Melissa Kacena

  • 1894 Citations
  • 25 h-Index
19972020

Research output per year

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Publications

2015

Surgical Fixation Hardware for Regeneration of Long Bone Segmental Defects: Translating Large Animal Model and Human Experiences

Jewell, E., Rytlewski, J., Anglen, J. O., McKinley, T. O., Shively, K. D., Chu, T. M. G. & Kacena, M. A., Dec 1 2015, In : Clinical Reviews in Bone and Mineral Metabolism. 13, 4, p. 222-231 10 p.

Research output: Contribution to journalReview article

1 Scopus citations
2014

CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche

Chitteti, B. R., Kobayashi, M., Cheng, Y., Zhang, H., Poteat, B. A., Broxmeyer, H. E., Pelus, L. M., Hanenberg, H., Zollman, A., Kamocka, M. M., Carlesso, N., Cardoso, A. A., Kacena, M. A. & Srour, E. F., Jul 24 2014, In : Blood. 124, 4, p. 519-529 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Histopathology and diagnostic approaches to the myeloproliferative neoplasms

Salazar, C., Balamohan, S. M., Millikan, P. D., Raskind, W. H. & Kacena, M. A., Jul 1 2014, Myeloproliferative Disorders: Symptoms, Risk Factors and Treatment Options. Nova Science Publishers, Inc., p. 55-73 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tips and techniques for processing and sectioning undecalcified murine bone specimens

Bemenderfer, T. B., Harris, J. S., Condon, K. W. & Kacena, M. A., 2014, Methods in Molecular Biology. Vol. 1130. p. 123-147 25 p. (Methods in Molecular Biology; vol. 1130).

Research output: Chapter in Book/Report/Conference proceedingChapter

Tips and techniques for processing and sectioning undecalcified murine bone specimens

Bemenderfer, T. B., Harris, J. S., Condon, K. W. & Kacena, M. A., 2014, Skeletal Development and Repair: Methods and Protocols. Humana Press Inc., p. 123-147 25 p. (Methods in Molecular Biology; vol. 1130).

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations
2013

A review of mouse critical size defect models in weight bearing bones

Harris, J. S., Bemenderfer, T. B., Wessel, A. R. & Kacena, M. A., Jul 1 2013, In : Bone. 55, 1, p. 241-247 7 p.

Research output: Contribution to journalReview article

25 Scopus citations

CD166 and regulation of hematopoiesis

Chitteti, B. R., Bethel, M., Kacena, M. A. & Srour, E. F., Jul 1 2013, In : Current opinion in hematology. 20, 4, p. 273-280 8 p.

Research output: Contribution to journalReview article

10 Scopus citations

Hierarchical organization of osteoblasts reveals the significant role of CD166 in hematopoietic stem cell maintenance and function

Chitteti, B. R., Cheng, Y. H., Kacena, M. A. & Srour, E. F., May 1 2013, In : Bone. 54, 1, p. 58-67 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

In Vitro Construction of 2D and 3D simulations of the murine hematopoietic niche

Reddy Chitteti, B., Bethel, M., Voytik-Harbin, S. L., Kacena, M. A. & Srour, E. F., 2013, Stem Cell Niche: Methods and Protocols. Humana Press Inc., p. 43-56 14 p. (Methods in Molecular Biology; vol. 1035).

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency

He, Y., Childress, P., Hood, M., Alvarez, M., Kacena, M. A., Hanlon, M., McKee, B., Bidwell, J. P. & Yang, F. C., Feb 1 2013, In : Stem cells and development. 22, 3, p. 492-500 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation

Cheng, Y. H., Hooker, R. A., Nguyen, K., Gerard-O'Riley, R., Waning, D. L., Chitteti, B. R., Meijome, T. E., Chua, H. L., Plett, A. P., Orschell, C. M., Srour, E. F., Mayo, L. D., Pavalko, F. M., Bruzzaniti, A. & Kacena, M. A., Jun 2013, In : Journal of Bone and Mineral Research. 28, 6, p. 1434-1445 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

