John Nurnberger

  • Joyce & Iver Small Professor of Psychiatry, Psychiatry
  • 35346 Citations
  • 91 h-Index
1968 …2019
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Publications 1968 2019

2016
4 Citations (Scopus)

Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk

Roberts, G., Wen, W., Frankland, A., Perich, T., Holmes-Preston, E., Levy, F., Lenroot, R. K., Hadzi-Pavlovic, D., Nurnberger, J., Breakspear, M. & Mitchell, P. B., Aug 1 2016, In : Psychological Medicine. 46, 11, p. 2385-2396 12 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Corpus Callosum
Major Depressive Disorder
Anisotropy
White Matter
8 Citations (Scopus)

Risk factors for suicide in bipolar i disorder in two prospectively studied cohorts

Coryell, W., Kriener, A., Butcher, B., Nurnberger, J., McMahon, F., Berrettini, W. & Fiedorowicz, J., Jan 15 2016, In : Journal of Affective Disorders. 190, p. 1-5 5 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Suicide
Depression
Odds Ratio
National Institute of Mental Health (U.S.)
19 Citations (Scopus)

The Pharmacogenomics of Bipolar Disorder study (PGBD): Identification of genes for lithium response in a prospective sample

Oedegaard, K. J., Alda, M., Anand, A., Andreassen, O. A., Balaraman, Y., Berrettini, W. H., Bhattacharjee, A., Brennand, K. J., Burdick, K. E., Calabrese, J. R., Calkin, C. V., Claasen, A., Coryell, W. H., Craig, D., DeModena, A., Frye, M., Gage, F. H., Gao, K., Garnham, J., Gershon, E. & 18 others, Jakobsen, P., Leckband, S. G., McCarthy, M. J., McInnis, M. G., Maihofer, A. X., Mertens, J., Morken, G., Nievergelt, C. M., Nurnberger, J., Pham, S., Schoeyen, H., Shekhtman, T., Shilling, P. D., Szelinger, S., Tarwater, B., Yao, J., Zandi, P. P. & Kelsoe, J. R., May 5 2016, In : BMC Psychiatry. 16, 1, 129.

Research output: Contribution to journalArticle

Pharmacogenetics
Bipolar Disorder
Lithium
Genes
Genome-Wide Association Study
30 Citations (Scopus)

Toward precision psychiatry: Statistical platform for the personalized characterization of natural behaviors

Torres, E. B., Isenhower, R. W., Nguyen, J., Whyatt, C., Nurnberger, J., Jose, J. V., Silverstein, S. M., Papathomas, T. V., Sage, J. & Cole, J., Feb 2 2016, In : Frontiers in Neurology. 7, FEB, 8.

Research output: Contribution to journalArticle

Nervous System Diseases
Psychiatry
Behavioral Sciences
Numismatics
Brain Diseases
9 Citations (Scopus)

Transgenerational latent early-life associated regulation unites environment and genetics across generations

Lahiri, D., Maloney, B., Bayon, B. L., Chopra, N., White, F., Greig, N. H. & Nurnberger, J., Mar 1 2016, In : Epigenomics. 8, 3, p. 373-387 15 p.

Research output: Contribution to journalArticle

Environmental Exposure
Epigenomics
Gene Expression
Pregnancy
2015
11 Citations (Scopus)
Drinking
Genotype
Alcohols
Alcoholism
Single Nucleotide Polymorphism
3 Citations (Scopus)

A genome wide association study of fast beta EEG in families of European ancestry

Meyers, J. L., Zhang, J., Manz, N., Rangaswamy, M., Kamarajan, C., Wetherill, L., Chorlian, D. B., Kang, S. J., Bauer, L., Hesselbrock, V., Kramer, J., Kuperman, S., Nurnberger, J., Tischfield, J., Wang, J. C., Edenberg, H., Goate, A., Foroud, T. & Porjesz, B., Sep 15 2015, (Accepted/In press) In : International Journal of Psychophysiology.

Research output: Contribution to journalArticle

Racemases and Epimerases
Genome-Wide Association Study
Dermatan Sulfate
Electroencephalography
Genes
16 Citations (Scopus)
Bipolar Disorder
National Institute of Mental Health (U.S.)
Depressive Disorder
Clinical Protocols
Area Under Curve
27 Citations (Scopus)

Association of substance dependence phenotypes in the COGA sample

Wetherill, L., Agrawal, A., Kapoor, M., Bertelsen, S., Bierut, L. J., Brooks, A., Dick, D., Hesselbrock, M., Hesselbrock, V., Koller, D. L., Le, N., Nurnberger, J., Salvatore, J. E., Schuckit, M., Tischfield, J. A., Wang, J. C., Xuei, X., Edenberg, H., Porjesz, B., Bucholz, K. & 2 others, Goate, A. M. & Foroud, T., May 1 2015, In : Addiction Biology. 20, 3, p. 617-627 11 p.

Research output: Contribution to journalArticle

Substance-Related Disorders
Phenotype
Single Nucleotide Polymorphism
Diagnostic and Statistical Manual of Mental Disorders
Alcoholism
5 Citations (Scopus)

Characteristics of Bipolar I patients grouped by externalizing disorders

Swaminathan, S., Koller, D. L., Foroud, T., Edenberg, H., Xuei, X., Niculescu, A. & Nurnberger, J., Jul 1 2015, In : Journal of Affective Disorders. 178, p. 206-214 9 p., 7324.

