Jianjian Shi

  • 1946 Citations
  • 20 h-Index
19962019
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Publications 1996 2019

  • 1946 Citations
  • 20 h-Index
  • 35 Article
2019
1 Citation (Scopus)
Focal Adhesion Protein-Tyrosine Kinases
Myosin Light Chains
Autophagy
Sirolimus
Cardiac Myocytes
2018
2 Citations (Scopus)

Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxicity

Shi, J., Surma, M. & Wei, L., Jan 1 2018, In : Oncotarget. 9, 16, p. 12995-13008 14 p.

Research output: Contribution to journalArticle

Doxorubicin
Cardiac Myocytes
Autophagy
Genes
Injections
2016
42 Citations (Scopus)

Novel Insights into the Roles of Rho Kinase in Cancer

Wei, L., Surma, M., Shi, S., Lambert-Cheatham, N. & Shi, J., Jan 2 2016, (Accepted/In press) In : Archivum Immunologiae et Therapiae Experimentalis. p. 1-20 20 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Neoplasms
Apoptosis
Monomeric GTP-Binding Proteins
Actin Cytoskeleton
13 Citations (Scopus)

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis

Yue, X., Lin, X., Yang, T., Yang, X., Yi, X., Jiang, X., Li, X., Li, T., Guo, J., Dai, Y., Shi, J., Wei, L., Youker, K. A., Torre-Amione, G., Yu, Y., Andrade, K. C. & Chang, J., Mar 1 2016, In : Hypertension. 67, 3, p. 597-605 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Vascular Endothelial Growth Factor A
Heart Failure
Down-Regulation
rho GTP-Binding Proteins
5 Citations (Scopus)

ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells

Kapur, R., Shi, J., Ghosh, J., Munugalavadla, V., Sims, E., Martin, H., Wei, L. & Mali, R. S., Mar 29 2016, In : Oncotarget. 7, 13, p. 16936-16947 12 p.

Research output: Contribution to journalArticle

Lim Kinases
Mast Cells
Actins
Growth
Bone Marrow
2015
22 Citations (Scopus)

Dissecting the mechanisms of doxorubicin and oxidative stress-induced cytotoxicity: The involvement of actin cytoskeleton and ROCK1

Wei, L., Surma, M., Gough, G., Shi, S., Lambert-Cheatham, N., Chang, J. & Shi, J., Jul 2 2015, In : PLoS One. 10, 7, e0131763.

Research output: Contribution to journalArticle

doxorubicin
Oxidative stress
Cytotoxicity
microfilaments
Actin Cytoskeleton
2014
11 Citations (Scopus)

Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure

Yue, X., Yang, X., Lin, X., Yang, T., Yi, X., Dai, Y., Guo, J., Li, T., Shi, J., Wei, L., Fan, G. C., Chen, C. & Chang, J., 2014, In : Cell Death and Disease. 5, 6, e1284.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cardiomyopathies
Heart Failure
Hemodynamics
Guanosine
17 Citations (Scopus)

ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment

Surma, M., Handy, C., Chang, J., Kapur, R., Wei, L. & Shi, J., Mar 4 2014, In : PLoS One. 9, 3, e90758.

Research output: Contribution to journalArticle

doxorubicin
Doxorubicin
protective effect
reactive oxygen species
Reactive Oxygen Species
20 Citations (Scopus)

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance

Lee, S. H., Huang, H., Choi, K., Lee, D. H., Shi, J., Liu, T., Chun, K. H., Seo, J. A., Lima, I. S., Zabolotny, J. M., Wei, L. & Kim, Y. B., Feb 1 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 3

Research output: Contribution to journalArticle

Insulin Resistance
Adipose Tissue
Protein Isoforms
Diet
Obese Mice
2013
24 Citations (Scopus)

Determination of trace amount of Cu2+ with a multi-responsive colorimetric and reversible chemosensor

Mi, Y. S., Cao, Z., Chen, Y. T., Xie, Q. F., Xu, Y. Y., Luo, Y. F., Shi, J. & Xiang, J. N., Sep 21 2013, In : Analyst. 138, 18, p. 5274-5280 7 p.

Research output: Contribution to journalArticle

Rhodamines
sensor
Atomic spectroscopy
Sensors
atomic absorption spectroscopy
16 Citations (Scopus)

Dissecting the roles of ROCK isoforms in stress-induced cell detachment

Shi, J., Surma, M., Zhang, L. & Wei, L., May 15 2013, In : Cell Cycle. 12, 10, p. 1492-1500 9 p.

