John Turchi

  • 3511 Citations
  • 35 h-Index
1991 …2019
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Publications 1991 2019

  • 3511 Citations
  • 35 h-Index
  • 83 Article
  • 3 Chapter
  • 1 Review article
2019

Small-molecule inhibitor screen for DNA repair proteins

Turchi, J. & VanderVere-Carozza, P. S., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 217-221 5 p. (Methods in Molecular Biology; vol. 1999).

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA Repair
DNA Damage
Fluorescence Polarization
Acids
Protein Kinases
2018
1 Citation (Scopus)

Characterization of thermally activated metalloenediyne cytotoxicity in human melanoma cells

Keller, E. J., Porter, M., Garrett, J. E., Varie, M., Wang, H., Pollok, K., Turchi, J., Zaleski, J. M. & Dynlacht, J., Aug 1 2018, In : Radiation Research. 190, 2, p. 107-116 10 p.

Research output: Contribution to journalArticle

hyperthermia
Melanoma
deoxyribonucleic acid
Temperature
Fever
19 Citations (Scopus)

Modulating DNA Repair Pathways to Improve Precision Genome Engineering

Pawelczak, K. S., Gavande, N. S., VanderVere-Carozza, P. S. & Turchi, J., Feb 16 2018, In : ACS Chemical Biology. 13, 2, p. 389-396 8 p.

Research output: Contribution to journalReview article

DNA Repair
Repair
Genes
Genome
DNA
2017
2 Citations (Scopus)

Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction

Gavande, N. S., Vandervere-Carozza, P., Mishra, A. K., Vernon, T. L., Pawelczak, K. S. & Turchi, J., Oct 12 2017, In : Journal of Medicinal Chemistry. 60, 19, p. 8055-8070 16 p.

Research output: Contribution to journalArticle

Xeroderma Pigmentosum Group A Protein
Xeroderma Pigmentosum
DNA Repair
Solubility
DNA
2016
21 Citations (Scopus)

DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer

Sears, C., Cooney, S. A., Chin-Sinex, H., Mendonca, M. & Turchi, J., Apr 1 2016, In : DNA Repair. 40, p. 35-46 12 p.

Research output: Contribution to journalArticle

Ionizing radiation
Ionizing Radiation
Non-Small Cell Lung Carcinoma
Cisplatin
DNA Damage
107 Citations (Scopus)

DNA repair targeted therapy: The past or future of cancer treatment?

Gavande, N. S., VanderVere-Carozza, P. S., Hinshaw, H. D., Jalal, S., Sears, C., Pawelczak, K. S. & Turchi, J., 2016, (Accepted/In press) In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

DNA Repair
DNA Damage
Neoplasms
Therapeutics
Fanconi Anemia
3 Citations (Scopus)

Targeting the nucleotide excision repair pathway for therapeutic applications

Gavande, N. S., VanderVere-Carozza, P. S., Pawelczak, K. S. & Turchi, J., Jun 21 2016, DNA Repair in Cancer Therapy: Molecular Targets and Clinical Applications: Second Edition. Elsevier Inc., p. 135-150 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA Repair
Therapeutics
DNA Damage
Neoplasms
Xeroderma Pigmentosum
2015
17 Citations (Scopus)

Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer

Mishra, A. K., Dormi, S. S., Turchi, A. M., Woods, D. S. & Turchi, J., Jan 1 2015, In : Biochemical Pharmacology. 93, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

A-Form DNA
Replication Protein A
Chemotherapy
Protein Transport
Ovarian Neoplasms
10 Citations (Scopus)

Recognition of DNA termini by the cterminal region of the Ku80 and the dnadependent protein kinase catalytic subunit

Woods, D. S., Sears, C. & Turchi, J., May 15 2015, In : PLoS One. 10, 5, e0127321.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
protein subunits
protein kinases
Protein Kinases
Catalytic Domain
2014
10 Citations (Scopus)

Exploring a structural protein-drug interactome for new therapeutics in lung cancer

Peng, X., Wang, F., Li, L., Bum-Erdene, K., Xu, D., Wang, B., Sinn, A. A., Pollok, K., Sandusky, G., Li, L., Turchi, J., Jalal, S. & Meroueh, S., Mar 2014, In : Molecular BioSystems. 10, 3, p. 581-591 11 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Pharmaceutical Preparations
Proteins
Therapeutics
Neoplasms
1 Citation (Scopus)

Testing the Metal of ERCC2 in predicting the response to platinum-based therapy

Turchi, J., Woods, D. S. & VanderVere-Carozza, P., Oct 1 2014, In : Cancer Discovery. 4, 10, p. 1118-1119 2 p.

