Jesus Delgado-Calle

  • 995 Citations
  • 20 h-Index
20082019
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Publications 2008 2019

2019
1 Citation (Scopus)

2D and 3D In Vitro Co-Culture for Cancer and Bone Cell Interaction Studies

Marino, S., Bishop, R. T., de Ridder, D., Delgado-Calle, J. & Reagan, M. R., Jan 1 2019, In : Methods in molecular biology (Clifton, N.J.). 1914, p. 71-98 28 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Coculture Techniques
Cell Communication
Osteocytes
Osteoclasts

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts

Delgado-Calle, J., Kurihara, N., Atkinson, E. G., Nelson, J., Miyagawa, K., Galmarini, C. M., Roodman, G. D. & Bellido, T., Apr 12 2019, In : Oncotarget. 10, 28, p. 2709-2721 13 p.

Research output: Contribution to journalArticle

Osteoclasts
Multiple Myeloma
Dexamethasone
Bone Development
Osteoblasts

Corrigendum: H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells

Fernández, A. F., Bayón, G. F., Urdinguio, R. G., Toraño, E. G., García, M. G., Carella, A., Petrus-Reurer, S., Ferrero, C., Martinez-Camblor, P., Cubillo, I., García-Castro, J., Delgado-Calle, J., Pérez-Campo, F. M., Riancho, J. A., Bueno, C., Menéndez, P., Mentink, A., Mareschi, K., Claire, F., Fagnani, C. & 10 others, Medda, E., Toccaceli, V., Brescianini, S., Moran, S., Esteller, M., Stolzing, A., de Boer, J., Nisticò, L., Stazi, M. A. & Fraga, M. F., Apr 1 2019, In : Genome research. 29, 4

Research output: Contribution to journalComment/debate

Open Access
Stem Cells
DNA
corrigendum
2018
5 Citations (Scopus)

MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production

Delgado-Calle, J., Hancock, B., Likine, E. F., Sato, A., McAndrews, K., Sanudo, C., Bruzzaniti, A., Riancho, J. A., Tonra, J. R. & Bellido, T., May 1 2018, In : FASEB Journal. 32, 5, p. 2878-2890 13 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 14
Osteocytes
Parathyroid Hormone
Bone
Bone and Bones
2017
24 Citations (Scopus)

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth

Delgado-Calle, J., Anderson, J., Cregor, M. D., Condon, K. W., Kuhstoss, S. A., Plotkin, L., Bellido, T. & Roodman, G. D., Dec 1 2017, In : Leukemia. 31, 12, p. 2686-2694 9 p.

Research output: Contribution to journalArticle

Bone Diseases
Multiple Myeloma
Pharmacology
Growth
Neoplasms

Osteoclasts control lipid secretion to regulate breast cancer bone metastasis

Delgado-Calle, J., Mar 1 2017, In : Endocrinology. 158, 3, p. 458-460 3 p.

Research output: Contribution to journalShort survey

Bone Neoplasms
Osteoclasts
Breast Neoplasms
Neoplasm Metastasis
Lipids
1 Citation (Scopus)

Osteocytes and Their Messengers as Targets for the Treatment of Multiple Myeloma

Delgado-Calle, J., Mar 1 2017, In : Clinical Reviews in Bone and Mineral Metabolism. 15, 1, p. 49-56 8 p.

Research output: Contribution to journalReview article

Osteocytes
Multiple Myeloma
Bone and Bones
Therapeutics
Pain
49 Citations (Scopus)

Role and mechanism of action of sclerostin in bone

Delgado-Calle, J., Sato, A. & Bellido, T., Mar 1 2017, In : Bone. 96, p. 29-37 9 p.