Research output: Contribution to journalArticle

Mood Disorders
Calcium Channels
Bipolar Disorder
Genes
Single Nucleotide Polymorphism
6 Citations (Scopus)

Confirmatory test of two factors and four subtypes of bipolar disorder based on lifetime psychiatric co-morbidity

Monahan, P., Stump, T., Coryell, W. H., Harezlak, J., Marcoulides, G. A., Liu, H., Steeger, C. M., Mitchell, P. B., Wilcox, H. C., Hulvershorn, L., Glowinski, A. L., Iyer-Eimerbrink, P. A., McInnis, M. & Nurnberger, J., Jul 30 2015, In : Psychological Medicine. 45, 10, p. 2181-2196 16 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Psychiatry
Morbidity
Statistical Factor Analysis
Diagnostic and Statistical Manual of Mental Disorders
165 Citations (Scopus)

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

Mertens, J., Wang, Q. W., Kim, Y., Yu, D. X., Pham, S., Yang, B., Zheng, Y., Diffenderfer, K. E., Zhang, J., Soltani, S., Eames, T., Schafer, S. T., Boyer, L., Marchetto, M. C., Nurnberger, J., Calabrese, J. R., Ødegaard, K. J., McCarthy, M. J., Zandi, P. P., Alba, M. & 6 others, Nievergelt, C. M., Mi, S., Brennand, K. J., Kelsoe, J. R., Gage, F. H. & Yao, J., Nov 5 2015, In : Nature. 527, 7576, p. 95-99 5 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Lithium
Neurons
Induced Pluripotent Stem Cells
Therapeutics
7 Citations (Scopus)

Further analyses of genetic association between GRM8 and alcohol dependence symptoms among young adults

Long, E. C., Aliev, A., Wang, J. C., Edenberg, H., Nurnberger, J., Hesselbrock, V., Porjesz, B. & Dick, D. M., May 1 2015, In : Journal of Studies on Alcohol and Drugs. 76, 3, p. 414-418 5 p.

Research output: Contribution to journalArticle

Alcoholism
young adult
Young Adult
alcohol
Alcohols
13 Citations (Scopus)

Genetic and childhood trauma interaction effect on age of onset in bipolar disorder: An exploratory analysis

BiGS Collaborative & Koller, D. L., 2015, In : Journal of Affective Disorders. 179, p. 1-5 5 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Age of Onset
Single Nucleotide Polymorphism
Wounds and Injuries
Gene Ontology
13 Citations (Scopus)

Genome-wide association data suggest ABCB1 and immune-related gene sets may be involved in adult antisocial behavior

Salvatore, J. E., Edwards, A. C., McClintick, J., Bigdeli, T. B., Adkins, A., Aliev, F., Edenberg, H., Foroud, T., Hesselbrock, V., Kramer, J., Nurnberger, J., Schuckit, M., Tischfield, J. A., Xuei, X. & Dick, D. M., Apr 28 2015, In : Translational Psychiatry. 5, 4, e558.

Research output: Contribution to journalArticle

Genome
Diagnostic and Statistical Manual of Mental Disorders
Genes
Alcoholism
Single Nucleotide Polymorphism
47 Citations (Scopus)

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

Hou, L., Bergen, S. E., Akula, N., Song, J., Hultman, C. M., Landén, M., Adli, M., Alda, M., Ardau, R., Arias, B., Aubry, J. M., Backlund, L., Badner, J. A., Barrett, T. B., Bauer, M., Baune, B. T., Bellivier, F., Benabarre, A., Bengesser, S., Berrettini, W. H. & 119 others, Bhattacharjee, A. K., Biernacka, J. M., Birner, A., Bloss, C. S., Brichant-Petitjean, C., Bui, E. T., Byerley, W., Cervantes, P., Chillotti, C., Cichon, S., Colom, F., Coryell, W., Craig, D. W., Cruceanu, C., Czerski, P. M., Davis, T., Dayer, A., Degenhardt, F., Del Zompo, M., DePaulo, J. R., Edenberg, H., Étain, B., Falkai, P., Foroud, T., Forstner, A. J., Frisén, L., Frye, M. A., Fullerton, J. M., Gard, S., Garnham, J. S., Gershon, E. S., Goes, F. S., Greenwood, T. A., Grigoroiu-Serbanescu, M., Hauser, J., Heilbronner, U., Heilmann-Heimbach, S., Herms, S., Hipolito, M., Hitturlingappa, S., Hoffmann, P., Hofmann, A., Jamain, S., Jiménez, E., Kahn, J. P., Kassem, L., Kelsoe, J. R., Kittel-Schneider, S., Kliwicki, S., Koller, D. L., König, B., Lackner, N., Laje, G., Lang, M., Lavebratt, C., Lawson, W. B., Leboyer, M., Leckband, S. G., Liu, C., Maaser, A., Mahon, P. B., Maier, W., Maj, M., Manchia, M., Martinsson, L., McCarthy, M. J., McElroy, S. L., McInnis, M. G., McKinney, R., Mitchell, P. B., Mitjans, M., Mondimore, F. M., Monteleone, P., Mühleisen, T. W., Nievergelt, C. M., Nöthen, M. M., Novák, T., Nurnberger, J., Nwulia, E. A., Ösby, U., Pfennig, A., Potash, J. B., Propping, P., Reif, A., Reininghaus, E., Rice, J., Rietschel, M., Rouleau, G. A., Rybakowski, J. K., Schalling, M., Scheftner, W. A., Schofield, P. R., Schork, N. J., Schulze, T. G., Schumacher, J., Schweizer, B. W., Severino, G., Shekhtman, T., Shilling, P. D., Simhandl, C., Slaney, C. M., Smith, E. N., Squassina, A., Stamm, T., Stopkova, P., Streit, F., Strohmaier, J., Szelinger, S., Tighe, S. K., Tortorella, A., Turecki, G., Vieta, E., Volkert, J., Witt, S. H., Wright, A., Zandi, P. P., Zhang, P., Zollner, S. & McMahon, F. J., 2015, In : Human Molecular Genetics. 25, 15, p. 3383-3394 12 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Bipolar Disorder
X Chromosome
Lithium
Odds Ratio
32 Citations (Scopus)

