Larry Jones

  • 13277 Citations
  • 67 h-Index
1971 …2015
If you made any changes in Pure, your changes will be visible here soon.

Publications 1971 2015

  • 13277 Citations
  • 67 h-Index
  • 199 Article
2015
10 Citations (Scopus)

Acute reversal of phospholamban inhibition facilitates the rhythmic whole-cell propagating calcium waves in isolated ventricular myocytes

Chan, Y. H., Tsai, W. C., Song, Z., Ko, C. Y., Qu, Z., Weiss, J. N., Lin, S-F., Chen, P-S., Jones, L. & Chen, Z., Mar 1 2015, In : Journal of Molecular and Cellular Cardiology. 80, p. 126-135 10 p.

Research output: Contribution to journalArticle

Calcium Signaling
Muscle Cells
Sarcoplasmic Reticulum
Calcium-Transporting ATPases
phospholamban
8 Citations (Scopus)

Transitions of protein traffic from cardiac ER to junctional SR

Sleiman, N. H., McFarland, T. P., Jones, L. & Cala, S. E., Apr 1 2015, In : Journal of Molecular and Cellular Cardiology. 81, p. 34-45 12 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Proteins
Protein Transport
Fluorescence Microscopy
Cardiac Myocytes
2014
13 Citations (Scopus)

Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: Relevance to arrhythmias and bio-pacemaker design

Sirenko, S., Maltsev, V. A., Maltseva, L. A., Yang, D., Lukyanenko, Y., Vinogradova, T. M., Jones, L. & Lakatta, E. G., Jan 2014, In : Journal of Molecular and Cellular Cardiology. 66, p. 106-115 10 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Muscle Cells
Cardiac Arrhythmias
Phosphorylation
Proteins
2013
7 Citations (Scopus)

Altered calsequestrin glycan processing is common to diverse models of canine heart failure

Jacob, S., Sleiman, N. H., Kern, S., Jones, L., Sala-Mercado, J. A., McFarland, T. P., Sabbah, H. H. & Cala, S. E., May 2013, In : Molecular and Cellular Biochemistry. 377, 1-2, p. 11-21 11 p.

Research output: Contribution to journalArticle

Calsequestrin
Polysaccharides
Canidae
Heart Failure
Processing
52 Citations (Scopus)

The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum

Akin, B. L., Hurley, T., Chen, Z. & Jones, L., Oct 18 2013, In : Journal of Biological Chemistry. 288, 42, p. 30181-30191 11 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Pumps
Calcium
Reticulum
Calcium-Transporting ATPases
2012
15 Citations (Scopus)
Reticulum
Sarcoplasmic Reticulum
Protein Binding
Adenosine Triphosphatases
Pumps
2011

Changes in metabolic profile and population of skeletal muscle fibers of mice overexpressing calsequestrin: Influence of losartan

Punkt, K., Kusche, T., Günther, S., Adams, V., Jones, L. & Neumann, J., Sep 2011, In : Acta Histochemica. 113, 5, p. 547-555 9 p.

Research output: Contribution to journalArticle

Calsequestrin
Losartan
Metabolome
Skeletal Muscle Fibers
Heart Failure
5 Citations (Scopus)

Sarcoplasmic reticulum Ca2+ release in neonatal rat cardiac myocytes

Gergs, U., Kirchhefer, U., Buskase, J., Kiele-Dunsche, K., Buchwalow, I. B., Jones, L., Schmitz, W., Traub, O. & Neumann, J., Nov 2011, In : Journal of Molecular and Cellular Cardiology. 51, 5, p. 682-688 7 p.

Research output: Contribution to journalArticle

Calsequestrin
Sarcoplasmic Reticulum
Cardiac Myocytes
Excitation Contraction Coupling
Ryanodine Receptor Calcium Release Channel
2010
18 Citations (Scopus)

Ca2+ binding to site I of the cardiac Ca2+ pump is sufficient to dissociate phospholamban

Chen, Z., Akin, B. L. & Jones, L., Jan 29 2010, In : Journal of Biological Chemistry. 285, 5, p. 3253-3260 8 p.

Research output: Contribution to journalArticle

Binding Sites
Pumps
Adenosine Triphosphatases
Adenosine Triphosphate
Conformations
7 Citations (Scopus)

Losartan reduces mortality in a genetic model of heart failure

Günther, S., Baba, H. A., Hauptmann, S., Holzhausen, H. J., Großmann, C., Punkt, K., Kusche, T., Jones, L., Gergs, U. & Neumann, J., Sep 2010, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 382, 3, p. 265-278 14 p.

