Kenneth Cornetta

  • 8310 Citations
  • 45 h-Index
1977 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

Filter
Article
2020

Transitioning from development to commercial: risk-based guidance for critical materials management in cell therapies

Scott, M., Clarke, D., Lipsitz, Y., Brandwein, H., Allickson, J., Alzebdeh, D., Aleksic, S., Kraft, C., Lhu, L. & Cornetta, K., 2020, (Accepted/In press) In : Cytotherapy.

Research output: Contribution to journalArticle

2019

Ind-enabling studies for a clinical trial to genetically program a persistent cancer-targeted immune system

Puig-Saus, C., Parisi, G., Garcia-Diaz, A., Krystofinski, P. E., Sandoval, S., Zhang, R., Champhekar, A. S., McCabe, J., Cheung-Lau, G. C., Truong, N. A., Vega-Crespo, A., Komenan, M. D. S., Pang, J., Macabali, M. H., Saco, J. D., Goodwin, J. L., Bolon, B., Seet, C. S., Montel-Hagen, A., Crooks, G. M. & 17 others, Hollis, R. P., Campo-Fernandez, B., Bischof, D., Cornetta, K., Gschweng, E. H., Adelson, C., Nguyen, A., Yang, L., Witte, O. N., Baltimore, D., Comin-Anduix, B., Kohn, D. B., Wang, X., Cabrera, P., Kaplan-Lefko, P. J., Berent-Maoz, B. & Ribas, A., Feb 1 2019, In : Clinical Cancer Research. 25, 3, p. 1000-1011 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products

Cornetta, K., Duffy, L., Turtle, C. J., Jensen, M., Forman, S., Binder-Scholl, G., Fry, T., Chew, A., Maloney, D. G. & June, C. H., Jan 3 2018, In : Molecular Therapy. 26, 1, p. 280-288 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Screening Clinical Cell Products for Replication Competent Retrovirus: The National Gene Vector Biorepository Experience

Cornetta, K., Duffy, L., Feldman, S. A., Mackall, C. L., Davila, M. L., Curran, K. J., Junghans, R. P., Tang, J. Y., Kochenderfer, J. N., O'Cearbhaill, R., Archer, G., Kiem, H. P., Shah, N. N., Delbrook, C., Kaplan, R., Brentjens, R. J., Rivière, I., Sadelain, M. & Rosenberg, S. A., Sep 21 2018, In : Molecular Therapy - Methods and Clinical Development. 10, p. 371-378 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Clinical efficacy of gene-modified stem cells in adenosine deaminase-deficient immunodeficiency

Shaw, K. L., Garabedian, E., Mishra, S., Barman, P., Davila, A., Carbonaro, D., Shupien, S., Silvin, C., Geiger, S., Nowicki, B., Smogorzewska, E. M., Brown, B., Wang, X., De Oliveira, S., Choi, Y., Ikeda, A., Terrazas, D., Fu, P. Y., Yu, A., Fernandez, B. C. & 24 others, Cooper, A. R., Engel, B., Podsakoff, G., Balamurugan, A., Anderson, S., Muul, L., Jagadeesh, G. J., Kapoor, N., Tse, J., Moore, T. B., Purdy, K., Rishi, R., Mohan, K., Skoda-Smith, S., Buchbinder, D., Abraham, R. S., Scharenberg, A., Yang, O. O., Cornetta, K., Gjertson, D., Hershfield, M., Sokolic, R., Candotti, F. & Kohn, D. B., May 1 2017, In : Journal of Clinical Investigation. 127, 5, p. 1689-1699 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Lentivirus mediated correction of artemis-deficient severe combined immunodeficiency

Punwani, D., Kawahara, M., Yu, J., Sanford, U., Roy, S., Patel, K., Carbonaro, D. A., Karlen, A. D., Khan, S., Cornetta, K., Rothe, M., Schambach, A., Kohn, D. B., Malech, H. L., McIvor, R. S., Puck, J. M. & Cowan, M. J., Jan 1 2017, In : Human gene therapy. 28, 1, p. 112-124 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2016

Differences in vector-genome processing and illegitimate integration of non-integrating lentiviral vectors

Shaw, A. M., Joseph, G. L., Jasti, A. C., Sastry-Dent, L., Witting, S. & Cornetta, K., Oct 20 2016, (Accepted/In press) In : Gene Therapy.

