. A., Wu, Y., Flannick, J., Fuchsberger, C., Gamazon, E. R., Gaulton, K. J., Im, H. K. & 243 others, Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimäki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B. R., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., Depristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., de Angelis, M. H., Maguire, J., Neale, B. M., Poplin, R., Purcell, S., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., Varga, T. V., Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Hale, D. E., Fowler, S. P., Arya, R., Defronzo, R. A., Abboud, H. E., Syvänen, A. C., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Mägi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Müller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S. T., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J. Y., Han, B. G., Käräjämäki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., E Mel Ander, O. L., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., U, J. L., Khor, C. C., Chia, K. S., Lim, W. Y., Cheng, C. Y., Chan, E., Shyong Tai, E., Aung, T., Linneberg, A., Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Na Kravi C, J., Jørgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Kat, K. H., Farmer, A. J., Frayling, T. M., O’rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stan?cáková, A., Barroso, I., Bharadwaj, D., Chan, J., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Antero Kesaniemi, Y., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jørgensen, T., Hansen, T., Pedersen, O., Kuusisto, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M., Jul 1 2017, In : Diabetes. 66, 7, p. 2019-2032 14 p.

Research output: Contribution to journalArticle

Open Access
Type 2 Diabetes Mellitus
Fasting
Insulin
Exome
Population
6 Citations (Scopus)

Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya

Temu, T. M., Lane, K. A., Shen, C., Ng’ang’a, L., Akwanalo, C. O., Chen, P-S., Emonyi, W., Heckbert, S. R., Koech, M. M., Manji, I., Vatta, M., Velazquez, E. J., Wessel, J., Kimaiyo, S., Inui, T. & Bloomfield, G. S., Sep 1 2017, In : PLoS One. 12, 9, e0185204.

Research output: Contribution to journalArticle

Kenya
Atrial Fibrillation
Developing countries
Heart Valve Diseases
heart diseases
109 Citations (Scopus)

Exome-wide association study of plasma lipids in >300,000 individuals

Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Angelantonio, E. DI., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 207 others, Boehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M. P., Ebeling, T., Eiriksdottir, G., Esko, T., Farmaki, A. E., Feitosa, M. F., Ferrario, M., Ferrieres, J., Ford, I., Fornage, M., Franks, P. W., Frayling, T. M., Frikke-Schmidt, R., Fritsche, L. G., Frossard, P., Fuster, V., Ganesh, S. K., Gao, W., Garcia, M. E., Gieger, C., Giulianini, F., Goodarzi, M. O., Grallert, H., Grarup, N., Groop, L., Grove, M. L., Gudnason, V., Hansen, T., Harris, T. B., Hayward, C., Hirschhorn, J. N., Holmen, O. L., Huffman, J., Huo, Y., Hveem, K., Jabeen, S., Jackson, A. U., Jakobsdottir, J., Jarvelin, M. R., Jensen, G. B., Jørgensen, M. E., Jukema, J. W., Justesen, J. M., Kamstrup, P. R., Kanoni, S., Karpe, F., Kee, F., Khera, A. V., Klarin, D., Koistinen, H. A., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T., Langenberg, C., Langsted, A., Launer, L. J., Lauritzen, T., MLiewald, D. C., Lin, L. A., Linneberg, A., Loos, R. J. F., Lu, Y., Lu, X., Mägi, R., Malarstig, A., Manichaikul, A., Manning, A. K., Mäntyselkä, P., Marouli, E., Masca, N. G. D., Maschio, A., Meigs, J. B., Melander, O., Metspalu, A., Morris, A. P., Morrison, A. C., Mulas, A., Müller-Nurasyid, M., Munroe, P. B., Neville, M. J., Nielsen, S. F., Nielsen, J. B., Nordestgaard, B. G., Ordovas, J. M., Mehran, R., O'Donnell, C. J., Orho-Melander, M., Molony, C. M., Muntendam, P., Padmanabhan, S., Palmer, C. N. A., Pasko, D., Patel, A. P., Pedersen, O., Perola, M., Peters, A., Pisinger, C., Pistis, G., Polasek, O., Poulter, N., Psaty, B. M., Rader, D. J., Rasheed, A., Rauramaa, R., Reilly, D. F., Reiner, A. P., Renström, F., Rich, S. S., Ridker, P. M., Rioux, J. D., Robertson, N. R., Roden, D. M., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sanna, S., Sattar, N., Schmidt, E. M., Scott, R. A., Sever, P., Sevilla, R. S., Shaffer, C. M., Sim, X., Sivapalaratnam, S., Small, K. S., Smith, A. V., Smith, B. H., Somayajula, S., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stirrups, K. E., Stitziel, N., Strauch, K., Stringham, H. M., Surendran, P., Tada, H., Tall, A. R., Tang, H., Tardif, J. C., Taylor, K. D., Trompet, S., Tsao, P. S., Tuomilehto, J., Tybjaerg-Hansen, A., Zuydam, N. R. V., Varbo, A., Varga, T. V., Virtamo, J., Waldenberger, M., Wang, N., Wareham, N. J., Warren, H. R., Weeke, P. E., Weinstock, J., Wessel, J., Wilson, J. G., Wilson, P. W. F., Xu, M., Yaghootkar, H., Young, R., Zeggini, E., Zhang, H., Zheng, N. S., Zhang, W., Zhang, Y., Zhou, W., Zhou, Y., Zoledziewska, M., Howson, J. M. M., Danesh, J., McCarthy, M. I., Cowan, C. A., Abecasis, G., Deloukas, P., Musunuru, K., Willer, C. J. & Kathiresan, S., Dec 1 2017, In : Nature Genetics. 49, 12, p. 1758-1766 9 p.

