• 11928 Citations
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1992 …2020

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2020

Bcl6 and Blimp1 reciprocally regulate ST2+ Treg–cell development in the context of allergic airway inflammation

Koh, B., Ulrich, B. J., Nelson, A. S., Panangipalli, G., Kharwadkar, R., Wu, W., Xie, M. M., Fu, Y., Turner, M. J., Paczesny, S., Janga, S. C., Dent, A. L. & Kaplan, M. H., Jan 1 2020, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Open Access

Calcitriol regulates the differentiation of IL-9-secreting Th9 cells by modulating the transcription factor PU.1

Vyas, S. P., Hansda, A. K., Kaplan, M. H. & Goswami, R., Mar 1 2020, In : Journal of Immunology. 204, 5, p. 1201-1213 13 p.

Research output: Contribution to journalArticle

Ex vivo culture of mouse skin activates an interleukin 1 alpha-dependent inflammatory response

Zhou, H. M., Slominski, R. M., Seymour, L. J., Bell, M. C., Dave, P., Atumonye, J., Wright, W., Dawes, A., Griesenauer, B., Paczesny, S., Kaplan, M. H., Spandau, D. F. & Turner, M. J., Jan 1 2020, In : Experimental Dermatology. 29, 1, p. 102-106 5 p.

Research output: Contribution to journalArticle

T follicular regulatory cells and IL-10 promote food antigen-specific IgE

Xie, M. M., Chen, Q., Liu, H., Yang, K., Koh, B., Wu, H., Maleki, S. J., Hurlburt, B. K., Cook-Mills, J., Kaplan, M. H. & Dent, A. L., Jul 1 2020, In : The Journal of clinical investigation. 130, 7, p. 3820-3832 13 p.

Research output: Contribution to journalArticle

Open Access

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL

Rodriguez, S., Abundis, C., Boccalatte, F., Mehrotra, P., Chiang, M. Y., Yui, M. A., Wang, L., Zhang, H., Zollman, A., Bonfim-Silva, R., Kloetgen, A., Palmer, J., Sandusky, G., Wunderlich, M., Kaplan, M. H., Mulloy, J. C., Marcucci, G., Aifantis, I., Cardoso, A. A. & Carlesso, N., May 1 2020, In : Leukemia. 34, 5, p. 1241-1252 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells

Augusto, L., Martynowicz, J., Amin, P. H., Alakhras, N. S., Kaplan, M. H., Wek, R. C. & Sullivan, W. J., Aug 2020, In : mBio. 11, 4, p. 1-13 13 p., e00915-20.

Research output: Contribution to journalArticle

Open Access
2019

BAtF-interacting proteins dictate specificity in th subset activity

Fu, Y., Koh, B., Kuwahara, M., Ulrich, B. J., Kharwadkar, R., Yamashita, M. & Kaplan, M. H., Oct 1 2019, In : Journal of Immunology. 203, 7, p. 1989-1998 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Garg, G., Muschaweckh, A., Moreno, H., Vasanthakumar, A., Floess, S., Lepennetier, G., Oellinger, R., Zhan, Y., Regen, T., Hiltensperger, M., Peter, C., Aly, L., Knier, B., Palam, L. R., Kapur, R., Kaplan, M. H., Waisman, A., Rad, R., Schotta, G., Huehn, J. & 2 others, Kallies, A. & Korn, T., Feb 12 2019, In : Cell Reports. 26, 7, p. 1854-1868.e5

Research output: Contribution to journalArticle

14 Scopus citations

Covalent heterobivalent inhibitor design for inhibition of IgE-dependent penicillin allergy in a murine model

Deak, P. E., Kim, B., Koh, B., Qayum, A. A., Kiziltepe, T., Kaplan, M. H. & Bilgicer, B., 2019, In : Journal of Immunology. 203, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen

Deak, P. E., Kim, B., Qayum, A. A., Shin, J., Vitalpur, G., Kloepfer, K. M., Turner, M. J., Smith, N., Shreffler, W. G., Kiziltepe, T., Kaplan, M. H. & Bilgicer, B., Apr 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 18, p. 8966-8974 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination

Frossi, B., Antoniali, G., Yu, K., Akhtar, N., Kaplan, M. H., Kelley, M. R., Tell, G. & Pucillo, C. E. M., Mar 29 2019, In : Journal of Biological Chemistry. 294, 13, p. 5198-5207 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

PD-1hi CD8+ resident memory T cells balance immunity and fibrotic sequelae

Wang, Z., Wang, S., Goplen, N. P., Li, C., Cheon, I. S., Dai, Q., Huang, S., Shan, J., Ma, C., Ye, Z., Xiang, M., Limper, A. H., Porquera, E. C., Kohlmeier, J. E., Kaplan, M., Zhang, N., Johnson, A. J., Vassallo, R. & Sun, J., Jan 1 2019, In : Science Immunology. 4, 36, eaaw1217.

Research output: Contribution to journalArticle

3 Scopus citations

PPAR-γ in macrophages limits pulmonary inflammation and promotes host recovery following respiratory viral infection

Huang, S., Zhu, B., Cheon, I. S., Goplen, N. P., Jiang, L., Zhang, R., Stokes Peebles, R., Mack, M., Kaplan, M. H., Limper, A. H. & Sun, J., May 1 2019, In : Journal of virology. 93, 9, e00030-19.

Research output: Contribution to journalArticle

6 Scopus citations

PU.1 controls fibroblast polarization and tissue fibrosis

Wohlfahrt, T., Rauber, S., Uebe, S., Luber, M., Soare, A., Ekici, A., Weber, S., Matei, A. E., Chen, C. W., Maier, C., Karouzakis, E., Kiener, H. P., Pachera, E., Dees, C., Beyer, C., Daniel, C., Gelse, K., Kremer, A. E., Naschberger, E., Stürzl, M. & 14 others, Butter, F., Sticherling, M., Finotto, S., Kreuter, A., Kaplan, M. H., Jüngel, A., Gay, S., Nutt, S. L., Boykin, D. W., Poon, G. M. K., Distler, O., Schett, G., Distler, J. H. W. & Ramming, A., Feb 21 2019, In : Nature. 566, 7744, p. 344-349 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

The Il9 CNS-25 regulatory element controls mast cell and basophil IL-9 production

Qayum, A. A., Koh, B., Martin, R. K., Kenworthy, B. T., Kharwadkar, R., Fu, Y., Wu, W., Conrad, D. H. & Kaplan, M. H., Sep 1 2019, In : Journal of Immunology. 203, 5, p. 1111-1121 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., Ye, Z., Beckermann, K. E., Wu, Y., Jenkins, J. W., Siska, P. J., Vincent, B. G., Prakash, Y. S., Peikert, T., Edelson, B. T., Taneja, R., Kaplan, M. H., Rathmell, J. C., Dong, H., Hitosugi, T. & 1 others, Sun, J., Sep 17 2019, In : Immunity. 51, 3, p. 491-507.e7

Research output: Contribution to journalArticle

10 Scopus citations
2018

A conserved enhancer regulates Il9 expression in multiple lineages

Koh, B., Abdul Qayum, A., Srivastava, R., Fu, Y., Ulrich, B. J., Janga, S. C. & Kaplan, M. H., Dec 1 2018, In : Nature communications. 9, 1, 4803.

