Kenneth Nephew

  • 10346 Citations
  • 58 h-Index
1987 …2019
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  • 36 Similar Profiles
Ovarian Neoplasms Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
DNA Methylation Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
Estrogen Receptors Medicine & Life Sciences
MicroRNAs Medicine & Life Sciences
Methylation Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

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NIH Grants 1995 2019

Carboplatin
Epigenomics
Ovarian Neoplasms
Platinum
Transferases

Interrogating Epigenetic Changes in Cancer Genomes

Nephew, K., Saltz, J., Friedman, A., Davuluri, R., Charis, E. & Huang, T. H.

National Institutes of Health

9/30/042/29/16

Project: Research project

CpG Islands
Drug Resistance
Methylation
Genome
Ovarian Neoplasms
DNA Methylation
Ovarian Neoplasms
Methylation
Epigenomics
Neoplastic Stem Cells
Tamoxifen
Tretinoin
Uterus
Fenretinide
Breast Neoplasms

Publications 1987 2019

MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ breast cancer

Milevskiy, M. J. G., Gujral, U., Del Lama Marques, C., Stone, A., Northwood, K., Burke, L. J., Gee, J. M. W., Nephew, K., Clark, S. & Brown, M. A., Jan 1 2019, In : British Journal of Cancer.

Research output: Contribution to journalArticle

MicroRNAs
Biomarkers
Breast Neoplasms
Annexins
Chromatin

Poly-ADP-Ribosylation of Estrogen Receptor-Alpha by PARP1 mediates antiestrogen resistance in human breast cancer cells

Pulliam, N., Tang, J., Wang, W., Fang, F., Sood, R., O'Hagan, H., Miller, K., Clarke, R. & Nephew, K., Jan 1 2019, In : Cancers. 11, 1, 43.

Research output: Contribution to journalArticle

Open Access
Estrogen Receptor Modulators
Estrogen Receptor alpha
Tamoxifen
Adenosine Diphosphate
Estrogen Receptors

The tumor microenvironment of high grade serous ovarian cancer

Stack, M. S., Nephew, K., Burdette, J. E. & Mitra, A., Jan 1 2019, In : Cancers. 11, 1, 21.

Research output: Contribution to journalEditorial

Open Access
Tumor Microenvironment
Ovarian Neoplasms
9 Citations (Scopus)

An effective epigenetic-PARP inhibitor combination therapy for breast and ovarian cancers independent of BRCA mutations

Pulliam, N., Fang, F., Ozes, A. R., Tang, J., Adewuyi, A., Keer, H., Lyons, J., Baylin, S. B., Matei, D., Nakshatri, H., Rassool, F. V., Miller, K. & Nephew, K., Jul 1 2018, In : Clinical Cancer Research. 24, 13, p. 3163-3175 13 p.

Research output: Contribution to journalArticle

Epigenomics
Ovarian Neoplasms
Breast Neoplasms
Mutation
Methyltransferases
11 Citations (Scopus)

A phase i clinical trial of guadecitabine and carboplatin in platinum-resistant, recurrent ovarian cancer: Clinical, pharmacokinetic, and pharmacodynamic analyses

Matei, D., Ghamande, S., Roman, L., Secord, A. A., Nemunaitis, J., Markham, M. J., Nephew, K., Jueliger, S., Oganesian, A., Naim, S., Su, X. Y., Keer, H., Azab, M. & Fleming, G. F., May 15 2018, In : Clinical Cancer Research. 24, 10, p. 2285-2293 9 p.

Research output: Contribution to journalArticle

Carboplatin
Platinum
Ovarian Neoplasms
Pharmacokinetics
Clinical Trials