Larry Jones

  • 13457 Citations
  • 67 h-Index
1971 …2015

Research output per year

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Publications

  • 13457 Citations
  • 67 h-Index
  • 194 Article
  • 3 Review article
  • 2 Comment/debate
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Article
2015

Acute reversal of phospholamban inhibition facilitates the rhythmic whole-cell propagating calcium waves in isolated ventricular myocytes

Chan, Y. H., Tsai, W. C., Song, Z., Ko, C. Y., Qu, Z., Weiss, J. N., Lin, S. F., Chen, P. S., Jones, L. R. & Chen, Z., Mar 1 2015, In : Journal of Molecular and Cellular Cardiology. 80, p. 126-135 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Transitions of protein traffic from cardiac ER to junctional SR

Sleiman, N. H., McFarland, T. P., Jones, L. R. & Cala, S. E., Apr 1 2015, In : Journal of Molecular and Cellular Cardiology. 81, p. 34-45 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: Relevance to arrhythmias and bio-pacemaker design

Sirenko, S., Maltsev, V. A., Maltseva, L. A., Yang, D., Lukyanenko, Y., Vinogradova, T. M., Jones, L. R. & Lakatta, E. G., Jan 1 2014, In : Journal of Molecular and Cellular Cardiology. 66, p. 106-115 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

Altered calsequestrin glycan processing is common to diverse models of canine heart failure

Jacob, S., Sleiman, N. H., Kern, S., Jones, L. R., Sala-Mercado, J. A., McFarland, T. P., Sabbah, H. H. & Cala, S. E., May 1 2013, In : Molecular and Cellular Biochemistry. 377, 1-2, p. 11-21 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum

Akin, B. L., Hurley, T. D., Chen, Z. & Jones, L. R., Oct 18 2013, In : Journal of Biological Chemistry. 288, 42, p. 30181-30191 11 p.

Research output: Contribution to journalArticle

58 Scopus citations
2012
16 Scopus citations
2011

Changes in metabolic profile and population of skeletal muscle fibers of mice overexpressing calsequestrin: Influence of losartan

Punkt, K., Kusche, T., Günther, S., Adams, V., Jones, L. R. & Neumann, J., Sep 1 2011, In : Acta Histochemica. 113, 5, p. 547-555 9 p.

Research output: Contribution to journalArticle

Sarcoplasmic reticulum Ca2+ release in neonatal rat cardiac myocytes

Gergs, U., Kirchhefer, U., Buskase, J., Kiele-Dunsche, K., Buchwalow, I. B., Jones, L. R., Schmitz, W., Traub, O. & Neumann, J., Nov 1 2011, In : Journal of Molecular and Cellular Cardiology. 51, 5, p. 682-688 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010

Ca2+ binding to site I of the cardiac Ca2+ pump is sufficient to dissociate phospholamban

Chen, Z., Akin, B. L. & Jones, L. R., Jan 29 2010, In : Journal of Biological Chemistry. 285, 5, p. 3253-3260 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Losartan reduces mortality in a genetic model of heart failure

Günther, S., Baba, H. A., Hauptmann, S., Holzhausen, H. J., Großmann, C., Punkt, K., Kusche, T., Jones, L. R., Gergs, U. & Neumann, J., Sep 1 2010, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 382, 3, p. 265-278 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
20 Scopus citations
2009

Ablation of triadin causes loss of cardiac Ca 2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias

Chopra, N., Yang, T., Asghari, P., Moore, E. D., Huke, S., Akin, B., Cattolica, R. A., Perez, C. F., Hlaing, T., Knollmann-Ritschel, B. E. C., Jones, L. R., Pessah, I. N., Allen, P. D., Franzini-Armstrong, C. & Knollmann, B. C., May 5 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 18, p. 7636-7641 6 p.

Research output: Contribution to journalArticle

92 Scopus citations

Intracellular calcium dynamics and acceleration of sinus rhythm by β-adrenergic stimulation

Joung, B., Tang, L., Maruyama, M., Han, S., Chen, Z., Stucky, M., Jones, L. R., Fishbein, M. C., Weiss, J. N., Chen, P. S. & Lin, S. F., Feb 17 2009, In : Circulation. 119, 6, p. 788-796 9 p.