Research output: Contribution to journalArticle

Bone and Bones
Osteochondrodysplasias
Anabolic Agents
Osteocytes
Bone Neoplasms
1 Citation (Scopus)

Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease

McDonald, M. M. & Delgado-Calle, J., Sep 27 2017, (Accepted/In press) In : Current Osteoporosis Reports. p. 1-10 10 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Bone Diseases
Bone and Bones
Neoplasms
Therapeutics
2016
16 Citations (Scopus)

Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells

Toraño, E. G., Bayón, G. F., del Real, Á., Sierra, M. I., García, M. G., Carella, A., Belmonte, T., Urdinguio, R. G., Cubillo, I., García-Castro, J., Delgado-Calle, J., Pérez-Campo, F. M., Riancho, J. A., Fraga, M. F. & Fernández, A. F., 2016, In : Journal of Translational Medicine. 14, 1, 207.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Bone
Bone Marrow
Epigenomics
64 Citations (Scopus)
Osteocytes
Tumor Microenvironment
Multiple Myeloma
Bone Marrow
Cell Proliferation
34 Citations (Scopus)

Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor

Delgado-Calle, J., Tu, X., Pacheco-Costa, R., Mcandrews, K., Edwards, R., Pellegrini, G. G., Kuhlenschmidt, K., Olivos, N., Robling, A., Peacock, M., Plotkin, L. & Bellido, T., 2016, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Parathyroid Hormone Receptor Type 1
Parathyroid Hormone
Bone and Bones
Dentin
Bone Resorption

Functional study of promoter gene polymorphisms of sclerostin

Pérez-Campo, F. M., Sañudo, C., Krebesova, R., Delgado-Calle, J. & Riancho, J. A., Jan 1 2016, In : Revista de Osteoporosis y Metabolismo Mineral. 8, 4, p. 121-126 6 p.

Research output: Contribution to journalArticle

Alleles
Genes
Bone Density
Single Nucleotide Polymorphism
Wnt Signaling Pathway
4 Citations (Scopus)

Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies

Pérez-Campo, F. M., May, T., Zauers, J., Sañudo, C., Delgado-Calle, J., Arozamena, J., Berciano, M. T., Lafarga, M. & Riancho, J. A., Apr 2 2016, (Accepted/In press) In : Journal of Bone and Mineral Metabolism. p. 1-11 11 p.

Research output: Contribution to journalArticle

Epigenomics
Cell Line
decitabine
Deoxycytidine
Bone Matrix
36 Citations (Scopus)
Glucocorticoids
Osteoporosis
Catenins
Osteogenesis
Bone and Bones
2015
33 Citations (Scopus)

Analysis of the bone MicroRNome in osteoporotic fractures

Garmilla-Ezquerra, P., Sañudo, C., Delgado-Calle, J., Pérez-Nuñez, M. I., Sumillera, M. & Riancho, J. A., Nov 29 2015, In : Calcified Tissue International. 96, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

Osteoporotic Fractures
Hip Fractures
MicroRNAs
Bone and Bones
Osteoporosis
54 Citations (Scopus)

H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells

Fernández, A. F., Bayón, G. F., Urdinguio, R. G., Toraño, E. G., García, M. G., Carella, A., Petrus-Reurer, S., Ferrero, C., Martinez-Camblor, P., Cubillo, I., García-Castro, J., Delgado-Calle, J., Pérez-Campo, F. M., Riancho, J. A., Bueno, C., Menéndez, P., Mentink, A., Mareschi, K., Claire, F., Fagnani, C. & 10 others, Medda, E., Toccaceli, V., Brescianini, S., Moran, S., Esteller, M., Stolzing, A., De Boer, J., Nistico, L., Stazi, M. A. & Fraga, M. F., Jan 1 2015, In : Genome Research. 25, 1, p. 27-40 14 p.

Research output: Contribution to journalArticle

DNA Methylation
Stem Cells
Chromatin
DNA
DNA Fingerprinting
98 Citations (Scopus)

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

Tu, X., Delgado-Calle, J., Condon, K. W., Maycas, M., Zhang, H., Carlesso, N., Taketo, M. M., Burr, D., Plotkin, L. & Bellido, T., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. E478-E486

Research output: Contribution to journalArticle

Osteocytes
Catenins
Bone and Bones
Osteoblasts
Osteoclasts
2014

Advances in the study of the mechanisms involved in the modulation of the expression of sclerostin in human cells

Delgado-Calle, J., P�rez-Campo, F. M. & Riancho, J. A., Jan 1 2014, In : Revista de Osteoporosis y Metabolismo Mineral. 6, 4, p. 103-108 6 p.

