Merrill Benson

  • 13806 Citations
  • 61 h-Index
1961 …2020

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Publications

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Article
2020

Early data on long-term efficacy and safety of inotersen in patients with hereditary transthyretin amyloidosis: a 2-year update from the open-label extension of the NEURO-TTR trial

Brannagan, T. H., Wang, A. K., Coelho, T., Waddington Cruz, M., Polydefkis, M. J., Dyck, P. J., Plante-Bordeneuve, V., Berk, J. L., Barroso, F., Merlini, G., Conceição, I., Hughes, S. G., Kwoh, J., Jung, S. W., Guthrie, S., Pollock, M., Benson, M. D., Gertz, M., Drachman, B., Gorevic, P. & 13 others, Heitner, S., Scheinberg, M., Schmidt, H., Whelan, C., Adams, D., Campistol Plana, J. M., Gamez, J., Gane, E., Kristen, A., Obici, L., Salvi, F., Souza Bulle Oliveira, A. & Vita, G., Aug 1 2020, In : European Journal of Neurology. 27, 8, p. 1374-1381 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Inotersen preserves or improves quality of life in hereditary transthyretin amyloidosis

Coelho, T., Yarlas, A., Waddington-Cruz, M., White, M. K., Sikora Kessler, A., Lovley, A., Pollock, M., Guthrie, S., Ackermann, E. J., Hughes, S. G., Karam, C., Khella, S., Gertz, M., Merlini, G., Obici, L., Schmidt, H. H., Polydefkis, M., Dyck, P. J. B., Brannagan, T. H., Conceição, I. & 2 others, Benson, M. D. & Berk, J. L., Apr 1 2020, In : Journal of neurology. 267, 4, p. 1070-1079 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Inotersen therapy of transthyretin amyloid cardiomyopathy

Dasgupta, N. R., Rissing, S. M., Smith, J., Jung, J. & Benson, M. D., Jan 2 2020, In : Amyloid. 27, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2019

A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH

Ueda, M., Okada, M., Mizuguchi, M., Kluve-Beckerman, B., Kanenawa, K., Isoguchi, A., Misumi, Y., Tasaki, M., Ueda, A., Kanai, A., Sasaki, R., Masuda, T., Inoue, Y., Nomura, T., Shinriki, S., Shuto, X. T., Kai, H., Yamashita, T., Matsui, H., Benson, M. D. & 1 others, Ando, Y., Jul 19 2019, In : Journal of Biological Chemistry. 294, 29, p. 11259-11275 17 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils

Saelices, L., Nguyen, B. A., Chung, K., Wang, Y., Ortega, A., Lee, J. H., Coelho, T., Bijzet, J., Benson, M. D. & Eisenberg, D. S., Apr 12 2019, In : Journal of Biological Chemistry. 294, 15, p. 6130-6141 12 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

A transgenic mouse model reproduces human hereditary systemic amyloidosis

Chabert, M., Rousset, X., Colombat, M., Lacasa, M., Kakanakou, H., Bourderioux, M., Brousset, P., Burlet-Schiltz, O., Liepnieks, J. J., Kluve-Beckerman, B., Lambert, G., Châtelet, F. P., Benson, M. D. & Kalopissis, A. D., Sep 2019, In : Kidney international. 96, 3, p. 628-641 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
2018

Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee

Benson, M. D., Buxbaum, J. N., Eisenberg, D. S., Merlini, G., Saraiva, M. J. M., Sekijima, Y., Sipe, J. D. & Westermark, P., Oct 2 2018, In : Amyloid. 25, 4, p. 215-219 5 p.

Research output: Contribution to journalArticle

124 Scopus citations

Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition

Saelices, L., Chung, K., Lee, J. H., Cohn, W., Whitelegge, J. P., Benson, M. D. & Eisenberg, D. S., Jul 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 29, p. E6741-E6750

Research output: Contribution to journalArticle

10 Scopus citations

Hereditary transthyretin amyloidosis: baseline characteristics of patients in the NEURO-TTR trial

Waddington-Cruz, M., Ackermann, E. J., Polydefkis, M., Heitner, S. B., Dyck, P. J., Barroso, F. A., Wang, A. K., Berk, J. L., Dyck, P. J. B., Monia, B. P., Hughes, S. G., Tai, L., Jesse Kwoh, T., Jung, S. W., Coelho, T., Benson, M. D. & Gertz, M. A., Jul 3 2018, In : Amyloid. 25, 3, p. 180-188 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Inotersen treatment for patients with Hereditary transthyretin amyloidosis

Benson, M. D., Waddington-Cruz, M., Berk, J. L., Polydefkis, M., Dyck, P. J., Wang, A. K., Planté-Bordeneuve, V., Barroso, F. A., Merlini, G., Obici, L., Scheinberg, M., Brannagan, T. H., Litchy, W. J., Whelan, C., Drachman, B. M., Adams, D., Heitner, S. B., Conceição, I., Schmidt, H. H., Vita, G. & 15 others, Campistol, J. M., Gamez, J., Gorevic, P. D., Gane, E., Shah, A. M., Solomon, S. D., Monia, B. P., Hughes, S. G., Jesse Kwoh, T., McEvoy, B. W., Jung, S. W., Baker, B. F., Ackermann, E. J., Gertz, M. A. & Coelho, T., Jul 5 2018, In : New England Journal of Medicine. 379, 1, p. 22-31 10 p.

