Karen Pollok

  • 4516 Citations
  • 34 h-Index
1989 …2020

Research output per year

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Publications

  • 4516 Citations
  • 34 h-Index
  • 96 Article
  • 8 Review article
  • 1 Comment/debate
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Article
2020

How old is too old? In vivo engraftment of human peripheral bloodstem cells cryopreserved for up to 18 years - implications for clinical transplantation and stability programs

Underwood, J., Rahim, M., West, C., Britton, R., Skipworth, E., Graves, V., Sexton, S., Harris, H., Schwering, D., Sinn, A., Pollok, K., Robertson, K. A., Goebel, W. S. & Hege, K. M., May 26 2020, In : World Journal of Stem Cells. 12, 5, p. 359-367 9 p.

Research output: Contribution to journalArticle

Open Access
2019

Gene co-expression networks restructured gene fusion in rhabdomyosarcoma cancers

Helm, B. R., Zhan, X., Pandya, P. H., Murray, M. E., Pollok, K. E., Renbarger, J. L., Ferguson, M. J., Han, Z., Ni, D., Zhang, J. & Huang, K., Sep 2019, In : Genes. 10, 9, 665.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcoma

Cheng, L., Pandya, P. H., Liu, E., Chandra, P., Wang, L., Murray, M. E., Carter, J., Ferguson, M., Saadatzadeh, M. R., Bijangi-Visheshsaraei, K., Marshall, M., Li, L., Pollok, K. E. & Renbarger, J. L., Jan 31 2019, In : BMC Medical Genomics. 12, 23.

Research output: Contribution to journalArticle

5 Scopus citations

Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction

Bum-Erdene, K., Zhou, D., Gonzalez-Gutierrez, G., Ghozayel, M. K., Si, Y., Xu, D., Shannon, H. E., Bailey, B. J., Corson, T. W., Pollok, K. E., Wells, C. D. & Meroueh, S. O., Mar 21 2019, In : Cell Chemical Biology. 26, 3, p. 378-389.e13

Research output: Contribution to journalArticle

13 Scopus citations
2018

Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma

Osman, H., Elsahy, D., Saadatzadeh, M. R., Pollok, K. E., Yocom, S., Hattab, E. M., Georges, J. & Cohen-Gadol, A. A., Jun 2018, In : World Neurosurgery. 114, p. e1310-e1315

Research output: Contribution to journalArticle

6 Scopus citations

Characterization of thermally activated metalloenediyne cytotoxicity in human melanoma cells

Keller, E. J., Porter, M., Garrett, J. E., Varie, M., Wang, H., Pollok, K. E., Turchi, J. J., Zaleski, J. M. & Dynlacht, J. R., Aug 1 2018, In : Radiation research. 190, 2, p. 107-116 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Melanoma LAMP-2C modulates tumor growth and autophagy

Pérez, L., Sinn, A. L., Sandusky, G., Pollok, K. & Blum, J., Aug 29 2018, In : Frontiers in Cell and Developmental Biology. 6, AUG, 101.

Research output: Contribution to journalArticle

2 Scopus citations

Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14

Sishtla, K., Pitt, N., Shadmand, M., O’Hare, M. N., Sulaiman, R. S., Sinn, A. L., Condon, K., Pollok, K. E., Sandusky, G. E. & Corson, T. W., Dec 1 2018, In : Scientific reports. 8, 1, 16152.

