Lei Wei

  • 5421 Citations
  • 35 h-Index
1988 …2020

Research output per year

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Publications

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Article
2020

ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice

Wei, L., Surma, M., Yang, Y., Tersey, S. & Shi, J., Jan 1 2020, In : FASEB Journal. 34, 1, p. 474-493 20 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging

Shi, J., Surma, M., Yang, Y. & Wei, L., Jun 1 2019, In : FASEB Journal. 33, 6, p. 7348-7362 15 p.

Research output: Contribution to journalArticle

7 Scopus citations
2018

Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxicity

Shi, J., Surma, M. & Wei, L., Jan 1 2018, In : Oncotarget. 9, 16, p. 12995-13008 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis

Yue, X., Lin, X., Yang, T., Yang, X., Yi, X., Jiang, X., Li, X., Li, T., Guo, J., Dai, Y., Shi, J., Wei, L., Youker, K. A., Torre-Amione, G., Yu, Y., Andrade, K. C. & Chang, J., Mar 1 2016, In : Hypertension. 67, 3, p. 597-605 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells

Kapur, R., Shi, J., Ghosh, J., Munugalavadla, V., Sims, E., Martin, H., Wei, L. & Mali, R. S., Mar 29 2016, In : Oncotarget. 7, 13, p. 16936-16947 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Dissecting the mechanisms of doxorubicin and oxidative stress-induced cytotoxicity: The involvement of actin cytoskeleton and ROCK1

Wei, L., Surma, M., Gough, G., Shi, S., Lambert-Cheatham, N., Chang, J. & Shi, J., Jul 2 2015, In : PloS one. 10, 7, e0131763.

Research output: Contribution to journalArticle

24 Scopus citations
2014

Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure

Yue, X., Yang, X., Lin, X., Yang, T., Yi, X., Dai, Y., Guo, J., Li, T., Shi, J., Wei, L., Fan, G. C., Chen, C. & Chang, J., Jun 2014, In : Cell Death and Disease. 5, 6, e1284.

Research output: Contribution to journalArticle

12 Scopus citations

ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment

Surma, M., Handy, C., Chang, J., Kapur, R., Wei, L. & Shi, J., Mar 4 2014, In : PLoS ONE. 9, 3, e90758.

Research output: Contribution to journalArticle

22 Scopus citations

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance

Lee, S. H., Huang, H., Choi, K., Lee, D. H., Shi, J., Liu, T., Chun, K. H., Seo, J. A., Lima, I. S., Zabolotny, J. M., Wei, L. & Kim, Y. B., Feb 1 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 3, p. E332-E343

Research output: Contribution to journalArticle

29 Scopus citations
2013

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

Shi, J., Wu, X., Surma, M., Vemula, S., Zhang, L., Yang, Y., Kapur, R. & Wei, L., Feb 1 2013, In : Cell Death and Disease. 4, 2

Research output: Contribution to journalArticle

91 Scopus citations
2012

Downregulation of doxorubicin-induced myocardial apoptosis accompanies postnatal heart maturation

Shi, J., Zhang, L., Zhang, Y. W., Surma, M., Mark Payne, R. & Wei, L., Apr 15 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 8, p. H1603-H1613

Research output: Contribution to journalArticle

23 Scopus citations

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, Vemula, S., Shi, J., Wei, L., Kapur, R., Lopez, C. K., Gerby, B., Ballerini, P., Pflumio, F., Gilliland, D. G., Goldberg, L., Birger, Y., Izraeli, S., Gamis, A. S., Smith, F. O., Woods, W. G., Taub, J., Scherer, C. A., Bradner, J. E., Goh, B. C., Mercher, T., Carpenter, A. E., Gould, R. J., Clemons, P. A., Carr, S. A., Root, D. E., Schreiber, S. L., Stern, A. M. & Crispino, J. D., Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.

Research output: Contribution to journalArticle

88 Scopus citations

Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1

Yang, X., Li, Q., Lin, X., Ma, Y., Yue, X., Tao, Z., Wang, F., Mckeehan, W. L., Wei, L., Schwartz, R. J. & Chang, J., May 2012, In : FASEB Journal. 26, 5, p. 2105-2116 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Regulation of the actin cytoskeleton by rho kinase controls antigen presentation by CD1d

Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J. & Brutkiewicz, R. R., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1689-1698 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53

Vemula, S., Shi, J., Mali, R. S., Ma, P., Liu, Y., Hanneman, P., Koehler, K. R., Hashino, E., Wei, L. & Kapur, R., Oct 4 2012, In : Blood. 120, 14, p. 2868-2878 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
7 Scopus citations
2011

Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease

Zhou, L., Liu, F., Huang, X. R., Liu, F., Chen, H., Chung, A. C. K., Shi, J., Wei, L., Lan, H. Y. & Fu, P., Nov 1 2011, In : American journal of nephrology. 34, 5, p. 468-475 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Rho-kinase in development and heart failure: Insights from genetic models

Shi, J., Zhang, L. & Wei, L., Mar 1 2011, In : Pediatric Cardiology. 32, 3, p. 297-304 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R. J., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. S. & Kapur, R., Sep 1 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

59 Scopus citations

ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency

Zhang, L., Valdez, J. M., Zhang, B., Wei, L., Chang, J. & Xin, L., Apr 1 2011, In : PloS one. 6, 3, e18271.

