Michael Eadon

  • 419 Citations
  • 11 h-Index
20052019
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Publications 2005 2019

  • 419 Citations
  • 11 h-Index
  • 27 Article
  • 2 Chapter
  • 2 Review article
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Article
2019
1 Citation (Scopus)

Analytical validity of a genotyping assay for use with personalized antihypertensive and chronic kidney disease therapy

Collins, K. S., Pratt, V. M., Stansberry, W. M., Medeiros, E. B., Kannegolla, K., Swart, M., Skaar, T., Chapman, A. B., Decker, B., Moorthi, R. & Eadon, M., Jan 1 2019, In : Pharmacogenetics and Genomics. 29, 1, p. 18-22 5 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Antihypertensive Agents
Hypertension
Disease Progression
Kidney Diseases
5 Citations (Scopus)

Bacterial sepsis triggers an antiviral response that causes translation shutdown

Hato, T., Maier, B., Syed, F., Myslinski, J., Zollman, A., Plotkin, Z., Eadon, M. & Dagher, P., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI123284.

Research output: Contribution to journalArticle

Antiviral Agents
Sepsis
Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factors
Kidney

Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial

Fulton, C. R., Zang, Y., Desta, Z., Rosenman, M., Holmes, A., Decker, B., Zhang, Y., T Callaghan, J., Pratt, V. M., Levy, K., Gufford, B. T., Dexter, P., Skaar, T. & Eadon, M., Apr 1 2019, In : Pharmacogenomics. 20, 6, p. 397-408 12 p.

Research output: Contribution to journalArticle

Tramadol
Codeine
Drug Interactions
Cytochrome P-450 CYP2D6
Pharmaceutical Preparations

Increasing Nephrologist Awareness of Symptom Burden in Older Hospitalized End-Stage Renal Disease Patients

Jawed, A., Moe, S. M., Moorthi, R. N., Torke, A. M. & Eadon, M. T., Jan 1 2019, (Accepted/In press) In : American Journal of Nephrology.

Research output: Contribution to journalArticle

Chronic Kidney Failure
Symptom Assessment
Physicians
Pruritus
Palliative Care

RegSNPs-intron: A computational framework for predicting pathogenic impact of intronic single nucleotide variants

Lin, H., Hargreaves, K. A., Li, R., Reiter, J. L., Wang, Y., Mort, M., Cooper, D. N., Zhou, Y., Zhang, C., Eadon, M. T., Dolan, M. E., Ipe, J., Skaar, T. C. & Liu, Y., Nov 28 2019, In : Genome Biology. 20, 1, 254.

Research output: Contribution to journalArticle

Open Access
Introns
introns
Nucleotides
nucleotides
assay
2018
1 Citation (Scopus)

Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness

Fulton, C. R., Swart, M., De Luca, T., Liu, S. N., Collins, K. S., Desta, Z., Gufford, B. T. & Eadon, M. T., Nov 1 2018, In : Journal for Nurse Practitioners. 14, 10, p. 697-704.e1

Research output: Contribution to journalArticle

Precision Medicine
Pharmacogenetics
Patient Care
Nurses
Safety
3 Citations (Scopus)

Pharmacogenomic studies of hypertension: Paving the way for personalized antihypertensive treatment

Eadon, M., Kanuri, S. H. & Chapman, A. B., Jan 3 2018, In : Expert Review of Precision Medicine and Drug Development. 3, 1, p. 33-47 15 p.

Research output: Contribution to journalArticle

Antihypertensive Agents
Hypertension
trandolapril
Pharmacogenetics
Genotype
1 Citation (Scopus)

Quantitative Large-Scale Three-Dimensional Imaging of Human Kidney Biopsies: A Bridge to Precision Medicine in Kidney Disease

Winfree, S., Dagher, P., Dunn, K., Eadon, M., Ferkowicz, M., Barwinska, D., Kelly, K., Sutton, T. & Ashkar (El-Achkar), T., Jun 5 2018, (Accepted/In press) In : Nephron. p. 1-6 6 p.

Research output: Contribution to journalArticle

Precision Medicine
Three-Dimensional Imaging
Kidney Diseases
Kidney
Biopsy
1 Citation (Scopus)

Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes

Gufford, B. T., Robarge, J. D., Eadon, M., Gao, H., Lin, H., Liu, Y., Desta, Z. & Skaar, T., Apr 1 2018, In : Pharmacology Research and Perspectives. 6, 2, e00386.