The changing balance between osteoblastogenesis and adipogenesis in aging and its impact on hematopoiesis

Bethel, M., Chitteti, B. R., Srour, E. F. & Kacena, M. A., Jun 1 2013, In : Current Osteoporosis Reports. 11, 2, p. 99-106 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

The effects of GATA-1 and NF-E2 deficiency on bone biomechanical, biochemical, and mineral properties

Kacena, M. A., Gundberg, C. M., Kacena, W. J., Landis, W. J., Boskey, A. L., Bouxsein, M. L. & Horowitz, M. C., Jul 2013, In : Journal of cellular physiology. 228, 7, p. 1594-1600 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Megakaryocytes regulate expression of Pyk2 isoforms and caspase-mediated cleavage of actin in osteoblasts

Kacena, M. A., Eleniste, P. P., Cheng, Y. H., Huang, S., Shivanna, M., Meijome, T. E., Mayo, L. D. & Bruzzanit, A., May 18 2012, In : Journal of Biological Chemistry. 287, 21, p. 17257-17268 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Nmp4/CIZ closes the parathyroid hormone anabolic window

Bidwell, J. P., Childress, P., Alvarez, M. B., Hood, M., He, Y., Pavalko, F. M., Kacena, M. A. & Yang, F. C., 2012, In : Critical Reviews in Eukaryotic Gene Expression. 22, 3, p. 205-218 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Osteoclast formation and function and its role in skeletal bone disease

Bethel, M., Bruzzaniti, A. & Kacena, M. A., Sep 1 2012, Osteoclasts: Morphology, Functions and Clinical Implications. Nova Science Publishers, Inc., p. 31-52 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

DMSO regulates osteoclast development in vitro

Lemieux, J. M., Wu, G., Morgan, J. A. & Kacena, M. A., Mar 1 2011, In : In Vitro Cellular and Developmental Biology - Animal. 47, 3, p. 260-267 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hematopoietic cell regulation of osteoblast proliferation and differentiation

Bethel, M., Srour, E. F. & Kacena, M. A., Jun 1 2011, In : Current osteoporosis reports. 9, 2, p. 96-102 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Impact of maturational status on the ability of osteoblasts to enhance the hematopoietic function of stem and progenitor cells

Cheng, Y. H., Chitteti, B. R., Streicher, D. A., Morgan, J. A., Rodriguez-Rodriguez, S., Carlesso, N., Srour, E. F. & Kacena, M. A., May 2011, In : Journal of Bone and Mineral Research. 26, 5, p. 1111-1121 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Inherited thrombocytopenia due to GATA-1 mutations

Millikan, P. D., Balamohan, S. M., Raskind, W. H. & Kacena, M. A., 2011, In : Seminars in Thrombosis and Hemostasis. 37, 6, p. 682-689 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Nmp4/CIZ suppresses the response of bone to anabolic parathyroid hormone by regulating both osteoblasts and osteoclasts

Childress, P., Philip, B. K., Robling, A. G., Bruzzaniti, A., Kacena, M. A., Bivi, N., Plotkin, L. I., Heller, A. & Bidwell, J. P., Jul 2011, In : Calcified Tissue International. 89, 1, p. 74-89 16 p.

Research output: Contribution to journalArticle

12 Scopus citations
2010

Immature and mature megakaryocytes enhance osteoblast proliferation and inhibit osteoclast formation

Ciovacco, W. A., Cheng, Y. H., Horowitz, M. C. & Kacena, M. A., Mar 1 2010, In : Journal of Cellular Biochemistry. 109, 4, p. 774-781 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function

Chitteti, B. R., Cheng, Y. H., Poteat, B., Rodriguez-Rodriguez, S., Goebel, W. S., Carlesso, N., Kacena, M. A. & Srour, E. F., Apr 22 2010, In : Blood. 115, 16, p. 3239-3248 10 p.