Integrating mRNA and miRNA weighted gene co-expression networks with eQTLs in the nucleus accumbens of subjects with alcohol dependence

Mamdani, M., Williamson, V., McMichael, G. O., Blevins, T., Aliev, F., Adkins, A., Hack, L., Bigdeli, T., Van Der Vaart, A. D., Web, B. T., Bacanu, S. A., Kalsi, G., Kendler, K. S., Miles, M. F., Dick, D., Riley, B. P., Dumur, C., Vladimirov, V. I., Hesselbrock, V., Edenberg, H. & 29 others, Nurnberger, J., Foroud, T., Kuperman, S., Kramer, J., Porjesz, B., Bierut, L., Goate, A., Rice, J., Bucholz, K., Schuckit, M., Tischfield, J., Almasy, L., Taylor, R., Dick, D., Bauer, L., Koller, D., O'Connor, S., Wetherill, L., Xuei, X., Chan, G., Kang, S., Manz, N., Rangaswamy, M., Rohrbaugh, J., Wang, J. C., Brooks, A., Aliev, F., Parsian, A. & Reilly, M., Sep 18 2015, In : PLoS One. 10, 9, e0137671.

Research output: Contribution to journalArticle

Nucleus Accumbens
alcohol abuse
MicroRNAs
microRNA
Alcoholism
96 Citations (Scopus)

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder

Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Feb 5 2015, In : American Journal of Human Genetics. 96, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle

Major Depressive Disorder
Bipolar Disorder
Psychiatry
Schizophrenia
Sample Size
2 Citations (Scopus)

Positive selection on loci associated with drug and alcohol dependence

Sadler, B., Haller, G., Edenberg, H., Tischfield, J., Brooks, A., Kramer, J., Schuckit, M., Nurnberger, J. & Goate, A., Aug 13 2015, In : PLoS One. 10, 8, e0134393.

Research output: Contribution to journalArticle

drug abuse
alcohol abuse
Intelligence
Alcoholism
Substance-Related Disorders
348 Citations (Scopus)

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium & International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), Feb 17 2015, In : Nature Neuroscience. 18, 2, p. 199-209 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Histones
Psychiatry
Post-Synaptic Density
Genomics
65 Citations (Scopus)

Rare variants in neuronal excitability genes influence risk for bipolar disorder

The Bipolar Genome Study, Mar 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 11, p. 3576-3581 6 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Genes
Pedigree
5' Untranslated Regions
Genome-Wide Association Study
27 Citations (Scopus)

What clinical features precede the onset of bipolar disorder?

Perich, T., Lau, P., Hadzi-Pavlovic, D., Roberts, G., Frankland, A., Wright, A., Green, M., Breakspear, M., Corry, J., Radlinska, B., McCormack, C., Joslyn, C., Levy, F., Lenroot, R., Nurnberger, J. & Mitchell, P. B., Mar 1 2015, In : Journal of Psychiatric Research. 62, p. 71-77 7 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Anxiety Disorders
Mood Disorders
Onset
Sample Size
2014
21 Citations (Scopus)

An ADH1B variant and peer drinking in progression to adolescent drinking milestones: Evidence of a gene-by-environment interaction

Olfson, E., Edenberg, H., Nurnberger, J., Agrawal, A., Bucholz, K. K., Almasy, L. A., Chorlian, D., Dick, D. M., Hesselbrock, V. M., Kramer, J. R., Kuperman, S., Porjesz, B., Schuckit, M. A., Tischfield, J. A., Wang, J. C., Wetherill, L., Foroud, T., Rice, J., Goate, A. & Bierut, L. J., Oct 1 2014, In : Alcoholism: Clinical and Experimental Research. 38, 10, p. 2541-2549 9 p.

Research output: Contribution to journalArticle

Gene-Environment Interaction
Alcohol Dehydrogenase
Drinking
Genes
Alcohols
407 Citations (Scopus)

Convergence of genes and cellular pathways dysregulated in autism spectrum disorders