Research output: Contribution to journalArticle

Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition

Marisol Herrera-Perez, R., Voytik-Harbin, S. L., Sarkaria, J. N., Pollok, K. E., Fishel, M. L. & Rickus, J. L., Mar 2018, In : PloS one. 13, 3, e0194183.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Combination therapy in a xenograft model of glioblastoma: Enhancement of the antitumor activity of temozolomide by an MDM2 antagonist

Wang, H., Cai, S., Bailey, B. J., Saadatzadeh, M. R., Ding, J., Tonsing-Carter, E., Georgiadis, T. M., Gunter, T. Z., Long, E. C., Minto, R. E., Gordon, K. R., Sen, S. E., Cai, W., Eitel, J. A., Waning, D. L., Bringman, L. R., Wells, C. D., Murray, M. E., Sarkaria, J. N., Gelbert, L. M. & 5 others, Jones, D. R., Cohen-Gadol, A. A., Mayo, L. D., Shannon, H. E. & Pollok, K. E., Feb 2017, In : Journal of neurosurgery. 126, 2, p. 446-459 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer

Solzak, J. P., Atale, R. V., Hancock, B. A., Sinn, A. L., Pollok, K. E., Jones, D. R. & Radovich, M., Dec 1 2017, In : npj Breast Cancer. 3, 1, 0016.

Research output: Contribution to journalArticle

12 Scopus citations

Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell-like spheroids, and tumor xenografts through multiple cell signaling pathways

Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Wang, H., Nguyen, A., Kamocka, M. M., Cai, W., Cohen-Gadol, A. A., Halum, S. L., Sarkaria, J. N., Pollok, K. E. & Safa, A. R., Dec 2017, In : Journal of neurosurgery. 127, 6, p. 1219-1230 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Use of Precision Medicine Molecular Profiling of Baseline Tumor Specimen May Not Benefit Outcomes in Children With Relapsed or Refractory Pediatric Sarcomas

Carter, J., Cheng, L., Zucker, J., Marshall, M., Pollok, K., Murray, M., Li, L. & Renbarger, J., Mar 1 2017, In : Clinical Pharmacology and Therapeutics. 101, 3, p. 328-330 3 p.

Research output: Contribution to journalArticle

2016

Hypoxia-inducible factor-1α regulates CD55 in airway epithelium

Pandya, P. H., Fisher, A. J., Mickler, E. A., Temm, C. J., Lipking, K. P., Gracon, A., Rothhaar, K., Sandusky, G. E., Murray, M., Pollok, K., Renbarger, J., Blum, J. S., Lahm, T. & Wilkes, D. S., Dec 2016, In : American journal of respiratory cell and molecular biology. 55, 6, p. 889-898 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
22 Scopus citations

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo

Huang, W., Dong, Z., Chen, Y., Wang, F., Wang, C. J., Peng, H., He, Y., Hangoc, G., Pollok, K., Sandusky, G., Fu, X. Y., Broxmeyer, H. E., Zhang, Z. Y., Liu, J. Y. & Zhang, J. T., Feb 11 2016, In : Oncogene. 35, 6, p. 783-792 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

The Immune System in Cancer Pathogenesis: Potential Therapeutic Approaches

Pandya, P. H., Murray, M. E., Pollok, K. E. & Renbarger, J. L., 2016, In : Journal of Immunology Research. 2016, 4273943.

Research output: Contribution to journalArticle

35 Scopus citations
2015

Activation of death-associated protein kinase in human peritumoral tissue: A potential therapeutic target

Gao, X., Wang, H., Pollok, K. E., Chen, J. & Cohen-Gadol, A. A., Oct 1 2015, In : Journal of Clinical Neuroscience. 22, 10, p. 1655-1660 6 p., 6063.

Research output: Contribution to journalArticle

2 Scopus citations

Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines

Harvey, K. A., Xu, Z., Saaddatzadeh, M. R., Wang, H., Pollok, K., Cohen-Gadol, A. A. & Siddiqui, R. A., Mar 2015, In : Journal of neurosurgery. 122, 3, p. 547-556 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Longitudinal bioluminescence imaging of primary versus abdominal metastatic tumor growth in Orthotopic pancreatic tumor models in NSG Mice

Shannon, H. E., Fishel, M. L., Xie, J., Gu, D., McCarthy, B. P., Riley, A. A., Sinn, A. L., Silver, J. M., Peterman, K., Kelley, M. R., Hanenberg, H., Korc, M., Pollok, K. E. & Territo, P. R., Jan 2015, In : Pancreas. 44, 1, p. 64-75 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Potentiation of carboplatin-mediated DNA damage by the Mdm2 modulator Nutlin-3a in a humanized orthotopic breast-to-lung metastatic model