Research output: Contribution to journalArticle

Xenobiotics
Rifampin
MicroRNAs
Hepatocytes
Midazolam
2017
2 Citations (Scopus)

Clinical and educational impact of pharmacogenomics testing: A case series from the INGENIOUS trial

Pierson, R. C., Gufford, B. T., Desta, Z. & Eadon, M., Jun 1 2017, In : Pharmacogenomics. 18, 9, p. 835-841 7 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Referral and Consultation
Clinical Pharmacology
Genomics
Drug Interactions

Genetic variants contributing to colistin cytotoxicity: Identification of TGIF1 and HOXD10 using a population genomics approach

Eadon, M., Hause, R. J., Stark, A. L., Cheng, Y. H., Wheeler, H. E., Burgess, K. S., Benson, E., Cunningham, P. N., Bacallao, R., Dagher, P., Skaar, T. & Dolan, M. E., Mar 18 2017, In : International Journal of Molecular Sciences. 18, 3, 661.

Research output: Contribution to journalArticle

Colistin
Metagenomics
Cytotoxicity
Proteins
proteins
4 Citations (Scopus)

Healthcare outcomes in undocumented immigrants undergoing two emergency dialysis approaches

Sher, S. J., Aftab, W., Moorthi, R., Moe, S., Weaver, C., Messina, F., Martinez-Hoover, N. M., Anderson, M. & Eadon, M., 2017, In : Clinical Nephrology. 88, 4, p. 181-189 9 p.

Research output: Contribution to journalArticle

Dialysis
Emergencies
Delivery of Health Care
Medicaid
Kidney
3 Citations (Scopus)

Large-scale 3-dimensional quantitative imaging of tissues: State-of-the-art and translational implications

Winfree, S., Ferkowicz, M. J., Dagher, P., Kelly, K., Eadon, M., Sutton, T., Markel, T. A., Yoder, M., Dunn, K. & Ashkar (El-Achkar), T., 2017, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Tissue
Imaging techniques
Research Personnel
Technology
Precision Medicine
10 Citations (Scopus)

Quantitative three-dimensional tissue cytometry to study kidney tissue and resident immune cells

Winfree, S., Khan, S., Micanovic, R., Eadon, M., Kelly, K., Sutton, T., Phillips, C., Dunn, K. & Ashkar (El-Achkar), T., Jul 1 2017, In : Journal of the American Society of Nephrology. 28, 7, p. 2108-2118 11 p.

Research output: Contribution to journalArticle

Kidney
Flow Cytometry
Software
Biopsy
Spatial Analysis
2016
18 Citations (Scopus)

Implementation of a pharmacogenomics consult service to support the INGENIOUS trial

Eadon, M., Desta, Z., Levy, K., Decker, B., Pierson, R., Pratt, V., Callaghan, J., Rosenman, M., Carpenter, J., Holmes, A., Mcdonald, C., Benson, E., Patil, A., Vuppalanchi, R., Gufford, B., Dave, N., Robarge, J., Hyder, M., Haas, D., Kreutz, R. & 3 others, Dexter, P., Skaar, T. & Flockhart, D., 2016, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Safety-net Providers
Credentialing
Pharmacogenetics
Vulnerable Populations
Poverty
16 Citations (Scopus)

Lessons Learned When Introducing Pharmacogenomic Panel Testing into Clinical Practice

Rosenman, M., Decker, B., Levy, K., Holmes, A., Pratt, V. M. & Eadon, M., 2016, (Accepted/In press) In : Value in Health.

Research output: Contribution to journalArticle

Genomics
Pharmacogenetics
Delivery of Health Care
National Human Genome Research Institute (U.S.)
Safety-net Providers
18 Citations (Scopus)

Rifampin regulation of drug transporters gene expression and the association of microRNAs in human hepatocytes

Benson, E., Eadon, M., Desta, Z., Liu, Y., Lin, H., Burgess, K. S., Segar, M. W., Gaedigk, A. & Skaar, T., Apr 26 2016, In : Frontiers in Pharmacology. 7, APR, 111.

Research output: Contribution to journalArticle

Drug and Narcotic Control
Rifampin
MicroRNAs
Hepatocytes
Gene Expression
2015
1 Citation (Scopus)

A two-week regimen of high-dose integrase inhibitors does not cause nephrotoxicity in mice

Eadon, M., Zhang, H., Skaar, T., Hato, T., Dagher, P., Gupta, S. & Desta, Z., Jan 1 2015, In : Antiviral Chemistry and Chemotherapy. 24, 2, p. 72-76 5 p.