Research output: Contribution to journalReview article

Bone and Bones
CpG Islands
Epigenomics
Bone Density
Methylation
7 Citations (Scopus)

A sclerostin super-producer cell line derived from the human cell line SaOS-2: A new tool for the study of the molecular mechanisms driving sclerostin expression

Pérez-Campo, F. M., Sañudo, C., Delgado-Calle, J., Arozamena, J., Zarrabeitia, M. T. & Riancho, J. A., 2014, In : Calcified Tissue International. 95, 2, p. 194-199 6 p.

Research output: Contribution to journalArticle

Cell Line
Homeostasis
Clone Cells
Bone and Bones
CpG Islands
16 Citations (Scopus)

Nitric oxide is involved in the down-regulation of SOST expression induced by mechanical loading

Delgado-Calle, J., Riancho, J. A. & Klein-Nulend, J., 2014, In : Calcified Tissue International. 94, 4, p. 414-422 9 p.

Research output: Contribution to journalArticle

Pulsatile Flow
Nitric Oxide
Down-Regulation
Conditioned Culture Medium
Bone and Bones
38 Citations (Scopus)

Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes

Ben-awadh, A. N., Delgado-Calle, J., Tu, X., Kuhlenschmidt, K., Allen, M., Plotkin, L. & Bellido, T., 2014, In : Endocrinology. 155, 8, p. 2797-2809 13 p.

Research output: Contribution to journalArticle

Parathyroid Hormone Receptor Type 1
Osteocytes
Bone Resorption
Skeleton
Genes
31 Citations (Scopus)
Osteocytes
Bone Diseases
Multiple Myeloma
Osteogenesis
Bone and Bones

The role of DNA methylation in common skeletal disorders

Delgado-Calle, J. & Riancho, J. A., Jan 1 2014, Specific Gene Expression and Epigenetics: The Interplay Between the Genome and its Environment. Apple Academic Press, p. 91-112 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA Methylation
Bone
Bone and Bones
Tissue
Connective Tissue
2013
23 Citations (Scopus)

Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders

García-Ibarbia, C., Delgado-Calle, J., Casafont, I., Velasco, J., Arozamena, J., Pérez-Núñez, M. I., Alonso, M. A., Berciano, M. T., Ortiz, F., Pérez-Castrillón, J. L., Fernández, A. F., Fraga, M. F., Zarrabeitia, M. T. & Riancho, J. A., Dec 15 2013, In : Gene. 532, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Epigenomics
Catenins
Osteoarthritis
Methylation
77 Citations (Scopus)

Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis

Delgado-Calle, J., Fernández, A. F., Sainz, J., Zarrabeitia, M. T., Sañudo, C., García-Renedo, R., Pérez-Núñez, M. I., García-Ibarbia, C., Fraga, M. F. & Riancho, J. A., Jan 2013, In : Arthritis and Rheumatism. 65, 1, p. 197-205 9 p.

Research output: Contribution to journalArticle

Osteoarthritis
Methylation
Osteoporosis
Genome
Bone and Bones
25 Citations (Scopus)

Role of BMPs in the regulation of sclerostin as revealed by an epigenetic modifier of human bone cells

Delgado-Calle, J., Arozamena, J., Pérez-López, J., Bolado-Carrancio, A., Sañudo, C., Agudo, G., de la Vega, R., Alonso, M. A., Rodríguez-Rey, J. C. & Riancho, J. A., Apr 30 2013, In : Molecular and Cellular Endocrinology. 369, 1-2, p. 27-34 8 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Epigenomics
Bone
Bone and Bones
Bone Morphogenetic Protein 2
2012

Alteración del apoyo anterointerno como secuela del tratamiento quirúrgico del hallux valgus.

Translated title of the contribution: [Disruption of anterointernal weight bearing: sequelae of surgical treatment of hallux valgus].García-Renedo, R. J., Carranza-Bencano, A., Delgado-Calle, J., Núñez-Samper, M. & Llanos-Alcázar, L. F., 2012, In : Acta ortopédica mexicana. 26, 6, p. 393-397 5 p.

