Jianjian Shi

  • 2062 Citations
  • 21 h-Index
19962020
If you made any changes in Pure, your changes will be visible here soon.

Publications 1996 2020

  • 2062 Citations
  • 21 h-Index
  • 29 Article
  • 7 Review article
Filter
Article
2020

ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice

Wei, L., Surma, M., Yang, Y., Tersey, S. & Shi, J., Jan 1 2020, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 1, p. 474-493 20 p.

Research output: Contribution to journalArticle

Open Access
Adipogenesis
White Adipose Tissue
Brown Adipose Tissue
Phosphotransferases
Fats
2019
3 Citations (Scopus)
Focal Adhesion Protein-Tyrosine Kinases
Myosin Light Chains
Autophagy
Sirolimus
Cardiac Myocytes
2018
4 Citations (Scopus)

Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxicity

Shi, J., Surma, M. & Wei, L., Jan 1 2018, In : Oncotarget. 9, 16, p. 12995-13008 14 p.

Research output: Contribution to journalArticle

Doxorubicin
Cardiac Myocytes
Autophagy
Genes
Injections
2016
59 Citations (Scopus)

Novel Insights into the Roles of Rho Kinase in Cancer

Wei, L., Surma, M., Shi, S., Lambert-Cheatham, N. & Shi, J., Jan 2 2016, (Accepted/In press) In : Archivum Immunologiae et Therapiae Experimentalis. p. 1-20 20 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Neoplasms
Apoptosis
Monomeric GTP-Binding Proteins
Actin Cytoskeleton
13 Citations (Scopus)

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis

Yue, X., Lin, X., Yang, T., Yang, X., Yi, X., Jiang, X., Li, X., Li, T., Guo, J., Dai, Y., Shi, J., Wei, L., Youker, K. A., Torre-Amione, G., Yu, Y., Andrade, K. C. & Chang, J., Mar 1 2016, In : Hypertension. 67, 3, p. 597-605 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Vascular Endothelial Growth Factor A
Heart Failure
Down-Regulation
rho GTP-Binding Proteins
5 Citations (Scopus)

ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells

Kapur, R., Shi, J., Ghosh, J., Munugalavadla, V., Sims, E., Martin, H., Wei, L. & Mali, R. S., Mar 29 2016, In : Oncotarget. 7, 13, p. 16936-16947 12 p.

Research output: Contribution to journalArticle

Lim Kinases
Mast Cells
Actins
Growth
Bone Marrow
2015
23 Citations (Scopus)

Dissecting the mechanisms of doxorubicin and oxidative stress-induced cytotoxicity: The involvement of actin cytoskeleton and ROCK1

Wei, L., Surma, M., Gough, G., Shi, S., Lambert-Cheatham, N., Chang, J. & Shi, J., Jul 2 2015, In : PLoS ONE. 10, 7, e0131763.

Research output: Contribution to journalArticle

doxorubicin
Oxidative stress
Cytotoxicity
microfilaments
Actin Cytoskeleton
2014
11 Citations (Scopus)

Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure

Yue, X., Yang, X., Lin, X., Yang, T., Yi, X., Dai, Y., Guo, J., Li, T., Shi, J., Wei, L., Fan, G. C., Chen, C. & Chang, J., Jun 2014, In : Cell Death and Disease. 5, 6, e1284.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cardiomyopathies
Heart Failure
Hemodynamics
Guanosine
20 Citations (Scopus)

ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment

Surma, M., Handy, C., Chang, J., Kapur, R., Wei, L. & Shi, J., Mar 4 2014, In : PLoS ONE. 9, 3, e90758.

