Jingwu Xie

  • 6342 Citations
  • 32 h-Index
19962019

Research output per year

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Publications

  • 6342 Citations
  • 32 h-Index
  • 62 Article
  • 15 Review article
  • 1 Chapter
  • 1 Letter
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Article
2019

Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas

Wan, J., Dai, H., Zhang, X., Liu, S., Lin, Y., Somani, A. K., Xie, J. & Han, J., Jan 1 2019, (Accepted/In press) In : Genes and Diseases.

Research output: Contribution to journalArticle

Open Access

The role of GLI-SOX2 signaling axis for gemcitabine resistance in pancreatic cancer

Jia, Y., Gu, D., Wan, J., Yu, B., Zhang, X., Chiorean, E. G., Wang, Y. & Xie, J., Mar 7 2019, In : Oncogene. 38, 10, p. 1764-1777 14 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Functional significance of Hippo/YAP signaling for drug resistance in colorectal cancer

Song, R., Gu, D., Zhang, L., Zhang, X., Yu, B., Liu, B. & Xie, J., Nov 2018, In : Molecular Carcinogenesis. 57, 11, p. 1608-1615 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Simultaneous inhibition of MEK and Hh signaling reduces pancreatic cancer metastasis

Gu, D., Lin, H., Zhang, X., Fan, Q., Chen, S., Shahda, S., Liu, Y., Sun, J. & Xie, J., Nov 2018, In : Cancers. 10, 11, 403.

Research output: Contribution to journalArticle

4 Scopus citations
2017

GLI1-mediated regulation of side population is responsible for drug resistance in gastric cancer

Yu, B., Gu, D., Zhang, X., Li, J., Liu, B. & Xie, J., 2017, In : Oncotarget. 8, 16, p. 27412-27427 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

The role of GLI1 for 5-Fu resistance in colorectal cancer

Zhang, L., Song, R., Gu, D., Zhang, X., Yu, B., Liu, B. & Xie, J., Apr 13 2017, In : Cell and Bioscience. 7, 1, 17.

Research output: Contribution to journalArticle

16 Scopus citations

The role of GLI2-ABCG2 signaling axis for 5Fu resistance in gastric cancer

Yu, B., Gu, D., Zhang, X., Liu, B. & Xie, J., Aug 20 2017, In : Journal of Genetics and Genomics. 44, 8, p. 375-383 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer

Li, J., Gu, D., Lee, S. S. Y., Song, B., Bandyopadhyay, S., Chen, S., Konieczny, S. F., Ratliff, T. L., Liu, X., Xie, J. & Cheng, J. X., Dec 15 2016, In : Oncogene. 35, 50, p. 6378-6388 11 p.

Research output: Contribution to journalArticle

57 Scopus citations

SHP2 phosphatase as a novel therapeutic target for melanoma treatment

Zhang, R. Y., Yu, Z. H., Zeng, L., Zhang, S., Bai, Y., Miao, J., Chen, L., Xie, J. & Zhang, Z. Y., Jan 1 2016, In : Oncotarget. 7, 45, p. 73817-73829 13 p.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Genetic Evidence for XPC-KRAS Interactions During Lung Cancer Development

Zhang, X., He, N., Gu, D., Wickliffe, J., Salazar, J., Boldogh, I. & Xie, J., Oct 20 2015, In : Journal of Genetics and Genomics. 42, 10, p. 589-596 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Longitudinal bioluminescence imaging of primary versus abdominal metastatic tumor growth in Orthotopic pancreatic tumor models in NSG Mice

Shannon, H. E., Fishel, M. L., Xie, J., Gu, D., McCarthy, B. P., Riley, A. A., Sinn, A. L., Silver, J. M., Peterman, K., Kelley, M. R., Hanenberg, H., Korc, M., Pollok, K. E. & Territo, P. R., Jan 2015, In : Pancreas. 44, 1, p. 64-75 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pathways towards Precision Medicine in Cancer Management Using Genomic Information

Xie, J., Oct 20 2015, In : Journal of Genetics and Genomics. 42, 10, p. 515-516 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Tissue transglutaminase mediated tumor-stroma interaction promotes pancreatic cancer progression

Lee, J., Condello, S., Yakubov, B., Emerson, R., Caperell-Grant, A., Hitomi, K., Xie, J. & Matei, D., Oct 1 2015, In : Clinical Cancer Research. 21, 19, p. 4482-4493 12 p.