Research output: Contribution to journalArticle

Exome
Lipids
Cholesterol
Type 2 Diabetes Mellitus
Coronary Artery Disease
45 Citations (Scopus)

Methodological standards for meta-analyses and qualitative systematic reviews of cardiac prevention and treatment studies a scientific statement from the American Heart Association

Rao, G., Lopez-Jimenez, F., Boyd, J., D'Amico, F., Durant, N. H., Hlatky, M. A., Howard, G., Kirley, K., Masi, C., Powell-Wiley, T. M., Solomonides, A. E., West, C. P. & Wessel, J., Sep 1 2017, In : Circulation. 136, 10, p. e172-e194

Research output: Contribution to journalArticle

Meta-Analysis
Consensus
Decision Making
Cardiovascular Diseases
Referral and Consultation
16 Citations (Scopus)

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

Li, M., Li, Y., Weeks, O., Mijatovic, V., Teumer, A., Huffman, J. E., Tromp, G., Fuchsberger, C., Gorski, M., Lyytikäinen, L. P., Nutile, T., Sedaghat, S., Sorice, R., Tin, A., Yang, Q., Ahluwalia, T. S., Arking, D. E., Bihlmeyer, N. A., Böger, C. A., Carroll, R. J. & 136 others, Chasman, D. I., Cornelis, M. C., Dehghan, A., Faul, J. D., Feitosa, M. F., Gambaro, G., Gasparini, P., Giulianini, F., Heid, I., Huang, J., Imboden, M., Jackson, A. U., Jeff, J., Jhun, M. A., Katz, R., Kifley, A., Kilpeläinen, T. O., Kumar, A., Laakso, M., Li-Gao, R., Lohman, K., Lu, Y., Mägi, R., Malerba, G., Mihailov, E., Mohlke, K. L., Mook-Kanamori, D. O., Robino, A., Ruderfer, D., Salvi, E., Schick, U. M., Schulz, C. A., Smith, A. V., Smith, J. A., Traglia, M., Yerges-Armstrong, L. M., Zhao, W., Goodarzi, M. O., Kraja, A. T., Liu, C., Wessel, J., Boerwinkle, E., Borecki, I. B., Bork-Jensen, J., Bottinger, E. P., Braga, D., Brandslund, I., Brody, J. A., Campbell, A., Carey, D. J., Christensen, C., Coresh, J., Crook, E., Curhan, G. C., Cusi, D., De Boer, I. H., De Vries, A. P. J., Denny, J. C., Devuyst, O., Dreisbach, A. W., Endlich, K., Esko, T., Franco, O. H., Fulop, T., Gerhard, G. S., Glümer, C., Gottesman, O., Grarup, N., Gudnason, V., Hansen, T., Harris, T. B., Hayward, C., Hocking, L., Hofman, A., Hu, F. B., Husemoen, L. L. N., Jackson, R. D., Jørgensen, T., Jørgensen, M. E., Kähönen, M., Kardia, S. L. R., König, W., Kooperberg, C., Kriebel, J., Launer, L. J., Lauritzen, T., Lehtimäki, T., Levy, D., Linksted, P., Linneberg, A., Liu, Y., Loos, R. J. F., Lupo, A., Meisinger, C., Melander, O., Metspalu, A., Mitchell, P., Nauck, M., Nürnberg, P., Orho-Melander, M., Parsa, A., Pedersen, O., Peters, A., Peters, U., Polasek, O., Porteous, D., Probst-Hensch, N. M., Psaty, B. M., Qi, L., Raitakari, O. T., Reiner, A. P., Rettig, R., Ridker, P. M., Rivadeneira, F., Rossouw, J. E., Schmidt, F., Siscovick, D., Soranzo, N., Strauch, K., Toniolo, D., Turner, S. T., Uitterlinden, A. G., Ulivi, S., Velayutham, D., Völker, U., Völzke, H., Waldenberger, M., Wang, J. J., Weir, D. R., Witte, D., Kuivaniemi, H., Fox, C. S., Franceschini, N., Goessling, W., Köttgen, A. & Chu, A. Y., Mar 1 2017, In : Journal of the American Society of Nephrology. 28, 3, p. 981-994 14 p.