Tonsing-Carter, E., Bailey, B. J., Saadatzadeh, M. R., Ding, J., Wang, H., Sinn, A. L., Peterman, K. M., Spragins, T. K., Silver, J. M., Sprouse, A. A., Georgiadis, T. M., Gunter, T. Z., Long, E. C., Minto, R. E., Marchal, C. C., Batuello, C. N., Safa, A. R., Hanenberg, H., Territo, P. R., Sandusky, G. E. & 4 others, Mayo, L. D., Eischen, C. M., Shannon, H. E. & Pollok, K. E., Dec 1 2015, In : Molecular cancer therapeutics. 14, 12, p. 2850-2863 14 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

A heterobivalent ligand inhibits mast cell degranulation via selective inhibition of allergen-IgE interactions in vivo

Handlogten, M. W., Serezani, A. P., Sinn, A. L., Pollok, K. E., Kaplan, M. H. & Bilgicer, B., Mar 1 2014, In : Journal of Immunology. 192, 5, p. 2035-2041 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Exploring a structural protein-drug interactome for new therapeutics in lung cancer

Peng, X., Wang, F., Li, L., Bum-Erdene, K., Xu, D., Wang, B., Sinn, A. A., Pollok, K. E., Sandusky, G. E., Li, L., Turchi, J. J., Jalal, S. I. & Meroueh, S. O., Mar 2014, In : Molecular BioSystems. 10, 3, p. 581-591 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Multimodality imaging methods for assessing retinoblastoma orthotopic xenograft growth and development

Corson, T. W., Samuels, B. C., Wenzel, A. A., Geary, A. J., Riley, A. A., McCarthy, B. P., Hanenberg, H., Bailey, B. J., Rogers, P. I., Pollok, K. E., Rajashekhar, G. & Territo, P. R., Jun 5 2014, In : PloS one. 9, 6, e99036.

Research output: Contribution to journalArticle

15 Scopus citations

Phosphorylation of NMDA 2B at S1303 in human glioma peritumoral tissue: Implications for glioma epileptogenesis

Gao, X., Wang, H., Cai, S., Reza Saadatzadeh, M., Hanenberg, H., Pollok, K. E., Cohen-Gadol, A. A. & Chen, J., Jan 1 2014, In : Neurosurgical focus. 37, 6, E17.

Research output: Contribution to journalArticle

9 Scopus citations

Soypeptide lunasin in cytokine immunotherapy for lymphoma

Chang, H. C., Lewis, D., Tung, C. Y., Han, L., Henriquez, S. M. P., Voiles, L., Lupov, I. P., Pelloso, D., Sinn, A. L., Pollok, K. E., De Lumen, B. O., Li, F., Blum, J. S., Srivastava, S. & Robertson, M. J., Mar 2014, In : Cancer Immunology, Immunotherapy. 63, 3, p. 283-295 13 p.

Research output: Contribution to journalArticle

22 Scopus citations
2013

Design, synthesis, and evaluation of curcumin-derived arylheptanoids for glioblastoma and neuroblastoma cytotoxicity

Campos, C. A., Gianino, J. B., Bailey, B. J., Baluyut, M. E., Wiek, C., Hanenberg, H., Shannon, H. E., Pollok, K. E. & Ashfeld, B. L., Dec 15 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 24, p. 6874-6878 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Human proangiogenic circulating hematopoietic stem and progenitor cells promote tumor growth in an orthotopic melanoma xenograft model

Mund, J. A., Shannon, H., Sinn, A. L., Cai, S., Wang, H., Pradhan, K. R., Pollok, K. E. & Case, J., Oct 1 2013, In : Angiogenesis. 16, 4, p. 953-962 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Peripheral blood biomarkers of solid tumor angiogenesis in dogs: A polychromatic flow cytometry pilot study

