John Callaghan

  • 3419 Citations
  • 22 h-Index
1975 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

  • 3419 Citations
  • 22 h-Index
  • 47 Article
  • 8 Review article
  • 1 Letter
2019

Gender Differences in Demographic and Health Characteristics of the Million Veteran Program Cohort

VA Million Veteran Program, Jun 25 2019, In : Women's Health Issues. 29, p. S56-S66

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Pharmacogenetic testing in the Veterans Health Administration (VHA): policy recommendations from the VHA Clinical Pharmacogenetics Subcommittee

for the VHA Clinical Pharmacogenetics Subcommittee, Feb 1 2019, In : Genetics in Medicine. 21, 2, p. 382-390 9 p.

Research output: Contribution to journalReview article

8 Scopus citations

Response to Gammal et al

for the VHA Clinical Pharmacogenetics Subcommittee, Aug 1 2019, In : Genetics in Medicine. 21, 8, p. 1888-1889 2 p.

Research output: Contribution to journalLetter

1 Scopus citations
2018

Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)

VA Million Veteran Program, May 15 2018, In : American Journal of Cardiology. 121, 10, p. 1162-1168 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Association of interleukin 6 receptor variant with cardiovascular disease effects of interleukin 6 receptor blocking therapy: A phenome - Wide association study

Cai, T., Zhang, Y., Ho, Y. L., Link, N., Sun, J., Huang, J., Cai, T. A., Damrauer, S., Ahuja, Y., Honerlaw, J., Costa, L., Schubert, P., Hong, C., Gagnon, D., Sun, Y., Sun, Y. V., Gaziano, J. M., Wilson, P., Cho, K., Tsao, P. & 82 others, O'Donnell, C. J., Liao, K. P., Gaziano, M. J., Ramoni, R., Breeling, J., Chang, K. M., Huang, G., Muralidhar, S., Tsao, P. S., Moser, J., Whitbourne, S. B., Brewer, J. V., Concato, J., Warren, S., Argyres, D. P., Stephens, B., Brophy, M. T., Humphries, D. E., Do, N., Shayan, S., Nguyen, X. M. T., Pyarajan, S., Hauser, E., Zhao, H., McArdle, R., Dellitalia, L., Harley, J., Whittle, J., Beckham, J., Wells, J., Gutierrez, S., Gibson, G., Kaminsky, L., Villareal, G., Xu, J., Hamner, M., Haddock, K. S., Bhushan, S., Iruvanti, P., Godschalk, M., Ballas, Z., Buford, M., Mastorides, S., Klein, J., Ratcliffe, N., Florez, H., Swann, A., Murdoch, M., Sriram, P., Kinlay, S., Yeh, S. S., Washburn, R., Jhala, D., Aguayo, S., Cohen, D., Sharma, S., Callaghan, J., Oursler, K. A., Whooley, M., Ahuja, S., Gutierrez, A., Schifman, R., Greco, J., Rauchman, M., Servatius, R., Oehlert, M., Wallbom, A., Fernando, R., Morgan, T., Stapley, T., Sherman, S., Anderson, G., Sonel, E., Boyko, E., Meyer, L., Gupta, S., Fayad, J., Hung, A., Lichy, J., Hurley, R., Robey, B. & Striker, R., Sep 2018, In : JAMA cardiology. 3, 9, p. 849-857 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

DASH score and subsequent risk of coronary artery disease: The findings from million veteran program

on behalf of the VA Million Veteran Program, May 1 2018, In : Journal of the American Heart Association. 7, 9, e008089.

Research output: Contribution to journalArticle

10 Scopus citations
2016

CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network

Saito, Y., Stamp, L. K., Caudle, K. E., Hershfield, M. S., McDonagh, E. M., Callaghan, J. T., Tassaneeyakul, W., Mushiroda, T., Kamatani, N., Goldspiel, B. R., Phillips, E. J., Klein, T. E. & Lee, M. T. M., Jan 1 2016, In : Clinical Pharmacology and Therapeutics. 99, 1, p. 36-37 2 p.