Research output: Contribution to journalArticle

3 Scopus citations
2015

FHBG PET/CT imaging of CD34-TK75 transduced donor T cells in relapsed allogeneic stem cell transplant patients: Safety and feasibility

Eissenberg, L. G., Rettig, M. P., Ritchey, J. K., Prior, J. L., Schwarz, S. W., Frye, J., White, B. S., Fulton, R. S., Ghobadi, A., Cooper, M. L., Couriel, D. R., Seegulam, M. E., Piwnica-Worms, D., Dehdashti, F., Cornetta, K. & DiPersio, J. F., Jun 1 2015, In : Molecular Therapy. 23, 6, p. 1110-1122 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma

Chodon, T., Comin-Anduix, B., Chmielowski, B., Koya, R. C., Wu, Z., Auerbach, M., Ng, C., Avramis, E., Seja, E., Villanueva, A., McCannel, T. A., Ishiyama, A., Czernin, J., Radu, C. G., Wang, X., Gjertson, D. W., Cochran, A. J., Cornetta, K., Wong, D. J. L., Kaplan-Lefko, P. & 14 others, Hamid, O., Samlowski, W., Cohen, P. A., Daniels, G. A., Mukherji, B., Yang, L., Zack, J. A., Kohn, D. B., Heath, J. R., Glaspy, J. A., Witte, O. N., Baltimore, D., Economou, J. S. & Ribas, A., May 1 2014, In : Clinical Cancer Research. 20, 9, p. 2457-2465 9 p.

Research output: Contribution to journalArticle

112 Scopus citations

Development and evaluation of quality metrics for bioinformatics analysis of viral insertion site data generated using high throughput sequencing

Gao, H., Hawkins, T., Jasti, A., Chen, Y. H., Mockaitis, K., Dinauer, M. & Cornetta, K., Jun 1 2014, In : Biomedicines. 2, 2, p. 195-210 16 p.

Research output: Contribution to journalArticle

Preclinical demonstration of lentiviral vector-mediated correction of immunological and metabolic abnormalities in models of adenosine deaminase deficiency

Carbonaro, D. A., Zhang, L., Jin, X., Montiel-Equihua, C., Geiger, S., Carmo, M., Cooper, A., Fairbanks, L., Kaufman, M. L., Sebire, N. J., Hollis, R. P., Blundell, M. P., Senadheera, S., Fu, P. Y., Sahaghian, A., Chan, R. Y., Wang, X., Cornetta, K., Thrasher, A. J., Kohn, D. B. & 1 others, Gaspar, H. B., Mar 2014, In : Molecular Therapy. 22, 3, p. 607-622 16 p.

Research output: Contribution to journalArticle

53 Scopus citations

Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor

Wolstein, O., Boyd, M., Millington, M., Impey, H., Boyer, J., Howe, A., Delebecque, F., Cornetta, K., Rothe, M., Baum, C., Nicolson, T., Koldej, R., Zhang, J., Keech, N., Camba Colón, J., Breton, L., Bartlett, J., An, D. S., Chen, I. S., Burke, B. & 1 others, Symonds, G. P., Jan 8 2014, In : Molecular Therapy - Methods and Clinical Development. 1, p. 11 1 p., 11.

