Melissa Fishel

  • 2062 Citations
  • 26 h-Index
20022019

Research output per year

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Publications

  • 2062 Citations
  • 26 h-Index
  • 41 Article
  • 7 Review article
  • 3 Chapter
  • 1 Book
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Article
2019

Antitumor activity and mechanistic characterization of APE1/ReF-1 inhibitors in bladder cancer

Fishel, M. L., Xia, H., McGeown, J., McIlwain, D. W., Elbanna, M., Craft, A. A., Kaimakliotis, H. Z., Sandusky, G. E., Zhang, C., Pili, R., Kelley, M. R. & Jerde, T. J., 2019, In : Molecular cancer therapeutics. 18, 11, p. 1947-1960 14 p.

Research output: Contribution to journalArticle

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer

Shouksmith, A. E., Shah, F., Grimard, M. L., Gawel, J. M., Raouf, Y. S., Geletu, M., Berger-Becvar, A., De Araujo, E. D., Luchman, H. A., Heaton, W. L., Bakhshinyan, D., Adile, A. A., Venugopal, C., O'Hare, T., Deininger, M. W., Singh, S. K., Konieczny, S. F., Weiss, S., Fishel, M. L. & Gunning, P. T., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2651-2665 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

LTMG: a novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data

Wan, C., Chang, W., Zhang, Y., Shah, F., Lu, X., Zang, Y., Zhang, A., Cao, S., Fishel, M. L., Ma, Q. & Zhang, C., Oct 10 2019, In : Nucleic acids research. 47, 18, p. e111

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells

McIlwain, D. W., Fishel, M. L., Boos, A., Kelley, M. R. & Jerde, T. J., 2018, In : Oncotarget. 9, 13, p. 10962-10977 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival

Logsdon, D. P., Shah, F., Carta, F., Supuran, C. T., Kamocka, M., Jacobsen, M. H., Sandusky, G. E., Kelley, M. R. & Fishel, M. L., Dec 1 2018, In : Scientific reports. 8, 1, 13759.

Research output: Contribution to journalArticle

5 Scopus citations

Development of a Novel 3D Tumor-tissue Invasion Model for High-throughput, High-content Phenotypic Drug Screening

Puls, T. J., Tan, X., Husain, M., Whittington, C. F., Fishel, M. L. & Voytik-Harbin, S. L., Dec 1 2018, In : Scientific reports. 8, 1, 13039.

Research output: Contribution to journalArticle

9 Scopus citations

Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition

Marisol Herrera-Perez, R., Voytik-Harbin, S. L., Sarkaria, J. N., Pollok, K. E., Fishel, M. L. & Rickus, J. L., Mar 2018, In : PloS one. 13, 3, e0194183.

Research output: Contribution to journalArticle

10 Scopus citations

PTEN-Dependent Stabilization of MTSS1 Inhibits Metastatic Phenotype in Pancreatic Ductal Adenocarcinoma

Zeleniak, A. E., Huang, W., Fishel, M. L. & Hill, R., Jan 2018, In : Neoplasia (United States). 20, 1, p. 12-24 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularizations

Pasha, S. P. B. S., Sishtla, K., Sulaiman, R. S., Park, B., Shetty, T., Shah, F., Fishel, M. L., Wikel, J. H., Kelley, M. R. & Corson, T. W., Oct 2018, In : Journal of Pharmacology and Experimental Therapeutics. 367, 1, p. 108-118 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z. Y. & Lu, T., Jan 1 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing

Shah, F., Goossens, E., Atallah, N. M., Grimard, M., Kelley, M. R. & Fishel, M. L., Dec 2017, In : Molecular Oncology. 11, 12, p. 1711-1732 22 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

Richards, K. E., Zeleniak, A. E., Fishel, M. L., Wu, J., Littlepage, L. E. & Hill, R., Mar 30 2017, In : Oncogene. 36, 13, p. 1770-1778 9 p.