Research output: Contribution to journalArticle

Platinum
DNA Repair
Metals
Neoplasms
Therapeutics
54 Citations (Scopus)

The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer

Fang, F., Munck, J., Tang, J., Taverna, P., Wang, Y., Miller, D. F. B., Pilrose, J., Choy, G., Azab, M., Pawelczak, K. S., VanderVere-Carozza, P., Wagner, M., Lyons, J., Matei, D., Turchi, J. & Nephew, K., Dec 15 2014, In : Clinical Cancer Research. 20, 24, p. 6504-6516 13 p.

Research output: Contribution to journalArticle

DNA Methylation
Ovarian Neoplasms
Cisplatin
Platinum
Tumor Suppressor Genes
21 Citations (Scopus)

Unraveling the complexities of DNA-dependent protein kinase autophosphorylation

Neal, J. A., Sugiman-Marangos, S., VanderVere-Carozza, P., Wagner, M., Turchi, J., Lees-Miller, S. P., Junop, M. S. & Meek, K., 2014, In : Molecular and Cellular Biology. 34, 12, p. 2162-2175 14 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Phosphorylation
DNA
Catalytic Domain
Catalytic DNA
2013
81 Citations (Scopus)

Chemotherapy induced DNA damage response Convergence of drugs and pathways

Woods, D. & Turchi, J., May 2013, In : Cancer Biology and Therapy. 14, 5, p. 379-389 11 p.

Research output: Contribution to journalArticle

DNA Damage
Drug Therapy
Pharmaceutical Preparations
DNA Repair
Cell Cycle Checkpoints
35 Citations (Scopus)

Extracellular tissue transglutaminase activates noncanonical NF-κB signaling and promotes metastasis in ovarian cancer

Yakubov, B., Chelladurai, B., Schmitt, J., Emerson, R., Turchi, J. & Matei, D., 2013, In : Neoplasia. 15, 6, p. 609-619 11 p.

Research output: Contribution to journalArticle

NF-kappa B
Ovarian Neoplasms
Neoplasm Metastasis
CD44 Antigens
Proteins
28 Citations (Scopus)

Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma

Xu, J., Zeng, L. F., Shen, W., Turchi, J. & Zhang, Z-Y., Oct 4 2013, In : Biochemical and Biophysical Research Communications. 439, 4, p. 586-590 5 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cells
Phosphatidylinositol 3-Kinases
Tumors
2012
27 Citations (Scopus)
Joining
Cisplatin
Cells
Repair
DNA
5 Citations (Scopus)

Multiple protein-protein interactions within the DNA-PK complex are mediated by the C-terminus of Ku 80

Bennett, S. M., Woods, D. S., Pawelczak, K. S. & Turchi, J., 2012, In : International Journal of Biochemistry and Molecular Biology. 3, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Catalytic Domain
DNA
Joining
Proteins
3 Citations (Scopus)

Targeting the Nucleotide Excision Repair Pathway for Therapeutic Applications

Turchi, J. & Patrick, S. M., 2012, DNA Repair in Cancer Therapy. Elsevier Inc., p. 109-117 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA Repair
Platinum
Cisplatin
DNA Damage
Neoplasms
2011
16 Citations (Scopus)

Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ

Pawelczak, K. S., Bennett, S. M. & Turchi, J., Jun 15 2011, In : Antioxidants and Redox Signaling. 14, 12, p. 2531-2543 13 p.

Research output: Contribution to journalArticle

Deoxyribonucleases
Joining
Chemical activation
DNA
Processing
1 Citation (Scopus)

Current advances in DNA repair: Regulation of enzymes and pathways involved in maintaining genomic stability

Neher, T. M. & Turchi, J., Jun 15 2011, In : Antioxidants and Redox Signaling. 14, 12, p. 2461-2464 4 p.

Research output: Contribution to journalArticle

DNA Repair Enzymes
Genomic Instability
DNA Repair
Repair
DNA
64 Citations (Scopus)

DNA repair: From genome maintenance to biomarker and therapeutic target

Jalal, S., Earley, J. N. & Turchi, J., Nov 15 2011, In : Clinical Cancer Research. 17, 22, p. 6973-6984 12 p.

Research output: Contribution to journalArticle

DNA Repair
Biomarkers
Maintenance
Genome
Therapeutics
8 Citations (Scopus)

Identification of mre11 as a target for heat radiosensitization

Dynlacht, J., Batuello, C. N., Lopez, J. T., Kim, K. K. & Turchi, J., Sep 2011, In : Radiation Research. 176, 3, p. 323-332 10 p.

