Melissa Fishel

  • 1906 Citations
  • 24 h-Index
20022019
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Publications 2002 2019

  • 1906 Citations
  • 24 h-Index
  • 48 Article
  • 3 Chapter
  • 1 Book
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Article
2019

Antitumor activity and mechanistic characterization of APE1/ReF-1 inhibitors in bladder cancer

Fishel, M. L., Xia, H., McGeown, J., McIlwain, D. W., Elbanna, M., Craft, A. A., Kaimakliotis, H. Z., Sandusky, G. E., Zhang, C., Pili, R., Kelley, M. R. & Jerde, T. J., Jan 1 2019, In : Molecular cancer therapeutics. 18, 11, p. 1947-1960 14 p.

Research output: Contribution to journalArticle

Endonucleases
Urinary Bladder Neoplasms
Oxidation-Reduction
Cisplatin
Cell Proliferation

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer

Shouksmith, A. E., Shah, F., Grimard, M. L., Gawel, J. M., Raouf, Y. S., Geletu, M., Berger-Becvar, A., De Araujo, E. D., Luchman, H. A., Heaton, W. L., Bakhshinyan, D., Adile, A. A., Venugopal, C., O'Hare, T., Deininger, M. W., Singh, S. K., Konieczny, S. F., Weiss, S., Fishel, M. & Gunning, P. T., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2651-2665 15 p.

Research output: Contribution to journalArticle

Hydroxamic Acids
Histone Deacetylase Inhibitors
Pancreatic Neoplasms
Adenocarcinoma
Survival

LTMG: a novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data

Wan, C., Chang, W., Zhang, Y., Shah, F., Lu, X., Zang, Y., Zhang, A., Cao, S., Fishel, M. L., Ma, Q. & Zhang, C., Oct 10 2019, In : Nucleic acids research. 47, 18, p. e111

Research output: Contribution to journalArticle

Open Access
RNA
Small Cytoplasmic RNA
Gene Expression
Sensitivity and Specificity
Messenger RNA
2018
4 Citations (Scopus)

APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells

McIlwain, D. W., Fishel, M., Boos, A., Kelley, M. & Jerde, T., Jan 1 2018, In : Oncotarget. 9, 13, p. 10962-10977 16 p.

Research output: Contribution to journalArticle

Endonucleases
Cell Cycle Checkpoints
Oxidation-Reduction
Prostatic Neoplasms
Proteins
3 Citations (Scopus)

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival

Logsdon, D. P., Shah, F., Carta, F., Supuran, C. T., Kamocka, M., Jacobsen, M. H., Sandusky, G., Kelley, M. & Fishel, M., Dec 1 2018, In : Scientific Reports. 8, 1, 13759.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Cell Survival
Adenocarcinoma
Oxidation-Reduction
Neoplasms
3 Citations (Scopus)

Development of a Novel 3D Tumor-tissue Invasion Model for High-throughput, High-content Phenotypic Drug Screening

Puls, T. J., Tan, X., Husain, M., Whittington, C. F., Fishel, M. & Voytik-Harbin, S. L., Dec 1 2018, In : Scientific Reports. 8, 1, 13039.

Research output: Contribution to journalArticle

Preclinical Drug Evaluations
Neoplasms
Pancreatic Neoplasms
Phenotype
Collagen Type I
7 Citations (Scopus)

Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition

Marisol Herrera-Perez, R., Voytik-Harbin, S. L., Sarkaria, J. N., Pollok, K., Fishel, M. & Rickus, J. L., Mar 1 2018, In : PLoS One. 13, 3, e0194183.

Research output: Contribution to journalArticle

Tumor Microenvironment
stromal cells
Glioblastoma
Stromal Cells
Tumors
5 Citations (Scopus)

PTEN-Dependent Stabilization of MTSS1 Inhibits Metastatic Phenotype in Pancreatic Ductal Adenocarcinoma

Zeleniak, A. E., Huang, W., Fishel, M. & Hill, R., Jan 1 2018, In : Neoplasia (United States). 20, 1, p. 12-24 13 p.