Research output: Contribution to journalArticle

Exome
Kidney
Genes
ras Guanine Nucleotide Exchange Factors
Rho Guanine Nucleotide Exchange Factors
2016
37 Citations (Scopus)

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

CHD Exome+ Consortium, CARDIOGRAM Exome Consortium, GERAD-EC Consortium, Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) & Wessel, J., Jun 1 2016, In : Science Translational Medicine. 8, 341, 341ra76.

Research output: Contribution to journalArticle

Coronary Disease
Type 2 Diabetes Mellitus
Glucose
Pharmaceutical Preparations
Genes
4 Citations (Scopus)

A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans

Clapham, K. R., Chu, A. Y., Wessel, J., Natarajan, P., Flannick, J., Rivas, M. A., Sartori, S., Mehran, R., Baber, U., Fuster, V., Scott, R. A., Rader, D. J., Boehnke, M., McCarthy, M. I., Altshuler, D. M., Kathiresan, S. & Peloso, G. M., Jan 28 2016, (Accepted/In press) In : BMC Endocrine Disorders.

Research output: Contribution to journalArticle

Angiopoietins
Type 2 Diabetes Mellitus
Glucose
Mutation
Fasting
Glucokinase
C-Reactive Protein
Type 2 Diabetes Mellitus
Life Style
Triglycerides
1 Citation (Scopus)

Factors Motivating Individuals to Consider Genetic Testing for Type 2 Diabetes Risk Prediction

Wessel, J., Gupta, J. & de Groot, M., Jan 1 2016, In : PLoS One. 11, 1, e0147071.

Research output: Contribution to journalArticle

Genetic Testing
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
prediction
2015
5 Citations (Scopus)

Genetic mutations in African patients with atrial fibrillation: Rationale and design of the Study of Genetics of Atrial Fibrillation in an African Population (SIGNAL)

Bloomfield, G. S., Temu, T. M., Akwanalo, C. O., Chen, P-S., Emonyi, W., Heckbert, S. R., Koech, M. M., Manji, I., Shen, C., Vatta, M., Velazquez, E. J., Wessel, J., Kimaiyo, S. & Inui, T., Sep 1 2015, In : American Heart Journal. 170, 3, p. 455-464.e5

Research output: Contribution to journalArticle

Atrial Fibrillation
Mutation
Population
Heart Valve Diseases
Africa South of the Sahara
94 Citations (Scopus)

