Mark Kelley

  • 9754 Citations
  • 60 h-Index
1983 …2019
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  • 15 Similar Profiles
DNA Repair Medicine & Life Sciences
DNA-(Apurinic or Apyrimidinic Site) Lyase Medicine & Life Sciences
Oxidation-Reduction Medicine & Life Sciences
DNA Medicine & Life Sciences
Repair Chemical Compounds
Endonucleases Medicine & Life Sciences
Proteins Medicine & Life Sciences
DNA Damage Medicine & Life Sciences

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NIH Grants 1993 2017

Sensory Receptor Cells
DNA Repair
DNA Damage
Inflammation
Dinoprostone
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Recurrence
Oxidation-Reduction
T-Cell Leukemia
Pancreatic Neoplasms
Oxidation-Reduction
gemcitabine
Neoplasms
Adenocarcinoma

Publications 1983 2019

  • 9754 Citations
  • 60 h-Index
  • 194 Article
  • 3 Chapter
  • 2 Book
  • 1 Comment/debate

Antitumor activity and mechanistic characterization of APE1/ReF-1 inhibitors in bladder cancer

Fishel, M. L., Xia, H., McGeown, J., McIlwain, D. W., Elbanna, M., Craft, A. A., Kaimakliotis, H. Z., Sandusky, G. E., Zhang, C., Pili, R., Kelley, M. R. & Jerde, T. J., Jan 1 2019, In : Molecular cancer therapeutics. 18, 11, p. 1947-1960 14 p.

Research output: Contribution to journalArticle

Endonucleases
Urinary Bladder Neoplasms
Oxidation-Reduction
Cisplatin
Cell Proliferation

Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1

Trilles, R., Beglov, D., Chen, Q., He, H., Wireman, R., Reed, A., Chennamadhavuni, S., Panek, J. S., Brown, L. E., Vajda, S., Porco, J. A., Kelley, M. & Georgiadis, M., Jan 1 2019, In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Endonucleases
Neoplasms
Oxidants
DNA Repair
2 Citations (Scopus)

Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination

Frossi, B., Antoniali, G., Yu, K., Akhtar, N., Kaplan, M., Kelley, M., Tell, G. & Pucillo, C. E. M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 5198-5207 10 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Endonucleases
Human Activities
Immunoglobulin A
Genetic Recombination

Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway

Codrich, M., Comelli, M., Malfatti, M. C., Mio, C., Ayyildiz, D., Zhang, C., Kelley, M., Terrosu, G., Pucillo, C. E. M. & Tell, G., Oct 1 2019, In : DNA Repair. 82, 102675.

Research output: Contribution to journalArticle

Enzyme inhibition
Endonucleases
Metabolism
Colonic Neoplasms
Colorectal Neoplasms
4 Citations (Scopus)

APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells

McIlwain, D. W., Fishel, M., Boos, A., Kelley, M. & Jerde, T., Jan 1 2018, In : Oncotarget. 9, 13, p. 10962-10977 16 p.

Research output: Contribution to journalArticle

Endonucleases
Cell Cycle Checkpoints
Oxidation-Reduction
Prostatic Neoplasms
Proteins