Jianjian Shi

  • 2143 Citations
  • 22 h-Index
19962020

Research output per year

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Publications

  • 2143 Citations
  • 22 h-Index
  • 29 Article
  • 7 Review article
2020

ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice

Wei, L., Surma, M., Yang, Y., Tersey, S. & Shi, J., Jan 1 2020, In : FASEB Journal. 34, 1, p. 474-493 20 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging

Shi, J., Surma, M., Yang, Y. & Wei, L., Jun 1 2019, In : FASEB Journal. 33, 6, p. 7348-7362 15 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxicity

Shi, J., Surma, M. & Wei, L., Jan 1 2018, In : Oncotarget. 9, 16, p. 12995-13008 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Novel Insights into the Roles of Rho Kinase in Cancer

Wei, L., Surma, M., Shi, S., Lambert-Cheatham, N. & Shi, J., Jan 2 2016, (Accepted/In press) In : Archivum Immunologiae et Therapiae Experimentalis. p. 1-20 20 p.

Research output: Contribution to journalArticle

69 Scopus citations

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis

Yue, X., Lin, X., Yang, T., Yang, X., Yi, X., Jiang, X., Li, X., Li, T., Guo, J., Dai, Y., Shi, J., Wei, L., Youker, K. A., Torre-Amione, G., Yu, Y., Andrade, K. C. & Chang, J., Mar 1 2016, In : Hypertension. 67, 3, p. 597-605 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells

Kapur, R., Shi, J., Ghosh, J., Munugalavadla, V., Sims, E., Martin, H., Wei, L. & Mali, R. S., Mar 29 2016, In : Oncotarget. 7, 13, p. 16936-16947 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Dissecting the mechanisms of doxorubicin and oxidative stress-induced cytotoxicity: The involvement of actin cytoskeleton and ROCK1

Wei, L., Surma, M., Gough, G., Shi, S., Lambert-Cheatham, N., Chang, J. & Shi, J., Jul 2 2015, In : PloS one. 10, 7, e0131763.

Research output: Contribution to journalArticle

24 Scopus citations
2014

Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure

Yue, X., Yang, X., Lin, X., Yang, T., Yi, X., Dai, Y., Guo, J., Li, T., Shi, J., Wei, L., Fan, G. C., Chen, C. & Chang, J., Jun 2014, In : Cell Death and Disease. 5, 6, e1284.

Research output: Contribution to journalArticle

12 Scopus citations

ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment

Surma, M., Handy, C., Chang, J., Kapur, R., Wei, L. & Shi, J., Mar 4 2014, In : PLoS ONE. 9, 3, e90758.

Research output: Contribution to journalArticle

21 Scopus citations

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance

Lee, S. H., Huang, H., Choi, K., Lee, D. H., Shi, J., Liu, T., Chun, K. H., Seo, J. A., Lima, I. S., Zabolotny, J. M., Wei, L. & Kim, Y. B., Feb 1 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 3, p. E332-E343

Research output: Contribution to journalArticle

28 Scopus citations
2013

Determination of trace amount of Cu2+ with a multi-responsive colorimetric and reversible chemosensor

Mi, Y. S., Cao, Z., Chen, Y. T., Xie, Q. F., Xu, Y. Y., Luo, Y. F., Shi, J. J. & Xiang, J. N., Sep 21 2013, In : Analyst. 138, 18, p. 5274-5280 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dissecting the roles of ROCK isoforms in stress-induced cell detachment

Shi, J., Surma, M., Zhang, L. & Wei, L., May 15 2013, In : Cell Cycle. 12, 10, p. 1492-1500 9 p.

Research output: Contribution to journalReview article

17 Scopus citations

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

Shi, J., Wu, X., Surma, M., Vemula, S., Zhang, L., Yang, Y., Kapur, R. & Wei, L., Feb 1 2013, In : Cell Death and Disease. 4, 2

Research output: Contribution to journalArticle

89 Scopus citations

Rho kinases in cardiovascular physiology and pathophysiology: The effect of fasudil

Shi, J. & Wei, L., Oct 1 2013, In : Journal of cardiovascular pharmacology. 62, 4, p. 341-354 14 p.

Research output: Contribution to journalReview article

94 Scopus citations
2012

Downregulation of doxorubicin-induced myocardial apoptosis accompanies postnatal heart maturation

Shi, J., Zhang, L., Zhang, Y. W., Surma, M., Mark Payne, R. & Wei, L., Apr 15 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 8, p. H1603-H1613

Research output: Contribution to journalArticle

22 Scopus citations

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, Vemula, S., Shi, J., Wei, L., Kapur, R., Lopez, C. K., Gerby, B., Ballerini, P., Pflumio, F., Gilliland, D. G., Goldberg, L., Birger, Y., Izraeli, S., Gamis, A. S., Smith, F. O., Woods, W. G., Taub, J., Scherer, C. A., Bradner, J. E., Goh, B. C., Mercher, T., Carpenter, A. E., Gould, R. J., Clemons, P. A., Carr, S. A., Root, D. E., Schreiber, S. L., Stern, A. M. & Crispino, J. D., Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.