Research output: Contribution to journalArticle

34 Scopus citations
2013

A reporter system for replication-competent gammaretroviruses: the inGluc-MLV-DERSE assay

Aloia, A. L., Duffy, L., Pak, V., Lee, K. E., Sanchez-Martinez, S., Derse, D., Heidecker, G., Cornetta, K. & Rein, A., Feb 1 2013, In : Gene Therapy. 20, 2, p. 169-176 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies

Farag, S. S., Srivastava, S., Messina-Graham, S., Schwartz, J., Robertson, M. J., Abonour, R., Cornetta, K., Wood, L., Secrest, A., Strother, R. M., Jones, D. R. & Broxmeyer, H. E., Apr 1 2013, In : Stem cells and development. 22, 7, p. 1007-1015 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

Partnership between CTSI and Business Schools Can Promote Best Practices for Core Facilities and Resources

Reeves, L., Dunn-Jensen, L. M., Baldwin, T. T., Tatikonda, M. V. & Cornetta, K., Aug 2013, In : Clinical and translational science. 6, 4, p. 297-302 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A

Du, L. M., Nurden, P., Nurden, A. T., Nichols, T. C., Bellinger, D. A., Jensen, E. S., Haberichter, S. L., Merricks, E., Raymer, R. A., Fang, J., Koukouritaki, S. B., Jacobi, P. M., Hawkins, T. B., Cornetta, K., Shi, Q. & Wilcox, D. A., Dec 1 2013, In : Nature communications. 4, 2773.

Research output: Contribution to journalArticle

67 Scopus citations

Transgenic sheep generated by lentiviral vectors: Safety and integration analysis of surrogates and their offspring

Cornetta, K., Tessanne, K., Long, C., Yao, J., Satterfield, C. & Westhusin, M., Aug 2013, In : Transgenic Research. 22, 4, p. 737-745 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Vector production in an academic environment: A tool to assess production costs

Boeke, A., Doumas, P., Reeves, L., McClurg, K., Bischof, D., Sego, L., Auberry, A., Tatikonda, M. & Cornetta, K., Feb 1 2013, In : Human Gene Therapy Methods. 24, 1, p. 49-57 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012

A simple and effective method to generate lentiviral vectors for ex vivo gene delivery to mature human peripheral blood lymphocytes

Yang, S., Karne, N. K., Goff, S. L., Black, M. A., Xu, H., Bischof, D., Cornetta, K., Rosenberg, S. A., Morgan, R. A. & Feldman, S. A., Apr 1 2012, In : Human Gene Therapy Methods. 23, 2, p. 73-83 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Developing novel lentiviral vectors into clinical products

Leath, A. & Cornetta, K., 2012, In : Methods in Enzymology. 507, p. 89-108 20 p.

Research output: Contribution to journalArticle

12 Scopus citations

Efficient large volume lentiviral vector production using flow electroporation

Witting, S. R., Li, L. H., Jasti, A., Allen, C., Cornetta, K., Brady, J., Shivakumar, R. & Peshwa, M. V., Feb 1 2012, In : Human gene therapy. 23, 2, p. 243-249 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Using pulmozyme dnase treatment in lentiviral vector production

Shaw, A., Bischof, D., Jasti, A., Ernstberger, A., Hawkins, T. & Cornetta, K., Feb 1 2012, In : Human Gene Therapy Methods. 23, 1, p. 65-71 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2011

Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5-year cryopreserved cord blood

Broxmeyer, H. E., Lee, M. R., Hangoc, G., Cooper, S., Prasain, N., Kim, Y. J., Mallett, C., Ye, Z., Witting, S., Cornetta, K., Cheng, L. & Yoder, M. C., May 5 2011, In : Blood. 117, 18, p. 4773-4777 5 p.

Research output: Contribution to journalArticle

104 Scopus citations

Identifying viral integration sites using SeqMap 2.0

Hawkins, T. B., Dantzer, J., Peters, B., Dinauer, M., Mockaitis, K., Mooney, S. & Cornetta, K., Mar 1 2011, In : Bioinformatics. 27, 5, p. 720-722 3 p., btq722.