Research output: Contribution to journalArticle

doxorubicin
Doxorubicin
protective effect
reactive oxygen species
Reactive Oxygen Species
24 Citations (Scopus)

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance

Lee, S. H., Huang, H., Choi, K., Lee, D. H., Shi, J., Liu, T., Chun, K. H., Seo, J. A., Lima, I. S., Zabolotny, J. M., Wei, L. & Kim, Y. B., Feb 1 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 3, p. E332-E343

Research output: Contribution to journalArticle

Insulin Resistance
Adipose Tissue
Protein Isoforms
Diet
Obese Mice
2013
25 Citations (Scopus)

Determination of trace amount of Cu2+ with a multi-responsive colorimetric and reversible chemosensor

Mi, Y. S., Cao, Z., Chen, Y. T., Xie, Q. F., Xu, Y. Y., Luo, Y. F., Shi, J. J. & Xiang, J. N., Sep 21 2013, In : Analyst. 138, 18, p. 5274-5280 7 p.

Research output: Contribution to journalArticle

Rhodamines
sensor
Atomic spectroscopy
Sensors
atomic absorption spectroscopy
81 Citations (Scopus)

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

Shi, J., Wu, X., Surma, M., Vemula, S., Zhang, L., Yang, Y., Kapur, R. & Wei, L., Feb 1 2013, In : Cell Death and Disease. 4, 2

Research output: Contribution to journalArticle

Actin Cytoskeleton
Actin Depolymerizing Factors
Actomyosin
Stress Fibers
Phosphorylation
2012
20 Citations (Scopus)

Downregulation of doxorubicin-induced myocardial apoptosis accompanies postnatal heart maturation

Shi, J., Zhang, L., Zhang, Y. W., Surma, M., Mark Payne, R. & Wei, L., Apr 15 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 8, p. H1603-H1613

Research output: Contribution to journalArticle

Doxorubicin
Down-Regulation
Apoptosis
Caspase 3
Cardiac Myocytes
82 Citations (Scopus)

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, Vemula, S., Shi, J., Wei, L., Kapur, R., Lopez, C. K., Gerby, B., Ballerini, P., Pflumio, F., Gilliland, D. G., Goldberg, L., Birger, Y., Izraeli, S., Gamis, A. S., Smith, F. O., Woods, W. G., Taub, J., Scherer, C. A., Bradner, J. E., Goh, B. C., Mercher, T., Carpenter, A. E., Gould, R. J., Clemons, P. A., Carr, S. A., Root, D. E., Schreiber, S. L., Stern, A. M. & Crispino, J. D., Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.

Research output: Contribution to journalArticle

Leukemia, Megakaryoblastic, Acute
Aurora Kinase A
Polyploidy
Megakaryocytes
Small Interfering RNA
21 Citations (Scopus)

Regulation of the actin cytoskeleton by rho kinase controls antigen presentation by CD1d

Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J. & Brutkiewicz, R. R., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Antigen Presentation
Lim Kinases
Actin Cytoskeleton
Natural Killer T-Cells
24 Citations (Scopus)

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Vemula, S., Shi, J., Mali, R. S., Ma, P., Liu, Y., Hanneman, P., Koehler, K. R., Hashino, E., Wei, L. & Kapur, R., Oct 4 2012, In : Blood. 120, 14, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

Erythropoiesis
Survival
Stem cells
rho-Associated Kinases
Enhanced recovery
7 Citations (Scopus)
Atrial Remodeling
Pericardium
Hypertrophy
Action Potentials
Left Ventricular Hypertrophy
2011
24 Citations (Scopus)

Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease

Zhou, L., Liu, F., Huang, X. R., Liu, F., Chen, H., Chung, A. C. K., Shi, J., Wei, L., Lan, H. Y. & Fu, P., Nov 1 2011, In : American journal of nephrology. 34, 5, p. 468-475 8 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-2
Albuminuria
Diabetic Nephropathies
Streptozocin
Knockout Mice
6 Citations (Scopus)

Effects of rosiglitazone on abnormal lipid kinetics in HIV-associated dyslipidemic lipodystrophy: A stable isotope study

Sekhar, R. V., Patel, S. G., D'Amico, S., Shi, J., Balasubramanyam, A., Rehman, K., Jahoor, F. & Visnegarwala, F., Jun 1 2011, In : Metabolism: Clinical and Experimental. 60, 6, p. 754-760 7 p.