Research output: Contribution to journalArticle

Hot Temperature
heat
cells
proteins
strands
15 Citations (Scopus)

Interrogation of nucleotide excision repair capacity: Impact on platinum-based cancer therapy

Earley, J. N. & Turchi, J., Jun 15 2011, In : Antioxidants and Redox Signaling. 14, 12, p. 2465-2477 13 p.

Research output: Contribution to journalArticle

Platinum
DNA Repair
Repair
Nucleotides
DNA
26 Citations (Scopus)

Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatin

Neher, T. M., Bodenmiller, D., Fitch, R. W., Jalal, S. & Turchi, J., Oct 2011, In : Molecular Cancer Therapeutics. 10, 10, p. 1796-1806 11 p.

Research output: Contribution to journalArticle

Replication Protein A
Cisplatin
Lung Neoplasms
Cell Line
Cell Cycle
24 Citations (Scopus)

Targeting ovarian tumor cell adhesion mediated by tissue transglutaminase

Khanna, M., Chelladurai, B., Gavini, A., Li, L., Shao, M., Courtney, D., Turchi, J., Matei, D. & Meroueh, S., Apr 2011, In : Molecular Cancer Therapeutics. 10, 4, p. 626-636 11 p.

Research output: Contribution to journalArticle

Fibronectins
Cell Adhesion
Neoplasms
Cell-Matrix Junctions
Peptidyl Transferases
2010
21 Citations (Scopus)

Identification of novel small molecule inhibitors of the XPA protein using in silico based screening

Neher, T. M., Shuck, S. C., Liu, J. Y., Zhang, J-T. & Turchi, J., Oct 15 2010, In : ACS Chemical Biology. 5, 10, p. 953-965 13 p.

Research output: Contribution to journalArticle

Xeroderma Pigmentosum Group A Protein
Computer Simulation
Screening
Molecules
DNA
4 Citations (Scopus)
Telomere
Quenching
Fluorescence
DNA
Kinetics
17 Citations (Scopus)

Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct

Neher, T. M., Rechkunova, N. I., Lavrik, O. I. & Turchi, J., Feb 2 2010, In : Biochemistry. 49, 4, p. 669-678 10 p.

Research output: Contribution to journalArticle

Xeroderma Pigmentosum
DNA Adducts
Cisplatin
DNA
Repair
25 Citations (Scopus)
Exonucleases
Endonucleases
Purification
Repair
DNA
39 Citations (Scopus)
Replication Protein A
DNA
Maintenance
Chromosomal Instability
Genomic Instability
15 Citations (Scopus)

Targeting the OB-folds of replication protein A with small molecules

Anciano Granadillo, V. J., Earley, J. N., Shuck, S. C., Georgiadis, M., Fitch, R. W. & Turchi, J., 2010, In : Journal of Nucleic Acids. 2010, 304035.

Research output: Contribution to journalArticle

Replication Protein A
Molecules
DNA
A-Form DNA
Oncology

The launch of international journal of biochemistry and molecular biology

Zhang, J-T., Turchi, J., Kumar, R., Hong, W., Shaw, G. & Wang, D., 2010, In : International Journal of Biochemistry and Molecular Biology. 1, 1, p. 1 1 p.

Research output: Contribution to journalArticle

Biochemistry
Molecular Biology
2009
17 Citations (Scopus)

Molecular analysis of Ku redox regulation

Bennett, S. M., Neher, T. M., Shatilla, A. & Turchi, J., Aug 28 2009, In : BMC Molecular Biology. 10, p. 86 1 p., 1471.

Research output: Contribution to journalArticle

Oxidation-Reduction
DNA
Cysteine
Insects
Diamide
39 Citations (Scopus)

Telomerase-associated protein 1, HSP90, and topoisomerase IIα associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates

Bhattacharyya, S., Keirsey, J., Russell, B., Kavecansky, J., Lillard-Wetherell, K., Tahmaseb, K., Turchi, J. & Groden, J., May 29 2009, In : Journal of Biological Chemistry. 284, 22, p. 14966-14977 12 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
HSP90 Heat-Shock Proteins
Type II DNA Topoisomerase
Telomerase
Telomere
2008
21 Citations (Scopus)
DNA End-Joining Repair
DNA-Activated Protein Kinase
DNA
Catalytic DNA
Double-Stranded DNA Breaks

A special issue on DNA damage responses and genome maintenance

Li, G. M., Chen, D. J., Mitra, S. & Turchi, J., Jan 2008, In : Cell Research. 18, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

DNA Damage
Maintenance
Genome
11 Citations (Scopus)

ATM mediates repression of DNA end-degradation in an ATP-dependent manner

Rahal, E. A., Henricksen, L. A., Li, Y., Turchi, J., Pawelczak, K. S. & Dixon, K., Mar 1 2008, In : DNA Repair. 7, 3, p. 464-475 12 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Adenosine Triphosphate
Repair
Degradation
DNA
27 Citations (Scopus)

DNA-dependent conformational changes in the Ku heterodimer

Lehman, J. A., Hoelz, D. J. & Turchi, J., Apr 15 2008, In : Biochemistry. 47, 15, p. 4359-4368 10 p.