Research output: Contribution to journalArticle

175 Scopus citations

Loss of MTSS1 results in increased metastatic potential in pancreatic cancer

Zeleniak, A. E., Huang, W., Brinkman, M. K., Fishel, M. L. & Hill, R., 2017, In : Oncotarget. 8, 10, p. 16473-16487 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Ref-1/APE1 as a transcriptional regulator and novel therapeutic target in pediatric T-cell leukemia

Ding, J., Fishel, M. L., Reed, A. M., McAdams, E., Czader, M. B., Cardoso, A. A. & Kelley, M. R., Jul 2017, In : Molecular cancer therapeutics. 16, 7, p. 1401-1411 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Applying small molecule signal transducer and activator of transcription-3 (STAT3) protein inhibitors as pancreatic cancer therapeutics

Arpin, C. C., Mac, S., Jiang, Y., Cheng, H., Grimard, M., Page, B. D. G., Kamocka, M. M., Haftchenary, S., Su, H., Ball, D. P., Rosa, D. A., Lai, P. S., Gómez-Biagi, R. F., Ali, A. M., Rana, R., Hanenberg, H., Kerman, K., McElyea, K. C., Sandusky, G. E., Gunning, P. T. & 1 others, Fishel, M. L., May 2016, In : Molecular cancer therapeutics. 15, 5, p. 794-805 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer

Bansal, N., Bosch, A., Leibovitch, B., Pereira, L., Cubedo, E., Yu, J., Pierzchalski, K., Jones, J. W., Fishel, M., Kane, M., Zelent, A., Waxman, S. & Farias, E., 2016, In : Oncotarget. 7, 28, p. 43689-43702 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
22 Scopus citations

Regulation of HIF1a under hypoxia by APE1/Ref-1 impacts CA9 expression: Dual targeting in patient-derived 3D pancreatic cancer models

Logsdon, D. P., Grimard, M., Luo, M., Shahda, S., Jiang, Y., Tong, Y., Yu, Z., Zyromski, N., Schipani, E., Carta, F., Supuran, C. T., Korc, M., Ivan, M., Kelley, M. R. & Fishel, M. L., Nov 2016, In : Molecular cancer therapeutics. 15, 11, p. 2722-2732 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer

Lee, J., Yakubov, B., Ivan, C., Jones, D. R., Caperell-Grant, A., Fishel, M., Cardenas, H. & Matei, D., Jan 1 2016, In : Neoplasia (United States). 18, 11, p. 689-698 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2

Fishel, M. L., Wu, X., Devlin, C. M., Logsdon, D. P., Jiang, Y., Luo, M., He, Y., Yu, Z., Tong, Y., Lipking, K. P., Maitra, A., Rajeshkumar, N. V., Scandura, G., Kelley, M. R. & Ivan, M., Jan 30 2015, In : Journal of Biological Chemistry. 290, 5, p. 3057-3068 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Longitudinal bioluminescence imaging of primary versus abdominal metastatic tumor growth in Orthotopic pancreatic tumor models in NSG Mice

Shannon, H. E., Fishel, M. L., Xie, J., Gu, D., McCarthy, B. P., Riley, A. A., Sinn, A. L., Silver, J. M., Peterman, K., Kelley, M. R., Hanenberg, H., Korc, M., Pollok, K. E. & Territo, P. R., Jan 2015, In : Pancreas. 44, 1, p. 64-75 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014

Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity

Parajuli, B., Georgiadis, T. M., Fishel, M. L. & Hurley, T. D., Mar 21 2014, In : ChemBioChem. 15, 5, p. 701-712 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells

Parajuli, B., Fishel, M. L. & Hurley, T. D., Jan 23 2014, In : Journal of Medicinal Chemistry. 57, 2, p. 449-461 13 p.

Research output: Contribution to journalArticle

34 Scopus citations
2012

APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1-STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival

Cardoso, A. A., Jiang, Y., Luo, M., Reed, A. M., Shahda, S., He, Y., Maitra, A., Kelley, M. R. & Fishel, M. L., Oct 19 2012, In : PloS one. 7, 10, e47462.

