John Turchi

  • 3662 Citations
  • 35 h-Index
1991 …2020

Research output per year

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Publications

2020

Structure-Guided Optimization of Replication Protein A (RPA)-DNA Interaction Inhibitors

Gavande, N. S., Gavande, N. S., Vandervere-Carozza, P. S., Pawelczak, K. S., Vernon, T. L., Jordan, M. R., Turchi, J. J., Turchi, J. J. & Turchi, J. J., Jun 11 2020, In : ACS Medicinal Chemistry Letters. 11, 6, p. 1118-1124 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Small-molecule inhibitor screen for DNA repair proteins

Turchi, J. J. & VanderVere-Carozza, P. S., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 217-221 5 p. (Methods in Molecular Biology; vol. 1999).

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

Characterization of thermally activated metalloenediyne cytotoxicity in human melanoma cells

Keller, E. J., Porter, M., Garrett, J. E., Varie, M., Wang, H., Pollok, K. E., Turchi, J. J., Zaleski, J. M. & Dynlacht, J. R., Aug 1 2018, In : Radiation research. 190, 2, p. 107-116 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Modulating DNA Repair Pathways to Improve Precision Genome Engineering

Pawelczak, K. S., Gavande, N. S., VanderVere-Carozza, P. S. & Turchi, J. J., Feb 16 2018, In : ACS chemical biology. 13, 2, p. 389-396 8 p.

Research output: Contribution to journalReview article

30 Scopus citations
2017

Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction

Gavande, N. S., Vandervere-Carozza, P., Mishra, A. K., Vernon, T. L., Pawelczak, K. S. & Turchi, J. J., Oct 12 2017, In : Journal of Medicinal Chemistry. 60, 19, p. 8055-8070 16 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer

Sears, C. R., Cooney, S. A., Chin-Sinex, H., Mendonca, M. S. & Turchi, J. J., Apr 1 2016, In : DNA Repair. 40, p. 35-46 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

DNA repair targeted therapy: The past or future of cancer treatment?

Gavande, N. S., VanderVere-Carozza, P. S., Hinshaw, H. D., Jalal, S., Sears, C., Pawelczak, K. S. & Turchi, J., 2016, (Accepted/In press) In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

134 Scopus citations

Targeting the nucleotide excision repair pathway for therapeutic applications

Gavande, N. S., VanderVere-Carozza, P. S., Pawelczak, K. S. & Turchi, J., Jun 21 2016, DNA Repair in Cancer Therapy: Molecular Targets and Clinical Applications: Second Edition. Elsevier Inc., p. 135-150 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
2015

Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer

Mishra, A. K., Dormi, S. S., Turchi, A. M., Woods, D. S. & Turchi, J. J., Jan 1 2015, In : Biochemical Pharmacology. 93, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Recognition of DNA termini by the cterminal region of the Ku80 and the dnadependent protein kinase catalytic subunit

Woods, D. S., Sears, C. R. & Turchi, J. J., May 15 2015, In : PloS one. 10, 5, e0127321.

Research output: Contribution to journalArticle

14 Scopus citations
2014

Exploring a structural protein-drug interactome for new therapeutics in lung cancer

Peng, X., Wang, F., Li, L., Bum-Erdene, K., Xu, D., Wang, B., Sinn, A. A., Pollok, K. E., Sandusky, G. E., Li, L., Turchi, J. J., Jalal, S. I. & Meroueh, S. O., Mar 2014, In : Molecular BioSystems. 10, 3, p. 581-591 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Testing the Metal of ERCC2 in predicting the response to platinum-based therapy

Turchi, J. J., Woods, D. S. & VanderVere-Carozza, P., Oct 1 2014, In : Cancer Discovery. 4, 10, p. 1118-1119 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer

Fang, F., Munck, J., Tang, J., Taverna, P., Wang, Y., Miller, D. F. B., Pilrose, J., Choy, G., Azab, M., Pawelczak, K. S., VanderVere-Carozza, P., Wagner, M., Lyons, J., Matei, D., Turchi, J. J. & Nephew, K. P., Dec 15 2014, In : Clinical Cancer Research. 20, 24, p. 6504-6516 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

Unraveling the complexities of DNA-dependent protein kinase autophosphorylation

Neal, J. A., Sugiman-Marangos, S., VanderVere-Carozza, P., Wagner, M., Turchi, J., Lees-Miller, S. P., Junop, M. S. & Meek, K., Jun 2014, In : Molecular and cellular biology. 34, 12, p. 2162-2175 14 p.