Research output: Contribution to journalReview article

60 Scopus citations

Implementation of a pharmacogenomics consult service to support the INGENIOUS trial

Eadon, M. T., Desta, Z., Levy, K. D., Decker, B. S., Pierson, R. C., Pratt, V. M., Callaghan, J. T., Rosenman, M. B., Carpenter, J. S., Holmes, A. M., McDonald, C. A., Benson, E. A., Patil, A. S., Vuppalanchi, R., Gufford, B. T., Dave, N., Robarge, J. D., Hyder, M. A., Haas, D. M., Kreutz, R. P. & 3 others, Dexter, P. R., Skaar, T. C. & Flockhart, D. A., Jul 1 2016, In : Clinical Pharmacology and Therapeutics. 100, 1, p. 63-66 4 p.

Research output: Contribution to journalReview article

21 Scopus citations

Inhibition of cytochrome P450 2B6 activity by voriconazole profiled using efavirenz disposition in healthy volunteers

Desta, Z., Metzger, I. F., Thong, N., Lu, J. B. L., Callaghan, J. T., Skaar, T. C., Flockhart, D. A. & Galinsky, R. E., Nov 2016, In : Antimicrobial Agents and Chemotherapy. 60, 11, p. 6813-6822 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Clinical pharmacogenetics implementation consortium guidelines for CYP2C9 and HLA-B genotypes and phenytoin dosing

Caudle, K. E., Rettie, A. E., Whirl-Carrillo, M., Smith, L. H., Mintzer, S., Lee, M. T., Klein, T. E. & Callaghan, J. T., Sep 17 2014, In : Clinical Pharmacology and Therapeutics. 96, 5, p. 542-548 7 p.

Research output: Contribution to journalReview article

125 Scopus citations

Clinical pharmacogenetics implementation consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 Update

Crews, K. R., Gaedigk, A., Dunnenberger, H. M., Leeder, J. S., Klein, T. E., Caudle, K. E., Haidar, C. E., Shen, D. D., Callaghan, J. T., Sadhasivam, S., Prows, C. A., Kharasch, E. D. & Skaar, T. C., Apr 2014, In : Clinical Pharmacology and Therapeutics. 95, 4, p. 376-382 7 p.

Research output: Contribution to journalArticle

332 Scopus citations

PharmGKB summary: Uric acid-lowering drugs pathway, pharmacodynamics

McDonagh, E. M., Thorn, C. F., Callaghan, J. T., Altman, R. B. & Klein, T. E., Sep 2014, In : Pharmacogenetics and Genomics. 24, 9, p. 464-476 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers

Metzger, I. F., Quigg, T. C., Epstein, N., Aregbe, A. O., Thong, N., Callaghan, J. T., Flockhart, D. A., Nguyen, A. T., Stevens, C. K., Gupta, S. K. & Desta, Z., Dec 1 2014, In : Current Therapeutic Research - Clinical and Experimental. 76, p. 64-69 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Clinical pharmacogenetics implementation consortium guidelines for human leukocyte antigen-b genotype and allopurinol dosing

Hershfield, M. S., Callaghan, J. T., Tassaneeyakul, W., Mushiroda, T., Thorn, C. F., Klein, T. E. & Lee, M. T. M., Feb 1 2013, In : Clinical Pharmacology and Therapeutics. 93, 2, p. 153-158 6 p.

Research output: Contribution to journalReview article

129 Scopus citations
2012

Clinical pharmacogenetics implementation consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype

Crews, K. R., Gaedigk, A., Dunnenberger, H. M., Klein, T. E., Shen, D. D., Callaghan, J. T., Kharasch, E. D. & Skaar, T. C., Feb 1 2012, In : Clinical Pharmacology and Therapeutics. 91, 2, p. 321-326 6 p.

Research output: Contribution to journalArticle

253 Scopus citations

Literature Based Drug Interaction Prediction with Clinical Assessment Using Electronic Medical Records: Novel Myopathy Associated Drug Interactions

Duke, J. D., Han, X., Wang, Z., Subhadarshini, A., Karnik, S. D., Li, X., Hall, S. D., Jin, Y., Callaghan, J. T., Overhage, M. J., Flockhart, D. A., Strother, R. M., Quinney, S. K. & Li, L., Aug 1 2012, In : PLoS computational biology. 8, 8, e1002614.