Research output: Contribution to journalArticle

Protein Isoforms
Stress Fibers
Focal Adhesions
Fibroblasts
Adherens Junctions
70 Citations (Scopus)

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

Shi, J., Wu, X., Surma, M., Vemula, S., Zhang, L., Yang, Y., Kapur, R. & Wei, L., Feb 2013, In : Cell Death and Disease. 4, 2

Research output: Contribution to journalArticle

Actin Cytoskeleton
Actin Depolymerizing Factors
Actomyosin
Stress Fibers
Phosphorylation
93 Citations (Scopus)

Rho kinases in cardiovascular physiology and pathophysiology: The effect of fasudil

Shi, J. & Wei, L., Oct 2013, In : Journal of Cardiovascular Pharmacology. 62, 4, p. 341-354 14 p.

Research output: Contribution to journalArticle

Cardiovascular Physiological Phenomena
rho-Associated Kinases
Cardiovascular Diseases
Protein Isoforms
Monomeric GTP-Binding Proteins
2012
19 Citations (Scopus)
Doxorubicin
Down-Regulation
Apoptosis
Caspase 3
Cardiac Myocytes
73 Citations (Scopus)

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, Vemula, S., Shi, J., Wei, L., Kapur, R., Lopez, C. K., Gerby, B., Ballerini, P., Pflumio, F., Gilliland, D. G., Goldberg, L., Birger, Y., Izraeli, S., Gamis, A. S., Smith, F. O., Woods, W. G., Taub, J., Scherer, C. A., Bradner, J. E., Goh, B. C., Mercher, T., Carpenter, A. E., Gould, R. J., Clemons, P. A., Carr, S. A., Root, D. E., Schreiber, S. L., Stern, A. M. & Crispino, J. D., Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.

Research output: Contribution to journalArticle

Leukemia, Megakaryoblastic, Acute
Aurora Kinase A
Polyploidy
Megakaryocytes
Small Interfering RNA
18 Citations (Scopus)

Regulation of JAK/STAT signalling by SOCS in the myocardium

Shi, J. & Wei, L., Dec 1 2012, In : Cardiovascular Research. 96, 3, p. 345-347 3 p.

Research output: Contribution to journalArticle

Janus Kinase 1
Cytokine Receptor gp130
Suppressor of Cytokine Signaling Proteins
STAT3 Transcription Factor
Gene Transfer Techniques
20 Citations (Scopus)

Regulation of the actin cytoskeleton by rho kinase controls antigen presentation by CD1d

Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J. & Brutkiewicz, R., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Antigen Presentation
Lim Kinases
Actin Cytoskeleton
Natural Killer T-Cells
23 Citations (Scopus)

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Vemula, S., Shi, J., Mali, R. S., Ma, P., Liu, Y., Hanneman, P., Koehler, K. R., Hashino, E., Wei, L. & Kapur, R., Oct 4 2012, In : Blood. 120, 14, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

Erythropoiesis
Survival
Stem cells
rho-Associated Kinases
Enhanced recovery
7 Citations (Scopus)
Atrial Remodeling
Pericardium
Hypertrophy
Action Potentials
Left Ventricular Hypertrophy
2011
21 Citations (Scopus)

Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease

Zhou, L., Liu, F., Huang, X. R., Liu, F., Chen, H., Chung, A. C. K., Shi, J., Wei, L., Lan, H. Y. & Fu, P., Nov 2011, In : American Journal of Nephrology. 34, 5, p. 468-475 8 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-2
Albuminuria
Diabetic Nephropathies
Streptozocin
Knockout Mice
21 Citations (Scopus)

Apoptosis in anthracycline cardiomyopathy

Shi, J., Abdelwahid, E. & Wei, L., Nov 2011, In : Current Pediatric Reviews. 7, 4, p. 329-336 8 p.

Research output: Contribution to journalArticle

Anthracyclines
Cardiomyopathies
Apoptosis
Cell Death
Cardiac Myocytes
6 Citations (Scopus)

Effects of rosiglitazone on abnormal lipid kinetics in HIV-associated dyslipidemic lipodystrophy: A stable isotope study

Sekhar, R. V., Patel, S. G., D'Amico, S., Shi, J., Balasubramanyam, A., Rehman, K., Jahoor, F. & Visnegarwala, F., Jun 2011, In : Metabolism: Clinical and Experimental. 60, 6, p. 754-760 7 p.

