Jianjian Shi &ndash; Publications

Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease

Zhou, L., Liu, F., Huang, X. R., Liu, F., Chen, H., Chung, A. C. K., Shi, J., Wei, L., Lan, H. Y. & Fu, P., Nov 2011, In : American Journal of Nephrology. 34, 5, p. 468-475 8 p.

Research output: Contribution to journal › Article

Low Density Lipoprotein Receptor-Related Protein-2

Albuminuria

Diabetic Nephropathies

Streptozocin

Knockout Mice

21 Citations (Scopus)

Apoptosis in anthracycline cardiomyopathy

Shi, J., Abdelwahid, E. & Wei, L., Nov 2011, In : Current Pediatric Reviews. 7, 4, p. 329-336 8 p.

Research output: Contribution to journal › Article

Anthracyclines

Cardiomyopathies

Apoptosis

Cell Death

Cardiac Myocytes

226 Citations (Scopus)

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

Zhang, Y. W., Shi, J., Li, Y. J. & Wei, L., Dec 2009, In : Archivum Immunologiae et Therapiae Experimentalis. 57, 6, p. 435-445 11 p.

Research output: Contribution to journal › Article

Cardiac Myocytes

Doxorubicin

Cardiomyopathies

Reactive Oxygen Species

Cell Death

24 Citations (Scopus)

Determination of trace amount of Cu2+ with a multi-responsive colorimetric and reversible chemosensor

Mi, Y. S., Cao, Z., Chen, Y. T., Xie, Q. F., Xu, Y. Y., Luo, Y. F., Shi, J. & Xiang, J. N., Sep 21 2013, In : Analyst. 138, 18, p. 5274-5280 7 p.

Research output: Contribution to journal › Article

Rhodamines

sensor

Atomic spectroscopy

Sensors

atomic absorption spectroscopy

1 Citation (Scopus)

Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging

Shi, J., Surma, M., Yang, Y. & Wei, L., Jun 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 6, p. 7348-7362 15 p.

Research output: Contribution to journal › Article

Focal Adhesion Protein-Tyrosine Kinases

Myosin Light Chains

Autophagy

Sirolimus

Cardiac Myocytes

39 Citations (Scopus)

Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy

Shi, J., Zhang, Y. W., Summers, L. J., Dorn, G. W. & Wei, L., Mar 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 551-560 10 p.

Research output: Contribution to journal › Article

rho-Associated Kinases

Cardiomegaly

Dilatation

Hypertrophy

Genes

3 Citations (Scopus)

Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxicity

Shi, J., Surma, M. & Wei, L., Jan 1 2018, In : Oncotarget. 9, 16, p. 12995-13008 14 p.

Research output: Contribution to journal › Article

Doxorubicin

Cardiac Myocytes

Autophagy

Genes

Injections

22 Citations (Scopus)

Dissecting the mechanisms of doxorubicin and oxidative stress-induced cytotoxicity: The involvement of actin cytoskeleton and ROCK1

Wei, L., Surma, M., Gough, G., Shi, S., Lambert-Cheatham, N., Chang, J. & Shi, J., Jul 2 2015, In : PLoS One. 10, 7, e0131763.

Research output: Contribution to journal › Article

doxorubicin

Oxidative stress

Cytotoxicity

microfilaments

Actin Cytoskeleton

16 Citations (Scopus)

Dissecting the roles of ROCK isoforms in stress-induced cell detachment

Shi, J., Surma, M., Zhang, L. & Wei, L., May 15 2013, In : Cell Cycle. 12, 10, p. 1492-1500 9 p.

Research output: Contribution to journal › Article

Protein Isoforms

Stress Fibers

Focal Adhesions

Fibroblasts

Adherens Junctions

76 Citations (Scopus)

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

Shi, J., Wu, X., Surma, M., Vemula, S., Zhang, L., Yang, Y., Kapur, R. & Wei, L., Feb 2013, In : Cell Death and Disease. 4, 2

Research output: Contribution to journal › Article

Actin Cytoskeleton

Actin Depolymerizing Factors

Actomyosin

Stress Fibers

Phosphorylation

20 Citations (Scopus)

Downregulation of doxorubicin-induced myocardial apoptosis accompanies postnatal heart maturation

Shi, J., Zhang, L., Zhang, Y. W., Surma, M., Payne, R. & Wei, L., Apr 15 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 8

Research output: Contribution to journal › Article

Doxorubicin

Down-Regulation

Apoptosis

Caspase 3

Cardiac Myocytes

6 Citations (Scopus)

Effects of rosiglitazone on abnormal lipid kinetics in HIV-associated dyslipidemic lipodystrophy: A stable isotope study

Sekhar, R. V., Patel, S. G., D'Amico, S., Shi, J., Balasubramanyam, A., Rehman, K., Jahoor, F. & Visnegarwala, F., Jun 2011, In : Metabolism: Clinical and Experimental. 60, 6, p. 754-760 7 p.