Pinto, D., Delaby, E., Merico, D., Barbosa, M., Merikangas, A., Klei, L., Thiruvahindrapuram, B., Xu, X., Ziman, R., Wang, Z., Vorstman, J. A. S., Thompson, A., Regan, R., Pilorge, M., Pellecchia, G., Pagnamenta, A. T., Oliveira, B., Marshall, C. R., Magalhaes, T. R., Lowe, J. K. & 92 others, Howe, J. L., Griswold, A. J., Gilbert, J., Duketis, E., Dombroski, B. A., De Jonge, M. V., Cuccaro, M., Crawford, E. L., Correia, C. T., Conroy, J., Conceição, I. C., Chiocchetti, A. G., Casey, J. P., Cai, G., Cabrol, C., Bolshakova, N., Bacchelli, E., Anney, R., Gallinger, S., Cotterchio, M., Casey, G., Zwaigenbaum, L., Wittemeyer, K., Wing, K., Wallace, S., Van Engeland, H., Tryfon, A., Thomson, S., Soorya, L., Rogé, B., Roberts, W., Poustka, F., Mouga, S., Minshew, N., McInnes, L. A., McGrew, S. G., Lord, C., Leboyer, M., Le Couteur, A. S., Kolevzon, A., Jiménez González, P., Jacob, S., Holt, R., Guter, S., Green, J., Green, A., Gillberg, C., Fernandez, B. A., Duque, F., Delorme, R., Dawson, G., Chaste, P., Café, C., Brennan, S., Bourgeron, T., Bolton, P. F., Bölte, S., Bernier, R., Baird, G., Bailey, A. J., Anagnostou, E., Almeida, J., Wijsman, E. M., Vieland, V. J., Vicente, A. M., Schellenberg, G. D., Pericak-Vance, M., Paterson, A. D., Parr, J. R., Oliveira, G., Nurnberger, J., Monaco, A. P., Maestrini, E., Klauck, S. M., Hakonarson, H., Haines, J. L., Geschwind, D. H., Freitag, C. M., Folstein, S. E., Ennis, S., Coon, H., Battaglia, A., Szatmari, P., Sutcliffe, J. S., Hallmayer, J., Gill, M., Cook, E. H., Buxbaum, J. D., Devlin, B., Gallagher, L., Betancur, C. & Scherer, S. W., May 1 2014, In : American Journal of Human Genetics. 94, 5, p. 677-694 18 p.

Research output: Contribution to journalArticle

Genes
Fragile X Syndrome
Intellectual Disability
Synapses
Chromatin
25 Citations (Scopus)

DSM-5 cannabis use disorder: A phenotypic and genomic perspective

Agrawal, A., Lynskey, M. T., Bucholz, K. K., Kapoor, M., Almasy, L., Dick, D. M., Edenberg, H., Foroud, T., Goate, A., Hancock, D. B., Hartz, S., Johnson, E. O., Hesselbrock, V., Kramer, J. R., Kuperman, S., Nurnberger, J., Schuckit, M. & Bierut, L. J., Jan 1 2014, In : Drug and Alcohol Dependence. 134, 1, p. 362-369 8 p.

Research output: Contribution to journalArticle

Cannabis
Polymorphism
Single Nucleotide Polymorphism
Genes
Nucleotides
14 Citations (Scopus)

Family-Based Association Analysis of Alcohol Dependence Criteria and Severity

Wetherill, L., Kapoor, M., Agrawal, A., Bucholz, K., Koller, D., Bertelsen, S. E., Le, N., Wang, J. C., Almasy, L., Hesselbrock, V., Kramer, J., Nurnberger, J., Schuckit, M., Tischfield, J. A., Xuei, X., Porjesz, B., Edenberg, H., Goate, A. M. & Foroud, T., Feb 2014, In : Alcoholism: Clinical and Experimental Research. 38, 2, p. 354-366 13 p.

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Diagnostic and Statistical Manual of Mental Disorders
Genes
Single Nucleotide Polymorphism
27 Citations (Scopus)

Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood

Dick, D. M., Cho, S. B., Latendresse, S. J., Aliev, F., Nurnberger, J., Edenberg, H., Schuckit, M., Hesselbrock, V. M., Porjesz, B., Bucholz, K., Wang, J. C., Goate, A., Kramer, J. R. & Kuperman, S., Nov 1 2014, In : Addiction Biology. 19, 6, p. 1055-1064 10 p.

Research output: Contribution to journalArticle

Alcoholic Intoxication
Alcohols
Alcoholism
Drinking
Linear Models
6 Citations (Scopus)

Genetics of Alcoholism

Iyer-Eimerbrink, P. A. & Nurnberger, J., 2014, In : Current Psychiatry Reports. 16, 12

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Genes
Gene-Environment Interaction
Impulsive Behavior
12 Citations (Scopus)

Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families

Kapoor, M., Wang, J. C., Wetherill, L., Le, N., Bertelsen, S., Hinrichs, A. L., Budde, J., Agrawal, A., Almasy, L., Bucholz, K., Dick, D. M., Harari, O., Xuei, X., Hesselbrock, V., Kramer, J., Nurnberger, J., Rice, J., Schuckit, M., Tischfield, J., Porjesz, B. & 4 others, Edenberg, H., Bierut, L., Foroud, T. & Goate, A., Sep 1 2014, In : Drug and Alcohol Dependence. 142, p. 56-62 7 p.

Research output: Contribution to journalArticle

Survival Analysis
Age of Onset
Alcoholism
Genes
Alcohols
104 Citations (Scopus)

Identification of pathways for bipolar disorder: A meta-analysis

Nurnberger, J., Koller, D. L., Jung, J., Edenberg, H., Foroud, T., Guella, I., Vawter, M. P. & Kelsoe, J. R., 2014, In : JAMA Psychiatry. 71, 6, p. 657-664 8 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Meta-Analysis
Genes
Genome-Wide Association Study
Psychiatry
7 Citations (Scopus)

Olfactory neurons obtained through nasal biopsy combined with laser-capture microdissection: a potential approach to study treatment response in mental disorders

Narayan, S., McLean, C., Sawa, A., Lin, S. Y., Rai, N., Hipolito, M. M. S., Cascella, N., Nurnberger, J., Ishizuka, K. & Nwulia, E. A., Dec 4 2014, In : Journal of visualized experiments : JoVE. 94