Research output: Contribution to journalArticle

69 Scopus citations
2007

QT effects of duloxetine at supratherapeutic doses: A placebo and positive controlled study

Zhang, L., Chappell, J., Gonzales, C. R., Small, D., Knadler, M. P., Callaghan, J. T., Francis, J. L., Desaiah, D., Leibowitz, M., Ereshefsky, L., Hoelscher, D., Leese, P. T. & Derby, M., Mar 1 2007, In : Journal of cardiovascular pharmacology. 49, 3, p. 146-153 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

The effects of supratherapeutic doses of duloxetine on blood pressure and pulse rate

Derby, M. A., Zhang, L., Chappell, J. C., Gonzales, C. R., Callaghan, J. T., Leibowitz, M., Ereshefsky, L., Hoelscher, D., Leese, P. T. & Mitchell, M. I., Jun 1 2007, In : Journal of cardiovascular pharmacology. 49, 6, p. 384-393 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2003

A Phase I and Pharmacokinetic Study of ILX-295501, an Oral Diarylsulfonylurea, on a Weekly for 3 Weeks Every 4-Week Schedule in Patients with Advanced Solid Malignancies

Forouzesh, B., Takimoto, C. H., Goetz, A., Diab, S., Hammond, L. A., Smetzer, L., Schwartz, G., Gazak, R., Callaghan, J. T., Von Hoff, D. D. & Rowinsky, E. K., Nov 15 2003, In : Clinical Cancer Research. 9, 15, p. 5540-5549 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

The conduct of in vitro and in vivo drug-drug interaction studies: A PhRMA perspective

Bjornsson, T. D., Callaghan, J. T., Einolf, H. J., Fischer, V., Gan, L., Grimm, S., Kao, J., King, S. P., Miwa, G., Ni, L., Kumar, G., McLeod, J., Obach, S. R., Roberts, S., Roe, A., Shah, A., Snikeris, F., Sullivan, J. T., Tweedie, D., Vega, J. M. & 2 others, Walsh, J. & Wrighton, S. A., May 1 2003, In : Journal of clinical pharmacology. 43, 5, p. 443-469 27 p.

Research output: Contribution to journalReview article

254 Scopus citations

The conduct of in vitro and in vivo drug-drug interaction studies: A Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

Bjornsson, T. D., Callaghan, J. T., Einolf, H. J., Fischer, V., Gan, L., Grimm, S., Kao, J., King, S. P., Miwa, G., Ni, L., Kumar, G., McLeod, J., Obach, R. S., Roberts, S., Roe, A., Shah, A., Snikeris, F., Sullivan, J. T., Tweedie, D., Vega, J. M. & 2 others, Walsh, J. & Wrighton, S. A., Jul 1 2003, In : Drug Metabolism and Disposition. 31, 7, p. 815-832 18 p.

Research output: Contribution to journalReview article

627 Scopus citations
2002

The effects of an oral contraceptive containing ethinyloestradiol and norgestrel on CYP3A activity

Wrighton, S. A., Callaghan, J. T., Hall, S. D., Mousa, O., Maya, J. F. & Gorski, J. C., Jan 1 2002, In : British Journal of Clinical Pharmacology. 53, 1, p. 67-74 8 p.

Research output: Contribution to journalArticle

51 Scopus citations
2000

Confidence interval criteria for assessment of dose proportionality

Smith, B. P., Vandenhende, F. R., DeSante, K. A., Farid, N. A., Welch, P. A., Callaghan, J. T. & Forgue, S. T., Jan 1 2000, In : Pharmaceutical Research. 17, 10, p. 1278-1283 6 p.

Research output: Contribution to journalArticle

225 Scopus citations
1999

Olanzapine: Pharmacokinetic and pharmacodynamic profile

Callaghan, J. T., Bergstrom, R. F., Ptak, L. R. & Beasley, C. M., Oct 6 1999, In : Clinical Pharmacokinetics. 37, 3, p. 177-193 17 p.