Research output: Contribution to journalArticle

77 Scopus citations
2007
47 Scopus citations

Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice

Chopra, N., Kannankeril, P. J., Yang, T., Hlaing, T., Holinstat, I., Ettensohn, K., Pfeifer, K., Akin, B., Jones, L. R., Franzini-Armstrong, C. & Knollmann, B. C., Sep 1 2007, In : Circulation research. 101, 6, p. 617-626 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure

Gergs, U., Berndt, T., Buskase, J., Jones, L. R., Kirchhefer, U., Müller, F. U., Schlüter, K. D., Schmitz, W. & Neumann, J., Jul 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 293, 1, p. H728-H734

Research output: Contribution to journalArticle

41 Scopus citations

Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity

Yuan, Q., Fan, G. C., Dong, M., Altschafl, B., Diwan, A., Ren, X., Hahn, H. H., Zhao, W., Waggoner, J. R., Jones, L. R., Jones, W. K., Bers, D. M., Dorn, G. W., Wang, H. S., Valdivia, H. H., Chu, G. & Kranias, E. G., Jan 1 2007, In : Circulation. 115, 3, p. 300-309 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin

Kirchhof, P., Klimas, J., Fabritz, L., Zwiener, M., Jones, L. R., Schäfers, M., Hermann, S., Boknik, P., Schmitz, W., Breithardt, G., Kirchhefer, U. & Neumann, J., May 1 2007, In : Journal of Molecular and Cellular Cardiology. 42, 5, p. 962-971 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Triadins modulate intracellular Ca2+ homeostasis but are not essential for excitation-contraction coupling in skeletal muscle

Shen, X., Franzini-Armstrong, C., Lopez, J. R., Jones, L. R., Kobayashi, Y. M., Wang, Y., Kerrick, W. G. L., Caswell, A. H., Potter, J. D., Miller, T., Allen, P. D. & Perez, C. F., Dec 28 2007, In : Journal of Biological Chemistry. 282, 52, p. 37864-37874 11 p.

Research output: Contribution to journalArticle

53 Scopus citations
2006

Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia

Knollmann, B. C., Chopra, N., Hlaing, T., Akin, B., Yang, T., Ettensohn, K., Knollmann, B. E. C., Horton, K. D., Weissman, N. J., Holinstat, I., Zhang, W., Roden, D. M., Jones, L. R., Franzini-Armstrong, C. & Pfeifer, K., Sep 1 2006, In : Journal of Clinical Investigation. 116, 9, p. 2510-2520 11 p.

Research output: Contribution to journalArticle

309 Scopus citations
34 Scopus citations

Overexpression of junctin causes adaptive changes in cardiac myocyte Ca2+ signaling

Kirchhefer, U., Hanske, G., Jones, L. R., Justus, I., Kaestner, L., Lipp, P., Schmitz, W. & Neumann, J., Feb 2006, In : Cell Calcium. 39, 2, p. 131-142 12 p.

Research output: Contribution to journalArticle

30 Scopus citations
2005

Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase activity in phospholemman-deficient mice

Jia, L. G., Donnet, C., Bogaev, R. C., Blatt, R. J., McKinney, C. E., Day, K. H., Berr, S. S., Jones, L. R., Moorman, J. R., Sweadner, K. J. & Tucker, A. L., Apr 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 288, 4 57-4, p. H1982-H1988

Research output: Contribution to journalArticle

52 Scopus citations
30 Scopus citations
2004

A beneficial role of cardiac P2X 4 receptors in heart failure: Rescue of the calsequestrin overexpression model of cardiomyopathy

Yang, A., Sonin, D., Jones, L., Barry, W. H. & Liang, B. T., Sep 1 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 287, 3 56-3, p. H1096-H1103

Research output: Contribution to journalArticle

35 Scopus citations

Age-dependent biochemical and contractile properties in atrium of transgenic mice overexpressing junctin