Research output: Contribution to journalArticle

rosiglitazone
HIV-Associated Lipodystrophy Syndrome
Nonesterified Fatty Acids
Isotopes
Lipolysis
28 Citations (Scopus)

Rho-kinase in development and heart failure: Insights from genetic models

Shi, J., Zhang, L. & Wei, L., Mar 1 2011, In : Pediatric Cardiology. 32, 3, p. 297-304 8 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Genetic Models
Protein Isoforms
Heart Failure
Phosphotransferases
54 Citations (Scopus)

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R. J., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. S. & Kapur, R., Sep 1 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cell Survival
Phosphatidylinositol 3-Kinases
Oncogenes
Acute Myeloid Leukemia
2010
82 Citations (Scopus)

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

Vemula, S., Shi, J., Hanneman, P., Wei, L. & Kapur, R., Mar 4 2010, In : Blood. 115, 9, p. 1785-1796 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Macrophages
Cell Movement
Chemical activation
Glycogen Synthase Kinase 3
37 Citations (Scopus)

ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice

Shi, J., Zhang, Y. W., Yang, Y., Zhang, L. & Wei, L., Nov 1 2010, In : Journal of Molecular and Cellular Cardiology. 49, 5, p. 819-828 10 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cardiomegaly
Cardiac Myocytes
Apoptosis
Peripartum Period
2009
78 Citations (Scopus)

Targeted disruption of ROCK1 causes insulin resistance in vivo

Lee, D. H., Shi, J., Jeoung, N. H., Kim, M. S., Zabolotny, J. M., Lee, S. W., White, M. F., Wei, L. & Kim, Y. B., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 11776-11780 5 p.

Research output: Contribution to journalArticle

Insulin Resistance
Insulin
Glucose
Skeletal Muscle
Phosphatidylinositol 3-Kinase
2008
40 Citations (Scopus)

Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy

Shi, J., Zhang, Y. W., Summers, L. J., Dorn, G. W. & Wei, L., Mar 1 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 551-560 10 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cardiomegaly
Dilatation
Hypertrophy
Genes
2006
17 Citations (Scopus)

Physiologic growth hormone replacement improves fasting lipid kinetics in patients with HIV lipodystrophy syndrome

D'Amico, S., Shi, J., Sekhar, R. V., Jahoor, F., Ellis, K. J., Rehman, K., Willis, J., Maldonado, M. & Balasubramanyam, A., Jul 1 2006, In : American Journal of Clinical Nutrition. 84, 1, p. 204-211 8 p.

Research output: Contribution to journalArticle

HIV-Associated Lipodystrophy Syndrome
Growth Hormone
Fasting
Lipolysis
Lipids
149 Citations (Scopus)

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

Zhang, Y. M., Bo, J., Taffet, G. E., Chang, J., Shi, J., Reddy, A. K., Michael, L. H., Schneider, M. D., Entman, M. L., Schwartz, R. J. & Wei, L., May 1 2006, In : FASEB Journal. 20, 7, p. 916-925 10 p.

Research output: Contribution to journalArticle

fibrosis
Fibrosis
heart
hypertrophy
Knockout Mice
2003
20 Citations (Scopus)

Short- and Long-Term Effects of Growth Hormone (GH) Replacement on Protein Metabolism in GH-Deficient Adults

Shi, J., Sekhar, R. V., Balasubramanyam, A., Ellis, K., Reeds, P. J., Jahoor, F. & Sharma, M. D., Dec 1 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 12, p. 5827-5833 7 p.

Research output: Contribution to journalArticle

Metabolism
Growth Hormone
Leucine
Proteins
Fats
1996
438 Citations (Scopus)

Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice

Mason, H. S., Ball, J. M., Shi, J. J., Jiang, X., Estes, M. K. & Arntzen, C. J., May 28 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 11, p. 5335-5340 6 p.

Research output: Contribution to journalArticle

Norwalk virus
Capsid Proteins
Solanum tuberosum
Tobacco
Virion