Research output: Contribution to journalArticle

27 Scopus citations
2013

Chemotherapy induced DNA damage response Convergence of drugs and pathways

Woods, D. & Turchi, J. J., May 1 2013, In : Cancer Biology and Therapy. 14, 5, p. 379-389 11 p.

Research output: Contribution to journalReview article

90 Scopus citations

Extracellular tissue transglutaminase activates noncanonical NF-κB signaling and promotes metastasis in ovarian cancer

Yakubov, B., Chelladurai, B., Schmitt, J., Emerson, R., Turchi, J. J. & Matei, D., Jan 1 2013, In : Neoplasia (United States). 15, 6, p. 609-619 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma

Xu, J., Zeng, L. F., Shen, W., Turchi, J. J. & Zhang, Z. Y., Oct 4 2013, In : Biochemical and Biophysical Research Communications. 439, 4, p. 586-590 5 p.

Research output: Contribution to journalArticle

28 Scopus citations
2012
29 Scopus citations

Multiple protein-protein interactions within the DNA-PK complex are mediated by the C-terminus of Ku 80

Bennett, S. M., Woods, D. S., Pawelczak, K. S. & Turchi, J. J., Apr 18 2012, In : International Journal of Biochemistry and Molecular Biology. 3, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting the Nucleotide Excision Repair Pathway for Therapeutic Applications

Turchi, J. J. & Patrick, S. M., Dec 1 2012, DNA Repair in Cancer Therapy. Elsevier Inc., p. 109-117 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2011

Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ

Pawelczak, K. S., Bennett, S. M. & Turchi, J. J., Jun 15 2011, In : Antioxidants and Redox Signaling. 14, 12, p. 2531-2543 13 p.

Research output: Contribution to journalReview article

16 Scopus citations

Current advances in DNA repair: Regulation of enzymes and pathways involved in maintaining genomic stability

Neher, T. M. & Turchi, J. J., Jun 15 2011, In : Antioxidants and Redox Signaling. 14, 12, p. 2461-2464 4 p.

Research output: Contribution to journalReview article

1 Scopus citations

DNA repair: From genome maintenance to biomarker and therapeutic target

Jalal, S., Earley, J. N. & Turchi, J. J., Nov 15 2011, In : Clinical Cancer Research. 17, 22, p. 6973-6984 12 p.

Research output: Contribution to journalReview article

66 Scopus citations

Identification of mre11 as a target for heat radiosensitization

Dynlacht, J. R., Batuello, C. N., Lopez, J. T., Kim, K. K. & Turchi, J. J., Sep 1 2011, In : Radiation research. 176, 3, p. 323-332 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Interrogation of nucleotide excision repair capacity: Impact on platinum-based cancer therapy

Earley, J. N. & Turchi, J. J., Jun 15 2011, In : Antioxidants and Redox Signaling. 14, 12, p. 2465-2477 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatin

Neher, T. M., Bodenmiller, D., Fitch, R. W., Jalal, S. I. & Turchi, J. J., Oct 2011, In : Molecular cancer therapeutics. 10, 10, p. 1796-1806 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Targeting ovarian tumor cell adhesion mediated by tissue transglutaminase

Khanna, M., Chelladurai, B., Gavini, A., Li, L., Shao, M., Courtney, D., Turchi, J. J., Matei, D. & Meroueh, S., Apr 1 2011, In : Molecular cancer therapeutics. 10, 4, p. 626-636 11 p.

Research output: Contribution to journalArticle

25 Scopus citations
2010

Identification of novel small molecule inhibitors of the XPA protein using in silico based screening

Neher, T. M., Shuck, S. C., Liu, J. Y., Zhang, J. T. & Turchi, J. J., Oct 15 2010, In : ACS chemical biology. 5, 10, p. 953-965 13 p.

Research output: Contribution to journalArticle

23 Scopus citations
4 Scopus citations

Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct

Neher, T. M., Rechkunova, N. I., Lavrik, O. I. & Turchi, J. J., Feb 2 2010, In : Biochemistry. 49, 4, p. 669-678 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
26 Scopus citations
46 Scopus citations

Targeting the OB-folds of replication protein A with small molecules

Anciano Granadillo, V. J., Earley, J. N., Shuck, S. C., Georgiadis, M. M., Fitch, R. W. & Turchi, J. J., Dec 1 2010, In : Journal of Nucleic Acids. 2010, 304035.