Kirchhefer, U., Baba, H. A., Hanske, G., Jones, L. R., Kirchhof, P., Schmitz, W. & Neumann, J., Nov 1 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 287, 5 56-5, p. H2216-H2225

Research output: Contribution to journalArticle

18 Scopus citations

Effects of Phospholemman Expression on Swelling-Activated ion Currents and Volume Regulation in Embryonic Kidney Cells

Davis, C. E., Patel, M. K., Miller, J. R., John, J. E., Jones, L. R., Tucker, A. L., Mounsey, J. P. & Moorman, J. R., Jan 1 2004, In : Neurochemical Research. 29, 1, p. 177-187 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Improved expression and characterization of Ca2+-ATPase and phospholamban in High-Five cells

Waggoner, J. R., Huffman, J., Griffith, B. N., Jones, L. R. & Mahaney, J. E., Mar 2004, In : Protein Expression and Purification. 34, 1, p. 56-67 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Protein interactions within calcium release units of muscle

Franzini-Armstrong, C., Tijskens, P. & Jones, L. R., Dec 1 2004, In : Journal of Muscle Research and Cell Motility. 25, 8, p. 586-587 2 p.

Research output: Contribution to journalArticle

The Role of Calsequestrin, Triadin, and Junctin Conferring Cardiac Ryanodine Receptor Responsiveness to Luminal Calcium

Györke, I., Hester, N., Jones, L. R. & Györke, S., Apr 2004, In : Biophysical journal. 86, 4, p. 2121-2128 8 p.

Research output: Contribution to journalArticle

Open Access
311 Scopus citations

Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to β-adrenergic agonists

Kirchhefer, U., Jones, L. R., Begrow, F., Boknik, P., Hein, L., Lohse, M. J., Riemann, B., Schmitz, W., Stypmann, J. & Neumann, J., Apr 1 2004, In : Cardiovascular research. 62, 1, p. 122-134 13 p.

Research output: Contribution to journalArticle

24 Scopus citations
2003

Impaired relaxation in transgenic mice overexpressing junctin

Kirchhefer, U., Neumann, J., Bers, D. M., Buchwalow, I. B., Fabritz, L., Hanske, G., Justus, I., Riemann, B., Schmitz, W. & Jones, L. R., Aug 1 2003, In : Cardiovascular research. 59, 2, p. 369-379 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Junctin and calsequestrin overexpression in cardiac muscle: The role of junctin and the synthetic and delivery pathways for the two proteins

Tijskens, P., Jones, L. R. & Franzini-Armstrong, C., Aug 1 2003, In : Journal of Molecular and Cellular Cardiology. 35, 8, p. 961-974 14 p.

Research output: Contribution to journalArticle

46 Scopus citations

Phospholemman, a single-span membrane protein, is an accessory protein of Na,K-ATPase in cerebellum and choroid plexus

Feschenko, M. S., Donnet, C., Wetzel, R. K., Asinovski, N. K., Jones, L. R. & Sweadner, K. J., Mar 15 2003, In : Journal of Neuroscience. 23, 6, p. 2161-2169 9 p.

Research output: Contribution to journalArticle

75 Scopus citations
48 Scopus citations
2002

Altered function in atrium of transgenic mice overexpressing triadin 1

Kirchhefer, U., Baba, H. A., Kobayashi, Y. M., Jones, L. R., Schmitz, W. & Neumann, J., Oct 1 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 4 52-4, p. H1334-H1343

Research output: Contribution to journalArticle

13 Scopus citations
58 Scopus citations

Modulation of gene expression in transgenic mouse hearts overexpressing calsequestrin

Ihara, Y., Suzuki, Y. J., Kitta, K., Jones, L. R. & Ikeda, T., Jul 2002, In : Cell Calcium. 32, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
2001

Artificial ion channels formed by a synthetic cyclic peptide

Wang, D., Guo, L., Zhang, J., Roeske, R. W., Jones, L. R., Chen, Z. & Pritchard, C., Aug 29 2001, In : Journal of Peptide Research. 57, 4, p. 301-306 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Cardiac-directed overexpression of wild-type α1B-adrenergic receptor induces dilated cardiomyopathy