Research output: Contribution to journalArticle

325 Scopus citations
2017

Assessing mNIS+7Ionis and international neurologists' proficiency in a familial amyloidotic polyneuropathy trial

Dyck, P. J., Kincaid, J. C., Dyck, P. J. B., Chaudhry, V., Goyal, N. A., Alves, C., Salhi, H., Wiesman, J. F., Labeyrie, C., Robinson-Papp, J., Cardoso, M., Laura, M., Ruzhansky, K., Cortese, A., Brannagan, T. H., Khoury, J., Khella, S., Waddington-Cruz, M., Ferreira, J., Wang, A. K. & 24 others, Pinto, M. V., Ayache, S. S., Benson, M. D., Berk, J. L., Coelho, T., Polydefkis, M., Gorevic, P., Adams, D. H., Plante-Bordeneuve, V., Whelan, C., Merlini, G., Heitner, S., Drachman, B. M., Conceição, I., Klein, C. J., Gertz, M. A., Ackermann, E. J., Hughes, S. G., Mauermann, M. L., Bergemann, R., Lodermeier, K. A., Davies, J. L., Carter, R. E. & Litchy, W. J., Nov 2017, In : Muscle and Nerve. 56, 5, p. 901-911 11 p.

Research output: Contribution to journalArticle

27 Scopus citations
32 Scopus citations
2016

Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines

Sipe, J. D., Benson, M., Buxbaum, J. N., Ikeda, S. I., Merlini, G., Saraiva, M. J. M. & Westermark, P., Oct 1 2016, In : Amyloid. 23, 4, p. 209-213 5 p.

Research output: Contribution to journalArticle

251 Scopus citations

Biochemical characterization of vitreous amyloid formed after liver transplantation

Liepnieks, J. J., Phan, A-D., Wise, R. J., Hrisomalos, F. N. & Benson, M., Apr 1 2016, (Accepted/In press) In : Amyloid. p. 1-2 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Suppressing transthyretin production in mice, monkeys and humans using 2nd-Generation antisense oligonucleotides

Ackermann, E. J., Guo, S., Benson, M., Booten, S., Freier, S., Hughes, S. G., Kim, T. W., Jesse Kwoh, T., Matson, J., Norris, D., Yu, R., Watt, A. & Monia, B. P., Jun 17 2016, (Accepted/In press) In : Amyloid. p. 1-10 10 p.

Research output: Contribution to journalArticle

62 Scopus citations
2015

Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

Gertz, M. A., Benson, M., Dyck, P. J., Grogan, M., Coelho, T., Cruz, M., Berk, J. L., Plante-Bordeneuve, V., Schmidt, H. H. J. & Merlini, G., Dec 1 2015, In : Journal of the American College of Cardiology. 66, 21, p. 2451-2466 16 p.

Research output: Contribution to journalArticle

158 Scopus citations

Hereditary systemic immunoglobulin light-chain amyloidosis

Benson, M., Liepnieks, J. J. & Kluve-Beckerman, B., 2015, In : Blood. 125, 21, p. 3281-3286 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Retrospective study of a TTR FAP cohort to modify NIS + 7 for therapeutic trials

Suanprasert, N., Berk, J. L., Benson, M. D., Dyck, P. J. B., Klein, C. J., Gollob, J. A., Bettencourt, B. R., Karsten, V. & Dyck, P. J., Sep 15 2014, In : Journal of the Neurological Sciences. 344, 1-2, p. 121-128 8 p.

Research output: Contribution to journalArticle

45 Scopus citations

The pathologic spectrum of oculoleptomeningeal amyloidosis with Val30Gly transthyretin gene mutation in a postmortem case

Martin, S. E., Benson, M. D. & Hattab, E. M., May 2014, In : Human pathology. 45, 5, p. 1105-1108 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Amyloid fibrils containing fragmented ATTR may be the standard fibril composition in ATTR amyloidosis

Ihse, E., Rapezzi, C., Merlini, G., Benson, M. D., Ando, Y., Suhr, O. B., Ikeda, S. I., Lavatelli, F., Obici, L., Quarta, C. C., Leone, O., Jono, H., Ueda, M., Lorenzini, M., Liepnieks, J., Ohshima, T., Tasaki, M., Yamashita, T. & Westermark, P., Sep 2013, In : Amyloid. 20, 3, p. 142-150 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Fibrinogen A alpha-chain amyloidosis: Report of the first case in Latin America