Research output: Contribution to journalArticle

35 Scopus citations
2014

Defective TGF-β signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors

Fan, Q., Gu, D., Liu, H., Yang, L., Zhang, X., Yoder, M. C., Kaplan, M. H. & Xie, J., Jan 15 2014, In : Cancer Research. 74, 2, p. 471-483 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
4 Scopus citations
2013

Cell population analyses during skin carcinogenesis

Gu, D., Fan, Q. & Xie, J., Jan 1 2013, In : Journal of visualized experiments : JoVE. 78, p. e50311

Research output: Contribution to journalArticle

2 Scopus citations

Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis

Gu, D., Liu, H., Su, G. H., Zhang, X., Chin-Sinex, H., Hanenberg, H., Mendonca, M. S., Shannon, H. E., Chiorean, E. G. & Xie, J., Jun 1 2013, In : Molecular cancer therapeutics. 12, 6, p. 1038-1048 11 p.

Research output: Contribution to journalArticle

38 Scopus citations
2012

Activation of Hedgehog Pathway in Gastrointestinal Cancers

Yang, L., Su, X. & Xie, J., 2012, In : Vitamins and Hormones. 88, p. 461-472 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis

Gu, D., Fan, Q., Zhang, X. & Xie, J., Nov 2 2012, In : Journal of Biological Chemistry. 287, 45, p. 38356-38366 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus

Yang, L., Wang, L. S., Chen, XL., Gatalica, Z., Qiu, S., Liu, Z., Stoner, G., Zhang, H., Weiss, H. & Xie, J., Apr 18 2012, In : International Journal of Biochemistry and Molecular Biology. 3, 1, p. 46-57 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P. S., Abdel-Rahman, S. Z., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T. K., Jun 1 2012, In : DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Rab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent manner

Chi, S., Xie, G., Liu, H., Chen, K., Zhang, X., Li, C. & Xie, J., Jun 1 2012, In : Cellular Signalling. 24, 6, p. 1222-1228 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
2011

Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer-associated prostate stromal cells

Shigemura, K., Huang, W. C., Li, X., Zhau, H. E., Zhu, G., Gotoh, A., Fujisawa, M., Xie, J., Marshall, F. F. & Chung, L. W. K., Dec 1 2011, In : Prostate. 71, 16, p. 1711-1722 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Expression of hedgehog signaling molecules in lung cancer

Huang, S., Yang, L., An, Y., Ma, X., Zhang, C., Xie, G., Chen, Z. Y., Xie, J. & Zhang, H., Sep 1 2011, In : Acta Histochemica. 113, 5, p. 564-569 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Identification of signature genes for detecting hedgehog pathway activation in esophageal cancer

Yang, L., Bian, Y., Huang, S., Ma, X., Zhang, C., Su, X., Chen, Z. J., Xie, J. & Zhang, H., Jun 1 2011, In : Pathology and Oncology Research. 17, 2, p. 387-391 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers

Yang, Y., Liu, H., Li, Z., Zhao, Z., Yip-Schneider, M., Fan, Q., Max Schmidt, C., Gabriela Chiorean, E., Xie, J., Cheng, L., Chen, J. H. & Zhang, J. T., Mar 7 2011, In : International Journal of Biochemistry and Molecular Biology. 2, 1, p. 89-98 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling

Fan, Q., Gu, D., He, M., Liu, H., Sheng, T., Xie, G., Li, C. X., Zhang, X., Wainwright, B., Garrossian, A., Garrossian, M., Gardner, D. & Xie, J., 2011, In : Chinese Journal of Cancer. 30, 7, p. 472-481 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Uncommon gnaq, MMP8, AKT3, EGFR, and PIK3R1 mutations in thyroid cancers

Murugan, A. K., Dong, J., Xie, J. & Xing, M., Jun 1 2011, In : Endocrine Pathology. 22, 2, p. 97-102 6 p.