Research output: Contribution to journalArticle

Microdissection
Laser Capture Microdissection
Biopsy
Nose
Mental Disorders
15 Citations (Scopus)

On the association of common and rare genetic variation influencing body mass index: A combined SNP and CNV analysis

Peterson, R. E., Maes, H. H., Lin, P., Kramer, J. R., Hesselbrock, V. M., Bauer, L. O., Nurnberger, J., Edenberg, H., Dick, D. M. & Webb, B. T., May 14 2014, In : BMC Genomics. 15, 1, 368.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Body Mass Index
Obesity
Morbid Obesity
Proxy
148 Citations (Scopus)

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia

Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Sep 11 2014, In : Molecular Psychiatry. 19, 9, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Dissection
Schizophrenia
Genome-Wide Association Study
Genetic Loci
12 Citations (Scopus)

Predictors of subgroups based on maximum drinks per occasion over six years for 833 adolescents and young adults in COGA

Schuckit, M. A., Smith, T. L., Danko, G. P., Bucholz, K. K., Agrawal, A., Dick, D. M., Nurnberger, J., Kramer, J., Hesselbrock, M., Saunders, G. & Hesselbrock, V., Jan 2014, In : Journal of Studies on Alcohol and Drugs. 75, 1, p. 24-34 11 p.

Research output: Contribution to journalArticle

young adult
Young Adult
Drinking
Trajectories
Alcohols
22 Citations (Scopus)

Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence

Haller, G., Kapoor, M., Budde, J., Xuei, X., Edenberg, H., Nurnberger, J., Kramer, J., Brooks, A., Tischfield, J., Almasy, L., Agrawal, A., Bucholz, K., Rice, J., Saccone, N., Bierut, L. & Goate, A., Feb 2014, In : Human Molecular Genetics. 23, 3, p. 810-819 10 p., ddt463.

Research output: Contribution to journalArticle

Cocaine-Related Disorders
Alcoholism
African Americans
Tobacco Use Disorder
Nicotinic Receptors
2 Citations (Scopus)

Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders

Correia, C. T., Conceição, I. C., Oliveira, B., Coelho, J., Sousa, I., Sequeira, A. F., Almeida, J., Café, C., Duque, F., Mouga, S., Roberts, W., Gao, K., Lowe, J. K., Thiruvahindrapuram, B., Walker, S., Marshall, C. R., Pinto, D., Nurnberger, J., Scherer, S. W., Geschwind, D. H. & 2 others, Oliveira, G. & Vicente, A. M., Apr 10 2014, In : Molecular Autism. 5, 1, 28.

Research output: Contribution to journalArticle

Annexins
Annexin A1
Genes
Gene Duplication
3' Untranslated Regions
6 Citations (Scopus)

Social contexts of remission from DSM-5 alcohol use disorder in a high-risk sample

Mccutcheon, V. V., Kramer, J. R., Edenberg, H., Nurnberger, J., Kuperman, S., Schuckit, M. A., Heath, A. C. & Bucholz, K. K., 2014, In : Alcoholism: Clinical and Experimental Research. 38, 7, p. 2015-2023 9 p.

Research output: Contribution to journalArticle

Alcohols
Drinking
Marriage
Population
Birth Order
17 Citations (Scopus)

The Autism Simplex Collection: An international, expertly phenotyped autism sample for genetic and phenotypic analyses

Buxbaum, J. D., Bolshakova, N., Brownfeld, J. M., Anney, R. J. L., Bender, P., Bernier, R., Cook, E. H., Coon, H., Cuccaro, M., Freitag, C. M., Hallmayer, J., Geschwind, D., Klauck, S. M., Nurnberger, J., Oliveira, G., Pinto, D., Poustka, F., Scherer, S. W., Shih, A., Sutcliffe, J. S. & 4 others, Szatmari, P., Vicente, A. M., Vieland, V. & Gallagher, L., 2014, In : Molecular Autism. 5, 1, 34.

Research output: Contribution to journalArticle

Autistic Disorder
National Institutes of Health (U.S.)
National Institute of Mental Health (U.S.)
Exome
Genetic Research
34 Citations (Scopus)

The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism

Hadley, D., Wu, Z. L., Kao, C., Kini, A., Mohamed-Hadley, A., Thomas, K., Vazquez, L., Qiu, H., Mentch, F., Pellegrino, R., Kim, C., Connolly, J., Glessner, J., Hakonarson, H., Pinto, D., Merikangas, A., Klei, L., Vorstman, J. A. S., Thompson, A., Regan, R. & 78 others, Pagnamenta, A. T., Oliveira, B., Magalhaes, T. R., Gilbert, J., Duketis, E., De Jonge, M. V., Cuccaro, M., Correia, C. T., Conroy, J., Conceiça, I. C., Chiocchetti, A. G., Casey, J. P., Bolshakova, N., Bacchelli, E., Anney, R., Zwaigenbaum, L., Wittemeyer, K., Wallace, S., Van Engeland, H., Soorya, L., Rogé, B., Roberts, W., Poustka, F., Mouga, S., Minshew, N., McGrew, S. G., Lord, C., Leboyer, M., Le Couteur, A. S., Kolevzon, A., Jacob, S., Guter, S., Green, J., Green, A., Gillberg, C., Fernandez, B. A., Duque, F., Delorme, R., Dawson, G., Brennan, S., Bourgeron, T., Bolton, P. F., Bölte, S., Bernier, R., Baird, G., Bailey, A. J., Anagnostou, E., Wijsman, E. M., Vieland, V. J., Vicente, A. M., Schellenberg, E. D., Pericak-Vance, M., Paterson, A. D., Parr, J. R., Oliveira, G., Almeida, J., Café, C., Nurnberger, J., Monaco, A. P., Maestrini, E., Klauck, S. M., Haines, J. L., Geschwind, D. H., Freitag, C. M., Folstein, S. E., Ennis, S., Coon, H., Battaglia, A., Szatmari, P., Sutcliffe, J. S., Hallmayer, J., Gill, M., Cook, E. H., Buxbaum, J. D., Devlin, B., Gallagher, L., Betancur, C. & Scherer, S. W., Jun 13 2014, In : Nature Communications. 5, 4074.