Machado, J. R., Silva, M. V. D., Neves, P. D. M. D. M., Oliveira, F. A. D., Corrêa, R. R. M., Rodrigues, W. V. D., Benson, M. & Reis, M. A. D., Mar 1 2013, In : Amyloid. 20, 1, p. 52-55 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Human SAA1-derived amyloid deposition in cell culture: A consistent model utilizing human peripheral blood mononuclear cells and serum-free medium

Ishii, W., Liepnieks, J. J., Yamada, T., Benson, M. D. & Kluve-Beckerman, B., Jun 2013, In : Amyloid. 20, 2, p. 61-71 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012

Amyloid fibril protein nomenclature: 2012 recommendations from the Nomenclature Committee of the International Society of Amyloidosis

Sipe, J. D., Benson, M. D., Buxbaum, J. N., Ikeda, S. I., Merlini, G., Saraiva, M. J. M. & Westermark, P., Dec 1 2012, In : Amyloid. 19, 4, p. 167-170 4 p.

Research output: Contribution to journalArticle

184 Scopus citations

Clinical development of an antisense therapy for the treatment of transthyretin-associated polyneuropathy

Ackermann, E. J., Guo, S., Booten, S., Alvarado, L., Benson, M., Hughes, S. & Monia, B. P., Jun 1 2012, In : Amyloid. 19, SUPPL. 1, p. 43-44 2 p.

Research output: Contribution to journalArticle

108 Scopus citations

Pathogenesis of transthyretin amyloidosis

Benson, M. D., Jun 1 2012, In : Amyloid. 19, SUPPL. 1, p. 14-15 2 p.

Research output: Contribution to journalArticle

28 Scopus citations

Solid organ transplantation for non-TTR hereditary amyloidosis: Report from the 1st International Workshop on the Hereditary Renal Amyloidoses

Stangou, A. J., Lobato, L., Zeldenrust, S., Rela, M., Portmann, B., Linke, R. P., Conceicao, I., Otto, G., Wilczek, H., Suhr, O., Azoulay, D., Grateau, G., Picken, M., O'Grady, J., Heaton, N., Ericzon, B. G. & Benson, M. D., Jun 2012, In : Amyloid. 19, SUPPL. 1, p. 81-84 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

κ I light chain AL amyloidosis presenting with rapidly progressive renal and hepatic failure with unusual renal amyloid distribution

Oe, Y., Nakaya, I., Yahata, M., Murata, O., Yaegashi, H., Sakuma, T., Sato, H., Liepnieks, J. J., Benson, M. D. & Soma, J., Jan 1 2012, In : Clinical Nephrology. 77, 1, p. 66-70 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

AA amyloidosis: Potential therapy with antisense oligonucleotides

Kluve-Beckerman, B., Hardwick, J., Du, L. & Benson, M. D., Jun 2011, In : Amyloid. 18, SUPPL. 1, p. 200-202 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

A new transthyretin mutation associated with leptomeningeal amyloidosis

Liepnieks, J. J., Dickson, D. W. & Benson, M. D., Jun 1 2011, In : Amyloid. 18, SUPPL. 1, p. 160-162 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Antisense oligonucleotide suppression of serum amyloid A reduces amyloid deposition in mice with AA amyloidosis

Kluve-Beckerman, B., Hardwick, J., Du, L., Benson, M. D., Monia, B. P., Watt, A., Crooke, R. M. & Mullick, A., Sep 1 2011, In : Amyloid. 18, 3, p. 136-146 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Antisense oligonucleotide therapy for TTR amyloidosis

Benson, M., Pandey, S., Abonour, R., Jazayeri, A., Siwkowski, A., Monia, B. & Kluve-Beckerman, B., Jun 2011, In : Amyloid. 18, SUPPL. 1, p. 60 1 p.

Research output: Contribution to journalArticle

Antisense oligonucleotide therapy for TTR amyloidosis

Benson, M. D., Pandey, S., Witchell, D., Jazayeri, A., Siwkowski, A., Monia, B. & Kluve-Beckerman, B., Jun 2011, In : Amyloid. 18, SUPPL. 1, p. 60 1 p.

Research output: Contribution to journalArticle

4 Scopus citations

A transgenic mouse model of human systemic Apoa2 amyloidosis

Benson, M. D., Kalopissis, A. D., Charbert, M., Liepnieks, J. J. & Kluve-Beckerman, B., Jun 1 2011, In : Amyloid. 18, SUPPL. 1, p. 32-33 2 p.

Research output: Contribution to journalArticle

4 Scopus citations

A transgenic mouse model of human systemic ApoA2 amyloidosis.