Research output: Contribution to journalReview article

422 Scopus citations
1998

Lack of effect of olanzapine on the pharmacokinetics of a single aminophylline dose in healthy men

Macias, W. L., Bergstrom, R. F., Cerimele, B. J., Kassahun, K., Tatum, D. E. & Callaghan, J. T., Nov 1 1998, In : Pharmacotherapy. 18, 6 I, p. 1237-1248 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
1997

Disposition and biotransformation of the antipsychotic agent olanzapine in humans

Kassahun, K., Mattiuz, E., Nyhart, E., Obermeyer, B., Gillespie, T., Murphy, A., Goodwin, R. M., Tupper, D., Callaghan, J. T. & Lemberger, L., Jan 1 1997, In : Drug Metabolism and Disposition. 25, 1, p. 81-93 13 p.

Research output: Contribution to journalArticle

198 Scopus citations

Olanzapine: Interaction study with imipramine

Callaghan, J. T., Cerimele, B. J., Kassahun, K. J., Nyhart, E. H., Hoyes-Beehler, P. J. & Kondraske, G. V., Oct 1997, In : Journal of Clinical Pharmacology. 37, 10, p. 971-978 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Olanzapine and warfarin drug interaction

Maya, J. F., Callaghan, J. T., Bergstrom, R. F., Cerimele, B. J., Kassahun, K., Nyhart, E. H. & Brater, D. C., Dec 1 1997, In : Clinical Pharmacology and Therapeutics. 61, 2, 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pharmacokinetic (PK) and pharmacodynamic (PD) interactions between fluvoxamine and olanzapine

Mäenpää, J., Wrighton, S., Bergstrom, R., Cerimele, B., Tatum, D., Hatcher, B. & Callaghan, J. T., Dec 1 1997, In : Clinical Pharmacology and Therapeutics. 61, 2, 1 p.

Research output: Contribution to journalArticle

30 Scopus citations
1990

Disposition in humans of racemic picenadol, an opioid analgesic

Franz, P. M., Anliker, S. L., Callaghan, J. T., DeSante, K. A., Dhahir, P. H., Nelson, R. L. & Rubin, A., Dec 1 1990, In : Drug Metabolism and Disposition. 18, 6, p. 968-973 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Relationship between steady-state plasma nizatidine concentrations and inhibition of basal and stimulated gastric acid secretion

Schneck, D. W., Callaghan, J. T., Bergstrom, R. F., Obermeyer, B. D. & Offen, W. W., Apr 1990, In : Clinical Pharmacology and Therapeutics. 47, 4, p. 499-503 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of serum prolactin determination in evaluation of impotent patient

Foster, R. S., Mulcahy, J. J., Callaghan, J. T., Crabtree, R. & Brashear, D., Dec 1990, In : Urology. 36, 6, p. 499-501 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Secretion of nizatidine into human breast milk after single and multiple doses

Obermeyer, B. D., Bergstrom, R. F., Callaghan, J. T., Knadler, M. P., Golichowski, A. & Rubin, A., Jun 1990, In : Clinical Pharmacology and Therapeutics. 47, 6, p. 724-730 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
1989

Effect of a leukotriene antagonist, LY171883, on cold air-induced bronchoconstriction in asthmatics

Israel, E., Juniper, E. F., Callaghan, J. T., Mathur, P. N., Morris, M. M., Dowell, A. R., Enas, G. G., Hargreave, F. E. & Drazen, J. M., Jan 1 1989, In : American Review of Respiratory Disease. 140, 5, p. 1348-1353 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
1988

Double-Blind Comparator Trials with Pinacidil, a Potassium Channel Opener

Callaghan, J. T., Goldberg, M. R. & Brunelle, R., Dec 1988, In : Drugs. 36, 7, p. 77-82 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Nizatidine disposition in subjects with normal and impaired renal function

Aronoff, G. R., Bergstrom, R. F., Bopp, R. J., Sloan, R. S. & Callaghan, J. T., Jun 1988, In : Clinical Pharmacology and Therapeutics. 43, 6, p. 688-695 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
1987