Research output: Contribution to journalArticle

Losartan
Genetic Models
Transgenic Mice
Calsequestrin
Heart Failure
20 Citations (Scopus)
Nucleotides
Thapsigargin
Vanadates
phospholamban
Pumps
2009
86 Citations (Scopus)

Ablation of triadin causes loss of cardiac Ca 2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias

Chopra, N., Yang, T., Asghari, P., Moore, E. D., Huke, S., Akin, B., Cattolica, R. A., Perez, C. F., Hlaing, T., Knollmann-Ritschel, B. E. C., Jones, L., Pessah, I. N., Allen, P. D., Franzini-Armstrong, C. & Knollmann, B. C., May 5 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 18, p. 7636-7641 6 p.

Research output: Contribution to journalArticle

Excitation Contraction Coupling
Cardiac Arrhythmias
Sarcoplasmic Reticulum
Ryanodine Receptor Calcium Release Channel
Genes
75 Citations (Scopus)

Intracellular calcium dynamics and acceleration of sinus rhythm by β-adrenergic stimulation

Joung, B., Tang, L., Maruyama, M., Han, S., Chen, Z., Stucky, M., Jones, L., Fishbein, M. C., Weiss, J. N., Chen, P-S. & Lin, S-F., Feb 17 2009, In : Circulation. 119, 6, p. 788-796 9 p.

Research output: Contribution to journalArticle

Sinoatrial Node
Adrenergic Agents
Isoproterenol
Calcium
Heart Atria
2007
44 Citations (Scopus)
Cyclic AMP-Dependent Protein Kinases
Adenosine Triphosphatases
Monoclonal Antibodies
Phosphorylation
Calcium-Transporting ATPases
86 Citations (Scopus)

Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice

Chopra, N., Kannankeril, P. J., Yang, T., Hlaing, T., Holinstat, I., Ettensohn, K., Pfeifer, K., Akin, B., Jones, L., Franzini-Armstrong, C. & Knollmann, B. C., Sep 2007, In : Circulation Research. 101, 6, p. 617-626 10 p.

Research output: Contribution to journalArticle

Calsequestrin
Sarcoplasmic Reticulum
Cardiac Arrhythmias
Ventricular Tachycardia
Muscle Cells
41 Citations (Scopus)

On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure

Gergs, U., Berndt, T., Buskase, J., Jones, L., Kirchhefer, U., Müller, F. U., Schlüter, K. D., Schmitz, W. & Neumann, J., Jul 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 1

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Heart Failure
Cardiac Myocytes
Muscle Cells
Proteins
68 Citations (Scopus)

Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity

Yuan, Q., Fan, G. C., Dong, M., Altschafl, B., Diwan, A., Ren, X., Hahn, H. H., Zhao, W., Waggoner, J. R., Jones, L., Jones, W. K., Bers, D. M., Dorn, G. W., Wang, H. S., Valdivia, H. H., Chu, G. & Kranias, E. G., Jan 2007, In : Circulation. 115, 3, p. 300-309 10 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Calcium
Cardiac Arrhythmias
Heart Block
Calcium Signaling
18 Citations (Scopus)

Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin

Kirchhof, P., Klimas, J., Fabritz, L., Zwiener, M., Jones, L., Schäfers, M., Hermann, S., Boknik, P., Schmitz, W., Breithardt, G., Kirchhefer, U. & Neumann, J., May 2007, In : Journal of Molecular and Cellular Cardiology. 42, 5, p. 962-971 10 p.

Research output: Contribution to journalArticle

Ventricular Tachycardia
Heart Rate
Cardiac Myocytes
Action Potentials
Cardiac Arrhythmias
53 Citations (Scopus)

Triadins modulate intracellular Ca2+ homeostasis but are not essential for excitation-contraction coupling in skeletal muscle

Shen, X., Franzini-Armstrong, C., Lopez, J. R., Jones, L., Kobayashi, Y. M., Wang, Y., Kerrick, W. G. L., Caswell, A. H., Potter, J. D., Miller, T., Allen, P. D. & Perez, C. F., Dec 28 2007, In : Journal of Biological Chemistry. 282, 52, p. 37864-37874 11 p.