Research output: Contribution to journalArticle

44 Scopus citations
2011

Impact of APE1/ref-1 redox inhibition on pancreatic tumor growth

Fishel, M. L., Jiang, Y., Rajeshkumar, N. V., Scandura, G., Sinn, A. L., He, Y., Shen, C., Jones, D. R., Pollok, K. E., Ivan, M., Maitra, A. & Kelley, M. R., Sep 2011, In : Molecular cancer therapeutics. 10, 9, p. 1698-1708 11 p.

Research output: Contribution to journalArticle

52 Scopus citations
2010
26 Scopus citations
69 Scopus citations
39 Scopus citations
2009

Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity

Tate, C. M., Fishel, M. L., Holleran, J. L., Egorin, M. J. & Skalnik, D. G., Dec 3 2009, In : DNA Repair. 8, 12, p. 1411-1423 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
45 Scopus citations
2008

Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress

Rabik, C. A., Fishel, M. L., Holleran, J. L., Kasza, K., Kelley, M. R., Egorin, M. J. & Dolan, M. E., Nov 2008, In : Journal of Pharmacology and Experimental Therapeutics. 327, 2, p. 442-452 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth

Fishel, M. L., He, Y., Reed, A. M., Chin-Sinex, H., Hutchins, G. D., Mendonca, M. S. & Kelley, M. R., Feb 1 2008, In : DNA Repair. 7, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: Small-molecule inhibition of the redox function of Ape1

Luo, M., Delaplane, S., Jiang, A., Reed, A., He, Y., Fishel, M., Nyland, R. L., Borch, R. F., Qiao, X., Georgiadis, M. M. & Kelley, M. R., Nov 1 2008, In : Antioxidants and Redox Signaling. 10, 11, p. 1853-1867 15 p.

Research output: Contribution to journalArticle

110 Scopus citations
2007
168 Scopus citations

Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide

Fishel, M. L., He, Y., Smith, M. L. & Kelley, M. R., Jan 1 2007, In : Clinical Cancer Research. 13, 1, p. 260-267 8 p.

Research output: Contribution to journalArticle

104 Scopus citations
2006

Role of GADD34 in modulation of cisplatin cytotoxicity

Fishel, M. L., Rabik, C. A., Bleibel, W. K., Li, X., Moschel, R. C. & Dolan, M. E., Jan 12 2006, In : Biochemical Pharmacology. 71, 3, p. 239-247 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2005

Effect of cell cycle inhibition on cisplatin-induced cytotoxicity

Fishel, M. L., Newell, D. R., Griffin, R. J., Davison, R., Wang, L. Z., Curtin, N. J., Zuhowski, E. G., Kasza, K., Egorin, M. J., Moschel, R. C. & Dolan, M. E., Jan 1 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 1, p. 206-213 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine

Fishel, M. L., Gamcsik, M. P., Delaney, S. M., Zuhowski, E. G., Maher, V. M., Karrison, T., Moschel, R. C., Egorin, M. J. & Dolan, M. E., Apr 1 2005, In : Cancer Chemotherapy and Pharmacology. 55, 4, p. 333-342 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2003

Enhancement of platinum-induced cytotoxicity by O6-Benzylguanine

Fishel, M. L., Delaney, S. M., Friesen, L. D., Hansen, R. J., Zuhowski, E. G., Moschel, R. C., Egorin, M. J. & Dolan, M. E., Jul 1 2003, In : Molecular cancer therapeutics. 2, 7, p. 633-640 8 p.

Research output: Contribution to journalArticle

31 Scopus citations
61 Scopus citations
2002

Implication of p53 in base excision dna repair: In vivo evidence

Seo, Y. R., Fishel, M., Amundsen, S., Kelley, M. & Smith, M. L., Jan 24 2002, In : Oncogene. 21, 5, p. 731-737 7 p.

Research output: Contribution to journalArticle

93 Scopus citations