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Wessel, J., Chu, A. Y., Willems, S. M., Wang, S., Yaghootkar, H., Brody, J. A., Dauriz, M., Hivert, M. F., Raghavan, S., Lipovich, L., Hidalgo, B., Fox, K., Huffman, J. E., An, P., Lu, Y., Rasmussen-Torvik, L. J., Grarup, N., Ehm, M. G., Li, L., Baldridge, A. S. & 184 others, Stančáková, A., Abrol, R., Besse, C., Boland, A., Bork-Jensen, J., Fornage, M., Freitag, D. F., Garcia, M. E., Guo, X., Hara, K., Isaacs, A., Jakobsdottir, J., Lange, L. A., Layton, J. C., Li, M., Hua Zhao, J., Meidtner, K., Morrison, A. C., Nalls, M. A., Peters, M. J., Sabater-Lleal, M., Schurmann, C., Silveira, A., Smith, A. V., Southam, L., Stoiber, M. H., Strawbridge, R. J., Taylor, K. D., Varga, T. V., Allin, K. H., Amin, N., Aponte, J. L., Aung, T., Barbieri, C., Bihlmeyer, N. A., Boehnke, M., Bombieri, C., Bowden, D. W., Burns, S. M., Chen, Y., Chen, Y. D., Cheng, C. Y., Correa, A., Czajkowski, J., Dehghan, A., Ehret, G. B., Eiriksdottir, G., Escher, S. A., Farmaki, A. E., Frånberg, M., Gambaro, G., Giulianini, F., Goddard, W. A., Goel, A., Gottesman, O., Grove, M. L., Gustafsson, S., Hai, Y., Hallmans, G., Heo, J., Hoffmann, P., Ikram, M. K., Jensen, R. A., Jørgensen, M. E., Jørgensen, T., Karaleftheri, M., Khor, C. C., Kirkpatrick, A., Kraja, A. T., Kuusisto, J., Lange, E. M., Lee, I. T., Lee, W. J., Leong, A., Liao, J., Liu, C., Liu, Y., Lindgren, C. M., Linneberg, A., Malerba, G., Mamakou, V., Marouli, E., Maruthur, N. M., Matchan, A., McKean-Cowdin, R., McLeod, O., Metcalf, G. A., Mohlke, K. L., Muzny, D. M., Ntalla, I., Palmer, N. D., Pasko, D., Peter, A., Rayner, N. W., Renström, F., Rice, K., Sala, C. F., Sennblad, B., Serafetinidis, I., Smith, J. A., Soranzo, N., Speliotes, E. K., Stahl, E. A., Stirrups, K., Tentolouris, N., Thanopoulou, A., Torres, M., Traglia, M., Tsafantakis, E., Javad, S., Yanek, L. R., Zengini, E., Becker, D. M., Bis, J. C., Brown, J. B., Adrienne Cupples, L., Hansen, T., Ingelsson, E., Karter, A. J., Lorenzo, C., Mathias, R. A., Norris, J. M., Peloso, G. M., Sheu, W. H. H., Toniolo, D., Vaidya, D., Varma, R., Wagenknecht, L. E., Boeing, H., Bottinger, E. P., Dedoussis, G., Deloukas, P., Ferrannini, E., Franco, O. H., Franks, P. W., Gibbs, R. A., Gudnason, V., Hamsten, A., Harris, T. B., Hattersley, A. T., Hayward, C., Hofman, A., Jansson, J. H., Langenberg, C., Launer, L. J., Levy, D., Oostra, B. A., O'Donnell, C. J., O'Rahilly, S., Padmanabhan, S., Pankow, J. S., Polasek, O., Province, M. A., Rich, S. S., Ridker, P. M., Rudan, I., Schulze, M. B., Smith, B. H., Uitterlinden, A. G., Walker, M., Watkins, H., Wong, T. Y., Zeggini, E., Laakso, M., Borecki, I. B., Chasman, D. I., Pedersen, O., Psaty, B. M., Shyong Tai, E., Van Duijn, C. M., Wareham, N. J., Waterworth, D. M., Boerwinkle, E., Linda Kao, W. H., Florez, J. C., Loos, R. J. F., Wilson, J. G., Frayling, T. M., Siscovick, D. S., Dupuis, J., Rotter, J. I., Meigs, J. B., Scott, R. A. & Goodarzi, M. O., 2015, In : Nature Communications. 6, 6897.

