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John Chirgwin

  • 24836 Citations
  • 47 h-Index
1972 …2018
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Neoplasm Metastasis Medicine & Life Sciences
Bone and Bones Medicine & Life Sciences
Thiosulfate Sulfurtransferase Medicine & Life Sciences
Bone Neoplasms Medicine & Life Sciences
Glucose-6-Phosphate Isomerase Medicine & Life Sciences
Insulin Medicine & Life Sciences
Genes Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

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NIH Grants

Role of Osteocytes in Myeloma Bone Disease

Chirgwin, J. & Suvannasankha, A.

Project: Research project

A Novel Agent to Suppress Tumor Growth in Bone, Prevent Cachectic Muscle Loss and Preserve Skeletal Integrity

Chirgwin, J. & Suvannasankha, A.

Project: Research project

Publications 1972 2018

  • 24836 Citations
  • 47 h-Index
  • 115 Article
  • 3 Chapter
  • 1 Conference contribution
  • 1 Review article

Small molecules inhibit ex vivo tumor growth in bone

Zhou, D., Bum-Erdene, K., Xu, D., Liu, D., Tompkins, D., Sulaiman, R. S., Corson, T., Chirgwin, J. & Meroueh, S., Dec 15 2018, In : Bioorganic and Medicinal Chemistry. 26, 23-24, p. 6128-6134 7 p.

Research output: Contribution to journal › Article

Bone Development
Tumors
Bone
Bone and Bones
Molecules
4 Citations (Scopus)

The role of Semaphorin 4D in bone remodeling and cancer metastasis

Lontos, K., Adamik, J., Tsagianni, A., Galson, D. L., Chirgwin, J. & Suvannasankha, A., Jun 19 2018, In : Frontiers in Endocrinology. 9, JUL, 322.

Research output: Contribution to journal › Review article

Bone Neoplasms
Bone Remodeling
Neoplasm Metastasis
Semaphorins
Neoplasms
5 Citations (Scopus)

Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis

Juárez, P., Fournier, P. G. J., Mohammad, K., McKenna, R. C., Davis, H. W., Peng, X. H., Niewolna, M., Mauviel, A., Chirgwin, J. & Guise, T., Oct 17 2017, In : Oncotarget. 8, 49, p. 86447-86462 16 p.

Research output: Contribution to journal › Article

zoledronic acid
Bone Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
57 Citations (Scopus)

Bidirectional notch signaling and osteocyte-derived factors in the bone marrow microenvironment promote tumor cell proliferation and bone destruction in multiple myeloma

Delgado-Calle, J., Anderson, J., Cregor, M. D., Hiasa, M., Chirgwin, J., Carlesso, N., Yoneda, T., Mohammad, K., Plotkin, L., Roodman, G. D. & Bellido, T., Mar 1 2016, In : Cancer Research. 76, 5, p. 1089-1100 12 p.

Research output: Contribution to journal › Article

Osteocytes
Tumor Microenvironment
Multiple Myeloma
Bone Marrow
Cell Proliferation
3 Citations (Scopus)

Cell adhesion molecule CD166 drives malignant progression and osteolytic disease in multiple myeloma

Xu, L., Mohammad, K., Wu, H., Crean, C., Poteat, B., Cheng, Y., Cardoso, A. A., Machal, C., Hanenberg, H., Abonour, R., Kacena, M., Chirgwin, J., Suvannasankha, A. & Srour, E., Dec 1 2016, In : Cancer Research. 76, 23, p. 6901-6910 10 p.

Research output: Contribution to journal › Article

Cell Adhesion Molecules
Multiple Myeloma
Disease Progression
Bone Marrow Cells
Bone Marrow