Lemire, I., Ducharme, A., Tardif, J. C., Poulin, F., Jones, L. R., Allen, B. G., Hébert, T. E. & Rindt, H., Aug 29 2001, In : American Journal of Physiology - Heart and Circulatory Physiology. 281, 2 50-2, p. H931-H938

Research output: Contribution to journalArticle

46 Scopus citations

Cardiac Hypertrophy and Impaired Relaxation in Transgenic Mice Overexpressing Triadin 1

Kirchhefer, U., Neumann, J., Baba, H. A., Begrow, F., Kobayashi, Y. M., Reinke, U., Schmitz, W. & Jones, L. R., Feb 9 2001, In : Journal of Biological Chemistry. 276, 6, p. 4142-4149 8 p.

Research output: Contribution to journalArticle

93 Scopus citations

Cardiac βARK1 inhibition prolongs survival and augments β blocker therapy in a mouse model of severe heart failure

Harding, V. B., Jones, L. R., Lefkowitz, R. J., Koch, W. J. & Rockman, H. A., May 8 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 10, p. 5809-5814 6 p.

Research output: Contribution to journalArticle

220 Scopus citations

Gene structure and expression of phospholemman in mouse

Bogaev, R. C., Jia, L. G., Kobayashi, Y. M., Palmer, C. J., Mounsey, J. P., Moorman, J. R., Jones, L. R. & Tucker, A. L., Jun 13 2001, In : Gene. 271, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Locating phospholamban in co-crystals with Ca2+-ATPase by cryoelectron microscopy

Young, H. S., Jones, L. R. & Stokes, D. L., Jan 1 2001, In : Biophysical journal. 81, 2, p. 884-894 11 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Structural alterations in cardiac calcium release units resulting from overexpression of junctin

Zhang, L., Franzini-Armstrong, C., Ramesh, V. & Jones, L. R., Jan 1 2001, In : Journal of Molecular and Cellular Cardiology. 33, 2, p. 233-247 15 p.

Research output: Contribution to journalArticle

53 Scopus citations
2000

Functional properties of transgenic mouse hearts overexpressing both calsequestrin and the Na+-Ca2+ exchanger

Linck, B., Bokník, P., Huke, S., Kirchhefer, U., Knapp, J., Lüss, H., Müller, F. U., Neumann, J., Tanriseven, Z., Vahlensieck, U., Baba, H. A., Jones, L. R., Philipson, K. D. & Schmitz, W., Aug 1 2000, In : Journal of Pharmacology and Experimental Therapeutics. 294, 2, p. 648-657 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Kinetics studies of the cardiac Ca-ATPase expressed in Sf21 cells: New insights on Ca-ATPase regulation by phospholamban

Mahaney, J. E., Autry, J. M. & Jones, L. R., Mar 2000, In : Biophysical Journal. 78, 3, p. 1306-1323 18 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Localization and characterization of the calsequestrin-binding domain of triadin 1. Evidence for a charged β-strand in mediating the protein-protein interaction

Kobayashi, Y. M., Alseikhan, B. A. & Jones, L. R., Jun 9 2000, In : Journal of Biological Chemistry. 275, 23, p. 17639-17646 8 p.

Research output: Contribution to journalArticle

101 Scopus citations

Modulation of focal and global Ca2+ release in calsequestrin-overexpressing mouse cardiomyocytes

Wang, W., Cleemann, L., Jones, L. R. & Morad, M., Apr 2000, In : Journal of Physiology. 524, 2, p. 399-414 16 p.

Research output: Contribution to journalArticle

32 Scopus citations

Phospholemman is a substrate for myotonic dystrophy protein kinase

Mounsey, J. P., John, J. E., Helmke, S. M., Bush, E. W., Gilbert, J., Roses, A. D., Perryman, M. B., Jones, L. R. & Moorman, J. R., Jul 28 2000, In : Journal of Biological Chemistry. 275, 30, p. 23362-23367 6 p.

Research output: Contribution to journalArticle

36 Scopus citations