Research output: Contribution to journalArticle

DNA
DNA-Activated Protein Kinase
Biotinylation
Catalytic Domain
Chemical activation
164 Citations (Scopus)

Eukaryotic nucleotide excision repair: From understanding mechanisms to influencing biology

Shuck, S. C., Short, E. A. & Turchi, J., Jan 2008, In : Cell Research. 18, 1, p. 64-72 9 p.

Research output: Contribution to journalArticle

DNA Repair
DNA
DNA Adducts
Biochemistry
Ligation
2006
35 Citations (Scopus)

Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex

Andrews, B. J., Lehman, J. A. & Turchi, J., May 12 2006, In : Journal of Biological Chemistry. 281, 19, p. 13596-13603 8 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Kinetics
DNA
Proteins
Quenching
22 Citations (Scopus)

Nitric oxide and cisplatin resistance: NO easy answers

Turchi, J., Mar 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 12, p. 4337-4338 2 p.

Research output: Contribution to journalArticle

Neoplasm Drug Resistance
Nitric Oxide Donors
Antineoplastic Agents
Cisplatin
Nitric Oxide
37 Citations (Scopus)

Pre-steady-state binding of damaged DNA by XPC-hHR23B reveals a kinetic mechanism for damage discrimination

Trego, K. S. & Turchi, J., Feb 14 2006, In : Biochemistry. 45, 6, p. 1961-1969 9 p.

Research output: Contribution to journalArticle

Kinetics
DNA
Cisplatin
Single-Stranded DNA
Assays
2005
82 Citations (Scopus)

Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of nonhomologous end joining

Boeckman, H. J., Trego, K. S. & Turchi, J., May 2005, In : Molecular Cancer Research. 3, 5, p. 277-285 9 p.

Research output: Contribution to journalArticle

Ionizing Radiation
Cisplatin
Neoplasms
DNA
DNA-Activated Protein Kinase
32 Citations (Scopus)

Differential activation of DNA-PK based on DNA strand orientation and sequence bias

Pawelczak, K. S., Andrews, B. J. & Turchi, J., 2005, In : Nucleic Acids Research. 33, 1, p. 152-161 10 p.

Research output: Contribution to journalArticle

DNA
Phosphotransferases
DNA End-Joining Repair
Polynucleotide 5'-Hydroxyl-Kinase
Catalytic DNA
51 Citations (Scopus)

DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage

Nuss, J. E., Patrick, S. M., Oakley, G. G., Alter, G. M., Robison, J. G., Dixon, K. & Turchi, J., Jun 14 2005, In : Biochemistry. 44, 23, p. 8428-8437 10 p.

Research output: Contribution to journalArticle

Replication Protein A
Phosphorylation
DNA Damage
DNA
Gels
47 Citations (Scopus)

DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair

Patrick, S. M., Oakley, G. G., Dixon, K. & Turchi, J., Jun 14 2005, In : Biochemistry. 44, 23, p. 8438-8448 11 p.

Research output: Contribution to journalArticle

Replication Protein A
DNA-Binding Proteins
DNA Replication
DNA Repair
DNA Damage
97 Citations (Scopus)

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

Zheng, L., Zhou, M., Chai, Q., Parrish, J., Xue, D., Patrick, S. M., Turchi, J., Yannone, S. M., Chen, D. & Shen, B., 2005, In : EMBO Reports. 6, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

Flap Endonucleases
DNA Replication
Endonucleases
DNA
Processing
2004
112 Citations (Scopus)

Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2

Lillard-Wetherell, K., Machwe, A., Langland, G. T., Combs, K. A., Behbehani, G. K., Schonberg, S. A., German, J., Turchi, J., Orren, D. K. & Groden, J., Sep 1 2004, In : Human Molecular Genetics. 13, 17, p. 1919-1932 14 p.

Research output: Contribution to journalArticle

Telomeric Repeat Binding Protein 2
Telomeric Repeat Binding Protein 1
Telomere Homeostasis
Telomere
Genetic Recombination
36 Citations (Scopus)

Development of a high-throughput screen for inhibitors of replication protein A and its role in nucleotide excision repair

Andrews, B. J. & Turchi, J., Apr 2004, In : Molecular Cancer Therapeutics. 3, 4, p. 385-391 7 p.

Research output: Contribution to journalArticle

Replication Protein A
DNA Repair
DNA
DNA Replication
A-Form DNA