Absorption studies of the H2-blocker nizatidine

Knadler, M. P., Bergstrom, R. F., Callaghan, J. T., Obermeyer, B. D. & Rubin, A., Nov 1987, In : Clinical Pharmacology and Therapeutics. 42, 5, p. 514-520 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

A pharmacokinetic profile of nizatidine in man

Callaghan, J. T., Bergstrom, R. F., Rubin, A., Chernish, S., Crabtree, R., Knadler, M. P., Obermeyer, B., Offen, W. W., Schneck, D. W., Aronoff, G. & Lasseter, K. C., Jan 1 1987, In : Scandinavian Journal of Gastroenterology. 22, S136, p. 9-17 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Nizatidine, an H2‐Receptor Antagonist: Disposition and Safety in the Elderly

Callaghan, J. T., Rubin, A., Knadler, M. P. & Bergstrom, R. F., Aug 1987, In : The Journal of Clinical Pharmacology. 27, 8, p. 618-624 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
1986

Nizatidine, an H2-blocker. Its metabolism and disposition in man

Knadler, M. P., Bergstrom, R. F., Callaghan, J. T. & Rubin, A., Jan 1 1986, In : Drug Metabolism and Disposition. 14, 2, p. 175-182 8 p.

Research output: Contribution to journalArticle

73 Scopus citations
1985

Intravenous nizatidine kinetics and acid suppression

Callaghan, J. T., Bergstrom, R. F., Obermeyer, B. D., King, E. P. & Offen, W. W., Feb 1985, In : Clinical Pharmacology and Therapeutics. 37, 2, p. 162-165 4 p.

Research output: Contribution to journalArticle

27 Scopus citations
1983

Correlation of in vivo and in vitro expression of cell-mediated immunity to mumps skin test antigen

Peterson, B. H., Callaghan, J. T., Steirnel, L. A. & Epirvette, W. W., Jun 1983, In : The Journal of Allergy and Clinical Immunology. 71, 6, p. 612-617 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Delayed hypersensitivity to mumps antigen in humans

Callaghan, J. T., Petersen, B. H., Smith, W. C., Epinette, W. W. & Ransburg, R. C., Jan 1983, In : Clinical Immunology and Immunopathology. 26, 1, p. 102-110 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effect of cholestyramine and colestipol on the absorption of phenytoin

Callaghan, J. T., Tsuru, M., Holtzman, J. L. & Hunninghake, D. B., Sep 1 1983, In : European Journal of Clinical Pharmacology. 24, 5, p. 675-678 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Suppression of mitogen-induced lymphocyte transformation in cigarette smokers

Petersen, B. H., Steimel, L. F. & Callaghan, J. T., Apr 1983, In : Clinical Immunology and Immunopathology. 27, 1, p. 135-140 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
1982

Correlation of in vivo and in vitro expression of cell mediated immunity to mumps skin test antigen

Petersen, B. H., Callaghan, J. T., Steimel, L. F. & Epinette, W. W., Jan 1 1982, In : International Journal of Immunopharmacology. 4, 4, 1 p.

Research output: Contribution to journalArticle

Gastric secretion of histamine after gastrin administration in normal human subjects

Verburg, K. M., Henry, D. P., Callaghan, J. T. & Bowsher, R. R., Jan 1 1982, In : Clinical Research. 30, 4, p. 726A

Research output: Contribution to journalArticle

Picenadol, an opioid with mu- and delta-receptor affinity

Callaghan, J. T. & Crabtree, R. E., Jan 1 1982, In : Clinical Research. 30, 4, p. 717A

Research output: Contribution to journalArticle

2 Scopus citations
1981

Clinical response of patients with galactorrhea to pergolide, a potent, long-acting dopaminergic ergot derivative

Callaghan, J. T., Cleary, R. E., Crabtree, R. & Lemberger, L., Jan 5 1981, In : Life Sciences. 28, 1, p. 95-102 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

CSF Perfusion to Treat Intraventricular Penicillin Toxicity

Callaghan, J. T., Ausman, J. I. & Clubb, R., Jun 1981, In : Archives of Neurology. 38, 6, p. 390-391 2 p.

Research output: Contribution to journalArticle

5 Scopus citations