Research output: Contribution to journalArticle

60 Scopus citations
2010

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

Vemula, S., Shi, J., Hanneman, P., Wei, L. & Kapur, R., Mar 4 2010, In : Blood. 115, 9, p. 1785-1796 12 p.

Research output: Contribution to journalArticle

85 Scopus citations

ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice

Shi, J., Zhang, Y. W., Yang, Y., Zhang, L. & Wei, L., Nov 1 2010, In : Journal of Molecular and Cellular Cardiology. 49, 5, p. 819-828 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
2009

Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation

Haudek, S. B., Gupta, D., Dewald, O., Schwartz, R. J., Wei, L., Trial, J. & Entman, M. L., Aug 2009, In : Cardiovascular research. 83, 3, p. 511-518 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Targeted disruption of ROCK1 causes insulin resistance in vivo

Lee, D. H., Shi, J., Jeoung, N. H., Kim, M. S., Zabolotny, J. M., Lee, S. W., White, M. F., Wei, L. & Kim, Y. B., May 1 2009, In : Journal of Biological Chemistry. 284, 18, p. 11776-11780 5 p.

Research output: Contribution to journalArticle

82 Scopus citations
2008

Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy

Shi, J., Zhang, Y. W., Summers, L. J., Dorn, G. W. & Wei, L., Mar 1 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 551-560 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2007

Double-inducible gene activation system for caspase 3 and 9 in epidermis

Shah, V. R., Koster, M. I., Roop, D. R., Spencer, D. M., Wei, L., Li, Q., Schwartz, R. J. & Chang, J., Apr 1 2007, In : Genesis. 45, 4, p. 194-199 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
2006

Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis

Chang, J., Xie, M., Shah, V. R., Schneider, M. D., Entman, M. L., Wei, L. & Schwartz, R. J., Sep 26 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 39, p. 14495-14500 6 p.

Research output: Contribution to journalArticle

171 Scopus citations

Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs

Iyer, D., Chang, D., Marx, J., Wei, L., Olson, E. M., Parmaceki, M. S., Balasubramanyam, A. & Schwartz, R. J., Mar 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 12, p. 4516-4521 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice

Fu, P., Liu, F., Su, S., Wang, W., Huang, X. R., Entman, M. L., Schwartz, R. J., Wei, L. & Lan, H. Y., Nov 1 2006, In : Journal of the American Society of Nephrology. 17, 11, p. 3105-3114 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

Zhang, Y. M., Bo, J., Taffet, G. E., Chang, J., Shi, J., Reddy, A. K., Michael, L. H., Schneider, M. D., Entman, M. L., Schwartz, R. J. & Wei, L., May 1 2006, In : FASEB Journal. 20, 7, p. 916-925 10 p.

Research output: Contribution to journalArticle

155 Scopus citations
2005

Cardiac-specific and ligand-inducible target gene expression in transgenic mice

Bo, J., Yu, W., Zhang, Y. M., Demayo, F. J. & Wei, L., Apr 2005, In : Journal of Molecular and Cellular Cardiology. 38, 4, p. 685-691 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

RhoA GTPase regulates L-type Ca2+ currents in cardiac myocytes

Yatani, A., Irie, K., Otani, T., Abdellatif, M. & Wei, L., Feb 1 2005, In : American Journal of Physiology - Heart and Circulatory Physiology. 288, 2 57-2, p. H650-H659

Research output: Contribution to journalArticle

35 Scopus citations
2004

Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-κB transcription factor

Kumar, A., Murphy, R., Robinson, P., Wei, L. & Boriek, A. M., Oct 1 2004, In : FASEB Journal. 18, 13, p. 1524-1535 12 p.

Research output: Contribution to journalArticle

88 Scopus citations

Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved.

Wei, L., Taffet, G. E., Khoury, D. S., Bo, J., Li, Y., Yatani, A., Delaughter, M. C., Klevitsky, R., Hewett, T. E., Robbins, J., Michael, L. H., Schneider, M. D., Entman, M. L. & Schwartz, R. J., May 2004, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18, 7, p. 857-859 3 p.