Research output: Contribution to journalArticle

fasting
Exome
Medical problems
glucose
Type 2 Diabetes Mellitus
2014
1 Citation (Scopus)

Genetic Testing and Type 2 Diabetes Risk Awareness

de Groot, M. & Wessel, J., Jul 19 2014, In : Diabetes Educator. 40, 4, p. 427-433 7 p.

Research output: Contribution to journalArticle

Genetic Testing
Type 2 Diabetes Mellitus
Libraries
Registries
Hospital Emergency Service
2012
69 Citations (Scopus)

Genome-wide meta-analyses of smoking behaviors in African Americans

David, S. P., Hamidovic, A., Chen, G. K., Bergen, A. W., Wessel, J., Kasberger, J. L., Brown, W. M., Petruzella, S., Thacker, E. L., Kim, Y., Nalls, M. A., Tranah, G. J., Sung, Y. J., Ambrosone, C. B., Arnett, D., Bandera, E. V., Becker, D. M., Becker, L., Berndt, S. I., Bernstein, L. & 59 others, Blot, W. J., Broeckel, U., Buxbaum, S. G., Caporaso, N., Casey, G., Chanock, S. J., Deming, S. L., Diver, W. R., Eaton, C. B., Evans, D. S., Evans, M. K., Fornage, M., Franceschini, N., Harris, T. B., Henderson, B. E., Hernandez, D. G., Hitsman, B., Hu, J. J., Hunt, S. C., Ingles, S. A., John, E. M., Kittles, R., Kolb, S., Kolonel, L. N., Le Marchand, L., Liu, Y., Lohman, K. K., McKnight, B., Millikan, R. C., Murphy, A., Neslund-Dudas, C., Nyante, S., Press, M., Psaty, B. M., Rao, D. C., Redline, S., Rodriguez-Gil, J. L., Rybicki, B. A., Signorello, L. B., Singleton, A. B., Smoller, J., Snively, B., Spring, B., Stanford, J. L., Strom, S. S., Swan, G. E., Taylor, K. D., Thun, M. J., Wilson, A. F., Witte, J. S., Yamamura, Y., Yanek, L. R., Yu, K., Zheng, W., Ziegler, R. G., Zonderman, A. B., Jorgenson, E., Haiman, C. A. & Furberg, H., 2012, In : Translational Psychiatry. 2, e119.

Research output: Contribution to journalArticle

African Americans
Meta-Analysis
Smoking
Genome
Single Nucleotide Polymorphism
16 Citations (Scopus)

Varenicline for smoking cessation: Nausea severity and variation in nicotinic receptor genes

Swan, G. E., Javitz, H. S., Jack, L. M., Wessel, J., Michel, M., Hinds, D. A., Stokowksi, R. P., Mcclure, J. B., Catz, S. L., Richards, J., Zbikowski, S. M., Deprey, M., Mcafee, T., Conti, D. V. & Bergen, A. W., Aug 2012, In : Pharmacogenomics Journal. 12, 4, p. 349-358 10 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Smoking Cessation
Nausea
Genes
Alleles
2011

Environmental and genetic contributions to indicators of oral malodor in twins

Bretz, W. A., Biesbrock, A., Corby, P. M., Corby, A. L., Bretz, W. G., Wessel, J. & Schork, N. J., Dec 2011, In : Twin Research and Human Genetics. 14, 6, p. 568-572 5 p.

Research output: Contribution to journalArticle

Sulfur Compounds
Dizygotic Twins
Monozygotic Twins
Tongue
Sweating
14 Citations (Scopus)

Naturally occurring variations in the human cholinesterase genes: Heritability and association with cardiovascular and metabolic traits

Valle, A. M., Radić, Z., Rana, B. K., Mahboubi, V., Wessel, J., Shih, P. A. B., Rao, F., O'Connor, D. T. & Taylor, P., Jul 2011, In : Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
Cholinesterases
Acetylcholinesterase
Single Nucleotide Polymorphism
Genes
2010
11 Citations (Scopus)

Human tyrosine hydroxylase natural allelic variation: Influence on autonomic function and hypertension

Rao, F., Zhang, K., Zhang, L., Rana, B. K., Wessel, J., Fung, M. M., Rodriguez-Flores, J. L., Taupenot, L., Ziegler, M. G. & OConnor, D. T., Nov 2010, In : Cellular and Molecular Neurobiology. 30, 8, p. 1391-1394 4 p.