Bentley, R. T., Mund, J. A., Pollok, K. E., Childress, M. O. & Case, J., May 1 2013, In : Veterinary Journal. 196, 2, p. 236-240 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Small-molecule inhibition of the uPAR·uPA interaction: Synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis

Mani, T., Wang, F., Knabe, W. E., Sinn, A. L., Khanna, M., Jo, I., Sandusky, G. E., Sledge, G. W., Jones, D. R., Khanna, R., Pollok, K. E. & Meroueh, S. O., Apr 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 7, p. 2145-2155 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Temozolomide-mediated DNA methylation in human myeloid precursor cells: Differential involvement of intrinsic and extrinsic apoptotic pathways

Wang, H., Cai, S., Ernstberger, A., Bailey, B. J., Wang, M. Z., Cai, W., Goebel, W. S., Czader, M. B., Crean, C., Suvannasankha, A., Shokolenkoc, I., Wilson, G. L., Baluyut, A. R., Mayo, L. D. & Pollok, K. E., May 15 2013, In : Clinical Cancer Research. 19, 10, p. 2699-2709 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity

Cai, S., Wang, H., Bailey, B., Ernstberger, A., Juliar, B. E., Sinn, A. L., Chan, R. J., Jones, D. R., Mayo, L. D., Baluyut, A. R., Goebel, W. S. & Pollok, K. E., Apr 15 2011, In : Clinical Cancer Research. 17, 8, p. 2195-2206 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Impact of APE1/ref-1 redox inhibition on pancreatic tumor growth

Fishel, M. L., Jiang, Y., Rajeshkumar, N. V., Scandura, G., Sinn, A. L., He, Y., Shen, C., Jones, D. R., Pollok, K. E., Ivan, M., Maitra, A. & Kelley, M. R., Sep 2011, In : Molecular cancer therapeutics. 10, 9, p. 1698-1708 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis

Wang, F., Li, J., Sinn, A. L., Knabe, W. E., Khanna, M., Jo, I., Silver, J. M., Oh, K., Li, L., Sandusky, G. E., Sledge, G. W., Nakshatri, H., Jones, D. R., Pollok, K. E. & Meroueh, S. O., Oct 27 2011, In : Journal of Medicinal Chemistry. 54, 20, p. 7193-7205 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
2010

Application of polychromatic flow cytometry to identify novel subsets of circulating cells with angiogenic potential

Estes, M. L., Mund, J. A., Mead, L. E., Prater, D. N., Cai, S., Wang, H., Pollok, K. E., Murphy, M. P., An, C. S. T., Srour, E. F., Ingram, D. A. & Case, J., Sep 1 2010, In : Cytometry Part A. 77, 9, p. 831-839 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma

Wang, X., Sinn, A. L., Pollok, K., Sandusky, G., Zhang, S., Chen, L., Liang, J., Crean, C. D., Suvannasankha, A., Abonour, R., Sidor, C., Bray, M. R. & Farag, S. S., Aug 1 2010, In : British journal of haematology. 150, 3, p. 313-325 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Selenomethionine or methylseleninic acid inhibits mutagenesis of a reporter gene in mouse bone marrow

Kumar, M. S., Pollok, K. E. & Smith, M. L., Feb 1 2010, In : Anticancer Research. 30, 2, p. 291-293 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

TGF-β1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer

Araki, S., Eitel, J. A., Batuello, C. N., Bijangi-Vishehsaraei, K., Xie, X. J., Danielpour, D., Pollok, K. E., Boothman, D. A. & Mayo, L. D., Jan 4 2010, In : Journal of Clinical Investigation. 120, 1, p. 290-302 13 p.