Research output: Contribution to journalArticle

11 Scopus citations

Mechanism for initiation of food allergy: Dependence on skin barrier mutations and environmental allergen costimulation

Walker, M. T., Green, J. E., Ferrie, R. P., Queener, A. M., Kaplan, M. H. & Cook-Mills, J. M., May 2018, In : Journal of Allergy and Clinical Immunology. 141, 5, p. 1711-1725.e9

Research output: Contribution to journalArticle

19 Scopus citations

Neonatal hyperoxia promotes asthma-like features through IL-33–dependent ILC2 responses

Cheon, I. S., Son, Y. M., Jiang, L., Goplen, N. P., Kaplan, M. H., Limper, A. H., Kita, H., Paczesny, S., Prakash, Y. S., Tepper, R., Ahlfeld, S. K. & Sun, J., Oct 2018, In : Journal of Allergy and Clinical Immunology. 142, 4, p. 1100-1112 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Opening the Black Box of Immunosuppression

Kaplan, M., Dec 1 2018, In : Journal of immunology (Baltimore, Md. : 1950). 201, 11, p. 3147-3148 2 p.

Research output: Contribution to journalArticle

Phenotyping acute and chronic atopic dermatitis-like lesions in Stat6VT mice identifies a role for IL-33 in disease pathogenesis

DaSilva-Arnold, S. C., Thyagarajan, A., Seymour, L. J., Yi, Q., Bradish, J. R., Al-Hassani, M., Zhou, H., Perdue, N. J., Nemeth, V., Krbanjevic, A., Serezani, A. P. M., Olson, M. R., Spandau, D. F., Travers, J. B., Kaplan, M. H. & Turner, M. J., Apr 1 2018, In : Archives of Dermatological Research. 310, 3, p. 197-207 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Platelet-activating factor-induced reduction in contact hypersensitivity responses is mediated by mast cells via cyclooxygenase-2-dependent mechanisms

Ocana, J. A., Romer, E., Sahu, R., Pawelzik, S. C., FitzGerald, G. A., Kaplan, M. H. & Travers, J. B., Jun 15 2018, In : Journal of Immunology. 200, 12, p. 4004-4011 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells

Hashimoto-Hill, S., Friesen, L., Park, S., Im, S., Kaplan, M. H. & Kim, C. H., Dec 1 2018, In : Nature communications. 9, 1, 3896.

Research output: Contribution to journalArticle

3 Scopus citations

STAT6 and furin are successive triggers for the production of TGF-β by T cells

Li, Y., Liu, W., Guan, X., Truscott, J., Creemers, J. W., Chen, H. L., Pesu, M., Abiad, R. G. E., Karacay, B., Urban, J. F., Elliott, D. E., Kaplan, M. H., Blazar, B. R. & Nedim Ince, M., Nov 1 2018, In : Journal of Immunology. 201, 9, p. 2612-2623 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

Kälin, S., Becker, M., Ott, V. B., Serr, I., Hosp, F., Mollah, M. M. H., Keipert, S., Lamp, D., Rohner-Jeanrenaud, F., Flynn, V. K., Scherm, M. G., Nascimento, L. F. R., Gerlach, K., Popp, V., Dietzen, S., Bopp, T., Krishnamurthy, P., Kaplan, M. H., Serrano, M., Woods, S. C. & 10 others, Tripal, P., Palmisano, R., Jastroch, M., Blüher, M., Wolfrum, C., Weigmann, B., Ziegler, A. G., Mann, M., Tschöp, M. H. & Daniel, C., Sep 5 2017, In : Cell Metabolism. 26, 3, p. 475-492.e7

Research output: Contribution to journalArticle

17 Scopus citations

Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice

Xie, M. M., Koh, B. H., Hollister, K., Wu, H., Sun, J., Kaplan, M. H. & Dent, A. L., Jul 2017, In : European Journal of Immunology. 47, 7, p. 1136-1141 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation

Cheung, K. L., Zhang, F., Jaganathan, A., Sharma, R., Zhang, Q., Konuma, T., Shen, T., Lee, J. Y., Ren, C., Chen, C. H., Lu, G., Olson, M. R., Zhang, W., Kaplan, M. H., Littman, D. R., Walsh, M. J., Xiong, H., Zeng, L. & Zhou, M. M., Mar 16 2017, In : Molecular Cell. 65, 6, p. 1068-1080.e5

Research output: Contribution to journalArticle

31 Scopus citations

Etv5 regulates il-10 production in th cells

Koh, B., Hufford, M. M., Sun, X. & Kaplan, M., Mar 1 2017, In : Journal of Immunology. 198, 5, p. 2165-2171 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