Research output: Contribution to journalArticle

85 Scopus citations

Regulation of JAK/STAT signalling by SOCS in the myocardium

Shi, J. & Wei, L., Dec 1 2012, In : Cardiovascular research. 96, 3, p. 345-347 3 p.

Research output: Contribution to journalReview article

19 Scopus citations

Regulation of the actin cytoskeleton by rho kinase controls antigen presentation by CD1d

Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J. & Brutkiewicz, R. R., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Vemula, S., Shi, J., Mali, R. S., Ma, P., Liu, Y., Hanneman, P., Koehler, K. R., Hashino, E., Wei, L. & Kapur, R., Oct 4 2012, In : Blood. 120, 14, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
7 Scopus citations
2011

Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease

Zhou, L., Liu, F., Huang, X. R., Liu, F., Chen, H., Chung, A. C. K., Shi, J., Wei, L., Lan, H. Y. & Fu, P., Nov 1 2011, In : American journal of nephrology. 34, 5, p. 468-475 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Apoptosis in anthracycline cardiomyopathy

Shi, J., Abdelwahid, E. & Wei, L., Nov 1 2011, In : Current Pediatric Reviews. 7, 4, p. 329-336 8 p.

Research output: Contribution to journalReview article

23 Scopus citations

Effects of rosiglitazone on abnormal lipid kinetics in HIV-associated dyslipidemic lipodystrophy: A stable isotope study

Sekhar, R. V., Patel, S. G., D'Amico, S., Shi, J., Balasubramanyam, A., Rehman, K., Jahoor, F. & Visnegarwala, F., Jun 1 2011, In : Metabolism: Clinical and Experimental. 60, 6, p. 754-760 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Rho kinase as a therapeutic target in cardiovascular disease

Surma, M., Wei, L. & Shi, J., Sep 1 2011, In : Future Cardiology. 7, 5, p. 657-671 15 p.

Research output: Contribution to journalReview article

117 Scopus citations

Rho-kinase in development and heart failure: Insights from genetic models

Shi, J., Zhang, L. & Wei, L., Mar 1 2011, In : Pediatric Cardiology. 32, 3, p. 297-304 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R. J., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. S. & Kapur, R., Sep 1 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

55 Scopus citations
2010

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

Vemula, S., Shi, J., Hanneman, P., Wei, L. & Kapur, R., Mar 4 2010, In : Blood. 115, 9, p. 1785-1796 12 p.

Research output: Contribution to journalArticle

83 Scopus citations

ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice

Shi, J., Zhang, Y. W., Yang, Y., Zhang, L. & Wei, L., Nov 1 2010, In : Journal of Molecular and Cellular Cardiology. 49, 5, p. 819-828 10 p.

Research output: Contribution to journalArticle

41 Scopus citations
2009

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

Zhang, Y. W., Shi, J., Li, Y. J. & Wei, L., Dec 1 2009, In : Archivum Immunologiae et Therapiae Experimentalis. 57, 6, p. 435-445 11 p.

Research output: Contribution to journalReview article

241 Scopus citations

Targeted disruption of ROCK1 causes insulin resistance in vivo

Lee, D. H., Shi, J., Jeoung, N. H., Kim, M. S., Zabolotny, J. M., Lee, S. W., White, M. F., Wei, L. & Kim, Y. B., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 11776-11780 5 p.

Research output: Contribution to journalArticle

81 Scopus citations
2008

Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy

Shi, J., Zhang, Y. W., Summers, L. J., Dorn, G. W. & Wei, L., Mar 1 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 551-560 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
2007

Rho kinase in the regulation of cell death and survival

Shi, J. & Wei, L., Apr 1 2007, In : Archivum Immunologiae et Therapiae Experimentalis. 55, 2, p. 61-75 15 p.

Research output: Contribution to journalReview article

176 Scopus citations
2006

Physiologic growth hormone replacement improves fasting lipid kinetics in patients with HIV lipodystrophy syndrome

D'Amico, S., Shi, J., Sekhar, R. V., Jahoor, F., Ellis, K. J., Rehman, K., Willis, J., Maldonado, M. & Balasubramanyam, A., Jul 1 2006, In : American Journal of Clinical Nutrition. 84, 1, p. 204-211 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

Zhang, Y. M., Bo, J., Taffet, G. E., Chang, J., Shi, J., Reddy, A. K., Michael, L. H., Schneider, M. D., Entman, M. L., Schwartz, R. J. & Wei, L., May 1 2006, In : FASEB Journal. 20, 7, p. 916-925 10 p.

Research output: Contribution to journalArticle

152 Scopus citations
2003

Short- and Long-Term Effects of Growth Hormone (GH) Replacement on Protein Metabolism in GH-Deficient Adults

Shi, J., Sekhar, R. V., Balasubramanyam, A., Ellis, K., Reeds, P. J., Jahoor, F. & Sharma, M. D., Dec 1 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 12, p. 5827-5833 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
1996

Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice

Mason, H. S., Ball, J. M., Shi, J. J., Jiang, X., Estes, M. K. & Arntzen, C. J., May 28 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 11, p. 5335-5340 6 p.

Research output: Contribution to journalArticle

444 Scopus citations