Mark Kelley

  • 9582 Citations
  • 60 h-Index
1983 …2019
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  • 13 Similar Profiles
DNA Repair Medicine & Life Sciences
DNA-(Apurinic or Apyrimidinic Site) Lyase Medicine & Life Sciences
Oxidation-Reduction Medicine & Life Sciences
DNA Medicine & Life Sciences
Repair Chemical Compounds
Endonucleases Medicine & Life Sciences
Proteins Medicine & Life Sciences
DNA Damage Medicine & Life Sciences

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NIH Grants 1993 2017

Sensory Receptor Cells
DNA Repair
DNA Damage
Precursor Cell Lymphoblastic Leukemia-Lymphoma
T-Cell Leukemia
Pancreatic Neoplasms

Publications 1983 2019

  • 9582 Citations
  • 60 h-Index
  • 193 Article
  • 3 Chapter
  • 2 Book
  • 1 Comment/debate

Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1

Trilles, R., Beglov, D., Chen, Q., He, H., Wireman, R., Reed, A., Chennamadhavuni, S., Panek, J. S., Brown, L. E., Vajda, S., Porco, J. A., Kelley, M. & Georgiadis, M., Jan 1 2019, In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Repair
2 Citations (Scopus)

Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination

Frossi, B., Antoniali, G., Yu, K., Akhtar, N., Kaplan, M., Kelley, M., Tell, G. & Pucillo, C. E. M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 5198-5207 10 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Human Activities
Immunoglobulin A
Genetic Recombination

Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway

Codrich, M., Comelli, M., Malfatti, M. C., Mio, C., Ayyildiz, D., Zhang, C., Kelley, M., Terrosu, G., Pucillo, C. E. M. & Tell, G., Oct 1 2019, In : DNA Repair. 82, 102675.

Research output: Contribution to journalArticle

Enzyme inhibition
Colonic Neoplasms
Colorectal Neoplasms
2 Citations (Scopus)

APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells

McIlwain, D. W., Fishel, M., Boos, A., Kelley, M. & Jerde, T., Jan 1 2018, In : Oncotarget. 9, 13, p. 10962-10977 16 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Prostatic Neoplasms
1 Citation (Scopus)

APX3330 promotes neurorestorative effects after stroke in type one diabetic rats

Yan, T., Venkat, P., Chopp, M., Zacharek, A., Yu, P., Ning, R., Qiao, X., Kelley, M. & Chen, J., Jun 1 2018, In : Aging and Disease. 9, 3, p. 453-466 14 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Plasminogen Activator Inhibitor 1
Matrix Metalloproteinase 9