Research output: Contribution to journalArticle

Tyrosine 3-Monooxygenase
Catecholamines
Hypertension
Epinephrine
Norepinephrine
11 Citations (Scopus)

Presymptomatic risk assessment for chronic non-communicable diseases

Padhukasahasram, B., Halperin, E., Wessel, J., Thomas, D. J., Silver, E., Trumbower, H., Cargill, M. & Stephan, D. A., 2010, In : PLoS One. 5, 12, e14338.

Research output: Contribution to journalArticle

noninfectious diseases
Risk assessment
risk assessment
Inborn Genetic Diseases
genetic disorders
51 Citations (Scopus)

Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence

Wessel, J., McDonald, S. M., Hinds, D. A., Stokowski, R. P., Javitz, H. S., Kennemer, M., Krasnow, R., Dirks, W., Hardin, J., Pitts, S. J., Michel, M., Jack, L., Ballinger, D. G., McClure, J. B., Swan, G. E. & Bergen, A. W., Nov 2010, In : Neuropsychopharmacology. 35, 12, p. 2392-2402 11 p.

Research output: Contribution to journalArticle

Tobacco Use Disorder
Nicotinic Receptors
Single Nucleotide Polymorphism
Nucleotides
Genes
2009
34 Citations (Scopus)

CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response

Beitelshees, A. L., Navare, H., Wang, D., Gong, Y., Wessel, J., Moss, J. I., Langaee, T. Y., Cooper-DeHoff, R. M., Sadee, W., Pepine, C. J., Schork, N. J. & Johnson, J. A., Aug 2009, In : Circulation: Cardiovascular Genetics. 2, 4, p. 362-370 9 p.

Research output: Contribution to journalArticle

Cardiovascular Diseases
Verapamil
trandolapril
Genes
Atenolol
8 Citations (Scopus)

Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: Influence on heritable autonomic traits in twin pairs

Rana, B. K., Wessel, J., Mahboubi, V., Rao, F., Haeller, J., Gayen, J. R., Eskin, E., Valle, A. M., Das, M., Mahata, S. K., Taupenot, L., Stridsberg, M., Talley, T. T., Ziegler, M. G., Smith, D. W., Schork, N. J., O'Connor, D. T. & Taylor, P., Nov 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 419-428 10 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Human Chromosomes
Blood Pressure
Nicotinic Agonists
Single Nucleotide Polymorphism
14 Citations (Scopus)

Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample

Hardin, J., He, Y., Javitz, H. S., Wessel, J., Krasnow, R. E., Tildesley, E., Hops, H., Swan, G. E. & Bergen, A. W., Dec 2009, In : Cancer Epidemiology Biomarkers and Prevention. 18, 12, p. 3399-3406 8 p.

Research output: Contribution to journalArticle

Nicotine
Single Nucleotide Polymorphism
Smoking
Substance Withdrawal Syndrome
Pedigree
2008
10 Citations (Scopus)

Adrenergic polymorphism and the human stress response

Rao, F., Zhang, L., Wessel, J., Zhang, K., Wen, G., Kennedy, B. P., Rana, B. K., Das, M., Rodriguez-Flores, J. L., Smith, D. W., Cadman, P. E., Salem, R. M., Mahata, S. K., Schork, N. J., Taupenot, L., Ziegler, M. G. & O'Connor, D. T., Dec 2008, Annals of the New York Academy of Sciences. Vol. 1148. p. 282-296 15 p. (Annals of the New York Academy of Sciences; vol. 1148).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Blood pressure
Tyrosine 3-Monooxygenase
Polymorphism
Adrenergic Agents
Catecholamines
17 Citations (Scopus)

DNA Sequence-Based Phenotypic Association Analysis

Schork, N. J., Wessel, J. & Malo, N., 2008, In : Advances in Genetics. 60, p. 195-217 23 p.