Research output: Contribution to journalArticle

15 Scopus citations

The launch of international journal of biochemistry and molecular biology

Zhang, J. T., Turchi, J., Kumar, R., Hong, W., Shaw, G. & Wang, D., Dec 1 2010, In : International Journal of Biochemistry and Molecular Biology. 1, 1, 1 p.

Research output: Contribution to journalEditorial

2009

Molecular analysis of Ku redox regulation

Bennett, S. M., Neher, T. M., Shatilla, A. & Turchi, J. J., Aug 28 2009, In : BMC Molecular Biology. 10, 1 p., 86.

Research output: Contribution to journalArticle

17 Scopus citations

Telomerase-associated protein 1, HSP90, and topoisomerase IIα associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates

Bhattacharyya, S., Keirsey, J., Russell, B., Kavecansky, J., Lillard-Wetherell, K., Tahmaseb, K., Turchi, J. J. & Groden, J., May 29 2009, In : Journal of Biological Chemistry. 284, 22, p. 14966-14977 12 p.

Research output: Contribution to journalArticle

40 Scopus citations
2008
21 Scopus citations

A special issue on DNA damage responses and genome maintenance

Li, G. M., Chen, D. J., Mitra, S. & Turchi, J. J., Jan 1 2008, In : Cell Research. 18, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

ATM mediates repression of DNA end-degradation in an ATP-dependent manner

Rahal, E. A., Henricksen, L. A., Li, Y., Turchi, J. J., Pawelczak, K. S. & Dixon, K., Mar 1 2008, In : DNA Repair. 7, 3, p. 464-475 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

DNA-dependent conformational changes in the Ku heterodimer

Lehman, J. A., Hoelz, D. J. & Turchi, J. J., Apr 15 2008, In : Biochemistry. 47, 15, p. 4359-4368 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Eukaryotic nucleotide excision repair: From understanding mechanisms to influencing biology

Shuck, S. C., Short, E. A. & Turchi, J. J., Jan 1 2008, In : Cell Research. 18, 1, p. 64-72 9 p.

Research output: Contribution to journalReview article

170 Scopus citations
2006
35 Scopus citations

Nitric oxide and cisplatin resistance: NO easy answers

Turchi, J. J., Mar 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 12, p. 4337-4338 2 p.

Research output: Contribution to journalComment/debate

24 Scopus citations

Pre-steady-state binding of damaged DNA by XPC-hHR23B reveals a kinetic mechanism for damage discrimination

Trego, K. S. & Turchi, J. J., Feb 14 2006, In : Biochemistry. 45, 6, p. 1961-1969 9 p.

Research output: Contribution to journalArticle

38 Scopus citations
2005

Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of nonhomologous end joining

Boeckman, H. J., Trego, K. S. & Turchi, J. J., May 2005, In : Molecular Cancer Research. 3, 5, p. 277-285 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

Differential activation of DNA-PK based on DNA strand orientation and sequence bias

Pawelczak, K. S., Andrews, B. J. & Turchi, J. J., Mar 7 2005, In : Nucleic acids research. 33, 1, p. 152-161 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage

Nuss, J. E., Patrick, S. M., Oakley, G. G., Alter, G. M., Robison, J. G., Dixon, K. & Turchi, J. J., Jun 14 2005, In : Biochemistry. 44, 23, p. 8428-8437 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair

Patrick, S. M., Oakley, G. G., Dixon, K. & Turchi, J. J., Jun 14 2005, In : Biochemistry. 44, 23, p. 8438-8448 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

Zheng, L., Zhou, M., Chai, Q., Parrish, J., Xue, D., Patrick, S. M., Turchi, J. J., Yannone, S. M., Chen, D. & Shen, B., Dec 8 2005, In : EMBO Reports. 6, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

99 Scopus citations
2004

Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2

Lillard-Wetherell, K., Machwe, A., Langland, G. T., Combs, K. A., Behbehani, G. K., Schonberg, S. A., German, J., Turchi, J. J., Orren, D. K. & Groden, J., Sep 1 2004, In : Human molecular genetics. 13, 17, p. 1919-1932 14 p.

Research output: Contribution to journalArticle

114 Scopus citations