Research output: Contribution to journalArticle

27 Scopus citations

Platelet gene therapy improves hemostatic function for integrin αIIbβ3-deficient dogs

Fang, J., Jensen, E. S., Boudreaux, M. K., Du, L. M., Hawkins, T. B., Koukouritaki, S. B., Cornetta, K. & Wilcox, D. A., Jun 7 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 23, p. 9583-9588 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Prophylaxis with Sirolimus and Tacrolimus ± Antithymocyte Globulin Reduces the Risk of Acute Graft-versus-Host Disease without an Overall Survival Benefit Following Allogeneic Stem Cell Transplantation

Rosenbeck, L. L., Kiel, P. J., Kalsekar, I., Vargo, C., Baute, J., Sullivan, C. K., Wood, L., Abdelqader, S., Schwartz, J., Srivastava, S., Abonour, R., Robertson, M. J., Nelson, R. P., Cornetta, K., Fausel, C. A. & Farag, S. S., Jun 1 2011, In : Biology of Blood and Marrow Transplantation. 17, 6, p. 916-922 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Rapid production of clinical-grade gammaretroviral vectors in expanded surface roller bottles using a "modified" step-filtration process for clearance of packaging cells

Feldman, S. A., Goff, S. L., Xu, H., Black, M. A., Kochenderfer, J. N., Johnson, L. A., Yang, J. C., Wang, Q., Parkhurst, M. R., Cross, S., Morgan, R. A., Cornetta, K. & Rosenberg, S. A., Jan 1 2011, In : Human gene therapy. 22, 1, p. 107-115 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Replication-competent lentivirus analysis of clinical grade vector products

Cornetta, K., Yao, J., Jasti, A., Koop, S., Douglas, M., Hsu, D., Couture, L. A., Hawkins, T. & Duffy, L., Mar 2011, In : Molecular Therapy. 19, 3, p. 557-566 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010

Alternate receptor usage of neuropilin-1 and glucose transporter protein 1 by the human T cell leukemia virus type 1

Jin, Q., Alkhatib, B., Cornetta, K. & Alkhatib, G., Jan 20 2010, In : Virology. 396, 2, p. 203-212 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Flexibility in cell targeting by pseudotyping lentiviral vectors.

Bischof, D. & Cornetta, K., 2010, In : Methods in molecular biology (Clifton, N.J.). 614, p. 53-68 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Flow-through electroporation based on constant voltage for large-volume transfection of cells

Geng, T., Zhan, Y., Wang, H. Y., Witting, S. R., Cornetta, K. G. & Lu, C., May 1 2010, In : Journal of Controlled Release. 144, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

70 Scopus citations
13 Scopus citations

Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model

Heruth, D. P., Hawkins, T., Logsdon, D. P., Gibson, M. I., Sokolovsky, I. V., Nsumu, N. N., Major, S. L., Fegley, B., Woods, G. M., Lewing, K. B., Neville, K. A., Cornetta, K., Peterson, K. R. & White, R. A., Nov 1 2010, In : Genomics. 96, 5, p. 303-307 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

Cavazzana-Calvo, M., Payen, E., Negre, O., Wang, G., Hehir, K., Fusil, F., Down, J., Denaro, M., Brady, T., Westerman, K., Cavallesco, R., Gillet-Legrand, B., Caccavelli, L., Sgarra, R., Maouche-Chrétien, L., Bernaudin, F., Girot, R., Dorazio, R., Mulder, G. J., Polack, A. & 18 others, Bank, A., Soulier, J., Larghero, J., Kabbara, N., Dalle, B., Gourmel, B., Socie, G., Chrétien, S., Cartier, N., Aubourg, P., Fischer, A., Cornetta, K., Galacteros, F., Beuzard, Y., Gluckman, E., Bushman, F., Hacein-Bey-Abina, S. & Leboulch, P., Sep 2010, In : Nature. 467, 7313, p. 318-322 5 p.

Research output: Contribution to journalArticle

858 Scopus citations

Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity

Ha, S. P., Klemen, N. D., Kinnebrew, G. H., Brandmaier, A. G., Marsh, J., Hangoc, G., Palmer, D. C., Restifo, N. P., Cornetta, K., Broxmeyer, H. E. & Touloukian, C. E., Dec 1 2010, In : Journal of Clinical Investigation. 120, 12, p. 4273-4288 16 p.

Research output: Contribution to journalArticle

20 Scopus citations
2009

Detection of replication competent retrovirus and lentivirus.