Research output: Contribution to journalArticle

95 Scopus citations

Involvement of integrins α3β1 and α5β1 and glycoprotein IIb in megakaryocyte-induced osteoblast proliferation

Lemieux, J. M., Horowitz, M. C. & Kacena, M. A., Apr 1 2010, In : Journal of Cellular Biochemistry. 109, 5, p. 927-932 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Megakaryocyte-bone cell interactions

Kacena, M. A. & Ciovacco, W. A., 2010, Osteoimmunology: Interactions of the Immune and Skeletal Systems II. Choi, Y. (ed.). p. 31-41 11 p. (Advances in Experimental Medicine and Biology; vol. 658).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations

Osteoblast lineage cells expressing high levels of Runx2 enhance hematopoietic progenitor cell proliferation and function

Chitteti, B. R., Cheng, Y. H., Streicher, D. A., Rodriguez-Rodriguez, S., Carlesso, N., Srour, E. F. & Kacena, M. A., Oct 1 2010, In : Journal of Cellular Biochemistry. 111, 2, p. 284-294 11 p.

Research output: Contribution to journalArticle

46 Scopus citations
2009

The effects of fixation and dehydration on the histological quality of undecalcified murine bone specimens embedded in methylmethacrylate

Troiano, N. W., Ciovacco, W. A. & Kacena, M. A., Mar 2009, In : Journal of Histotechnology. 32, 1, p. 27-31 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation

Ciovacco, W. A., Goldberg, C. G., Taylor, A. F., Lemieux, J. M., Horowitz, M. C., Donahue, H. J. & Kacena, M. A., Jan 1 2009, In : Bone. 44, 1, p. 80-86 7 p.

Research output: Contribution to journalArticle

57 Scopus citations
2008

Development of a femoral non-union model in the mouse

Oetgen, M. E., Merrell, G. A., Troiano, N. W., Horowitz, M. C. & Kacena, M. A., Oct 1 2008, In : Injury. 39, 10, p. 1119-1126 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Human phenotypes associated with GATA-1 mutations

Ciovacco, W. A., Raskind, W. H. & Kacena, M. A., Dec 31 2008, In : Gene. 427, 1-2, p. 1-6 6 p.

Research output: Contribution to journalReview article

68 Scopus citations

Paint chip analysis in a forensic investigation: Lessons learned from metal bone implants

Troiano, N. W., Goldberg, C. G., Schlachter, P. B. & Kacena, M. A., Mar 2008, In : Journal of Histotechnology. 31, 1, p. 25-27 3 p.

Research output: Contribution to journalArticle

Preservation of β-galactosidase transgene in decalcified murine bone specimens embedded in paraffin

Dann, P., Hens, J. R., Troiano, N. W., Wysolmerski, J. J. & Kacena, M. A., Jun 2008, In : Journal of Histotechnology. 31, 2, p. 61-64 4 p.

Research output: Contribution to journalArticle

The effects of storage conditions on the preservation of enzymatic activity in bone

Cosby, C. N., Troiano, N. W. & Kacena, M. A., Dec 2008, In : Journal of Histotechnology. 31, 4, p. 169-173 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

β-Galactosidase detection as an indicator of endogenous PTHrP in cartilage

Chen, X. S., Troiano, N. W. & Kacena, M. A., Mar 1 2008, In : Biotechnic and Histochemistry. 83, 2, p. 89-96 8 p.

Research output: Contribution to journalArticle

2007

Expression of bone morphogenetic proteins and their receptors in the bone marrow megakaryocytes of GATA-1low mice: A possible role in osteosclerosis

Garimella, R., Kacena, M. A., Tague, S. E., Wang, J., Horowitz, M. C. & Anderson, H. C., Jul 2007, In : Journal of Histochemistry and Cytochemistry. 55, 7, p. 745-752 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
2006

A reciprocal regulatory interaction between megakaryocytes, bone cells, and hematopoietic stem cells

Kacena, M. A., Gundberg, C. M. & Horowitz, M. C., Nov 1 2006, In : Bone. 39, 5, p. 978-984 7 p.

Research output: Contribution to journalReview article

71 Scopus citations

Bone implants: Processing, embedding, cutting, and histopathology

Troiano, N. W. & Kacena, M. A., Dec 2006, In : Journal of Histotechnology. 29, 4, p. 253-264 12 p.