Research output: Contribution to journalArticle

23 Scopus citations
2010

Identification of signature genes for detecting hedgehog signaling activation in gastric cancer

Yang, L., Huang, S., Bian, Y., Ma, X., Zhang, H. & Xie, J., May 1 2010, In : Molecular Medicine Reports. 3, 3, p. 473-478 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Requirement of TGF β signaling for SMO-mediated carcinogenesis

Fan, Q., He, M., Sheng, T., Zhang, X., Sinha, M., Luxon, B., Zhao, X. & Xie, J., Nov 19 2010, In : Journal of Biological Chemistry. 285, 47, p. 36570-36576 7 p.

Research output: Contribution to journalArticle

45 Scopus citations
2009

Activation of hedgehog signaling is not a frequent event in ovarian cancers

Yang, L., He, J., Huang, S., Zhang, X., Bian, Y., He, N., Zhang, H. & Xie, J., Nov 27 2009, In : Molecular Cancer. 8, 112.

Research output: Contribution to journalArticle

25 Scopus citations

MEK1 mutations, but not ERK2 mutations, occur in melanomas and colon carcinomas, but none in thyroid carcinomas

Murugan, A. K., Dong, J., Xie, J. & Xing, M., Jul 1 2009, In : Cell Cycle. 8, 13, p. 2122-2124 3 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Protein kinase Cδ negatively regulates hedgehog signaling by inhibition of Gli1 activity

Cai, Q., Li, J., Gao, T., Xie, J. & Evers, B. M., Jan 23 2009, In : Journal of Biological Chemistry. 284, 4, p. 2150-2158 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2008

Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1

Chattopadhyay, R., Das, S., Maiti, A. K., Boldogh, I., Xie, J., Hazra, T. K., Kohno, K., Mitra, S. & Bhakat, K. K., Dec 1 2008, In : Molecular and cellular biology. 28, 23, p. 7066-7080 15 p.

Research output: Contribution to journalArticle

89 Scopus citations
2007

Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene

Wickliffe, J. K., Herring, S. M., Hallberg, L. M., Galbert, L. A., Masters, O. E., Ammenheuser, M. M., Xie, J., Friedberg, E. C., Lloyd, R. S., Abdel-Rahman, S. Z. & Ward, J. B., Mar 20 2007, In : Chemico-Biological Interactions. 166, 1-3, p. 226-231 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Expressions of Sonic Hedgehog and VEGF in human gastric carcinoma and their clinical significance

Ma, X. L., Sun, H. J., Wang, Y. S., Huang, S. H., Xie, J. W. & Zhang, H. W., Dec 1 2007, In : Chinese Journal of Cancer Prevention and Treatment. 14, 24, p. 1879-1881 3 p.

Research output: Contribution to journalArticle

Loss of cell-adhesion molecule complexes in solid pseudopapillary tumor of pancreas

Tang, W. W., Stelter, A. A., French, S., Shen, S., Qiu, S., Venegas, R., Wen, J., Wang, H. Q. & Xie, J., May 30 2007, In : Modern Pathology. 20, 5, p. 509-513 5 p.

Research output: Contribution to journalArticle

51 Scopus citations

Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells

Ji, Z., Mei, F. C., Xie, J. & Cheng, X., May 11 2007, In : Journal of Biological Chemistry. 282, 19, p. 14048-14055 8 p.

Research output: Contribution to journalArticle

209 Scopus citations

Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas

Bian, Y. H., Huang, S. H., Yang, L., Ma, X. L., Xie, J. W. & Zhang, H. W., Mar 21 2007, In : World Journal of Gastroenterology. 13, 11, p. 1659-1665 7 p.