Research output: Contribution to journal › Article

rosiglitazone

HIV-Associated Lipodystrophy Syndrome

Nonesterified Fatty Acids

Isotopes

Lipolysis

438 Citations (Scopus)

Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice

Mason, H. S., Ball, J. M., Shi, J., Jiang, X., Estes, M. K. & Arntzen, C. J., May 28 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 11, p. 5335-5340 6 p.

Research output: Contribution to journal › Article

Norwalk virus

Capsid Proteins

Solanum tuberosum

Tobacco

Virion

80 Citations (Scopus)

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, Vemula, S., Shi, J., Wei, L., Kapur, R., Lopez, C. K., Gerby, B., Ballerini, P., Pflumio, F., Gilliland, D. G., Goldberg, L., Birger, Y., Izraeli, S., Gamis, A. S., Smith, F. O., Woods, W. G., Taub, J., Scherer, C. A., Bradner, J. E., Goh, B. C., Mercher, T., Carpenter, A. E., Gould, R. J., Clemons, P. A., Carr, S. A., Root, D. E., Schreiber, S. L., Stern, A. M. & Crispino, J. D., Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.

Research output: Contribution to journal › Article

Leukemia, Megakaryoblastic, Acute

Aurora Kinase A

Polyploidy

Megakaryocytes

Small Interfering RNA

53 Citations (Scopus)

Novel Insights into the Roles of Rho Kinase in Cancer

Wei, L., Surma, M., Shi, S., Lambert-Cheatham, N. & Shi, J., Jan 2 2016, (Accepted/In press) In : Archivum Immunologiae et Therapiae Experimentalis. p. 1-20 20 p.

Research output: Contribution to journal › Article

rho-Associated Kinases

Neoplasms

Apoptosis

Monomeric GTP-Binding Proteins

Actin Cytoskeleton

17 Citations (Scopus)

Physiologic growth hormone replacement improves fasting lipid kinetics in patients with HIV lipodystrophy syndrome

D'Amico, S., Shi, J., Sekhar, R. V., Jahoor, F., Ellis, K. J., Rehman, K., Willis, J., Maldonado, M. & Balasubramanyam, A., Jul 1 2006, In : American Journal of Clinical Nutrition. 84, 1, p. 204-211 8 p.

Research output: Contribution to journal › Article

HIV-Associated Lipodystrophy Syndrome

somatotropin

Growth Hormone

fasting

Fasting

18 Citations (Scopus)

Regulation of JAK/STAT signalling by SOCS in the myocardium

Shi, J. & Wei, L., Dec 1 2012, In : Cardiovascular Research. 96, 3, p. 345-347 3 p.

Research output: Contribution to journal › Article

Janus Kinase 1

Cytokine Receptor gp130

Suppressor of Cytokine Signaling Proteins

STAT3 Transcription Factor

Gene Transfer Techniques

21 Citations (Scopus)

Regulation of the actin cytoskeleton by rho kinase controls antigen presentation by CD1d

Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J. & Brutkiewicz, R., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1689-1698 10 p.

Research output: Contribution to journal › Article

rho-Associated Kinases

Antigen Presentation

Lim Kinases

Actin Cytoskeleton

Natural Killer T-Cells

111 Citations (Scopus)

Rho kinase as a therapeutic target in cardiovascular disease

Surma, M., Wei, L. & Shi, J., Sep 2011, In : Future Cardiology. 7, 5, p. 657-671 15 p.

Research output: Contribution to journal › Article

rho-Associated Kinases

Cardiovascular Diseases

Heart Failure

Phosphotransferases

Monomeric GTP-Binding Proteins

27 Citations (Scopus)

Rho-kinase in development and heart failure: Insights from genetic models

Shi, J., Zhang, L. & Wei, L., Mar 2011, In : Pediatric Cardiology. 32, 3, p. 297-304 8 p.

Research output: Contribution to journal › Article

rho-Associated Kinases

Genetic Models

Protein Isoforms

Heart Failure

Phosphotransferases

168 Citations (Scopus)

Rho kinase in the regulation of cell death and survival

Shi, J. & Wei, L., Apr 2007, In : Archivum Immunologiae et Therapiae Experimentalis. 55, 2, p. 61-75 15 p.

Research output: Contribution to journal › Article

rho-Associated Kinases

Cell Survival

Protein Isoforms

Cell Death

Apoptosis

54 Citations (Scopus)

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. & Kapur, R., Sep 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journal › Article

rho-Associated Kinases

Cell Survival

Phosphatidylinositol 3-Kinases

Oncogenes

Acute Myeloid Leukemia

94 Citations (Scopus)

Rho kinases in cardiovascular physiology and pathophysiology: The effect of fasudil

Shi, J. & Wei, L., Oct 2013, In : Journal of Cardiovascular Pharmacology. 62, 4, p. 341-354 14 p.

Research output: Contribution to journal › Article

Cardiovascular Physiological Phenomena

rho-Associated Kinases

Cardiovascular Diseases

Protein Isoforms

Monomeric GTP-Binding Proteins

13 Citations (Scopus)

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis

Yue, X., Lin, X., Yang, T., Yang, X., Yi, X., Jiang, X., Li, X., Li, T., Guo, J., Dai, Y., Shi, J., Wei, L., Youker, K. A., Torre-Amione, G., Yu, Y., Andrade, K. C. & Chang, J., Mar 1 2016, In : Hypertension. 67, 3, p. 597-605 9 p.