Research output: Contribution to journalArticle

Tumor Suppressor Proteins
Phosphoric Monoester Hydrolases
Adenocarcinoma
Phenotype
Down-Regulation
1 Citation (Scopus)

Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularizations

Pasha, S. P. B. S., Sishtla, K., Sulaiman, R. S., Park, B., Shetty, T., Shah, F., Fishel, M., Wikel, J. H., Kelley, M. & Corson, T., Oct 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 367, 1, p. 108-118 11 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Choroidal Neovascularization
Endothelial Cells
Eye Diseases
Macular Degeneration
2017
8 Citations (Scopus)

Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Prabhu, L., Wei, H., Chen, L., Demir, Ö., Sandusky, G., Sun, E., Wang, J., Mo, J., Zeng, L., Fishel, M., Safa, A., Amaro, R., Korc, M., Zhang, Z-Y. & Lu, T., 2017, In : Oncotarget. 8, 25, p. 39963-39977 15 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Pancreatic Neoplasms
Colorectal Neoplasms
Adenocarcinoma
Neoplasms
7 Citations (Scopus)

APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing

Shah, F., Goossens, E., Atallah, N. M., Grimard, M., Kelley, M. & Fishel, M., Dec 1 2017, In : Molecular Oncology. 11, 12, p. 1711-1732 22 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Adenocarcinoma
Gene Expression
Genes
Oxidation-Reduction
10 Citations (Scopus)

Loss of MTSS1 results in increased metastatic potential in pancreatic cancer

Zeleniak, A. E., Huang, W., Brinkman, M. K., Fishel, M. & Hill, R., 2017, In : Oncotarget. 8, 10, p. 16473-16487 15 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Neoplasm Metastasis
Cell Line
Neoplasms
5 Citations (Scopus)

Ref-1/APE1 as a transcriptional regulator and novel therapeutic target in pediatric T-cell leukemia

Ding, J., Fishel, M., Reed, A. M., McAdams, E., Czader, M., Cardoso, A. A. & Kelley, M., Jul 1 2017, In : Molecular Cancer Therapeutics. 16, 7, p. 1401-1411 11 p.

Research output: Contribution to journalArticle

T-Cell Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Oxidation-Reduction
Leukemia
Pediatrics
2016
17 Citations (Scopus)

Applying small molecule signal transducer and activator of transcription-3 (STAT3) protein inhibitors as pancreatic cancer therapeutics

Arpin, C. C., Mac, S., Jiang, Y., Cheng, H., Grimard, M., Page, B. D. G., Kamocka, M., Haftchenary, S., Su, H., Ball, D. P., Rosa, D. A., Lai, P. S., Gómez-Biagi, R. F., Ali, A. M., Rana, R., Hanenberg, H., Kerman, K., McElyea, K. C., Sandusky, G., Gunning, P. T. & 1 others, Fishel, M., May 1 2016, In : Molecular Cancer Therapeutics. 15, 5, p. 794-805 12 p.

Research output: Contribution to journalArticle

STAT Transcription Factors
STAT3 Transcription Factor
Pancreatic Neoplasms
Neoplasms
Coculture Techniques
2 Citations (Scopus)

Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer

Bansal, N., Bosch, A., Leibovitch, B., Pereira, L., Cubedo, E., Yu, J., Pierzchalski, K., Jones, J. W., Fishel, M., Kane, M., Zelent, A., Waxman, S. & Farias, E., 2016, In : Oncotarget. 7, 28, p. 43689-43702 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Retinoids
Carcinogenesis
Neoplasms
Protein Interaction Domains and Motifs
141 Citations (Scopus)

Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells

Richards, K. E., Zeleniak, A. E., Fishel, M., Wu, J., Littlepage, L. E. & Hill, R., Sep 26 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Exosomes
Pancreatic Neoplasms
gemcitabine
Adenocarcinoma
Drug Resistance
20 Citations (Scopus)
DNA-(Apurinic or Apyrimidinic Site) Lyase
Peripheral Nervous System Diseases
oxaliplatin
Drug Therapy
Sensory Receptor Cells
26 Citations (Scopus)

Regulation of HIF1a under hypoxia by APE1/Ref-1 impacts CA9 expression: Dual targeting in patient-derived 3D pancreatic cancer models

Logsdon, D. P., Grimard, M., Luo, M., Shahda, S., Jiang, Y., Tong, Y., Yu, Z., Zyromski, N., Schipani, E., Carta, F., Supuran, C. T., Korc, M., Ivan, M., Kelley, M. & Fishel, M., Nov 1 2016, In : Molecular Cancer Therapeutics. 15, 11, p. 2722-2732 11 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Hypoxia-Inducible Factor 1
Transcription Factor AP-1
Pancreatic Neoplasms
Oxidation-Reduction
59 Citations (Scopus)

STAT3 in the systemic inflammation of cancer cachexia

Zimmers, T., Fishel, M. & Bonetto, A., Jan 7 2016, (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalArticle

Cachexia
Inflammation
Neoplasms
Acute-Phase Reaction
Fats
11 Citations (Scopus)

Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer

Lee, J., Yakubov, B., Ivan, C., Jones, D. R., Caperell-Grant, A., Fishel, M., Cardenas, H. & Matei, D., 2016, In : Neoplasia (United States). 18, 11, p. 689-698 10 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Adenocarcinoma
Neoplasms
Tumor Microenvironment
2015
25 Citations (Scopus)

Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2

Fishel, M., Wu, X., Devlin, C. M., Logsdon, D. P., Jiang, Y., Luo, M., He, Y., Yu, Z., Tong, Y., Lipking, K. P., Maitra, A., Rajeshkumar, N. V., Scandura, G., Kelley, M. & Ivan, M., Jan 30 2015, In : Journal of Biological Chemistry. 290, 5, p. 3057-3068 12 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Endonucleases
Oxidation-Reduction
Tumors
DNA Repair
2014
24 Citations (Scopus)

Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity

Parajuli, B., Georgiadis, T. M., Fishel, M. & Hurley, T., Mar 21 2014, In : ChemBioChem. 15, 5, p. 701-712 12 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Cytotoxicity
Cyclophosphamide
Cells
Isoenzymes
3 Citations (Scopus)

Longitudinal Bioluminescence Imaging of Primary Versus Abdominal Metastatic Tumor Growth in Orthotopic Pancreatic Tumor Models in NSG Mice

Shannon, H. E., Fishel, M. L., Xie, J., Gu, D., McCarthy, B. P., Riley, A. A., Sinn, A. L., Silver, J. M., Peterman, K., Kelley, M. R., Hanenberg, H., Korc, M., Pollok, K. E. & Territo, P. R., Nov 18 2014, (Accepted/In press) In : Pancreas.

Research output: Contribution to journalArticle

Growth
Pancreatic Neoplasms
Neoplasms
Cell Count
Entropy
26 Citations (Scopus)

Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells

Parajuli, B., Fishel, M. & Hurley, T., Jan 23 2014, In : Journal of Medicinal Chemistry. 57, 2, p. 449-461 13 p.

Research output: Contribution to journalArticle

Cyclophosphamide
Aldehyde Dehydrogenase
Xenobiotics
Aldehydes
Neoplasms
79 Citations (Scopus)

Targeting DNA repair pathways for cancer treatment: What's new?

Kelley, M., Logsdon, D. & Fishel, M., 2014, In : Future Oncology. 10, 7, p. 1215-1237 23 p.