Research output: Contribution to journalArticle

Genetic Association Studies
Technology
Costs and Cost Analysis
High-Throughput Nucleotide Sequencing
Linkage Disequilibrium
11 Citations (Scopus)

Evidence for a heritable unidimensional symptom factor underlying obsessionality

Mathews, C. A., Greenwood, T., Wessel, J., Azzam, A., Garrido, H., Chavira, D. A., Chandavarkar, U., Bagnarello, M., Stein, M. & Schork, N. J., Sep 5 2008, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 147, 6, p. 676-685 10 p.

Research output: Contribution to journalArticle

Obsessive-Compulsive Disorder
Medical Students
Students
Equipment and Supplies
9 Citations (Scopus)

Inheritance of occlusal topography: a twin study.

Su, C. Y., Corby, P. M., Elliot, M. A., Studen-Pavlovich, D. A., Ranalli, D. N., Rosa, B., Wessel, J., Schork, N. J., Hart, T. C. & Bretz, W. A., Mar 2008, In : European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry. 9, 1, p. 19-24 6 p.

Research output: Contribution to journalArticle

Twin Studies
Tooth
Dizygotic Twins
Monozygotic Twins
2007
15 Citations (Scopus)

Accommodating pathway information in expression quantitative trait locus analysis

Wessel, J., Zapala, M. A. & Schork, N. J., Jul 2007, In : Genomics. 90, 1, p. 132-142 11 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Gene Expression
Software
Regression Analysis
Research Personnel
18 Citations (Scopus)

An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension

Wen, G., Wessel, J., Zhou, W., Ehret, G. B., Rao, F., Stridsberg, M., Mahata, S. K., Gent, P. M., Das, M., Cooper, R. S., Chakravarti, A., Zhou, H., Schork, N. J., O'Connor, D. T. & Hamilton, B. A., Jul 15 2007, In : Human Molecular Genetics. 16, 14, p. 1752-1764 13 p.

Research output: Contribution to journalArticle

Secretogranin II
Chromogranins
Transcription Factors
Alleles
Hypertension
75 Citations (Scopus)

C-reactive protein, an 'intermediate phenotype' for inflammation: Human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/β-adrenergic pathway loci

Wessel, J., Moratorio, G., Rao, F., Mahata, M., Zhang, L., Greene, W., Rana, B. K., Kennedy, B. P., Khandrika, S., Huang, P., Lillie, E. O., Shih, P. A. B., Smith, D. W., Wen, G., Hamilton, B. A., Ziegler, M. G., Witztum, J. L., Schork, N. J., Schmid-Schönbein, G. W. & O'Connor, D. T., Feb 2007, In : Journal of Hypertension. 25, 2, p. 329-343 15 p.

Research output: Contribution to journalArticle

Twin Studies
Adrenergic Agents
C-Reactive Protein
Blood Pressure
Inflammation
67 Citations (Scopus)

Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk

Zhang, L., Rao, F., Zhang, K., Khandrika, S., Das, M., Vaingankar, S. M., Bao, X., Rana, B. K., Smith, D. W., Wessel, J., Salem, R. M., Rodriguez-Flores, J. L., Mahata, S. K., Schork, N. J., Ziegler, M. G. & O'Connor, D. T., Sep 4 2007, In : Journal of Clinical Investigation. 117, 9, p. 2658-2671 14 p.

Research output: Contribution to journalArticle

GTP Cyclohydrolase
Medical Genetics
Nitric Oxide
Catecholamines
Pressoreceptors
39 Citations (Scopus)

Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding

Mathews, C. A., Nievergelt, C. M., Azzam, A., Garrido, H., Chavira, D. A., Wessel, J., Bagnarello, M., Reus, V. I. & Schork, N. J., Mar 5 2007, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 144, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

Obsessive-Compulsive Disorder
Lod Score
Genome
Hoarding
Genetic Markers
32 Citations (Scopus)

Heritability of oral microbial species in caries-active and caries-free twins

Corby, P. M. A., Bretz, W. A., Hart, T. C., Schork, N. J., Wessel, J., Lyons-Weiler, J. & Paster, B. J., Dec 2007, In : Twin Research and Human Genetics. 10, 6, p. 821-828 8 p.