Research output: Contribution to journalArticle

glutamates
Metabotropic Glutamate Receptors
Autistic Disorder
genes
Genes
31 Citations (Scopus)

Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence

Yan, J., Aliev, F., Webb, B. T., Kendler, K. S., Williamson, V. S., Edenberg, H., Agrawal, A., Kos, M. Z., Almasy, L., Nurnberger, J., Schuckit, M. A., Kramer, J. R., Rice, J. P., Kuperman, S., Goate, A. M., Tischfield, J. A., Porjesz, B. & Dick, D. M., 2014, In : Addiction Biology. 19, 4, p. 708-721 14 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Alcoholism
Single Nucleotide Polymorphism
Genes
Aptitude
2013
49 Citations (Scopus)

A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53

Wang, J. C., Foroud, T., Hinrichs, A. L., Le, N. X. H., Bertelsen, S., Budde, J. P., Harari, O., Koller, D. L., Wetherill, L., Agrawal, A., Almasy, L., Brooks, A. I., Bucholz, K., Dick, D., Hesselbrock, V., Johnson, E. O., Kang, S., Kapoor, M., Kramer, J., Kuperman, S. & 17 others, Madden, P. A. F., Manz, N., Martin, N. G., McClintick, J., Montgomery, G. W., Nurnberger, J., Rangaswamy, M., Rice, J., Schuckit, M., Tischfield, J. A., Whitfield, J. B., Xuei, X., Porjesz, B., Heath, A. C., Edenberg, H., Bierut, L. J. & Goate, A. M., Nov 2013, In : Molecular Psychiatry. 18, 11, p. 1218-1224 7 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pedigree
Alcoholism
Diagnostic and Statistical Manual of Mental Disorders
Genes
49 Citations (Scopus)

A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks

Kapoor, M., Wang, J. C., Wetherill, L., Le, N., Bertelsen, S., Hinrichs, A. L., Budde, J., Agrawal, A., Bucholz, K., Dick, D., Harari, O., Hesselbrock, V., Kramer, J., Nurnberger, J., Rice, J., Saccone, N., Schuckit, M., Tischfield, J., Porjesz, B., Edenberg, H. & 3 others, Bierut, L., Foroud, T. & Goate, A., Oct 2013, In : Human Genetics. 132, 10, p. 1141-1151 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Alcohol Drinking
Meta-Analysis
Alcoholism
Single Nucleotide Polymorphism
90 Citations (Scopus)

Autism: The Micro-Movement perspective

Torres, E. B., Brincker, M., Isenhower, R. W., Yanovich, P., Stigler, K., Nurnberger, J., Metaxas, D. N. & José, J. V., Apr 21 2013, In : Frontiers in Integrative Neuroscience. July 2013

Research output: Contribution to journalArticle

Autistic Disorder
Proprioception
Sensory Feedback
Aptitude
Peripheral Nervous System
16 Citations (Scopus)

Common biological networks underlie genetic risk for alcoholism in African- and European-American populations

Kos, M. Z., Yan, J., Dick, D. M., Agrawal, A., Bucholz, K. K., Rice, J. P., Johnson, E. O., Schuckit, M., Kuperman, S., Kramer, J., Goate, A. M., Tischfield, J. A., Foroud, T., Nurnberger, J., Hesselbrock, V., Porjesz, B., Bierut, L. J., Edenberg, H. & Almasy, L., Jul 2013, In : Genes, Brain and Behavior. 12, 5, p. 532-542 11 p.

Research output: Contribution to journalArticle

African Americans
Alcoholism
Genome-Wide Association Study
Population
Genes
96 Citations (Scopus)

Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants

Gamazon, E. R., Badner, J. A., Cheng, L., Zhang, C., Zhang, D., Cox, N. J., Gershon, E. S., Kelsoe, J. R., Greenwood, T. A., Nievergelt, C. M., Chen, C., McKinney, R., Shilling, P. D., Schork, N. J., Smith, E. N., Bloss, C. S., Nurnberger, J., Edenberg, H., Foroud, T., Koller, D. L. & 20 others, Scheftner, W. A., Coryell, W., Rice, J., Lawson, W. B., Nwulia, E. A., Hipolito, M., Byerley, W., McMahon, F. J., Schulze, T. G., Berrettini, W. H., Potash, J. B., Zandi, P. P., Mahon, P. B., McInnis, M. G., Zöllner, S., Zhang, P., Craig, D. W., Szelinger, S., Barrett, T. B. & Liu, C., Mar 2013, In : Molecular Psychiatry. 18, 3, p. 340-346 7 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Regulator Genes
Bipolar Disorder
Methylation
Single Nucleotide Polymorphism
25 Citations (Scopus)

Gender-specific gene-environment interaction in alcohol dependence: The impact of daily life events and GABRA2

Perry, B. L., Pescosolido, B. A., Bucholz, K., Edenberg, H., Kramer, J., Kuperman, S., Schuckit, M. A. & Nurnberger, J., 2013, In : Behavior Genetics. 43, 5, p. 402-414 13 p.