Research output: Contribution to journalArticle

rosiglitazone
HIV-Associated Lipodystrophy Syndrome
Nonesterified Fatty Acids
Isotopes
Lipolysis
108 Citations (Scopus)

Rho kinase as a therapeutic target in cardiovascular disease

Surma, M., Wei, L. & Shi, J., Sep 2011, In : Future Cardiology. 7, 5, p. 657-671 15 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cardiovascular Diseases
Heart Failure
Phosphotransferases
Monomeric GTP-Binding Proteins
27 Citations (Scopus)

Rho-kinase in development and heart failure: Insights from genetic models

Shi, J., Zhang, L. & Wei, L., Mar 2011, In : Pediatric Cardiology. 32, 3, p. 297-304 8 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Genetic Models
Protein Isoforms
Heart Failure
Phosphotransferases
54 Citations (Scopus)

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. & Kapur, R., Sep 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cell Survival
Phosphatidylinositol 3-Kinases
Oncogenes
Acute Myeloid Leukemia
2010
74 Citations (Scopus)

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

Vemula, S., Shi, J., Hanneman, P., Wei, L. & Kapur, R., Mar 4 2010, In : Blood. 115, 9, p. 1785-1796 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Macrophages
Cell Movement
Chemical activation
Glycogen Synthase Kinase 3
33 Citations (Scopus)

ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice

Shi, J., Zhang, Y. W., Yang, Y., Zhang, L. & Wei, L., Nov 2010, In : Journal of Molecular and Cellular Cardiology. 49, 5, p. 819-828 10 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cardiomegaly
Cardiac Myocytes
Apoptosis
Peripartum Period
2009
211 Citations (Scopus)

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

Zhang, Y. W., Shi, J., Li, Y. J. & Wei, L., Dec 2009, In : Archivum Immunologiae et Therapiae Experimentalis. 57, 6, p. 435-445 11 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Doxorubicin
Cardiomyopathies
Reactive Oxygen Species
Cell Death
77 Citations (Scopus)

Targeted disruption of ROCK1 causes insulin resistance in vivo

Lee, D. H., Shi, J., Jeoung, N. H., Kim, M. S., Zabolotny, J. M., Lee, S. W., White, M. F., Wei, L. & Kim, Y. B., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 11776-11780 5 p.

Research output: Contribution to journalArticle

Insulin Resistance
Insulin
Glucose
Skeletal Muscle
Phosphatidylinositol 3-Kinase
2008
38 Citations (Scopus)

Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy

Shi, J., Zhang, Y. W., Summers, L. J., Dorn, G. W. & Wei, L., Mar 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 551-560 10 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cardiomegaly
Dilatation
Hypertrophy
Genes
2007
162 Citations (Scopus)

Rho kinase in the regulation of cell death and survival

Shi, J. & Wei, L., Apr 2007, In : Archivum Immunologiae et Therapiae Experimentalis. 55, 2, p. 61-75 15 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cell Survival
Protein Isoforms
Cell Death
Apoptosis
2006
17 Citations (Scopus)

Physiologic growth hormone replacement improves fasting lipid kinetics in patients with HIV lipodystrophy syndrome

D'Amico, S., Shi, J., Sekhar, R. V., Jahoor, F., Ellis, K. J., Rehman, K., Willis, J., Maldonado, M. & Balasubramanyam, A., Jul 1 2006, In : American Journal of Clinical Nutrition. 84, 1, p. 204-211 8 p.

Research output: Contribution to journalArticle

HIV-Associated Lipodystrophy Syndrome
somatotropin
Growth Hormone
fasting
Fasting
145 Citations (Scopus)

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

Zhang, Y. M., Bo, J., Taffet, G. E., Chang, J., Shi, J., Reddy, A. K., Michael, L. H., Schneider, M. D., Entman, M. L., Schwartz, R. J. & Wei, L., May 2006, In : FASEB Journal. 20, 7, p. 916-925 10 p.

Research output: Contribution to journalArticle

fibrosis
Fibrosis
heart
hypertrophy
Knockout Mice
2003
19 Citations (Scopus)

Short- and Long-Term Effects of Growth Hormone (GH) Replacement on Protein Metabolism in GH-Deficient Adults

Shi, J., Sekhar, R. V., Balasubramanyam, A., Ellis, K., Reeds, P. J., Jahoor, F. & Sharma, M. D., Dec 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 12, p. 5827-5833 7 p.

Research output: Contribution to journalArticle

Metabolism
Growth Hormone
Leucine
Proteins
Fats
1996
437 Citations (Scopus)

Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice

Mason, H. S., Ball, J. M., Shi, J., Jiang, X., Estes, M. K. & Arntzen, C. J., May 28 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 11, p. 5335-5340 6 p.

Research output: Contribution to journalArticle

Norwalk virus
Capsid Proteins
Solanum tuberosum
Tobacco
Virion