Research output: Contribution to journalArticle

Integrase Inhibitors
Creatinine
Kidney
Water
Serum
2014
97 Citations (Scopus)

TNF-mediated damage to glomerular endothelium is an important determinant of acute kidney injury in sepsis

Xu, C., Chang, A., Hack, B. K., Eadon, M., Alper, S. L. & Cunningham, P. N., Jan 2014, In : Kidney International. 85, 1, p. 72-81 10 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Endothelium
Lipopolysaccharides
Sepsis
Albuminuria
11 Citations (Scopus)

Transcriptional profiling reveals that C5a alters microRNA in brain endothelial cells

Eadon, M., Jacob, A., Cunningham, P. N., Quigg, R. J., Garcia, J. G. N. & Alexander, J. J., 2014, In : Immunology. 143, 3, p. 363-373 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Endothelial Cells
Central Nervous System Lupus Vasculitis
Brain
Blood-Brain Barrier
2013
21 Citations (Scopus)

Cell cycle arrest in a model of colistin nephrotoxicity

Eadon, M., Hack, B. K., Alexander, J. J., Xu, C., Dolan, M. E. & Cunningham, P. N., Oct 1 2013, In : Physiological Genomics. 45, 19, p. 877-888 12 p.

Research output: Contribution to journalArticle

Colistin
Cell Cycle Checkpoints
Genes
Blood Urea Nitrogen
Gram-Negative Bacterial Infections
19 Citations (Scopus)

Curcumin alleviates immune-complex-mediated glomerulonephritis in factor-H-deficient mice

Jacob, A., Chaves, L., Eadon, M., Chang, A., Quigg, R. J. & Alexander, J. J., Jul 2013, In : Immunology. 139, 3, p. 328-337 10 p.

Research output: Contribution to journalArticle

Complement Factor H
Curcumin
Glomerulonephritis
Antigen-Antibody Complex
Serum Sickness
11 Citations (Scopus)

Genetic and epigenetic variants contributing to clofarabine cytotoxicity

Eadon, M., Wheeler, H. E., Stark, A. L., Zhang, X., Moen, E. L., Delaney, S. M., Im, H. K., Cunningham, P. N., Zhang, W. & Dolan, E. E., Oct 2013, In : Human Molecular Genetics. 22, 19, p. 4007-4020 14 p.

Research output: Contribution to journalArticle

Epigenomics
Cytosine
Single Nucleotide Polymorphism
HEK293 Cells
Small Interfering RNA
2012

Autologous creatinine clearance in a case of necrotizing fasciitis and anuria

Eadon, M. & Koyner, J. L., Mar 2012, In : American Journal of Nephrology. 35, 3, p. 225-229 5 p.

Research output: Contribution to journalArticle

Anuria
Necrotizing Fasciitis
Creatinine
Acute Kidney Injury
Wounds and Injuries
26 Citations (Scopus)

Endotoxemia alters tight junction gene and protein expression in the kidney

Eadon, M., Hack, B. K., Xu, C., Ko, B., Gary Toback, F. & Cunningham, P. N., Sep 15 2012, In : American Journal of Physiology - Renal Physiology. 303, 6

Research output: Contribution to journalArticle

Occludin
Tight Junction Proteins
Endotoxemia
Tight Junctions
Claudin-3
10 Citations (Scopus)

Whole blood viscosity: Effect of hemodialysis treatment and implications for access patency and vascular disease

Dhar, P., Eadon, M., Hallak, P., Munoz, R. A. & Hammes, M., 2012, In : Clinical Hemorheology and Microcirculation. 51, 4, p. 265-275 11 p.

Research output: Contribution to journalArticle

Blood Viscosity
Vascular Diseases
Renal Dialysis
Cell Aggregation
Dialysis
2005
45 Citations (Scopus)

Ternary complex formation of human immunodeficiency virus type 1 Env, CD4, and chemokine receptor captured as an intermediate of membrane fusion

Mkrtchyan, S. R., Markosyan, R. M., Eadon, M., Moore, J. P., Melikyan, G. B. & Cohen, F. S., Sep 2005, In : Journal of Virology. 79, 17, p. 11161-11169 9 p.

Research output: Contribution to journalArticle

CD4 Antigens
Membrane Fusion
Chemokine Receptors
Human immunodeficiency virus 1
HIV-1