Research output: Contribution to journalArticle

Excitation Contraction Coupling
Muscle
Skeletal Muscle
Homeostasis
Sarcoplasmic Reticulum
2006
295 Citations (Scopus)

Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia

Knollmann, B. C., Chopra, N., Hlaing, T., Akin, B., Yang, T., Ettensohn, K., Knollmann, B. E. C., Horton, K. D., Weissman, N. J., Holinstat, I., Zhang, W., Roden, D. M., Jones, L., Franzini-Armstrong, C. & Pfeifer, K., Sep 1 2006, In : Journal of Clinical Investigation. 116, 9, p. 2510-2520 11 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Cardiac Arrhythmias
Calsequestrin
Mutation
Polymorphic catecholergic ventricular tachycardia
33 Citations (Scopus)
Sarcoplasmic Reticulum
Pumps
Conformations
phospholamban
Cross-Linking Reagents
30 Citations (Scopus)

Overexpression of junctin causes adaptive changes in cardiac myocyte Ca2+ signaling

Kirchhefer, U., Hanske, G., Jones, L., Justus, I., Kaestner, L., Lipp, P., Schmitz, W. & Neumann, J., Feb 2006, In : Cell Calcium. 39, 2, p. 131-142 12 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Calsequestrin
Cardiac Myocytes
Excitation Contraction Coupling
Proteins
2005
51 Citations (Scopus)

Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase activity in phospholemman-deficient mice

Jia, L. G., Donnet, C., Bogaev, R. C., Blatt, R. J., McKinney, C. E., Day, K. H., Berr, S. S., Jones, L., Moorman, J. R., Sweadner, K. J. & Tucker, A. L., Apr 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 288, 4 57-4

Research output: Contribution to journalArticle

Hypertrophy
Cardiac Myocytes
Protein Isoforms
Sarcolemma
Wild Animals
30 Citations (Scopus)

Role of leucine 31 of phospholamban in structural and functional interactions with the ca2+ pump of cardiac sarcoplasmic reticulum

Chen, Z., Stokes, D. L. & Jones, L., Mar 18 2005, In : Journal of Biological Chemistry. 280, 11, p. 10530-10539 10 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Leucine
Pumps
Thapsigargin
Calcium-Transporting ATPases
2004
35 Citations (Scopus)
Calsequestrin
Purinergic P2X Receptors
Cardiomyopathies
Heart Failure
Ligand-Gated Ion Channels
18 Citations (Scopus)

Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin

Kirchhefer, U., Baba, H. A., Hanske, G., Jones, L., Kirchhof, P., Schmitz, W. & Neumann, J., Nov 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 287, 5 56-5

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Ryanodine Receptor Calcium Release Channel
Transgenic Mice
Heart Rate
Calsequestrin
23 Citations (Scopus)

Effects of Phospholemman Expression on Swelling-Activated ion Currents and Volume Regulation in Embryonic Kidney Cells

Davis, C. E., Patel, M. K., Miller, J. R., John, J. E., Jones, L., Tucker, A. L., Mounsey, J. P. & Moorman, J. R., Jan 2004, In : Neurochemical Research. 29, 1, p. 177-187 11 p.

Research output: Contribution to journalArticle

Swelling
Ions
Kidney
Cells
Cell Size
1 Citation (Scopus)
Purinergic P2X4 Receptors
Calsequestrin
Cardiomyopathies
Heart Failure
15 Citations (Scopus)

Improved expression and characterization of Ca2+-ATPase and phospholamban in High-Five cells

Waggoner, J. R., Huffman, J., Griffith, B. N., Jones, L. & Mahaney, J. E., Mar 2004, In : Protein Expression and Purification. 34, 1, p. 56-67 12 p.

Research output: Contribution to journalArticle

Calcium-Transporting ATPases
Insects
phospholamban
Assays
Proteins

Protein interactions within calcium release units of muscle

Franzini-Armstrong, C., Tijskens, P. & Jones, L., 2004, In : Journal of Muscle Research and Cell Motility. 25, 8, p. 586-587 2 p.