IL-4 impairs wound healing potential in the skin by repressing fibronectin expression

Serezani, A. P. M., Bozdogan, G., Sehra, S., Walsh, D., Krishnamurthy, P., Sierra Potchanant, E. A., Nalepa, G., Goenka, S., Turner, M. J., Spandau, D. F. & Kaplan, M. H., Jan 1 2017, In : Journal of Allergy and Clinical Immunology. 139, 1, p. 142-151.e5

Research output: Contribution to journalArticle

19 Scopus citations

Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation

Dobrian, A. D., Ma, K., Glenn, L. M., Hatcher, M. A., Haynes, B. A., Lehrer, E. J., Kaplan, M. H. & Nadler, J. L., 2017, In : Mediators of Inflammation. 2017, 5420718.

Research output: Contribution to journalArticle

3 Scopus citations

Paracrine IL-2 is required for optimal type 2 effector cytokine production

Olson, M. R., Ulrich, B. J., Hummel, S. A., Khan, I., Meuris, B., Cherukuri, Y., Dent, A. L., Janga, S. C. & Kaplan, M. H., Jun 1 2017, In : Journal of Immunology. 198, 11, p. 4352-4359 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Poly-ADP ribose polymerase-14 limits severity of allergic skin disease

Krishnamurthy, P., Da-Silva-Arnold, S., Turner, M. J., Travers, J. B. & Kaplan, M. H., Nov 2017, In : Immunology. 152, 3, p. 451-461 11 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors

Kobayashi, M., Nabinger, S. C., Bai, Y., Yoshimoto, M., Gao, R., Chen, S., Yao, C., Dong, Y., Zhang, L., Rodriguez, S., Yashiro-Ohtani, Y., Pear, W. S., Carlesso, N., Yoder, M. C., Kapur, R., Kaplan, M. H., Daniel Lacorazza, H., Zhang, Z. Y. & Liu, Y., Apr 1 2017, In : STEM CELLS. 35, 4, p. 1053-1064 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells

Rauber, S., Luber, M., Weber, S., Maul, L., Soare, A., Wohlfahrt, T., Lin, N. Y., DIetel, K., Bozec, A., Herrmann, M., Kaplan, M. H., Weigmann, B., Zaiss, M. M., Fearon, U., Veale, D. J., Cañete, J. D., DIstler, O., Rivellese, F., Pitzalis, C., Neurath, M. F. & 5 others, McKenzie, A. N. J., Wirtz, S., Schett, G., DIstler, J. H. W. & Ramming, A., Aug 1 2017, In : Nature Medicine. 23, 8, p. 938-944 7 p.

Research output: Contribution to journalArticle

92 Scopus citations

Specifically differentiated T cell subset promotes tumor immunity over fatal immunity

Ramadan, A., Griesenauer, B., Adom, D., Kapur, R., Hanenberg, H., Liu, C., Kaplan, M. H. & Paczesny, S., Dec 1 2017, In : Journal of Experimental Medicine. 214, 12, p. 3577-3596 20 p.

Research output: Contribution to journalArticle

21 Scopus citations

STAT3 activation impairs the stability of Th9 cells

Ulrich, B. J., Verdan, F. F., McKenzie, A. N. J., Kaplan, M. H. & Olson, M. R., Mar 15 2017, In : Journal of Immunology. 198, 6, p. 2302-2309 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

STAT4 regulates the CD8+ regulatory T Cell/T follicular helper cell axis and promotes atherogenesis in insulin-resistant Ldlr-/- Mice

Taghavie-Moghadam, P. L., Waseem, T. C., Hattler, J., Glenn, L. M., Dobrian, A. D., Kaplan, M. H., Yang, Y., Nurieva, R., Nadler, J. L. & Galkina, E. V., Nov 15 2017, In : Journal of Immunology. 199, 10, p. 3453-3465 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Increased prevalence of airway reactivity in children with eosinophilic esophagitis