Research output: Contribution to journalArticle

64 Scopus citations
2006

3,4-Epoxy-1-butene, a reactive metabolite of 1,3-butadiene, induces somatic mutations in Xpc-null mice

Wickliffe, J. K., Galbert, L. A., Ammenheuser, M. M., Herring, S. M., Xie, J., Masters, O. E., Friedberg, E. C., Lloyd, R. S. & Ward, J. B., Jan 1 2006, In : Environmental and Molecular Mutagenesis. 47, 1, p. 67-70 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Activation of the hedgehog pathway in a subset of lung cancers

Chi, S., Huang, S., Li, C., Zhang, X., He, N., Bhutani, M. S., Jones, D., Castro, C. Y., Logrono, R., Haque, A., Zwischenberger, J., Tyring, S. K., Zhang, H. & Xie, J., Nov 28 2006, In : Cancer Letters. 244, 1, p. 53-60 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Activation of the hedgehog pathway in human hepatocellular carcinomas

Huang, S., He, J., Zhang, X., Bian, Y., Yang, L., Xie, G., Zhang, K., Tang, W., Stelter, A. A., Wang, Q., Zhang, H. & Xie, J., Jul 1 2006, In : Carcinogenesis. 27, 7, p. 1334-1340 7 p.

Research output: Contribution to journalArticle

182 Scopus citations

Hedgehog signaling is activated in subsets of esophageal cancers

Ma, X., Sheng, T., Zhang, Y., Zhang, X., He, J., Huang, S., Chen, K., Sultz, J., Adegboyega, P. A., Zhang, H. & Xie, J., Jan 1 2006, In : International Journal of Cancer. 118, 1, p. 139-148 10 p.

Research output: Contribution to journalArticle

110 Scopus citations

Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal

Sheng, T., Chi, S., Zhang, X. & Xie, J., Jan 6 2006, In : Journal of Biological Chemistry. 281, 1, p. 9-12 4 p.

Research output: Contribution to journalArticle

91 Scopus citations

Study of Sonic hedgehog signaling pathway related molecules in gastric carcinoma

Ma, X. L., Sun, H. J., Wang, Y. S., Huang, S. H., Xie, J. W. & Zhang, H. W., Jul 7 2006, In : World Journal of Gastroenterology. 12, 25, p. 3965-3969 5 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Suppressing Wnt signaling by the hedgehog pathway through sFRP-1

He, J., Sheng, T., Stelter, A. A., Li, C., Zhang, X., Sinha, M., Luxon, B. A. & Xie, J., Nov 24 2006, In : Journal of Biological Chemistry. 281, 47, p. 35598-35602 5 p.

Research output: Contribution to journalArticle

94 Scopus citations
2005

A mechanism of hyperthermia-induced apoptosis in ras-transformed lung cells

Vertrees, R. A., Das, G. C., Coscio, A. M., Xie, J., Zwischenberger, J. B. & Boor, P. J., Oct 1 2005, In : Molecular Carcinogenesis. 44, 2, p. 111-121 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas

Ma, X., Chen, K., Huang, S., Zhang, X., Adegboyega, P. A., Evers, B. M., Zhang, H. & Xie, J., Oct 1 2005, In : Carcinogenesis. 26, 10, p. 1698-1705 8 p.

Research output: Contribution to journalArticle

174 Scopus citations

Regulation of lung cancer cell growth and invasiveness by β-TRCP

He, N., Li, C., Zhang, X., Sheng, T., Chi, S., Chen, K., Wang, Q., Vertrees, R., Logrono, R. & Xie, J., Jan 1 2005, In : Molecular Carcinogenesis. 42, 1, p. 18-28 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
2004

Activation of the hedgehog pathway in advanced prostate cancer

Sheng, T., Li, C., Zhang, X., Chi, S., He, N., Chen, K., McCormick, F., Gatalica, Z. & Xie, J., Oct 13 2004, In : Molecular Cancer. 3, 29.

Research output: Contribution to journalArticle

242 Scopus citations