Research output: Contribution to journalArticle

DNA Repair
Neoplasms
Therapeutics
Health Care Costs
DNA Damage
2012
41 Citations (Scopus)

APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1-STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival

Cardoso, A. A., Jiang, Y., Luo, M., Reed, A. M., Shahda, S., He, Y., Maitra, A., Kelley, M. & Fishel, M., Oct 19 2012, In : PLoS One. 7, 10, e47462.

Research output: Contribution to journalArticle

pancreatic neoplasms
Pancreatic Neoplasms
Oxidation-Reduction
cell viability
Cell Survival
85 Citations (Scopus)
DNA Repair
Oxidation-Reduction
Neoplasms
Proteins
Tumor Microenvironment
2011
50 Citations (Scopus)

Impact of APE1/ref-1 redox inhibition on pancreatic tumor growth

Fishel, M., Jiang, Y., Rajeshkumar, N. V., Scandura, G., Sinn, A. L., He, Y., Shen, C., Jones, D. R., Pollok, K., Ivan, M., Maitra, A. & Kelley, M., Sep 2011, In : Molecular Cancer Therapeutics. 10, 9, p. 1698-1708 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Oxidation-Reduction
Growth
Neoplasms
Transcription Factor AP-1
2010
23 Citations (Scopus)
Myeloid Leukemia
Myeloid Cells
Tretinoin
Oxidation-Reduction
Apoptosis
67 Citations (Scopus)
DNA-(Apurinic or Apyrimidinic Site) Lyase
Transcription Factor AP-1
Glioblastoma
Cell Survival
Endonucleases
35 Citations (Scopus)
Pancreatic Neoplasms
DNA Repair
Oxidation-Reduction
Cell Survival
Cell Cycle
2009
3 Citations (Scopus)

Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity

Tate, C. M., Fishel, M., Holleran, J. L., Egorin, M. J. & Skalnik, D. G., Dec 3 2009, In : DNA Repair. 8, 12, p. 1411-1423 13 p.

Research output: Contribution to journalArticle

Endonucleases
Embryonic Stem Cells
Stem cells
Epigenomics
Fingers
76 Citations (Scopus)

Going ape as an approach to cancer therapeutics

Bapat, A., Fishel, M. & Kelley, M., Mar 1 2009, In : Antioxidants and Redox Signaling. 11, 3, p. 651-667 17 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Hominidae
Transcription Factor AP-1
Repair
DNA Repair
45 Citations (Scopus)

Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: Use of APE1 small molecule inhibitors to delineate APE1 functions

Jiang, Y., Guo, C., Fishel, M., Wang, Z. Y., Vasko, M. & Kelley, M., Nov 2 2009, In : DNA Repair. 8, 11, p. 1273-1282 10 p.

Research output: Contribution to journalArticle

Oxidative stress
Neuroblastoma
Oxidative Stress
Repair
Molecules
24 Citations (Scopus)
DNA Repair
Neoplasms
Proteins
DNA Damage
Poisons
2008
77 Citations (Scopus)

DNA repair proteins as molecular targets for cancer therapeutics

Kelley, M. & Fishel, M., May 2008, In : Anti-Cancer Agents in Medicinal Chemistry. 8, 4, p. 417-425 9 p.

Research output: Contribution to journalArticle

DNA Repair
Neoplasms
Proteins
Therapeutics
Drug Resistance
29 Citations (Scopus)

Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress

Rabik, C. A., Fishel, M., Holleran, J. L., Kasza, K., Kelley, M., Egorin, M. J. & Dolan, M. E., Nov 2008, In : Journal of Pharmacology and Experimental Therapeutics. 327, 2, p. 442-452 11 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Cisplatin
DNA Damage
Apoptosis
Caspase 12
65 Citations (Scopus)

Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth

Fishel, M., He, Y., Reed, A. M., Chin-Sinex, H., Hutchins, G., Mendonca, M. & Kelley, M., Feb 1 2008, In : DNA Repair. 7, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

DNA Repair
Ovarian Neoplasms
Tumors
Repair
Cells
107 Citations (Scopus)

Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: Small-molecule inhibition of the redox function of Ape1

Luo, M., Delaplane, S., Jiang, A., Reed, A., He, Y., Fishel, M., Nyland, R. L., Borch, R. F., Qiao, X., Georgiadis, M. & Kelley, M., Nov 1 2008, In : Antioxidants and Redox Signaling. 10, 11, p. 1853-1867 15 p.