Benson, M. D., Kalopissis, A. D., Charbert, M., Liepnieks, J. J. & Kluve-Beckerman, B., Jun 1 2011, In : Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 18 Suppl 1, p. 27-28 2 p.

Research output: Contribution to journalArticle

Bortezomib (Velcade) treatment of AL amyloidosis: Indiana University experience

Abonour, R., Kramer, G., Suvannasankha, A. & Benson, M. D., Jun 2011, In : Amyloid. 18, SUPPL. 1, p. 151 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rapidly progressive AA cardiomyopathy

Ishii, W., Kluve-Beckerman, B., Liepnieks, J. J., Vakili, S. T. & Benson, M. D., Jun 1 2011, In : Amyloid. 18, SUPPL. 1, p. 203-205 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Rapidly progressive AA cardiomyopathy.

Ishii, W., Kluve-Beckerman, B., Liepnieks, J. J., Vakili, S. T. & Benson, M. D., Jun 1 2011, In : Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 18 Suppl 1, p. 198-200 3 p.

Research output: Contribution to journalArticle

Rate of progression of transthyretin amyloidosis

Benson, M. D., Teague, S. D., Kovacs, R., Feigenbaum, H., Jung, J. & Kincaid, J. C., Jul 15 2011, In : American Journal of Cardiology. 108, 2, p. 285-289 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
2010

Hereditary fibrinogen a α-chain amyloidosis: Phenotypic characterization of a systemic disease and the role of liver transplantation

Stangou, A. J., Banner, N. R., Hendry, B. M., Rela, M., Portmann, B., Wendon, J., Monaghan, M., MacCarthy, P., Buxton-Thomas, M., Mathias, C. J., Liepnieks, J. J., O'Grady, J., Heaton, N. D. & Benson, M. D., Apr 15 2010, In : Blood. 115, 15, p. 2998-3007 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

Progression of transthyretin amyloid neuropathy after liver transplantation

Liepnieks, J. J., Zhang, L. Q. & Benson, M. D., Jul 27 2010, In : Neurology. 75, 4, p. 324-327 4 p.

Research output: Contribution to journalArticle

85 Scopus citations

Suppression of choroid plexus transthyretin levels by antisense oligonucleotide treatment

Benson, M. D., Smith, R. A., Hung, G., Kluve-Beckerman, B., Showalter, A. D., Sloop, K. W. & Monia, B. P., Jun 1 2010, In : Amyloid. 17, 2, p. 43-49 7 p.

Research output: Contribution to journalArticle

31 Scopus citations
2009

Biochemical characterisation of amyloid by endomyocardial biopsy

Benson, M. D., Breall, J., Cummings, O. W. & Liepnieks, J. J., Mar 1 2009, In : Amyloid. 16, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

35 Scopus citations
2008

Leukocyte chemotactic factor 2: A novel renal amyloid protein

Benson, M. D., James, S., Scott, K., Liepnieks, J. J. & Kluve-Beckerman, B., Jul 2008, In : Kidney international. 74, 2, p. 218-222 5 p.

Research output: Contribution to journalArticle

92 Scopus citations
2007

A primer of amyloid nomenclature

Westermark, P., Benson, M. D., Buxbaum, J. N., Cohen, A. S., Frangione, B., Ikeda, S. I., Masters, C. L., Merlini, G., Saraiva, M. J. & Sipe, J. D., 2007, In : Amyloid. 14, 3, p. 179-183 5 p.

Research output: Contribution to journalArticle

245 Scopus citations

Cellular events associated with the initial phase of AA amyloidogenesis: Insights from a human monocyte model

Magy, N., Benson, M. D., Liepnieks, J. J. & Kluve-Beckerman, B., Apr 2 2007, In : Amyloid. 14, 1, p. 51-63 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Diagnostic performance of amyloid A protein quantification in fat tissue of patients with clinical AA amyloidosis

Hazenberg, B. P. C., Bijzet, J., Limburg, P. C., Skinner, M., Hawkins, P. N., Butrimiene, I., Livneh, A., Lesnyak, O., Nasonov, E. L., Filipowicz-Sosnowska, A., Gül, A., Merlini, G., Wiland, P., Özdogan, H., Gorevic, P. D., Maïz, H. B., Benson, M. D., Direskeneli, H., Kaarela, K., Garceau, D. & 2 others, Hauck, W. & Van Rijswijk, M. H., Jun 26 2007, In : Amyloid. 14, 2, p. 133-140 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Familial oculoleptomeningeal amyloidosis associated with primary angiitis of the CNS

Dowell, J. D., Fleck, J. D., Vakili, S. T. & Benson, M. D., Jan 1 2007, In : Neurology. 68, 1, p. 77-78 2 p.

Research output: Contribution to journalArticle

8 Scopus citations