Research output: Contribution to journalArticle

34 Scopus citations

Induction and reversal of cardiac phenotype of human hypertrophic cardiomyopathy mutation cardiac troponin T-Q92 in switch on-switch off bigenic mice

Lutucuta, S., Tsybouleva, N., Ishiyama, M., DeFreitas, G., Wei, L., Carabello, B. & Marian, A. J., Dec 7 2004, In : Journal of the American College of Cardiology. 44, 11, p. 2221-2230 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2003

Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading

Chang, J., Wei, L., Otani, T., Youker, K. A., Entman, M. L. & Schwartz, R. J., Jul 29 2003, In : Circulation. 108, 4, p. 407-413 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Novel phosphorylation target in the serum response factor MADS box regulates α-actin transcription

Iyer, D., Belaguli, N., Flück, M., Rowan, B. G., Wei, L., Weigel, N. L., Booth, F. W., Epstein, H. F., Schwartz, R. J. & Balasubramanyam, A., Jun 24 2003, In : Biochemistry. 42, 24, p. 7477-7486 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
2001

Rho kinases play an obligatory role in vertebrate embryonic organogenesis

Wei, L., Roberts, W., Wang, L., Yamada, M., Zhang, S., Zhao, Z., Rivkees, S. A., Schwartz, R. J. & Imanaka-Yoshida, K., 2001, In : Development. 128, 15, p. 2953-2962 10 p.

Research output: Contribution to journalArticle

186 Scopus citations

β1 integrin and organized actin filaments facilitate cardiomyocytes-specific RhoA-dependent activation of the skeletal α-actin promoter

Wei, L., Wang, L., Carson, J. A., Agan, J. E., Imanaka-Yoshida, K. & Schwartz, R. J., Apr 10 2001, In : FASEB Journal. 15, 3, p. 785-796 12 p.

Research output: Contribution to journalArticle

59 Scopus citations
2000

β-Integrin and PI 3-kinase regulate RhoA-dependent activation of skeletal α-actin promoter in myoblasts

Wei, L., Zhou, W., Wang, L. U. & Schwartz, R. J., Jun 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 278, 6 47-6, p. H1736-H1743

Research output: Contribution to journalArticle

33 Scopus citations
1998

RhoA signaling via serum response factor plays an obligatory role in myogenic differentiation

Wei, L., Zhou, W., Croissant, J. D., Johansen, F. E., Prywes, R., Balasubramanyam, A. & Schwartz, R. J., Nov 13 1998, In : Journal of Biological Chemistry. 273, 46, p. 30287-30294 8 p.

Research output: Contribution to journalArticle

133 Scopus citations
1996

Structural studies of receptor tyrosine kinases

Hubbard, S. R., Mohammadi, M., Schlessinger, J., Wei, L., Ellis, L. & Hendrickson, W. A., Dec 1 1996, In : FASEB Journal. 10, 6, p. A987

Research output: Contribution to journalArticle

1995

A basic residue C-terminal to tyrosine compromises its viability as a tyrosine kinase target

Keane, N. E., Quirk, P. G., Levine, B. A., Chavanieu, A., Calas, B., Gao, Y., Wei, L. & Ellis, L., Jan 1 1995, In : Biochemical Society transactions. 23, 2, p. 192S

Research output: Contribution to journalArticle

1 Scopus citations

Expression, characterization, and crystallization of the catalytic core of the human insulin receptor protein-tyrosine kinase domain

Wei, L., Hubbard, S. R., Hendrickson, W. A. & Ellis, L., Jan 1 1995, In : Journal of Biological Chemistry. 270, 14, p. 8122-8130 9 p.

Research output: Contribution to journalArticle

111 Scopus citations
1994

Crystal structure of the tyrosine kinase domain of the human insulin receptor

Hubbard, S. R., Wei, L. & Hendrickson, W. A., Jan 1 1994, In : Nature. 372, 6508, p. 746-754 9 p.

Research output: Contribution to journalArticle

889 Scopus citations

Phosphorylation Effects on Flanking Charged Residues: Structural Implications for Signal Transduction in Protein Kinases

Chavanieu, A., Keane, N. E., Quirk, P. G., Levine, B. A., Calas, B., Wei, L. & Ellis, L., Aug 1994, In : European Journal of Biochemistry. 224, 1, p. 115-123 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Protein kinase superfamily - comparisons of sequence data with three-dimensional structures

Wei, L., Hubbard, S. R., Smith, R. F. & Ellis, L., Jun 1994, In : Current Opinion in Structural Biology. 4, 3, p. 450-455 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Structural Determinants of Substrate Selection by the Human Insulin‐Receptor Protein‐Tyrosine Kinase

Keane, N. E., Chavanieu, A., Quirk, P. G., Evans, J. S., Levine, B. A., Calas, B., Wei, L. & Ellis, L., Dec 1994, In : European Journal of Biochemistry. 226, 2, p. 525-536 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structure-function analysis of angiotensin I-converting enzyme using monoclonal antibodies. Selective inhibition of the amino-terminal active site

Danilov, S., Jaspard, E., Churakova, T., Towbin, H., Savoie, F., Wei, L. & Alhenc- Gelas, F., Jan 1 1994, In : Journal of Biological Chemistry. 269, 43, p. 26806-26814 9 p.

Research output: Contribution to journalArticle

107 Scopus citations