Research output: Contribution to journalArticle

life events
Gene-Environment Interaction
genotype-environment interaction
alcohol abuse
Alcoholism
13 Citations (Scopus)

Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults

Chorlian, D. B., Rangaswamy, M., Manz, N., Wang, J. C., Dick, D., Almasy, L., Bauer, L., Bucholz, K., Foroud, T., Hesselbrock, V., Kang, S. J., Kramer, J., Kuperman, S., Nurnberger, J., Rice, J., Schuckit, M., Tischfield, J., Edenberg, H., Goate, A., Bierut, L. & 1 others, Porjesz, B., 2013, In : Behavior Genetics. 43, 5, p. 386-401 16 p.

Research output: Contribution to journalArticle

young adults
Age of Onset
Alcoholism
Young Adult
alcohol
30 Citations (Scopus)

Genetic influences on craving for alcohol

Agrawal, A., Wetherill, L., Bucholz, K. K., Kramer, J., Kuperman, S., Lynskey, M. T., Nurnberger, J., Schuckit, M., Tischfield, J. A., Edenberg, H., Foroud, T. & Bierut, L. J., Feb 2013, In : Addictive Behaviors. 38, 2, p. 1501-1508 8 p.

Research output: Contribution to journalArticle

Alcohols
Alcoholism
Genes
Polymorphism
Nucleotides
1026 Citations (Scopus)