Research output: Contribution to journalReview article

Glycolmethacrylate is superior to methylmethacrylate for histologic evaluation of biodegradable polymer scaffolds used for vascular tissue engineering

Roh, J. D., Kacena, M. A., Lopz-Soler, R. I., Coady, C. E., Troiano, N. W. & Breuer, C. K., Dec 2006, In : Journal of Histotechnology. 29, 4, p. 245-250 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Megakaryocyte-mediated inhibition of osteoclast development

Kacena, M. A., Nelson, T., Clough, M. E., Lee, S. K., Lorenzo, J. A., Gundberg, C. M. & Horowitz, M. C., Nov 1 2006, In : Bone. 39, 5, p. 991-999 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Optimization of methylmethacrylate infiltration duration in undecalcified murine bone specimens

Kacena, M. A., Halfon, J. K., Coady, C. E., Nelson, T. & Troiano, N. W., Mar 2006, In : Journal of Histotechnology. 29, 1, p. 21-27 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

The role of megakaryocytes in skeletal homeostasis and rheumatoid arthritis

Kacena, M. A. & Horowitz, M. C., Jul 2006, In : Current Opinion in Rheumatology. 18, 4, p. 405-410 6 p.

Research output: Contribution to journalReview article

9 Scopus citations
2005

Effects of long-term fixation on histological quality of undecalcified murine bones embedded in methylmethacrylate

Merrell, G. A., Troiano, N. W., Coady, C. E. & Kacena, M. A., May 1 2005, In : Biotechnic and Histochemistry. 80, 3-4, p. 139-146 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Loss of the transcription factor p45 NF-E2 results in a developmental arrest of megakaryocyte differentiation and the onset of a high bone mass phenotype

Kacena, M. A., Gundberg, C. M., Nelson, T. & Horowitz, M. C., Feb 2005, In : Bone. 36, 2, p. 215-223 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
2004

Effects of Ethanol Post-Fixation on the Histological, Histochemical, and Immunohistochemical Analysis of Murine Bone Specimens

Kacena, M. A., Troiano, N. W., Coady, C. E. & Horowitz, M. C., Mar 2004, In : Journal of Histotechnology. 27, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Evaluation of two different methylmethacrylate processing, infiltration, and embedding techniques on the histological, histochemical, and immunohistochemical analysis of murine bone specimens

Kacena, M. A., Troiano, N. W., Wilson, K. M., Coady, C. E. & Horowitz, M. C., Jun 1 2004, In : Journal of Histotechnology. 27, 2, p. 119-130 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Experiments with Osteoblasts Cultured under Hypergravity Conditions

Kacena, M. A., Todd, P., Gerstenfeld, L. C. & Landis, W. J., Jan 1 2004, In : Microgravity Science and Technology. 15, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

HistoChoice® as an alternative to formalin fixation of undecalcified bone specimens

Kacena, M. A., Troiano, N. W., Coady, C. E. & Horowitz, M. C., Oct 1 2004, In : Biotechnic and Histochemistry. 79, 5-6, p. 185-190 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2

Kacena, M. A., Shivdasani, R. A., Wilson, K., Xi, Y., Troiano, N., Nazarian, A., Gundberg, C. M., Bouxsein, M. L., Lorenzo, J. A. & Horowitz, M. C., Apr 2004, In : Journal of Bone and Mineral Research. 19, 4, p. 652-660 9 p.

Research output: Contribution to journalArticle

98 Scopus citations
2003

Decalcification of mounted bone sections enhances immunohistochemical staining

Kacena, M. A., Troiano, N. W., Coady, C. E. & Horowitz, M. C., Jun 2003, In : Journal of Histotechnology. 26, 2, p. 105-109 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Osteoblasts subjected to spaceflight and simulated space shuttle launch conditions

Kacena, M. A., Todd, P. & Landis, W. J., Nov 1 2003, In : In Vitro Cellular and Developmental Biology - Animal. 39, 10, p. 454-459 6 p.

Research output: Contribution to journalArticle

20 Scopus citations