Krupp, N. L., Sehra, S., Slaven, J. E., Kaplan, M. H., Gupta, S. & Tepper, R. S., May 1 2016, In : Pediatric pulmonology. 51, 5, p. 478-483 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Increased Th2 activity and diminished skin barrier function cooperate in allergic skin inflammation

Sehra, S., Krishnamurthy, P., Koh, B., Zhou, H. M., Seymour, L., Akhtar, N., Travers, J. B., Turner, M. J. & Kaplan, M. H., Nov 1 2016, In : European Journal of Immunology. 46, 11, p. 2609-2613 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mast Cells Regulate Epidermal Barrier Function and the Development of Allergic Skin Inflammation

Sehra, S., Serezani, A. P. M., Ocaña, J. A., Travers, J. B. & Kaplan, M. H., Jul 1 2016, In : Journal of Investigative Dermatology. 136, 7, p. 1429-1437 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

STAT3 impairs STAT5 activation in the development of IL-9-secreting T cells

Olson, M. R., Fortino Verdan, F., Hufford, M. M., Dent, A. L. & Kaplan, M. H., Apr 15 2016, In : Journal of Immunology. 196, 8, p. 3297-3304 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity

Varikuti, S., Oghumu, S., Natarajan, G., Kimble, J., Sperling, R. H., Moretti, E., Kaplan, M. & Satoskar, A. R., Nov 1 2016, In : International Immunology. 28, 11, p. 565-570 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Th9 cells in immunity and immunopathological diseases

Neurath, M. F. & Kaplan, M., Nov 29 2016, (Accepted/In press) In : Seminars in Immunopathology. p. 1-4 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

The ETS family transcription factors Etv5 and PU.1 function in parallel to promote Th9 cell development

Koh, B., Hufford, M. M., Pham, D., Olson, M. R., Wu, T., Jabeen, R., Sun, X. & Kaplan, M. H., Sep 15 2016, In : Journal of Immunology. 197, 6, p. 2465-2472 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2015

Altered STAT4 Isoform Expression in Patients with Inflammatory Bowel Disease

Jabeen, R., Miller, L., Yao, W., Gupta, S., Steiner, S. & Kaplan, M. H., Jul 20 2015, In : Inflammatory bowel diseases. 21, 10, p. 2383-2392 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

An inhibitory role for the transcription factor Stat3 in controlling IL-4 and Bcl6 expression in follicular helper T cells

Wu, H., Xu, L. L., Teuscher, P., Liu, H., Kaplan, M. H. & Dent, A. L., Sep 1 2015, In : Journal of Immunology. 195, 5, p. 2080-2089 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

CD4 T cells but not Th17 cells are required for mouse lung transplant obliterative bronchiolitis

Wu, Q., Gupta, P. K., Suzuki, H., Wagner, S. R., Zhang, C., Cummings, O. W., Fan, L., Kaplan, M. H., Wilkes, D. S. & Shilling, R. A., Jul 1 2015, In : American Journal of Transplantation. 15, 7, p. 1793-1804 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK

Ebel, M. E., Awe, O., Kaplan, M. H. & Kansas, G. S., Jun 15 2015, In : Journal of Immunology. 194, 12, p. 5781-5788 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Exhaled nitric oxide during infancy as a risk factor for asthma and airway hyperreactivity

Chang, D., Yao, W., Tiller, C. J., Kisling, J., Slaven, J. E., Yu, Z., Kaplan, M. H. & Tepper, R. S., Jan 1 2015, In : European Respiratory Journal. 45, 1, p. 98-106 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease

Becker, M., De Bastiani, M. A., Parisi, M. M., Guma, F. T. C. R., Markoski, M. M., Castro, M. A. A., Kaplan, M. H., Barbé-Tuana, F. M. & Klamt, F., Aug 25 2015, In : Scientific reports. 5, 13351.

Research output: Contribution to journalArticle

21 Scopus citations