Research output: Contribution to journalArticle

98 Scopus citations
2009

C-FLIP gene silencing eliminates tumor cells in breast cancer xenografts without affecting stromal cells

Day, T. W., Sinn, A. L., Huang, S., Pollok, K. E., Sandusky, G. E. & Safa, A. R., Oct 1 2009, In : Anticancer Research. 29, 10, p. 3883-3886 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Enhanced homing and engraftment of fresh but not ex vivo cultured murine marrow cells in submyeloablated hosts following CD26 inhibition by Diprotin A

Wyss, B. K., Donnelly, A. F. W., Zhou, D., Sinn, A. L., Pollok, K. E. & Goebel, W. S., Jul 1 2009, In : Experimental Hematology. 37, 7, p. 814-823 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

In vivo measurements of tumor metabolism and growth after administration of nzastaurin using small animal FDG positron emission tomography

Lahn, M., Pollok, K. E., Enas, N., McNulty, A., Graff, J., Cai, S., Hartwell, J. R., Ernstberger, A., Thornton, D., Brail, L. & Hutchins, G., 2009, In : Journal of Oncology. 596560.

Research output: Contribution to journalArticle

9 Scopus citations

Involvement of platelet-activating factor in ultraviolet B-induced hyperalgesia.

Zhang, Q., Sitzman, L. A., Al-Hassani, M., Cai, S., Pollok, K. E., Travers, J. B. & Hingtgen, C. M., Jan 2009, In : The Journal of investigative dermatology. 129, 1, p. 167-174 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg -/- mice in vivo

Li, Y., Chen, S., Yuan, J., Yang, Y., Li, J., Jin, M., Wu, X., Freund, M., Pollok, K., Hanenberg, H., Goebe, W. S. & Yang, F. C., Mar 5 2009, In : Blood. 113, 10, p. 2342-2351 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

PTEN and p53 are required for hypoxia induced expression of maspin in glioblastoma cells

Eitel, J. A., Bijangi-Vishehsaraei, K., Saadatzadeh, M. R., Bhavsar, J. R., Murphy, M. P., Pollok, K. E. & Mayo, L. D., Mar 15 2009, In : Cell Cycle. 8, 6, p. 896-901 6 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

The Xpc gene markedly affects cell survival in mouse bone marrow

Fischer, J. L., Kumar, M. A. S., Day, T. W., Hardy, T. M., Hamilton, S., Besch-Williford, C., Safa, A. R., Pollok, K. E. & Smith, M. L., Jul 2009, In : Mutagenesis. 24, 4, p. 309-316 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2008

A novel competitive repopulation strategy to quantitate engraftment of ex vivo manipulated murine marrow cells in submyeloablated hosts

Wyss, B. K., Meyers, J. L., Sinn, A. L., Cai, S., Pollok, K. E. & Goebel, W. S., Jan 1 2008, In : Experimental Hematology. 36, 4, p. 513-521 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Generation of stable vector-producing cells for retroviral vectors

Cornetta, K., Pollok, K. E. & Miller, A. D., Apr 1 2008, In : Cold Spring Harbor protocols. 3, 4

Research output: Contribution to journalArticle

1 Scopus citations

Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34+ NOD/SCID-repopulating cells

Liu, Y., Hangoc, G., Campbell, T. B., Goodman, M., Tao, W., Pollok, K., Srour, E. F. & Broxmeyer, H. E., Aug 1 2008, In : Experimental Hematology. 36, 8, p. 947-956 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

In vivo selection of hematopoietic stem cells transduced at a low multiplicity-of-infection with a foamy viral MGMTP140K vector

Cai, S., Ernstberger, A., Wang, H., Bailey, B. J., Hartwell, J. R., Sinn, A. L., Eckermann, O., Linka, Y., Goebel, W. S., Hanenberg, H. & Pollok, K. E., Mar 1 2008, In : Experimental Hematology. 36, 3, p. 283-292 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Retroviral vector production by transient transfection

Cornetta, K., Pollok, K. E. & Miller, A. D., Apr 1 2008, In : Cold Spring Harbor protocols. 3, 4

Research output: Contribution to journalArticle

2 Scopus citations