Research output: Contribution to journalArticle

Calsequestrin
Calcium-Binding Proteins
Muscle Proteins
Sarcoplasmic Reticulum
Mixed Function Oxygenases
299 Citations (Scopus)

The Role of Calsequestrin, Triadin, and Junctin Conferring Cardiac Ryanodine Receptor Responsiveness to Luminal Calcium

Györke, I., Hester, N., Jones, L. & Györke, S., Apr 2004, In : Biophysical Journal. 86, 4, p. 2121-2128 8 p.

Research output: Contribution to journalArticle

Calsequestrin
Ryanodine Receptor Calcium Release Channel
Calcium
Sarcoplasmic Reticulum
triadin
24 Citations (Scopus)

Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to β-adrenergic agonists

Kirchhefer, U., Jones, L., Begrow, F., Boknik, P., Hein, L., Lohse, M. J., Riemann, B., Schmitz, W., Stypmann, J. & Neumann, J., Apr 1 2004, In : Cardiovascular Research. 62, 1, p. 122-134 13 p.

Research output: Contribution to journalArticle

Adrenergic Agonists
Sarcoplasmic Reticulum
Calsequestrin
Ryanodine Receptor Calcium Release Channel
Caffeine
2003
44 Citations (Scopus)

Impaired relaxation in transgenic mice overexpressing junctin

Kirchhefer, U., Neumann, J., Bers, D. M., Buchwalow, I. B., Fabritz, L., Hanske, G., Justus, I., Riemann, B., Schmitz, W. & Jones, L., Aug 1 2003, In : Cardiovascular Research. 59, 2, p. 369-379 11 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Transgenic Mice
Calsequestrin
Ryanodine Receptor Calcium Release Channel
Proteins
45 Citations (Scopus)

Junctin and calsequestrin overexpression in cardiac muscle: The role of junctin and the synthetic and delivery pathways for the two proteins

Tijskens, P., Jones, L. & Franzini-Armstrong, C., Aug 1 2003, In : Journal of Molecular and Cellular Cardiology. 35, 8, p. 961-974 14 p.

Research output: Contribution to journalArticle

Calsequestrin
Sarcoplasmic Reticulum
Myocardium
Proteins
Ryanodine Receptor Calcium Release Channel
75 Citations (Scopus)

Phospholemman, a single-span membrane protein, is an accessory protein of Na,K-ATPase in cerebellum and choroid plexus

Feschenko, M. S., Donnet, C., Wetzel, R. K., Asinovski, N. K., Jones, L. & Sweadner, K. J., Mar 15 2003, In : Journal of Neuroscience. 23, 6, p. 2161-2169 9 p.

Research output: Contribution to journalArticle

Choroid Plexus
Cerebellum
Membrane Proteins
Antibodies
Protein Isoforms
47 Citations (Scopus)

Spatial and Dynamic Interactions between Phospholamban and the Canine Cardiac Ca2+ Pump Revealed with Use of Heterobifunctional Cross-linking Agents

Chen, Z., Stokes, D. L., Rice, W. J. & Jones, L., Nov 28 2003, In : Journal of Biological Chemistry. 278, 48, p. 48348-48356 9 p.

Research output: Contribution to journalArticle

Canidae
Pumps
Thapsigargin
Conformations
Nucleotides
2002
13 Citations (Scopus)

Altered function in atrium of transgenic mice overexpressing triadin 1

Kirchhefer, U., Baba, H. A., Kobayashi, Y. M., Jones, L., Schmitz, W. & Neumann, J., Oct 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 4 52-4

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Transgenic Mice
Ryanodine Receptor Calcium Release Channel
Proteins
Calsequestrin
57 Citations (Scopus)
Sulfhydryl Compounds
Cysteine
Pumps
Mutagenesis
phospholamban
25 Citations (Scopus)

Modulation of gene expression in transgenic mouse hearts overexpressing calsequestrin

Ihara, Y., Suzuki, Y. J., Kitta, K., Jones, L. & Ikeda, T., Jul 2002, In : Cell Calcium. 32, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

Calsequestrin
Transgenic Mice
Cardiomegaly
Gene Expression
ATP Translocases Mitochondrial ADP
2001
36 Citations (Scopus)

Artificial ion channels formed by a synthetic cyclic peptide

Wang, D., Guo, L., Zhang , J., Roeske, R. W., Jones, L., Chen, Z. & Pritchard, C., 2001, In : Journal of Peptide Research. 57, 4, p. 301-306 6 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Ion Channels
Peptides
Gramicidin
Membranes
46 Citations (Scopus)