Research output: Contribution to journal › Article

Hypoxia-Inducible Factor 1

Vascular Endothelial Growth Factor A

Heart Failure

Down-Regulation

rho GTP-Binding Proteins

11 Citations (Scopus)

Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure

Yue, X., Yang, X., Lin, X., Yang, T., Yi, X., Dai, Y., Guo, J., Li, T., Shi, J., Wei, L., Fan, G. C., Chen, C. & Chang, J., 2014, In : Cell Death and Disease. 5, 6, e1284.

Research output: Contribution to journal › Article

rho-Associated Kinases

Cardiomyopathies

Heart Failure

Hemodynamics

Guanosine

18 Citations (Scopus)

ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment

Surma, M., Handy, C., Chang, J., Kapur, R., Wei, L. & Shi, J., Mar 4 2014, In : PLoS One. 9, 3, e90758.

Research output: Contribution to journal › Article

doxorubicin

Doxorubicin

protective effect

reactive oxygen species

Reactive Oxygen Species

24 Citations (Scopus)

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Vemula, S., Shi, J., Mali, R. S., Ma, P., Liu, Y., Hanneman, P., Koehler, K. R., Hashino, E., Wei, L. & Kapur, R., Oct 4 2012, In : Blood. 120, 14, p. 2868-2878 11 p.

Research output: Contribution to journal › Article

Erythropoiesis

Survival

Stem cells

rho-Associated Kinases

Enhanced recovery

80 Citations (Scopus)

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

Vemula, S., Shi, J., Hanneman, P., Wei, L. & Kapur, R., Mar 4 2010, In : Blood. 115, 9, p. 1785-1796 12 p.

Research output: Contribution to journal › Article

Phosphorylation

Macrophages

Cell Movement

Chemical activation

Glycogen Synthase Kinase 3

23 Citations (Scopus)

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance

Lee, S. H., Huang, H., Choi, K., Lee, D. H., Shi, J., Liu, T., Chun, K. H., Seo, J. A., Lima, I. S., Zabolotny, J. M., Wei, L. & Kim, Y. B., Feb 1 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 3

Research output: Contribution to journal › Article

Insulin Resistance

Adipose Tissue

Protein Isoforms

Diet

Obese Mice

36 Citations (Scopus)

ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice

Shi, J., Zhang, Y. W., Yang, Y., Zhang, L. & Wei, L., Nov 2010, In : Journal of Molecular and Cellular Cardiology. 49, 5, p. 819-828 10 p.

Research output: Contribution to journal › Article

rho-Associated Kinases

Cardiomegaly

Cardiac Myocytes

Apoptosis

Peripartum Period

5 Citations (Scopus)

ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells

Kapur, R., Shi, J., Ghosh, J., Munugalavadla, V., Sims, E., Martin, H., Wei, L. & Mali, R. S., Mar 29 2016, In : Oncotarget. 7, 13, p. 16936-16947 12 p.

Research output: Contribution to journal › Article

Lim Kinases

Mast Cells

Actins

Growth

Bone Marrow

20 Citations (Scopus)

Short- and Long-Term Effects of Growth Hormone (GH) Replacement on Protein Metabolism in GH-Deficient Adults

Shi, J., Sekhar, R. V., Balasubramanyam, A., Ellis, K., Reeds, P. J., Jahoor, F. & Sharma, M. D., Dec 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 12, p. 5827-5833 7 p.

Research output: Contribution to journal › Article

Metabolism

Growth Hormone

Leucine

Proteins

Fats

7 Citations (Scopus)

Spatial variability in T-tubule and electrical remodeling of left ventricular epicardium in mouse hearts with transgenic Gαq overexpression-induced pathological hypertrophy

Tao, W., Shi, J., Dorn, G. W., Wei, L. & Rubart-von der Lohe, M., Sep 2012, In : Journal of Molecular and Cellular Cardiology. 53, 3, p. 409-419 11 p.

Research output: Contribution to journal › Article

Atrial Remodeling

Pericardium

Hypertrophy

Action Potentials

Left Ventricular Hypertrophy

149 Citations (Scopus)

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

Zhang, Y. M., Bo, J., Taffet, G. E., Chang, J., Shi, J., Reddy, A. K., Michael, L. H., Schneider, M. D., Entman, M. L., Schwartz, R. J. & Wei, L., May 2006, In : FASEB Journal. 20, 7, p. 916-925 10 p.

Research output: Contribution to journal › Article

fibrosis

Fibrosis

heart

hypertrophy

Knockout Mice

78 Citations (Scopus)

Targeted disruption of ROCK1 causes insulin resistance in vivo

Lee, D. H., Shi, J., Jeoung, N. H., Kim, M. S., Zabolotny, J. M., Lee, S. W., White, M. F., Wei, L. & Kim, Y. B., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 11776-11780 5 p.

Research output: Contribution to journal › Article

Insulin Resistance

Insulin

Glucose

Skeletal Muscle

Phosphatidylinositol 3-Kinase