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Lee, S. H., Ripke, S., Neale, B. M., Faraone, S. V., Purcell, S. M., Perlis, R. H., Mowry, B. J., Thapar, A., Goddard, M. E., Witte, J. S., Absher, D., Agartz, I., Akil, H., Amin, F., Andreassen, O. A., Anjorin, A., Anney, R., Anttila, V., Arking, D. E., Asherson, P. & 350 others, Azevedo, M. H., Backlund, L., Badner, J. A., Bailey, A. J., Banaschewski, T., Barchas, J. D., Barnes, M. R., Barrett, T. B., Bass, N., Battaglia, A., Bauer, M., Bayés, M., Bellivier, F., Bergen, S. E., Berrettini, W., Betancur, C., Bettecken, T., Biederman, J., Binder, E. B., Black, D. W., Blackwood, D. H. R., Bloss, C. S., Boehnke, M., Boomsma, D. I., Breen, G., Breuer, R., Bruggeman, R., Cormican, P., Buccola, N. G., Buitelaar, J. K., Bunney, W. E., Buxbaum, J. D., Byerley, W. F., Byrne, E. M., Caesar, S., Cahn, W., Cantor, R. M., Casas, M., Chakravarti, A., Chambert, K., Choudhury, K., Cichon, S., Cloninger, C. R., Collier, D. A., Cook, E. H., Coon, H., Cormand, B., Corvin, A., Coryell, W. H., Craig, D. W., Craig, I. W., Crosbie, J., Cuccaro, M. L., Curtis, D., Czamara, D., Datta, S., Dawson, G., Day, R., De Geus, E. J., Degenhardt, F., Djurovic, S., Donohoe, G. J., Doyle, A. E., Duan, J., Dudbridge, F., Duketis, E., Ebstein, R. P., Edenberg, H., Elia, J., Ennis, S., Etain, B., Fanous, A., Farmer, A. E., Ferrier, I. N., Flickinger, M., Fombonne, E., Foroud, T., Frank, J., Franke, B., Fraser, C., Freedman, R., Freimer, N. B., Freitag, C. M., Friedl, M., Frisén, L., Gallagher, L., Gejman, P. V., Georgieva, L., Gershon, E. S., Geschwind, D. H., Giegling, I., Gill, M., Gordon, S. D., Gordon-Smith, K., Green, E. K., Greenwood, T. A., Grice, D. E., Gross, M., Grozeva, D., Guan, W., Gurling, H., De Haan, L., Haines, J. L., Hakonarson, H., Hallmayer, J., Hamilton, S. P., Hamshere, M. L., Hansen, T. F., Hartmann, A. M., Hautzinger, M., Heath, A. C., Henders, A. K., Herms, S., Hickie, I. B., Hipolito, M., Hoefels, S., Holmans, P. A., Holsboer, F., Hoogendijk, W. J., Hottenga, J. J., Hultman, C. M., Hus, V., Ingason, A., Ising, M., Jamain, S., Jones, E. G., Jones, I., Jones, L., Tzeng, J. Y., Kähler, A. K., Kahn, R. S., Kandaswamy, R., Keller, M. C., Kennedy, J. L., Kenny, E., Kent, L., Kim, Y., Kirov, G. K., Klauck, S. M., Klei, L., Knowles, J. A., Kohli, M. A., Koller, D. L., Konte, B., Korszun, A., Krabbendam, L., Krasucki, R., Kuntsi, J., Kwan, P., Landén, M., Långström, N., Lathrop, M., Lawrence, J., Lawson, W. B., Leboyer, M., Ledbetter, D. H., Lee, P. H., Lencz, T., Lesch, K. P., Levinson, D. F., Lewis, C. M., Li, J., Lichtenstein, P., Lieberman, J. A., Lin, D. Y., Linszen, D. H., Liu, C., Lohoff, F. W., Loo, S. K., Lord, C., Lowe, J. K., Lucae, S., Macintyre, D. J., Madden, P. A. F., Maestrini, E., Magnusson, P. K. E., Mahon, P. B., Maier, W., Malhotra, A. K., Mane, S. M., Martin, C. L., Martin, N. G., Mattheisen, M., Matthews, K., Mattingsdal, M., Mccarroll, S. A., Mcghee, K. A., Mcgough, J. J., Mcgrath, P. J., Mcguffin, P., Mcinnis, M. G., Mcintosh, A., Mckinney, R., Mclean, A. W., Mcmahon, F. J., Mcmahon, W. M., Mcquillin, A., Medeiros, H., Medland, S. E., Meier, S., Melle, I., Meng, F., Meyer, J., Middeldorp, C. M., Middleton, L., Milanova, V., Miranda, A., Monaco, A. P., Montgomery, G. W., Moran, J. L., Moreno-De-Luca, D., Morken, G., Morris, D. W., Morrow, E. M., Moskvina, V., Muglia, P., Mühleisen, T. W., Muir, W. J., Müller-Myhsok, B., Murtha, M., Myers, R. M., Myin-Germeys, I., Neale, M. C., Nelson, S. F., Nievergelt, C. M., Nikolov, I., Nimgaonkar, V., Nolen, W. A., Nöthen, M. M., Nurnberger, J., Nwulia, E. A., Nyholt, D. R., O'dushlaine, C., Oades, R. D., Olincy, A., Oliveira, G., Olsen, L., Ophoff, R. A., Osby, U., Owen, M. J., Palotie, A., Parr, J. R., Paterson, A. D., Pato, C. N., Pato, M. T., Penninx, B. W., Pergadia, M. L., Pericak-Vance, M. A., Pickard, B. S., Pimm, J., Piven, J., Posthuma, D., Potash, J. B., Poustka, F., Propping, P., Puri, V., Quested, D. J., Quinn, E. M., Ramos-Quiroga, J. A., Rasmussen, H. B., Raychaudhuri, S., Rehnström, K., Reif, A., Ribasés, M., Rice, J. P., Rietschel, M., Roeder, K., Roeyers, H., Rossin, L., Rothenberger, A., Rouleau, G., Ruderfer, D., Rujescu, D., Sanders, A. R., Sanders, S. J., Santangelo, S. L., Sergeant, J. A., Schachar, R., Schalling, M., Schatzberg, A. F., Scheftner, W. A., Schellenberg, G. D., Scherer, S. W., Schork, N. J., Schulze, T. G., Schumacher, J., Schwarz, M., Scolnick, E., Scott, L. J., Shi, J., Shilling, P. D., Shyn, S. I., Silverman, J. M., Slager, S. L., Smalley, S. L., Smit, J. H., Smith, E. N., Sonuga-Barke, E. J. S., St. Clair, D., State, M., Steffens, M., Steinhausen, H. C., Strauss, J. S., Strohmaier, J., Stroup, T. S., Sutcliffe, J. S., Szatmari, P., Szelinger, S., Thirumalai, S., Thompson, R. C., Todorov, A. A., Tozzi, F., Treutlein, J., Uhr, M., Van Den Oord, E. J. C. G., Van Grootheest, G., Van Os, J., Vicente, A. M., Vieland, V. J., Vincent, J. B., Visscher, P. M., Walsh, C. A., Wassink, T. H., Watson, S. J., Weissman, M. M., Werge, T., Wienker, T. F., Wijsman, E. M., Willemsen, G., Williams, N., Willsey, A. J., Witt, S. H., Xu, W., Young, A. H., Yu, T. W., Zammit, S., Zandi, P. P., Zhang, P., Zitman, F. G., Zöllner, S., Devlin, B., Kelsoe, J. R., Sklar, P., Daly, M. J., O'donovan, M. C., Craddock, N., Sullivan, P. F., Smoller, J. W., Kendler, K. S. & Wray, N. R., Sep 2013, In : Nature Genetics. 45, 9, p. 984-994 11 p.

Research output: Contribution to journalArticle

Major Depressive Disorder
Single Nucleotide Polymorphism
Psychiatry
Schizophrenia
Bipolar Disorder
14 Citations (Scopus)

Genome-Wide Association Study of Irritable vs. Elated Mania Suggests Genetic Differences between Clinical Subtypes of Bipolar Disorder

Greenwood, T. A., Kelsoe, J. R., Kelsoe, J. R., Greenwood, T. A., Nievergelt, C. M., McKinney, R., Shilling, P. D., Smith, E. N., Schork, N. J., Bloss, C. S., Nurnberger, J. I., Edenberg, H. J., Foroud, T., Koller, D. L., Gershon, E. S., Liu, C., Badner, J. A., Scheftner, W. A., Lawson, W. B., Nwulia, E. A. & 16 others, Hipolito, M., Coryell, W., Potash, J. B., Rice, J., Byerley, W., McMahon, F. J., Nurnberger, J., Edenberg, H., Foroud, T., Mahon, P. B., McInnis, M. G., Zöllner, S., Zhang, P., Craig, D. W., Szelinger, S. & Barrett, T. B., Jan 17 2013, In : PLoS One. 8, 1, e53804.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Bipolar Disorder
Genes
Chromosomes
Genome