Sastry, L. & Cornetta, K., 2009, In : Methods in molecular biology (Clifton, N.J.). 506, p. 243-263 21 p.

Research output: Contribution to journalArticle

11 Scopus citations

Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation

Sadat, M. A., Dirscherl, S., Sastry, L., Dantzer, J., Pech, N., Griffin, S., Hawkins, T., Zhao, Y., Barese, C. N., Cross, S., Orazi, A., An, C., Goebel, W. S., Yoder, M. C., Li, X., Grez, M., Cornetta, K., Mooney, S. D. & Dinauer, M. C., Dec 3 2009, In : Gene Therapy. 16, 12, p. 1452-1464 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
2008

Automated analysis of viral integration sites in gene therapy research using the SeqMap web resource

Peters, B., Dirscherl, S., Dantzer, J., Nowacki, J., Cross, S., Li, X., Cornetta, K., Dinauer, M. C. & Mooney, S. D., 2008, In : Gene Therapy. 15, 18, p. 1294-1298 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Efficient and stable gene expression into human osteoclasts using an HIV-1-based lentiviral vector

Chu, K., Cornetta, K. G. & Econs, M. J., Jun 1 2008, In : DNA and Cell Biology. 27, 6, p. 315-320 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Generation of stable vector-producing cells for retroviral vectors

Cornetta, K., Pollok, K. E. & Miller, A. D., Apr 1 2008, In : Cold Spring Harbor protocols. 3, 4

Research output: Contribution to journalArticle

1 Scopus citations
13 Scopus citations

Retroviral vector production by transient transfection

Cornetta, K., Pollok, K. E. & Miller, A. D., Apr 1 2008, In : Cold Spring Harbor protocols. 3, 4

Research output: Contribution to journalArticle

2 Scopus citations

Retroviral vectors for gene transfer

Cornetta, K., Pollok, K. E. & Miller, A. D., Apr 1 2008, In : Cold Spring Harbor protocols. 3, 4

Research output: Contribution to journalArticle

2 Scopus citations

Transduction of cell lines by retroviral vectors

Cornetta, K., Pollok, K. E. & Miller, A. D., Apr 1 2008, In : Cold Spring Harbor protocols. 3, 4

Research output: Contribution to journalArticle

2 Scopus citations

Transduction of primary hematopoietic cells by retroviral vectors

Cornetta, K., Pollok, K. E. & Miller, A. D., Apr 1 2008, In : Cold Spring Harbor protocols. 3, 4

Research output: Contribution to journalArticle

2007

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene

Hsu, C., Jones, S. A., Cohen, C. J., Zheng, Z., Kerstann, K., Zhou, J., Robbins, P. F., Peng, P. D., Shen, X., Gomes, T. J., Dunbar, C. E., Munroe, D. J., Stewart, C., Cornetta, K., Wangsa, D., Ried, T., Rosenberg, S. A. & Morgan, R. A., Jun 15 2007, In : Blood. 109, 12, p. 5168-5177 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Enhanced green fluorescent protein is a nearly ideal long-term expression tracer for hematopoietic stem cells, whereas DsRed-Express fluorescent protein is not

Tao, W., Evans, B. G., Yao, J., Cooper, S., Cornetta, K., Ballas, C. B., Hangoc, G. & Broxmeyer, H. E., Mar 1 2007, In : STEM CELLS. 25, 3, p. 670-678 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization

Cai, L., Johnstone, B. H., Cook, T. G., Liang, Z., Traktuev, D., Cornetta, K., Ingram, D. A., Rosen, E. D. & March, K. L., Dec 2007, In : STEM CELLS. 25, 12, p. 3234-3243 10 p.

Research output: Contribution to journalArticle

159 Scopus citations
2006
19 Scopus citations

Decreased homing of retrovirally transduced human bone marrow CD34 + cells in the NOD/SCID mouse model

Hall, K. M., Horvath, T. L., Abonour, R., Cornetta, K. & Srour, E. F., Apr 1 2006, In : Experimental Hematology. 34, 4, p. 433-442 10 p.

Research output: Contribution to journalArticle

16 Scopus citations