Cardiac-directed overexpression of wild-type α1B-adrenergic receptor induces dilated cardiomyopathy

Lemire, I., Ducharme, A., Tardif, J. C., Poulin, F., Jones, L., Allen, B. G., Hébert, T. E. & Rindt, H., 2001, In : American Journal of Physiology - Heart and Circulatory Physiology. 281, 2 50-2

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Adrenergic Receptors
Myosin Heavy Chains
Cardiac Myocytes
Messenger RNA
93 Citations (Scopus)

Cardiac Hypertrophy and Impaired Relaxation in Transgenic Mice Overexpressing Triadin 1

Kirchhefer, U., Neumann, J., Baba, H. A., Begrow, F., Kobayashi, Y. M., Reinke, U., Schmitz, W. & Jones, L., Feb 9 2001, In : Journal of Biological Chemistry. 276, 6, p. 4142-4149 8 p.

Research output: Contribution to journalArticle

Cardiomegaly
Transgenic Mice
Sarcoplasmic Reticulum
Calsequestrin
Cardiac Myocytes
218 Citations (Scopus)

Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure

Harding, V. B., Jones, L., Lefkowitz, R. J., Koch, W. J. & Rockman, H. A., May 8 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 10, p. 5809-5814 6 p.

Research output: Contribution to journalArticle

Calsequestrin
Phosphotransferases
Heart Failure
Survival
Metoprolol
20 Citations (Scopus)

Gene structure and expression of phospholemman in mouse

Bogaev, R. C., Jia, L., Kobayashi, Y. M., Palmer, C. J., Mounsey, J. P., Moorman, J. R., Jones, L. & Tucker, A. L., Jun 13 2001, In : Gene. 271, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

Gene Expression
Complementary DNA
Introns
Genes
Dinucleotide Repeats
46 Citations (Scopus)

Locating phospholamban in co-crystals with Ca2+-ATPase by cryoelectron microscopy

Young, H. S., Jones, L. & Stokes, D. L., 2001, In : Biophysical Journal. 81, 2, p. 884-894 11 p.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
Calcium-Transporting ATPases
phospholamban
Sarcoplasmic Reticulum
Adrenergic Agents
53 Citations (Scopus)

Structural alterations in cardiac calcium release units resulting from overexpression of junctin

Zhang, L., Franzini-Armstrong, C., Ramesh, V. & Jones, L., 2001, In : Journal of Molecular and Cellular Cardiology. 33, 2, p. 233-247 15 p.

Research output: Contribution to journalArticle

Myocardium
Calcium
Calsequestrin
Ryanodine Receptor Calcium Release Channel
Sarcoplasmic Reticulum
2000
13 Citations (Scopus)

Functional properties of transgenic mouse hearts overexpressing both calsequestrin and the Na+-Ca2+ exchanger

Linck, B., Bokník, P., Huke, S., Kirchhefer, U., Knapp, J., Lüss, H., Müller, F. U., Neumann, J., Tanriseven, Z., Vahlensieck, U., Baba, H. A., Jones, L., Philipson, K. D. & Schmitz, W., Aug 2000, In : Journal of Pharmacology and Experimental Therapeutics. 294, 2, p. 648-657 10 p.

Research output: Contribution to journalArticle

Calsequestrin
Transgenic Mice
Sarcoplasmic Reticulum
Caffeine
Hypertrophy
19 Citations (Scopus)

Kinetics studies of the cardiac Ca-ATPase expressed in Sf21 cells: New insights on Ca-ATPase regulation by phospholamban

Mahaney, J. E., Autry, J. M. & Jones, L., Mar 2000, In : Biophysical Journal. 78, 3, p. 1306-1323 18 p.

Research output: Contribution to journalArticle

Sf9 Cells
Adenosine Triphosphatases
Adenosine Triphosphate
phospholamban
Hydrolysis
96 Citations (Scopus)

Localization and characterization of the calsequestrin-binding domain of triadin 1. Evidence for a charged β-strand in mediating the protein-protein interaction

Kobayashi, Y. M., Alseikhan, B. A. & Jones, L., Jun 9 2000, In : Journal of Biological Chemistry. 275, 23, p. 17639-17646 8 p.

Research output: Contribution to journalArticle

Calsequestrin
Proteins
Ryanodine Receptor Calcium Release Channel
Alanine
triadin