Research output: Contribution to journalArticle

Mouth
Tooth
Dental Plaque
Disease Susceptibility
Biofilms
6 Citations (Scopus)

Powerful designs for genetic association studies that consider twins and sibling pairs with discordant genotypes

Wessel, J., Schork, A. J., Tiwari, H. K. & Schork, N. J., Nov 2007, In : Genetic Epidemiology. 31, 7, p. 789-796 8 p.

Research output: Contribution to journalArticle

Genetic Association Studies
Siblings
Genotype
Technology
Phenotype
35 Citations (Scopus)

Renal albumin excretion: Twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism

Rao, F., Wessel, J., Wen, G., Zhang, L., Rana, B. K., Kennedy, B. P., Greenwood, T. A., Salem, R. M., Chen, Y., Khandrika, S., Hamilton, B. A., Smith, D. W., Holstein-Rathlou, N. H., Ziegler, M. G., Schork, N. J. & O'Connor, D. T., May 2007, In : Hypertension. 49, 5, p. 1015-1031 17 p.

Research output: Contribution to journalArticle

Twin Studies
Heredity
Adrenergic Agents
Albumins
Sorting Nexins
6 Citations (Scopus)

Single nucleotide polymorphism discovery and haplotype analysis of Ca2+-dependent K+ channel beta-1 subunit

Gong, Y., Beitelshees, A. L., Wessel, J., Langaee, T. Y., Schork, N. J. & Johnson, J. A., Apr 2007, In : Pharmacogenetics and Genomics. 17, 4, p. 267-275 9 p.

Research output: Contribution to journalArticle

Haplotypes
Single Nucleotide Polymorphism
Gene Frequency
Genes
Exons
71 Citations (Scopus)

Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: Discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo

Rao, F., Zhang, L., Wessel, J., Zhang, K., Wen, G., Kennedy, B. P., Rana, B. K., Das, M., Rodriguez-Flores, J. L., Smith, D. W., Cadman, P. E., Salem, R. M., Mahata, S. K., Schork, N. J., Taupenot, L., Ziegler, M. G. & O'Connor, D. T., Aug 2007, In : Circulation. 116, 9, p. 993-1006 14 p.

Research output: Contribution to journalArticle

Medical Genetics
Tyrosine 3-Monooxygenase
Catecholamines
Blood Pressure
Enzymes
2006
118 Citations (Scopus)

Generalized genomic distance-based regression methodology for multilocus association analysis

Wessel, J. & Schork, N. J., Nov 2006, In : American Journal of Human Genetics. 79, 5, p. 792-806 15 p.

Research output: Contribution to journalArticle

Haplotypes
Genotype
Genetic Association Studies
Phylogeny
Diploidy
68 Citations (Scopus)

Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: Role of heredity

Seasholtz, T. M., Wessel, J., Rao, F., Rana, B. K., Khandrika, S., Kennedy, B. P., Lillie, E. O., Ziegler, M. G., Smith, D. W., Schork, N. J., Brown, J. H. & O'Connor, D. T., May 2006, In : Hypertension. 47, 5, p. 937-947 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Heredity
Vascular Resistance
Blood Pressure
Hypertension
2005
59 Citations (Scopus)

A comprehensive literature review of haplotyping software and methods for use with unrelated individuals

Salem, R. M., Wessel, J. & Schork, N. J., Mar 2005, In : Human Genomics. 2, 1, p. 39-66 28 p.

Research output: Contribution to journalArticle

Haplotypes
Software
HapMap Project
Search Engine
DNA
73 Citations (Scopus)

Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: Prediction of catecholamines and response to stress in twins

Zhang, L., Rao, F., Wessel, J., Kennedy, B. P., Rana, B. K., Taupenot, L., Lillie, E. O., Cockburn, M., Schork, N. J., Ziegler, M. G. & O'Connor, D. T., Jan 2005, In : Physiological Genomics. 19, p. 277-291 15 p.

Research output: Contribution to journalArticle

Tyrosine 3-Monooxygenase
Catecholamines
Alleles
Hypertension
Heart Rate