Research output: Contribution to journalArticle

Hallux Valgus
Weight-Bearing
Metatarsalgia
Metatarsal Bones
Arthrodesis
68 Citations (Scopus)

DNA methylation contributes to the regulation of sclerostin expression in human osteocytes

Delgado-Calle, J., Sañudo, C., Bolado, A., Fernández, A. F., Arozamena, J., Pascual-Carra, M. A., Rodriguez-Rey, J. C., Fraga, M. F., Bonewald, L. & Riancho, J. A., Apr 2012, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 27, 4, p. 926-937 12 p.

Research output: Contribution to journalArticle

Osteocytes
DNA Methylation
Osteoblasts
Methylation
CpG Islands
29 Citations (Scopus)

Do epigenetic marks govern bone mass and homeostasis?

Delgado-Calle, J., Garmilla, P. & Riancho, J. A., May 2012, In : Current Genomics. 13, 3, p. 252-263 12 p.

Research output: Contribution to journalArticle

Bone Remodeling
Epigenomics
Homeostasis
Osteoclasts
Osteoblasts
61 Citations (Scopus)

Role of DNA methylation in the regulation of the RANKL-OPG system in human bone

Delgado-Calle, J., Sañudo, C., Fernández, A. F., García-Renedo, R., Fraga, M. F. & Riancho, J. A., 2012, In : Epigenetics : official journal of the DNA Methylation Society. 7, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

Osteoprotegerin
DNA Methylation
Methylation
Bone and Bones
CpG Islands
13 Citations (Scopus)

The role of DNA methylation in common skeletal disorders

Delgado-Calle, J. & Riancho, J. A., Oct 22 2012, In : Biology. 1, 3, p. 698-713 16 p.

Research output: Contribution to journalArticle

DNA methylation
DNA Methylation
Bone
bones
Bone and Bones
2011
55 Citations (Scopus)

Epigenetic regulation of alkaline phosphatase in human cells of the osteoblastic lineage

Delgado-Calle, J., Sañudo, C., Sánchez-Verde, L., García-Renedo, R. J., Arozamena, J. & Riancho, J. A., Oct 2011, In : Bone. 49, 4, p. 830-838 9 p.

Research output: Contribution to journalArticle

Cell Lineage
Osteoblasts
Epigenomics
Alkaline Phosphatase
DNA Methylation
10 Citations (Scopus)

Mecanismos de interacción osteoblasto-osteoclasto

Translated title of the contribution: Osteoblast-osteoclast interaction mechanismsRiancho, J. A. & Delgado-Calle, J., Sep 2011, In : Reumatologia Clinica. 7, SUPPL.2, p. 1-4 4 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteoblasts
Osteocytes
Macrophage Colony-Stimulating Factor
Bone Remodeling
26 Citations (Scopus)

Osteocyte deficiency in hip fractures

Delgado-Calle, J., Arozamena, J., García-Renedo, R., García-Ibarbia, C., Pascual-Carra, M. A., González-Macías, J. & Riancho, J. A., Oct 2011, In : Calcified Tissue International. 89, 4, p. 327-334 8 p.

Research output: Contribution to journalArticle

Osteocytes
Hip Fractures
Caspase 3
Apoptosis
Hip Osteoarthritis
2010
46 Citations (Scopus)

Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk

Cárcamo-Orive, I., Gaztelumendi, A., Delgado-Calle, J., Tejados, N., Dorronsoro, A., Fernández-Rueda, J., Pennington, D. J. & Trigueros, C., Oct 2010, In : Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 25, 10, p. 2115-2125 11 p.

Research output: Contribution to journalArticle

Adipogenesis
Glucocorticoid Receptors
Transcription Factor AP-1
Mesenchymal Stromal Cells
Cell Differentiation
2008
49 Citations (Scopus)

ERK2 protein regulates the proliferation of human mesenchymal stem cells without affecting their mobilization and differentiation potential

Cárcamo-Orive, I., Tejados, N., Delgado-Calle, J., Gaztelumendi, A., Otaegui, D., Lang, V. & Trigueros, C., May 1 2008, In : Experimental Cell Research. 314, 8, p. 1777-1788 12 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Intercellular Signaling Peptides and Proteins
Adipocytes
Proteins
Cell Cycle Resting Phase