Research output: Contribution to journalArticle

Endothelial cells
DNA Repair
Oxidation-Reduction
Repair
Endothelial Cells
2007
163 Citations (Scopus)
DNA Repair
Neurons
DNA Damage
Mitochondrial DNA
Reactive Oxygen Species
102 Citations (Scopus)

Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide

Fishel, M., He, Y., Smith, M. L. & Kelley, M., Jan 1 2007, In : Clinical Cancer Research. 13, 1, p. 260-267 8 p.

Research output: Contribution to journalArticle

temozolomide
Alkylating Agents
DNA Repair
Ovarian Neoplasms
DNA Glycosylases
187 Citations (Scopus)

The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target

Fishel, M. & Kelley, M., Jun 2007, In : Molecular Aspects of Medicine. 28, 3-4, p. 375-395 21 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Repair
Oxidation-Reduction
Repair
DNA
2006
9 Citations (Scopus)

Role of GADD34 in modulation of cisplatin cytotoxicity

Fishel, M., Rabik, C. A., Bleibel, W. K., Li, X., Moschel, R. C. & Dolan, M. E., Jan 12 2006, In : Biochemical Pharmacology. 71, 3, p. 239-247 9 p.

Research output: Contribution to journalArticle

Cytotoxicity
Cisplatin
Modulation
Head and Neck Neoplasms
Carboplatin
2005
20 Citations (Scopus)

Effect of cell cycle inhibition on cisplatin-induced cytotoxicity

Fishel, M., Newell, D. R., Griffin, R. J., Davison, R., Wang, L. Z., Curtin, N. J., Zuhowski, E. G., Kasza, K., Egorin, M. J., Moschel, R. C. & Dolan, M. E., Jan 2005, In : Journal of Pharmacology and Experimental Therapeutics. 312, 1, p. 206-213 8 p.

Research output: Contribution to journalArticle

S 6
Guanine
Cisplatin
Cell Cycle
Thioguanine
15 Citations (Scopus)

Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine

Fishel, M., Gamcsik, M. P., Delaney, S. M., Zuhowski, E. G., Maher, V. M., Karrison, T., Moschel, R. C., Egorin, M. J. & Dolan, M. E., Apr 2005, In : Cancer Chemotherapy and Pharmacology. 55, 4, p. 333-342 10 p.

Research output: Contribution to journalArticle

DNA Repair
Cisplatin
Cytotoxicity
Glutathione
Repair
2003
31 Citations (Scopus)

Enhancement of platinum-induced cytotoxicity by O6-Benzylguanine

Fishel, M., Delaney, S. M., Friesen, L. D., Hansen, R. J., Zuhowski, E. G., Moschel, R. C., Egorin, M. J. & Dolan, M. E., Jul 2003, In : Molecular Cancer Therapeutics. 2, 7, p. 633-640 8 p.

Research output: Contribution to journalArticle

Platinum
Cisplatin
temozolomide
Carboplatin
Cricetulus
60 Citations (Scopus)
DNA Glycosylases
DNA Repair
DNA Damage
Mitochondria
DNA
2002
92 Citations (Scopus)

Implication of p53 in base excision dna repair: In vivo evidence

Seo, Y. R., Fishel, M., Amundsen, S., Kelley, M. & Smith, M. L., Jan 24 2002, In : Oncogene. 21, 5, p. 731-737 7 p.

Research output: Contribution to journalArticle

DNA Repair
Methyl Methanesulfonate
DNA Damage
Null Lymphocytes
p53 Genes